DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nmdar1 and glr-4

DIOPT Version :9

Sequence 1:	NP_730940.1	Gene:	Nmdar1 / 40665	FlyBaseID:	FBgn0010399	Length:	997	Species:	Drosophila melanogaster
Sequence 2:	NP_001254126.1	Gene:	glr-4 / 174258	WormBaseID:	WBGene00001615	Length:	951	Species:	Caenorhabditis elegans

Alignment Length:	998	Identity:	257/998 - (25%)
Similarity:	432/998 - (43%)	Gaps:	185/998 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 CRPLFGLAIVLLVAPIDAAQRHTASDNPSTYNIGGVLS-NSDSEEHFSTTIKHLNFDQQYVPRKV 72
            ||.:.|.:|:|::..|    .::|:|:  .::||.:.: .|.:.||....|...|.:.....:..
Worm     5 CRLVRGFSILLVIFYI----ANSAADD--RFHIGTIANRGSFAYEHLRYAIDRWNTEHGAHTQIK 63

  Fly    73 TYYDKTIRMDKNPIKTVFNVCDKLIENRVYAVVVSHEQTSGDLSPAAVSYTSGFYSIPVIGISS- 136
            ......||.|.|..:   .:|: :::..:.|||:|:|::..|  ...:.....:::||.:.:.|
Worm    64 FSIVSPIRYDNNYEE---RMCE-IMQQGIVAVVLSNEESEQD--SQLIKSMCHYFNIPCLSLQST 122

  Fly   137 --RDAA--------------------FSDKNIHVSFLRTVPPYYHQADVWLEMLSHFAYTKVIII 179
              ||:.                    |.|......||..   |.|.:|  ||.||.....|.|:
Worm   123 SLRDSVSDFVTLLGPSRGAGARATSEFLDSMRWTGFLLA---YQHGSD--LEDLSPLMQYKQIV- 181

  Fly   180 HSSDTDGRAILGRFQTTSQTYYDDVDVRATVELIVEFEPKLESFTEHLIDMKTAQSRVYLMYAST 244
               ||.||.|             .:.:|.......::||.|:     .:..:..|:.:.:...:.
Worm   182 ---DTGGRRI-------------HIKIRRLPNNTDDYEPFLK-----YVKTRLKQTNIIIHSNNI 225

  Fly   245 EDAQVIFRDAGEYNMTGEGHVWIVTEQAL-----FSNNTPD-----GVLGLQL----EHAHSDKG 295
            .....:.:.|...||......::.|...|     |.||...     .:.||||    ....:...
Worm   226 TVLYNLLQQARGLNMAEPPFSYVFTNTDLSLLEDFLNNMYGASFHCNITGLQLVKNDPMMKTQLA 290

  Fly   296 HIRDSVYVLASAIKEMISNETIAEAPKDCG---DSAVNWESGKRL---FQYLKSRNITGETGQVA 354
            ...::|||:..:|..|   ..:..||:...   ||...|..|:.:   .:.||.||..  ||.|.
Worm   291 LTSEAVYVVGMSIYRM---RELGHAPRQSSIMCDSHDIWSDGRIMNEGIRKLKLRNQL--TGDVQ 350

  Fly   355 FDDNGDR---IYAGYDVINIREQQKKHVVGKFS------YDSMRA-KMRMRIN-DSEIIWPGKQR 408
            |..||:|   :|.|...||  .|..|  :|.:|      :||..| :....|: |||.:
Worm   351 FKSNGERDDIMYHGVGRIN--SQFVK--LGNWSEKRGWNFDSRYANRWEFDIDPDSEDL------ 405

  Fly   409 RKPEGIMIPTHLRLLTIEEKPFVYVRRMGDDEFRCEPDERPCPLFNNSDATANEFCCRGYCIDLL 473
               ||:    |||::...|:|||.  :.|::::                        .|:|||||
Worm   406 ---EGL----HLRVVVYLEEPFVI--KTGENQY------------------------EGFCIDLL 437

