DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nmdar1 and Grik5

DIOPT Version :9

Sequence 1:	NP_730940.1	Gene:	Nmdar1 / 40665	FlyBaseID:	FBgn0010399	Length:	997	Species:	Drosophila melanogaster
Sequence 2:	XP_030098003.1	Gene:	Grik5 / 14809	MGIID:	95818	Length:	1003	Species:	Mus musculus

Alignment Length:	1061	Identity:	258/1061 - (24%)
Similarity:	430/1061 - (40%)	Gaps:	229/1061 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 IGGVLSNSDSEEHFSTTIKHLNFDQQYVPRKVTYYDKTIRMDKNPIKTVFNVCDKLIENRVYAVV 105
            |.|:: ...::......|..|..|.||                   :|...:| :::...|.:|:
Mouse    51 INGII-EVPAKARVEVDIFELQRDSQY-------------------ETTDTMC-QILPKGVVSVL 94

  Fly   106 VSHEQTSGDLSPAAVSYTSGFYSIPVIGISSRDAAFSDKNIHVSFLR--TVPPYYHQADVWL--- 165
               ..:|...|.:.||:..|...||.|.:...:..      .:.:||  :|..|....||.|
Mouse    95 ---GPSSSPASASTVSHICGEKEIPHIKVGPEETP------RLQYLRFASVSLYPSNEDVSLAVS 150

  Fly   166 EMLSHFAYTKVIIIHSS-------DTDGRAILGRFQTTSQTYYDDVDVRATVELIVEF-EPKLES 222
            .:|..|.|....:|.:.       :...|..|...:|.|....|  |.|....|:.|. :.|:.:
Mouse   151 RILKSFNYPSASLICAKAECLLRLEELVRGFLISKETLSVRMLD--DSRDPTPLLKEIRDDKVST 213

  Fly   223 FTEHLIDMKTAQSRVYLMYASTEDAQVIF-----------RDAGEYNMTGEGHVWIVTEQ----- 271
            .   :||...:.|.:.|..:....:.:.|           ..|.|..||...:.:|:|..
Mouse   214 I---IIDANASISHLVLRLSLNLSSPLGFPRSLPLGLSCVLQASELGMTSAFYKYILTTMDFPIL 275

  Fly   272 ---------------ALFSNN---TPDGVLGLQLEHAHSDKGH-----------IRDSVYVLASA 307
                           ::|:.:   .|:.|..|.:....:.:..           :.|:|:|:.||
Mouse   276 HLDGIVEDSSNILGFSMFNTSHPFYPEFVRSLNMSWRENCEASTYPGPALSAALMFDAVHVVVSA 340

  Fly   308 IKEMISNETIAEAPKDCGDSAVNWESGKRLFQYLKSRNITGETGQVAFDDNGDRIYAGYDVINIR 372
            ::|:..::.|...|..| .||..|..|..|..||:.....|.||:|.|:..|.|  ..|.:..:.
Mouse   341 VRELNRSQEIGVKPLAC-TSANIWPHGTSLMNYLRMVEYDGLTGRVEFNSKGQR--TNYTLRILE 402

  Fly   373 EQQKKH-VVGKFSYDSMRAKMR---MRINDSEIIWPGKQRRKPEGIMIPTHLRLLTIEEKPFVYV 433
            :.::.| .:|.: |.:....|.   :.||.|:             .:....|.:.||.|.|:|.
Mouse   403 KSRQGHREIGVW-YSNRTLAMNATTLDINLSQ-------------TLANKTLVVTTILENPYVM- 452

  Fly   434 RRMGDDEFRCEPDERPCPLFNNSDATANEFCCRGYCIDLLIELSKRINFTYDLALSPDGQFGHYI 498
                         .||     |..|.:......|:|:|:|.||::.:.|.|.|.|..||.:
Mouse   453 -------------RRP-----NFQALSGNERFEGFCVDMLRELAELLRFRYRLRLVEDGLY---- 495

