Protein Alignment Nmdar1 and Grin3b

DIOPT Version :10

• Sequence 1: NP_730940.1
• Gene: Nmdar1 / 40665
• FlyBaseID: FBgn0010399
• Length: 997
• Species: Drosophila melanogaster
• Sequence 2: NP_579842.2
• Gene: Grin3b / 170796
• RGDID: 621705
• Length: 1002
• Species: Rattus norvegicus
• Alignment Length: 919
• Identity: 223/919 - (24%)
• Similarity: 378/919 - (41%)
• Gaps: 176/919 - (19%)

  Fly   130 PVIGISSRDAAFSDKNIHVSFLRTVPPYYHQADVWLEMLSHFAYTKVIIIHSSDTDGRA-ILGRF 193
            ||:.:..|:..        :.|....|::.|.| |...|.......|.::.:...:..| :|.|
  Rat   126 PVVSVLRREVR--------TALGAPTPFHLQLD-WASPLETILDVLVSLVRAHAWEDIALVLCR- 180

  Fly   194 QTTSQTYYDDVDVRATVELIVEFEPKLESFTEHLIDMKTAQSR---------------------- 236
                        ||....|:..:........:.::|:....||
  Rat   181 ------------VRDPGSLVTLWTNHASQAPKFVLDLSRLDSRNDSLRAGLALLGALEGGGTPVP 233

  Fly   237 -VYLMYASTEDAQVIFRDAGEYNMTGEGHVWI----VTEQALFSNNTPDGVLGLQLEHAHSDKGH 296
             ..|:..||..|..:...|      ..|..|:    :..:||.:...|.|||.|.....||.:..
  Rat   234 AAVLLGCSTARAHEVLEAA------PPGPQWLLGTPLPAEALPTTGLPPGVLALGETEQHSLEAV 292

  Fly   297 IRDSVYVLASAIKEMI---SNETIAEAPKDCGD--SAVNWESGKRLFQYLKSRNITGETGQVAFD 356
            :.|.|.::|.|:..|.   ....:..|..:|.|  :..:..:|:.|.::|.:.:..|.||.|
  Rat   293 VHDMVELVAQALSSMALVHPERALLPAVVNCDDLKTGGSEATGRTLARFLGNTSFQGRTGAV--- 354

  Fly   357 DNGDRIYAGYDVINIREQQKKHVVGKFSYDSMRAKMRMRI---NDSEI-IWPGKQRRK---PEGI 414
                 ...|...:::....|   |.....|.:.|.....:   .|.:: ..||....:   |.|.
  Rat   355 -----WVTGSSQVHVSRHFK---VWSLRRDPLGAPAWATVGSWQDGQLDFQPGAAALRVPSPSGT 411

  Fly   415 MIPTHLRLLTIEEKPFVYVRRMGDDEFRCEPDERPC----------------PLFNNSDATANEF 463
            .....||::|:.|.|||:.|. .|::.:| |..:.|                .|.|.|.......
  Rat   412 QARPKLRVVTLVEHPFVFTRE-SDEDGQC-PAGQLCLDPGTNDSARLDALFAALVNGSVPRTLRR 474

  Fly   464 CCRGYCIDLLIELSKRINFTYDLALSPDGQFGHYILRNNTGAMTLRKEWTGLIGELVNERADMIV 528
            ||.|||||||..|::.:.|.::|.:..||::|  .||:.        .||||:|:|:..||.|.|
  Rat   475 CCYGYCIDLLERLAEDLAFDFELYIVGDGKYG--ALRDG--------RWTGLVGDLLAGRAHMAV 529

  Fly   529 APLTINPERAEYIEFSKPFKYQGITILEKKPSRSSTLVSFLQPFSNTLWILVMVSVHVVALVLYL 593
            ...:||..|::.::|:.||....:.|:.:....:|.:.:|:.|...::|:.|..::|:.||.|.|
  Rat   530 TSFSINSARSQVVDFTSPFFSTSLGIMVRTRDTASPIGAFMWPLHWSMWVGVFAALHLTALFLTL 594

  Fly   594 LDRFSPFGRFKLSHSDSNEEKALNLSSAVWFAWGVLLNSGIGEGTPRSFSARVLGMVWAGFAMII 658
            .:..||:|   |:....|.....:.|||:...:.:|....:...||:..:.|.|..:||.|.:::
  Rat   595 YEWRSPYG---LTPRGRNRGTVFSYSSALNLCYAILFGRTVSSKTPKCPTGRFLMNLWAIFCLLV 656

  Fly   659 VASYTANLAAFLVLERPKTKLSGINDARLRNTMENLTCATVKGSSVDMYFRRQVELSNMYRTMEA 723
            ::||||||||.:|.::...:||||:|.:|.:..:.....||..||.:.|.:  .....|:..|..
  Rat   657 LSSYTANLAAVMVGDKTFEELSGIHDPKLHHPSQGFRFGTVWESSAEAYIK--ASFPEMHAHMRR 719

  Fly   724 NNYATAEQAIQDVKKG--KLMAFIWDSSRLEYEAS--KDCELVTAGELFGRSGYGIGLQKGSPWT 784
            ::..|....:..:...  ||.|||.|.|.|:||.|  .||:|:|.|:.|...||||||.:.||.|
  Rat   720 HSAPTTPHGVAMLTSDPPKLNAFIMDKSLLDYEVSIDADCKLLTVGKPFAIEGYGIGLPQNSPLT 784

  Fly   785 DAVTLAILEFHESGFMEKLDKQWIFHGHVQQNCELFEKTPN-TLGLKNMAGVFILVGVGIAGGVG 848
            ..::..|..:..|||::.|..:|  :..|.....:|..|.. .:|:.:.:|:|:|:.:|:...:.
  Rat   785 SNLSEFISRYKSSGFIDLLHDKW--YKMVPCGKRVFAVTETLQMGVYHFSGLFVLLCLGLGSALL 847

  Fly   849 LIIIEVIYKK---HQVKKQKRLDIARHAADKWRGTIEKRKTIRASLAMQRQYNVGLNSTHAPGTI 910
            ..:.|.::.:   .::::..:|....|.:.|                :.|..|.|
  Rat   848 TSLGEHVFYRLVLPRIRRGNKLQYWLHTSQK----------------IHRALNTG---------- 886

  Fly   911 SLAVDKRRYPRLGQ--RLGPERAWPGD-------AADVLRIRRPYEL----------GNPGQSPK 956
                     |..||  |...||:.|.|       |....|:||..|.          |..|....
  Rat   887 ---------PPEGQQERAEQERSGPKDELPATDGAGRWRRVRRAVERERRVRFLLEPGEAGGDRP 942

  Fly   957 VMAANQPGM 965
            .:.:|.||:
  Rat   943 WLCSNGPGL 951

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	37..405	CDD:380602	56/311 (18%)
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	131/420 (31%)
		CaM_bdg_C0	854..882	CDD:402271	3/30 (10%)
Grin3b	NP_579842.2	PBP1_iGluR_NMDA_NR3	19..401	CDD:380600	58/313 (19%)
		PBP2_iGluR_NMDA_Nr3	414..808	CDD:270438	130/412 (32%)
		Lig_chan	574..841	CDD:459656	85/273 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	882..910		10/46 (22%)
		Involved in the trafficking and surface expression of NMDARs. /evidence=ECO:0000250|UniProtKB:Q91ZU9	951..984		0/1 (0%)