  Fly   474 IELSKRINFTYDLALSPDGQFGHYILRNNTGAMTLRKEWTGLIGELVNERADMIVAPLTINPERA 538
            .|:::.:.|.|.:....||.:|   :.:.:|      .|.|:||.|....||:.::.:||...||
Worm   438 NEMTQVLKFNYTIIEVQDGTYG---IEDESG------RWNGIIGALQRHEADLSLSAVTITYSRA 493

  Fly   539 EYIEFSKPFKYQGITILEKKPSRSS---TLVSFLQPFSNTLWILVMVSVHVVALVLYLLDRFSPF 600
            |.::|:.||.:.||:||..:.|..:   :|.:||:|.|.|:||.:::|..:|:..:::|.:|||:
Worm   494 EVVDFTLPFMHLGISILLARTSEETDKGSLWTFLEPLSLTVWISLLISYCIVSYSMHILAKFSPY 558

  Fly   601 GRFKLSHSD-------SNEEKALNLSSAVWFAWGVLLNSGIGEGTPRSFSARVLGMVWAGFAMII 658
            ..:.|...|       .|::....:.::.||..|.|:..| .:..||:.:.|::.:||..|..||
Worm   559 EWYNLERIDERDFENIKNQKNQFTVLNSFWFTMGSLMQQG-SDVIPRAAATRLIAVVWWMFTQII 622

  Fly   659 VASYTANLAAFLVLERPKTKLSGINDARLRNTMENLTCATVKGSSVDMYFRRQVEL-SNMYRTME 722
            ::||||.|||||.:||..|.:....|  |.|..:........||::|.:...::.: ..|:..||
Worm   623 ISSYTAQLAAFLTVERMSTPIESTQD--LANQQKIRYGVLKSGSTMDFFRESKIPMYERMWSVME 685

  Fly   723 ANN----YATAEQAIQDVKKGKLMAFIWDSSRLEYEASKDCELVTAGELFGRSGYGIGLQKGSPW 783
            :::    ..::.:.|..||.|. .|::.:||.|||...:||||.:.|.|....||||.|.||||.
Worm   686 SSSPGVFVNSSREGIARVKSGG-YAYMMESSMLEYYLERDCELQSIGGLLDSKGYGIALPKGSPL 749

  Fly   784 TDAVTLAILEFHESGFMEKLDKQWIFHGHVQQNC--ELFEKTPNTLGLKNMAGVFILVGVGIAGG 846
            .|.::..:|:..|...:|.|..:|........:|  ...||..|:.. :|:.|:|.::..|:...
Worm   750 RDILSRTVLQLQERTILEALKNKWWRDRREGPSCGPPPSEKATNSKP-QNIFGIFYVLLTGLIVA 813

  Fly   847 VGLIIIE-VIYKKHQVKKQKRLDIARHAADKWRGT---IEKRKTIRASLAMQRQYNVGLNSTHAP 907
            ..|...| .|..:|:..:.| |.|.....|.:||.   .::|..:|..........|.:::.|.|
Worm   814 FLLACGEYCIESRHEAFRLK-LTIVGKFMDWYRGNSNDSKQRSKLRNMQLDTAGQEVSISTRHDP 877

  Fly   908 GTISLAVDKRRYPRLGQRLGPER 930
            .|       ...|.|..|..|.|
Worm   878 PT-------PPQPALTSRPDPTR 893

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	12..405	CDD:107374	101/447 (23%)
		ANF_receptor	58..371	CDD:279440	78/358 (22%)
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	124/417 (30%)
		HisJ	451..>558	CDD:223904	32/106 (30%)
		Periplasmic_Binding_Protein_Type_2	<516..651	CDD:304360	43/144 (30%)
		Lig_chan	575..838	CDD:278489	84/276 (30%)
		CaM_bdg_C0	854..882	CDD:287524	8/30 (27%)
glr-4	NP_001254126.1	PBP1_iGluR_Kainate	30..385	CDD:107377	88/396 (22%)
		ANF_receptor	45..365	CDD:279440	76/357 (21%)
		Periplasmic_Binding_Protein_Type_2	410..775	CDD:304360	122/403 (30%)
		Lig_chan	533..810	CDD:278489	84/281 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910