  Fly   499 LRNNTGAMTLRKEWTGLIGELVN-ERADMIVAPLTINPERAEYIEFSKPFKYQGITILEK-KPSR 561
                 ||......|||::|||:| ::||:.||..||..||.:.|:|||||...||:||.: ...|
Mouse   496 -----GAPEPNGSWTGMVGELINRQKADLAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGR 555

  Fly   562 SSTLVSFLQPFSNTLWILVMVSVHVVALVLYLLDRFSPFGRFK----LSHSDSNEEKALNLSSAV 622
            .....|||.|||..:|:.::::...|:.||:|..|.||:..:.    |.......|....|.:::
Mouse   556 KPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARPHILENQYTLGNSL 620

  Fly   623 WFAWGVLLNSGIGEGTPRSFSARVLGMVWAGFAMIIVASYTANLAAFLVLERPKTKLSGINDARL 687
            ||..|..:..| .|..||:.|.|.:..||..|.:||::||||||||||.::|.:..:...:|..
Mouse   621 WFPVGGFMQQG-SEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLA- 683

  Fly   688 RNTMENLTCATVKGSSVDMYFRRQVELSNMYRTMEAN-NYATAEQA---IQDVKKG------KLM 742
              ...|:...|:...|...:|:     ::.|:|.:.. ||..::|.   ::..::|      ...
Mouse   684 --DQTNIEYGTIHAGSTMTFFQ-----NSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNSRY 741

  Fly   743 AFIWDSSRLEYEASKDCELVTAGELFGRSGYGIGLQKGSPWTDAVTLAILEFHESGFMEKLDKQW 807
            ||:.:|:..||....:|.|...|.|....|||||:..|||:.|.:|||||:..|:..:|.|.::|
Mouse   742 AFLLESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKRKW 806

  Fly   808 IFHGHVQQNCELFEKTPNTLGLKNMAGVFILVGVGIAGGVGLIIIEVIYKKHQVKKQKRLDIARH 872
            ...|...:.   .:.....||::|:.|:|:::..|:...|.:.::|.|:...:..:.:.:.:.:.
Mouse   807 WEGGRCPKE---EDHRAKGLGMENIGGIFVVLICGLIIAVFVAVMEFIWSTRRSAESEEVSVCQE 868

  Fly   873 AADKWRGTIEKRKTIRASLAMQRQYNVGLNSTHAPGTISLAVDKRRYPRL--------------G 923
            ...:.|..:..|||.|:    :|:...|     .|....|::...|..||              |
Mouse   869 MLQELRHAVSCRKTSRS----RRRRRPG-----GPSRALLSLRAVREMRLSNGKLYSAGAGGDAG 924

  Fly   924 QRLGPERAWPGDAADVLRIRRPYELGNPG-------QSP-------------KVMAANQPGMPMP 968
            ...||:|.                |.:||       |:|             ::.|....|...|
Mouse   925 AHGGPQRL----------------LDDPGPPGGPRPQAPTPCTHVRVCQECRRIQALRASGAGAP 973

  Fly   969 MLGKTRPQQSVLPPRYSPGYT 989
            ..|...|.::..|||..||.|
Mouse   974 PRGLGTPAEATSPPRPRPGPT 994

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	12..405	CDD:107374	86/425 (20%)
		ANF_receptor	58..371	CDD:279440	77/370 (21%)
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	131/416 (31%)
		HisJ	451..>558	CDD:223904	41/108 (38%)
		Periplasmic_Binding_Protein_Type_2	<516..651	CDD:304360	49/140 (35%)
		Lig_chan	575..838	CDD:278489	80/276 (29%)
		CaM_bdg_C0	854..882	CDD:287524	2/27 (7%)
Grik5	XP_030098003.1	PBP1_iGluR_Kainate_KA1_2	23..424	CDD:380616	83/411 (20%)
Grik5	XP_030098003.1	Periplasmic_Binding_Protein_Type_2	437..808	CDD:419667	130/407 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910