DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nmdar1 and nmr-1

DIOPT Version :9

Sequence 1:	NP_730940.1	Gene:	Nmdar1 / 40665	FlyBaseID:	FBgn0010399	Length:	997	Species:	Drosophila melanogaster
Sequence 2:	NP_495033.2	Gene:	nmr-1 / 173929	WormBaseID:	WBGene00003774	Length:	1025	Species:	Caenorhabditis elegans

Alignment Length:	907	Identity:	339/907 - (37%)
Similarity:	486/907 - (53%)	Gaps:	116/907 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 EHFSTTIKHLNFD---QQYVPRKVTYYDKTIRMDKNPIKTVFNVCDKLIENRVYAVVVSHEQTSG 113
            |.|.:|..||..|   ..:|..|..  |..:.:.::      .||.:::.:.:.:|:.|...||.
Worm    49 EVFGSTSYHLGNDTISAAFVDAKSG--DNRLELTQD------IVCSQMLNHSLASVIFSPLLTSS 105

  Fly   114 ----DLSPAAVSYTSGFYSIPVIGISSRDAAFSDKNIHVSFLRTVPPYYHQADVWLEMLSHFAYT 174
                ||..:: :||..||.:||:|:..|||.||.|||:.:|:|...|...:|.|:|.||....|.
Worm   106 SRFIDLVTSS-AYTLSFYKLPVVGVMVRDAEFSKKNIYPTFVRPTAPLSDEAFVFLHMLLSLKYR 169

  Fly   175 KVIIIH-SSDTDGRAILGRFQTTSQTYYDDVDVRATVELIVEFEPKLESFTEHLID-----MKTA 233
            :|:::. ..|.:....:..|:...      |:.:..|:..:|.|     ..|:|.|     .:..
Worm   170 QVVVLSVKRDINADQFVEEFEKRR------VEFKIIVQRYIEVE-----LNENLNDTLAESFEEV 223

  Fly   234 QSRVYLMYASTEDAQVIFRDAGEYNMTGEGHVWIVTEQALFSNNTPDGVLGLQL-EHAHSDKGHI 297
            .|.:.:::|..:||..||.:||:  :||:|.||||:|.|..::|.|:|.||.:| :.|.|   .:
Worm   224 TSNIIVLFAKKDDAVRIFANAGD--LTGKGKVWIVSESAGEAHNVPNGSLGCRLGQTAFS---VL 283

  Fly   298 RDSVYVLASAIKEMISNETIAE--APKDCGDSAVN--WESGKRLFQYLKSRNITGE-----TGQV 353
            |||..:|.||: |.|..|:..:  .|.:|...:|:  |.|       |::..:..|     |.:|
Worm   284 RDSFSILKSAM-ETIFRESKIDIFPPVECDRDSVDAEWNS-------LQAPALLNEICGTSTSRV 340

  Fly   354 AFDDNGDRIYAGYDVINIREQQKKHVVGKFSYDSMRAKMRMRINDSEIIWPGKQRRKPEGIMIPT 418
            .|:|..:||...||:||...::|:  ||....|.      :|:::..|.|.|  ..||..|.:|.
Worm   341 HFNDKCERIGVEYDIINFHMERKQ--VGNMVGDI------LRLDEDSIEWAG--GTKPLEISLPK 395

  Fly   419 HLRLLTIEEKPFVYVRRMGD-----------------DEFRCEPDERPCPL-FNNSDATANEFCC 465
            |||::|:.:.||||...:|.                 |:.........||| ..||   ...|||
Worm   396 HLRVVTVADPPFVYTTPIGSPSQCAELGNTVVEWSIFDKIVVSGPWYSCPLTLENS---TEYFCC 457

  Fly   466 RGYCIDLLIELS-----KRINFTYDLALSPDGQFGHYILRNNTGAMTLRKEWTGLIGELVNERAD 525
            .|..||||..||     ..|:.::..:|..:..:| .:..:.|..:|:    :|:||||..:.||
Worm   458 AGLAIDLLSNLSLPEANNSIDTSFTFSLHLNESYG-VVQASETTGITI----SGVIGELDGDTAD 517

