Protein Alignment Nmdar1 and gria3a

DIOPT Version :10

• Sequence 1: NP_730940.1
• Gene: Nmdar1 / 40665
• FlyBaseID: FBgn0010399
• Length: 997
• Species: Drosophila melanogaster
• Sequence 2: XP_073805840.1
• Gene: gria3a / 170452
• ZFINID: ZDB-GENE-020125-5
• Length: 940
• Species: Danio rerio
• Alignment Length: 1010
• Identity: 255/1010 - (25%)
• Similarity: 407/1010 - (40%)
• Gaps: 286/1010 - (28%)

  Fly    31 TASDNPSTYNIGGVLSNSDSEEH--FSTTIKHLNFDQQYVPRKVTYYDKTIRMDKNPIKTVFNVC 93
            |.:..|:..||||:...|..:||  |...::..|.:|              .:.:.|....:||
Zfish    19 TQAGFPNQINIGGLFMRSTVQEHSAFRFAVQLYNTNQ--------------NITEKPFHLNYNV- 68

  Fly    94 DKLIENRVYAVVVSHEQTSGDLSPAAVSYTSGFYSIPVIGISSRDAAFSDKN-----------IH 147
            |.|..:..::  |:|...|        .::.|.|:|         ..|.|:.           :|
Zfish    69 DNLESSNSFS--VTHAFCS--------QFSRGVYAI---------FGFYDRRSMNTLTSFCGALH 114

  Fly   148 VSFLRTVPPYYHQADV-------------WLEMLSHFAYTKVIIIHSSDTD----------GRAI 189
            .||:  .|.:....||             .|.:|:|:.:.|.:.::  |||          ..|:
Zfish   115 TSFI--TPSFPTDTDVQFVLQMRPSLRGALLSLLAHYKWEKFVYLY--DTDRGFSILQAIMESAV 175

  Fly   190 LGRFQTTSQTYYDDVDVRATVELIVEFEPKLESFTEHLIDMKTAQSRVYLMYASTEDAQVIFRDA 254
            :..:|.|:::..:.||......:|.|.:.:.|.  ..|||.:..:....|       .||:.  |
Zfish   176 MNNWQVTARSVGNIVDPLEYRRIIEEMDRRQEK--RFLIDCEVERINSIL-------EQVVI--A 229

  Fly   255 GEYNMTGEGHVWIVTEQALFSNNTPD-------GVLGLQL---------------------EHAH 291
            |:   ...|:.:|:.... |:|.:.|       .:.|.|:                     |...
Zfish   230 GK---NSRGYHYILANLG-FTNMSLDKVFSGGANITGFQIINPDSPIVQQFLQRWERLDEREFPE 290

  Fly   292 SDKGHIR-------DSVYVLASAIKEM------ISNETIAEAPKDC-GDSAVNWESGKRLFQYLK 342
            |....::       |::.|:|.|.:.:      ||....|   .|| .:.||.|..|..:.:.||
Zfish   291 SRSSPLKYTSALTHDAILVIAEAFRYLRRQRVDISRRGSA---GDCLANPAVPWSQGIDIERALK 352

  Fly   343 SRNITGETGQVAFDDNGDRIYAGYDVINIREQQKKHVVGKFSYDSMRAKMRMRINDSE-IIWPGK 406
            ...:.|.||.:.||..|.|.....||.    :.|.....|..|          .|:.| .::..:
Zfish   353 MVQVQGMTGNIQFDSFGRRSNYTVDVY----EMKPGGARKIGY----------WNEFEKFVYIVE 403

  Fly   407 QRRKPEGIMIPTH-LRLLTIEEKPFV-----YVRRMGDDEFRCEPDERPCPLFNNSDATANEFCC 465
            |:...|...:... :.:.||.|.|:|     |::..|:|.:
Zfish   404 QQVTNESSSVENRTIVVTTIMEAPYVMYKRNYMQLEGNDRY------------------------ 444

  Fly   466 RGYCIDLLIELSKRINFTYDLALSPDGQFGHYILRNNTGAMTLRKEWTGLIGELVNERADMIVAP 530
            .|||:||..|::|.:...|.|::..||::|   .|:..     .|.|.|::||||..|||:.|||
Zfish   445 EGYCVDLASEIAKHVGIKYKLSIVADGKYG---ARDPE-----TKTWNGMVGELVYGRADIAVAP 501

  Fly   531 LTINPERAEYIEFSKPFKYQGITILEKKPSRSST-LVSFLQPFSNTLWILVMVSVHVVALVLYLL 594
            |||...|.|.|:|||||...||:|:.|||.:|.. :.|||.|.:..:|:.::.:...|::||:|:
Zfish   502 LTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLV 566

  Fly   595 DRFSPFGRFKLSHSDSNEE-----------KALNLSSAVWFAWGVLLNSGIGEGTPRSFSARVLG 648
            .||||:.    .|.|.|||           ....:.:::||:.|..:..|. :.:|||.|.|::|
Zfish   567 SRFSPYE----WHLDDNEETKDPQTPPDPPNDFGIFNSLWFSLGAFMQQGC-DISPRSLSGRIVG 626

  Fly   649 MVWAGFAMIIVASYTANLAAFLVLERPKTKLSGINDARLRNTMENLTCATVKGSSVDMYFRRQ-- 711
            .||..|.:||::||||||||||.:||   .:|.|..|........:...|:...|...:|||.
Zfish   627 GVWWFFTLIIISSYTANLAAFLTVER---MVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKI 688

  Fly   712 VELSNMYRTMEANN----YATAEQAIQDVKKGK-LMAFIWDSSRLEY-EASKDCELVTAGELFGR 770
            .....|:..|::..    ..|....:..|:|.| ..||:.:|:..|| |..|.|:.:..|.....
Zfish   689 AVYEKMWSYMKSAEPSVFVKTTPDGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDS 753

  Fly   771 SGYGIGLQKGSPWTDAVTLAILEFHESGFMEKLDKQWIF-------------HGHVQQNCELFE- 821
            .|||:...|||....||.||:|:.:|.|.::||..:|.:             |   :..|....
Zfish   754 KGYGVATPKGSALRSAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKH---KARCPTVSL 815

  Fly   822 -----KTP---------------------------------------NTLGLKNMAGVFILVGVG 842
                 :||                                       :.|.|.|:||||.:
Zfish   816 WLTDIRTPVNLAVLKLSEQGILDKLKNKWWYDKGECGTKDSGSKDKTSALSLSNVAGVFYI---- 876

  Fly   843 IAGGVGL----IIIEVIYKKHQVKKQKRLDIARHA 873
            :.||:||    .::|..||.||  :.|||.:|::|
Zfish   877 LVGGLGLAMTVALVEFCYKSHQ--ETKRLKLAKNA 909

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	37..405	CDD:380602	90/446 (20%)
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	137/439 (31%)
		CaM_bdg_C0	854..882	CDD:402271	9/20 (45%)
gria3a	XP_073805840.1	None