Protein Alignment Nmdar1 and Grik1

DIOPT Version :10

• Sequence 1: NP_730940.1
• Gene: Nmdar1 / 40665
• FlyBaseID: FBgn0010399
• Length: 997
• Species: Drosophila melanogaster
• Sequence 2: NP_001391957.1
• Gene: Grik1 / 14805
• MGIID: 95814
• Length: 949
• Species: Mus musculus
• Alignment Length: 944
• Identity: 239/944 - (25%)
• Similarity: 415/944 - (43%)
• Gaps: 140/944 - (14%)

  Fly    35 NPSTYNIGGVLSNSDSEE------HFSTTIKHLNFDQQYVPRKVTYYD-KTIRMDKNPIKTVFNV 92
            :|....|||:....::|.      .|...:..:|.::..:|.....|| :.|.: .:..:.....
Mouse    33 SPQVLRIGGIFETVENEPVNVEELAFKFAVTSINRNRTLMPNTTLTYDIQRINL-FDSFEASRRA 96

  Fly    93 CDKLIENRVYAVVVSHEQTSGDLSPAAVSYTSGFYSIPVIGISSRDAAFSDKNIHVSFLRTVPPY 157
            ||:|..........||..     |.:||........:|.|....:..:..::::.  ::...|.|
Mouse    97 CDQLALGVAALFGPSHSS-----SVSAVQSICNALEVPHIQTRWKHPSVDNRDLF--YINLYPDY 154

  Fly   158 YHQADVWLEMLSHFAYTKVIIIHSSDTDGRAILGRFQTTSQTYYDDVDVRATVELIVEFEPKLES 222
            ...:...|:::.::.:..|.::: .|:.|...|.........|...:.:|.......:.:|.|:
Mouse   155 AAISRAVLDLVLYYNWKTVTVVY-EDSTGLIRLQELIKAPSRYNIKIKIRQLPSGNKDAKPLLK- 217

  Fly   223 FTEHLIDMKTAQSRVYLMYASTEDAQVIFRDAGEYNMTGEGHVWIVTEQALFS-----------N 276
                  :||..:....:...|.|.|..|.:......|..|.:.:..|...||:           |
Mouse   218 ------EMKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYYHYFFTTLDLFALDLELYRYSGVN 276

  Fly   277 NTPDGVLGLQLEHAHS---------------------------DKGHIRDSVYVLASAIKEMISN 314
            .|...:|.:...|..|                           :...:.|:||::|.| ....|.
Mouse   277 MTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLLDGVMTTEAALMYDAVYMVAIA-SHRASQ 340

  Fly   315 ETIAEAPKDCGDSAVNWESGKRLFQYLKSRNITGETGQVAFD-DNGDRIYAGYDVINIREQQKKH 378
            .|::..  .| .....|..|.|....:|.....|.||::.|: .:|.|.....|:|:::|:..:.
Mouse   341 LTVSSL--QC-HRHKPWRLGPRFMNLIKEARWDGLTGRITFNKTDGLRKDFDLDIISLKEEGTEK 402

  Fly   379 VVGKFSYDSMRAKMRMRI--NDSEIIWPGKQRRKPEGI---MIPTHLRLLTIEEKPFVYVRRMGD 438
            ..|:.|....:...::.|  ::|.:......|.:...|   :....|.:.||.|:|:|..|:  .
Mouse   403 ASGEVSKHLYKVWKKIGIWNSNSGLNMTDGNRDRSNNITDSLANRTLIVTTILEEPYVMYRK--S 465

  Fly   439 DEFRCEPDERPCPLFNNSDATANEFCCRGYCIDLLIELSKRINFTYDLALSPDGQFGHYILRNNT 503
            |:          ||:.|     :.|  .|||:|||.|||..:.|.||:.|.|||::|   .:|:.
Mouse   466 DK----------PLYGN-----DRF--EGYCLDLLKELSNILGFLYDVKLVPDGKYG---AQNDK 510

  Fly   504 GAMTLRKEWTGLIGELVNERADMIVAPLTINPERAEYIEFSKPFKYQGITILEKKPSRSST-LVS 567
            |      ||.|::.||::.|||:.||||||...|.:.|:|||||...||:||.:||:.::. :.|
Mouse   511 G------EWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFS 569

  Fly   568 FLQPFSNTLWILVMVSVHVVALVLYLLDRFSPFGRFK--LSHSDSN-EEKALNLSSAVWFAWGVL 629
            ||.|.|..:|:.|:::...|:.||:::.||:|:..:.  ..:.||: .|....|.::.||..|.|
Mouse   570 FLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGAL 634

  Fly   630 LNSGIGEGTPRSFSARVLGMVWAGFAMIIVASYTANLAAFLVLERPKTKLSGINDARLRNTME-- 692
            :..| .|..|::.|.|::|.:|..|.:||::||||||||||.:||.::.:...:|...:..:|
Mouse   635 MQQG-SELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYG 698

  Fly   693 ----NLTCATVKGSSVDMYFRRQVELSNMYRTMEANNYATAEQAIQDVKKGKLMAFIWDSSRLEY 753
                ..|....|.|.:..|.:....:|:..::....|   :::.||.|.... .|.:.:|:.:||
Mouse   699 AVRDGSTMTFFKKSKISTYEKMWAFMSSRQQSALVKN---SDEGIQRVLTTD-YALLMESTSIEY 759

  Fly   754 EASKDCELVTAGELFGRSGYGIGLQKGSPWTDAVTLAILEFHESGFMEKLDKQWIFHGHVQQNC- 817
            ...::|.|...|.|....|||:|...|||:.|.:|:|||:..|.|.:..:.::| :.|:   .|
Mouse   760 VTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKW-WRGN---GCP 820

  Fly   818 ELFEKTPNTLGLKNMAGVFILVGVGIAGGVGLIIIEVIYKKHQVKKQKRLDIARHAADKWRGTIE 882
            |...|..:.||::|:.|:||::..|:...|.:.|.|.||     |.:|..||.           :
Mouse   821 EEDSKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFIY-----KSRKNNDIE-----------Q 869

  Fly   883 KRKTIRASLAMQRQYNVGLNSTHAPGTISLAVDK 916
            |.|:.|.....:.:...     |...|.||.|:|
Mouse   870 KGKSSRLRFYFRNKVRF-----HGSKTESLGVEK 898

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	37..405	CDD:380602	72/415 (17%)
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	137/411 (33%)
		CaM_bdg_C0	854..882	CDD:402271	6/27 (22%)
Grik1	NP_001391957.1	PBP1_iGluR_Kainate	38..431	CDD:380605	72/412 (17%)
		Periplasmic_Binding_Protein_Type_2	446..815	CDD:473866	135/402 (34%)