  Fly   526 MIVAPLTINPERAEYIEFSKPFKYQGITILEKKPSRSSTLVSFLQPFSNTLWILVMVSVHVVALV 590
            |.:..:||||||...::|::|:.|.||.||||...|.|.:.|||||..::||..:.:||.:|.|.
Worm   518 MAIGGITINPERERIVDFTEPWLYHGIRILEKNIPRDSPMQSFLQPLQSSLWTALFISVILVGLA 582

  Fly   591 LYLLDRFSPFGRF----KLSHSDSNEE----------KALNLSSAVWFAWGVLLNSGIGEGTPRS 641
            :|.||..|||.||    |....|..:|          :.:|...|:||.||||||||:.|.||||
Worm   583 IYCLDFKSPFERFYQADKEMEQDLKKEFELWIGKDADENVNFGEAMWFVWGVLLNSGVSEKTPRS 647

  Fly   642 FSARVLGMVWAGFAMIIVASYTANLAAFLVLERPKTKLSGINDARLRNTMENLTCATVKGSSVDM 706
            .||||||:||.||.||:||||||||||||||::|:..|:|:.|.||||...|.:..||..|:|..
Worm   648 CSARVLGIVWCGFCMIMVASYTANLAAFLVLDQPEKGLTGVTDPRLRNPSANFSFGTVLNSNVYQ 712

  Fly   707 YFRRQVELSNMYRTMEANNYATAEQAIQDVKKGKLMAFIWDSSRLEYEASKDCELVTAGELFGRS 771
            ||:|.||||:|:|.||.:|...|.:|:..:..|.|.||||||:|||:||::.|||.|.|.|||||
Worm   713 YFKRHVELSSMFRKMEPHNVRRASEAVHSLLNGSLDAFIWDSTRLEFEAARHCELRTRGSLFGRS 777

  Fly   772 GYGIGLQKGSPWTDAVTLAILEFHESGFMEKLDKQWIFHGHVQQNCEL-FEKTPNTLGLKNMAGV 835
            .|||||||.||||..:|.|||...|||.|||||::||..|  ..||.: ..|:|..|||.||..:
Worm   778 AYGIGLQKNSPWTPHITSAILRMSESGVMEKLDQKWIDRG--GPNCVVEAHKSPARLGLVNMKDI 840

  Fly   836 FILVGVGIAGGVGLIIIEVIYKKHQVKKQKRLDIARHAADKWRGTI--EKRKTIRASLAMQR 895
            ||||..|:|.|:.|..:||.|.:....|.:|..|......||....  :||:..|....:.|
Worm   841 FILVSSGVALGIFLSFVEVSYGRRLADKGRRRRIVTRYFQKWHDLTLGKKRRPYRLKYNLDR 902

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	12..405	CDD:107374	109/375 (29%)
		ANF_receptor	58..371	CDD:279440	98/335 (29%)
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	198/437 (45%)
		HisJ	451..>558	CDD:223904	41/112 (37%)
		Periplasmic_Binding_Protein_Type_2	<516..651	CDD:304360	69/148 (47%)
		Lig_chan	575..838	CDD:278489	146/277 (53%)
		CaM_bdg_C0	854..882	CDD:287524	7/29 (24%)
nmr-1	NP_495033.2	Periplasmic_Binding_Protein_type1	19..384	CDD:385651	109/375 (29%)
		PBP2_iGluR_NMDA_Nr1	394..822	CDD:270437	198/437 (45%)
		Lig_chan	567..844	CDD:365843	147/278 (53%)
		LITAF	949..1017	CDD:197841
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156560
Domainoid	1	1.000	261	1.000	Domainoid score	I1054
eggNOG	1	0.900	-	-		E1_KOG4440
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7187
Inparanoid	1	1.050	494	1.000	Inparanoid score	I766
Isobase	1	0.950	-	0	Normalized mean entropy	S4386
OMA	1	1.010	-	-		QHG49285
OrthoDB	1	1.010	-	-		D108757at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		oto17637
orthoMCL	1	0.900	-	-		OOG6_107231
Panther	1	1.100	-	-	LDO	PTHR18966
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4690
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.790