DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nmdar1 and Grin3b

DIOPT Version :9

Sequence 1:	NP_730940.1	Gene:	Nmdar1 / 40665	FlyBaseID:	FBgn0010399	Length:	997	Species:	Drosophila melanogaster
Sequence 2:	NP_579842.2	Gene:	Grin3b / 170796	RGDID:	621705	Length:	1002	Species:	Rattus norvegicus

Alignment Length:	919	Identity:	223/919 - (24%)
Similarity:	378/919 - (41%)	Gaps:	176/919 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 PVIGISSRDAAFSDKNIHVSFLRTVPPYYHQADVWLEMLSHFAYTKVIIIHSSDTDGRA-ILGRF 193
            ||:.:..|:..        :.|....|::.|.| |...|.......|.::.:...:..| :|.|
  Rat   126 PVVSVLRREVR--------TALGAPTPFHLQLD-WASPLETILDVLVSLVRAHAWEDIALVLCR- 180

  Fly   194 QTTSQTYYDDVDVRATVELIVEFEPKLESFTEHLIDMKTAQSR---------------------- 236
                        ||....|:..:........:.::|:....||
  Rat   181 ------------VRDPGSLVTLWTNHASQAPKFVLDLSRLDSRNDSLRAGLALLGALEGGGTPVP 233

  Fly   237 -VYLMYASTEDAQVIFRDAGEYNMTGEGHVWI----VTEQALFSNNTPDGVLGLQLEHAHSDKGH 296
             ..|:..||..|..:...|      ..|..|:    :..:||.:...|.|||.|.....||.:..
  Rat   234 AAVLLGCSTARAHEVLEAA------PPGPQWLLGTPLPAEALPTTGLPPGVLALGETEQHSLEAV 292

  Fly   297 IRDSVYVLASAIKEMI---SNETIAEAPKDCGD--SAVNWESGKRLFQYLKSRNITGETGQVAFD 356
            :.|.|.::|.|:..|.   ....:..|..:|.|  :..:..:|:.|.::|.:.:..|.||.|
  Rat   293 VHDMVELVAQALSSMALVHPERALLPAVVNCDDLKTGGSEATGRTLARFLGNTSFQGRTGAV--- 354

  Fly   357 DNGDRIYAGYDVINIREQQKKHVVGKFSYDSMRAKMRMRI---NDSEI-IWPGKQRRK---PEGI 414
                 ...|...:::....|   |.....|.:.|.....:   .|.:: ..||....:   |.|.
  Rat   355 -----WVTGSSQVHVSRHFK---VWSLRRDPLGAPAWATVGSWQDGQLDFQPGAAALRVPSPSGT 411

  Fly   415 MIPTHLRLLTIEEKPFVYVRRMGDDEFRCEPDERPC----------------PLFNNSDATANEF 463
            .....||::|:.|.|||:.|. .|::.:| |..:.|                .|.|.|.......
  Rat   412 QARPKLRVVTLVEHPFVFTRE-SDEDGQC-PAGQLCLDPGTNDSARLDALFAALVNGSVPRTLRR 474

  Fly   464 CCRGYCIDLLIELSKRINFTYDLALSPDGQFGHYILRNNTGAMTLRKEWTGLIGELVNERADMIV 528
            ||.|||||||..|::.:.|.::|.:..||::|  .||:.        .||||:|:|:..||.|.|
  Rat   475 CCYGYCIDLLERLAEDLAFDFELYIVGDGKYG--ALRDG--------RWTGLVGDLLAGRAHMAV 529

  Fly   529 APLTINPERAEYIEFSKPFKYQGITILEKKPSRSSTLVSFLQPFSNTLWILVMVSVHVVALVLYL 593
            ...:||..|::.::|:.||....:.|:.:....:|.:.:|:.|...::|:.|..::|:.||.|.|
  Rat   530 TSFSINSARSQVVDFTSPFFSTSLGIMVRTRDTASPIGAFMWPLHWSMWVGVFAALHLTALFLTL 594

  Fly   594 LDRFSPFGRFKLSHSDSNEEKALNLSSAVWFAWGVLLNSGIGEGTPRSFSARVLGMVWAGFAMII 658
            .:..||:|   |:....|.....:.|||:...:.:|....:...||:..:.|.|..:||.|.:::
  Rat   595 YEWRSPYG---LTPRGRNRGTVFSYSSALNLCYAILFGRTVSSKTPKCPTGRFLMNLWAIFCLLV 656

  Fly   659 VASYTANLAAFLVLERPKTKLSGINDARLRNTMENLTCATVKGSSVDMYFRRQVELSNMYRTMEA 723
            ::||||||||.:|.::...:||||:|.:|.:..:.....||..||.:.|.:  .....|:..|..
  Rat   657 LSSYTANLAAVMVGDKTFEELSGIHDPKLHHPSQGFRFGTVWESSAEAYIK--ASFPEMHAHMRR 719

  Fly   724 NNYATAEQAIQDVKKG--KLMAFIWDSSRLEYEAS--KDCELVTAGELFGRSGYGIGLQKGSPWT 784
            ::..|....:..:...  ||.|||.|.|.|:||.|  .||:|:|.|:.|...||||||.:.||.|
  Rat   720 HSAPTTPHGVAMLTSDPPKLNAFIMDKSLLDYEVSIDADCKLLTVGKPFAIEGYGIGLPQNSPLT 784

  Fly   785 DAVTLAILEFHESGFMEKLDKQWIFHGHVQQNCELFEKTPN-TLGLKNMAGVFILVGVGIAGGVG 848
            ..::..|..:..|||::.|..:|  :..|.....:|..|.. .:|:.:.:|:|:|:.:|:...:.
  Rat   785 SNLSEFISRYKSSGFIDLLHDKW--YKMVPCGKRVFAVTETLQMGVYHFSGLFVLLCLGLGSALL 847

  Fly   849 LIIIEVIYKK---HQVKKQKRLDIARHAADKWRGTIEKRKTIRASLAMQRQYNVGLNSTHAPGTI 910
            ..:.|.::.:   .::::..:|....|.:.|                :.|..|.|
  Rat   848 TSLGEHVFYRLVLPRIRRGNKLQYWLHTSQK----------------IHRALNTG---------- 886

  Fly   911 SLAVDKRRYPRLGQ--RLGPERAWPGD-------AADVLRIRRPYEL----------GNPGQSPK 956
                     |..||  |...||:.|.|       |....|:||..|.          |..|....
  Rat   887 ---------PPEGQQERAEQERSGPKDELPATDGAGRWRRVRRAVERERRVRFLLEPGEAGGDRP 942

  Fly   957 VMAANQPGM 965
            .:.:|.||:
  Rat   943 WLCSNGPGL 951

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	12..405	CDD:107374	56/311 (18%)
		ANF_receptor	58..371	CDD:279440	51/273 (19%)
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	131/420 (31%)
		HisJ	451..>558	CDD:223904	37/106 (35%)
		Periplasmic_Binding_Protein_Type_2	<516..651	CDD:304360	36/134 (27%)
		Lig_chan	575..838	CDD:278489	84/267 (31%)
		CaM_bdg_C0	854..882	CDD:287524	3/30 (10%)
Grin3b	NP_579842.2	PBP1_iGluR_NMDA_NR3	21..405	CDD:107372	58/317 (18%)
		PBP2_iGluR_NMDA_Nr3	414..808	CDD:270438	130/412 (32%)
		Lig_chan	576..842	CDD:278489	85/272 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	882..910		10/46 (22%)
		Involved in the trafficking and surface expression of NMDARs. /evidence=ECO:0000250	951..984		0/1 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910