DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nmdar1 and Grin2b

DIOPT Version :9

Sequence 1:	NP_730940.1	Gene:	Nmdar1 / 40665	FlyBaseID:	FBgn0010399	Length:	997	Species:	Drosophila melanogaster
Sequence 2:	NP_001350679.1	Gene:	Grin2b / 14812	MGIID:	95821	Length:	1482	Species:	Mus musculus

Alignment Length:	970	Identity:	278/970 - (28%)
Similarity:	456/970 - (47%)	Gaps:	153/970 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 CRPLFGLAIVLLVAPIDAAQRHTASDNPSTYNIGGVLSNSDSE-----EHFSTTIKHLNFDQQYV 68
            |.|.|.|  ||.|..:..::..:....|| ..|..:|..:..|     .|......||:    .|
Mouse     8 CSPKFWL--VLAVLAVSGSKARSQKSAPS-IGIAVILVGTSDEVAIKDAHEKDDFHHLS----VV 65

  Fly    69 PRKVTYYDKTIRMDK-NPIKTVFNVCDKLIENRVYAVVVSHEQTSGDLSPAAVSYTSGFYSIPVI 132
            ||.     :.:.|:: :|...:..:||.:.:.::..||.: :.|..:.....:.:.|.....|::
Mouse    66 PRV-----ELVAMNETDPKSIITRICDLMSDRKIQGVVFA-DDTDQEAIAQILDFISAQTLTPIL 124

  Fly   133 GI-SSRDAAFSDKNIHVSFLRTVPPYYHQADVWLEMLSHFAYTKVIIIHSSDTDGRAILGRFQTT 196
            || .......:||:....|.:..|....||.|.|.::..:.:....|:               ||
Mouse   125 GIHGGSSMIMADKDESSMFFQFGPSIEQQASVMLNIMEEYDWYIFSIV---------------TT 174

  Fly   197 SQTYYDDV--DVRATVE-LIVEFEPKLESFTEHLIDM-------------KTAQSRVYLMYASTE 245
            ....|.|.  .:|:|:| ..|.:|  ||...  |:||             |..||.:.|:|.:.|
Mouse   175 YFPGYQDFVNKIRSTIENSFVGWE--LEEVL--LLDMSLDDGDSKIQNQLKKLQSPIILLYCTKE 235

  Fly   246 DAQVIFRDAGEYNMTGEGHVWIVTEQALFSNNT-----PDGVLGLQL-EHAHSDKGHIRDSVYVL 304
            :|..||..|....:||.|:.|||........:|     |.|::.:.. |..:.....:||.:.::
Mouse   236 EATYIFEVANSVGLTGYGYTWIVPSLVAGDTDTVPSEFPTGLISVSYDEWDYGLPARVRDGIAII 300

  Fly   305 ASAIKEMISNETIAEAPKDCGDSAVNWESGKRLFQ------YLKSRNITGETGQVAFDDNGDRIY 363
            .:|..:|:|..:....||   .|..|... ||::|      ||  .|:|.|...::|.::|.:::
Mouse   301 TTAASDMLSEHSFIPEPK---SSCYNTHE-KRIYQSNMLNRYL--INVTFEGRNLSFSEDGYQMH 359

  Fly   364 AGYDVINIREQQKKHVVGKFSYDSMRAKMRMRINDSEIIWPGKQRRKPEGIMIPT------HLRL 422
            ....:|.:.:::|...|||:...|::.|.        .:||   |..||     |      ||.:
Mouse   360 PKLVIILLNKERKWERVGKWKDKSLQMKY--------YVWP---RMCPE-----TEEQEDDHLSI 408

  Fly   423 LTIEEKPFVYVRRMGDDEFRCEPDERPCPLFNNSDATANE------FCCRGYCIDLLIELSKRIN 481
            :|:||.|||.|..:......|..:..||.....|:...:|      .||:|:|||:|.::||.:.
Mouse   409 VTLEEAPFVIVESVDPLSGTCMRNTVPCQKRIISENKTDEEPGYIKKCCKGFCIDILKKISKSVK 473

  Fly   482 FTYDLALSPDGQFGHYILRNNTGAMTLRKEWTGLIGELVNERADMIVAPLTINPERAEYIEFSKP 546
            |||||.|..:|:.|..|  |.|        |.|:|||:|.:||.|.|..||||.||:|.::||.|
Mouse   474 FTYDLYLVTNGKHGKKI--NGT--------WNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVP 528

  Fly   547 FKYQGITILEKKPSRSSTLVS---FLQPFSNTLWILVMVSVHVV-ALVLYLLDRFSPFGRFKLSH 607
            |...||:::   .|||:..||   ||:|||..:|:::.|.:.:| |:.:::.:.|||.| :....
Mouse   529 FIETGISVM---VSRSNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVG-YNRCL 589

  Fly   608 SDSNEE--KALNLSSAVWFAWGVLLNSGIGEGTPRSFSARVLGMVWAGFAMIIVASYTANLAAFL 670
            :|..|.  .:..:..|:|..||::.|:.:....|:..:::::..|||.||:|.:||||||||||:
Mouse   590 ADGREPGGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFM 654

  Fly   671 VLERPKTKLSGINDARLRNTME---NLTCATVKGSSVDMYFRRQVELSNMYRTMEANNYATAEQA 732
            :.|....::||::|.:.:...:   .....||...|.:...|.  ..:.|:..|...|....:.|
Mouse   655 IQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRN--NYAEMHAYMGKFNQRGVDDA 717

  Fly   733 IQDVKKGKLMAFIWDSSRLEYEASKD--CELVT--AGELFGRSGYGIGLQKGSPWTDAVTLAILE 793
            :..:|.|||.|||:|::.|.|.|.:|  |:|||  :|::|..:||||.:||.|.|...|.||||:
Mouse   718 LLSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQKDSGWKRQVDLAILQ 782

  Fly   794 FHESGFMEKLDKQWIFHG--HVQQNCELFEKTPNTLGLKNMAGVFILVGVGIAGGVGLIIIEVIY 856
            ....|.||:|:..|: .|  |.::|    |...:.|.:.||||||.::|..:|..:...|.|.::
Mouse   783 LFGDGEMEELEALWL-TGICHNEKN----EVMSSQLDIDNMAGVFYMLGAAMALSLITFICEHLF 842

  Fly   857 K---KH------QVKKQKRLDIARHAADKWRG-TIEKRKTIRASLAMQRQYNVGLNSTHA 906
            .   :|      ..|......|:|.......| .||:|:::..|      ....:|:||:
Mouse   843 YWQFRHCFMGVCSGKPGMVFSISRGIYSCIHGVAIEERQSVMNS------PTATMNNTHS 896

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	12..405	CDD:107374	97/427 (23%)
		ANF_receptor	58..371	CDD:279440	79/342 (23%)
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	151/427 (35%)
		HisJ	451..>558	CDD:223904	45/112 (40%)
		Periplasmic_Binding_Protein_Type_2	<516..651	CDD:304360	47/140 (34%)
		Lig_chan	575..838	CDD:278489	91/274 (33%)
		CaM_bdg_C0	854..882	CDD:287524	5/37 (14%)
Grin2b	NP_001350679.1	PBP1_iGluR_NMDA_NR2	33..388	CDD:380601	90/390 (23%)
		PBP2_iGluR_NMDA_Nr2	403..803	CDD:270436	148/416 (36%)
		NMDAR2_C	840..1482	CDD:402274	12/63 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910