Protein Alignment Nmdar1 and Grid1

DIOPT Version :10

• Sequence 1: NP_730940.1
• Gene: Nmdar1 / 40665
• FlyBaseID: FBgn0010399
• Length: 997
• Species: Drosophila melanogaster
• Sequence 2: NP_032192.2
• Gene: Grid1 / 14803
• MGIID: 95812
• Length: 1009
• Species: Mus musculus
• Alignment Length: 1058
• Identity: 243/1058 - (22%)
• Similarity: 442/1058 - (41%)
• Gaps: 196/1058 - (18%)

  Fly    37 STYNIGGVLSNSDSEEH--FSTTIKHLNFDQQYV-PRKVTYYDKTIRMDKNPIKTVFNVCDKLIE 98
            |..:||.:...:.:::.  |...:..|:.:...: ..|:||..|.|..: ||.:.|...|| |:.
Mouse    22 SIIHIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSEKITYSIKVIEAN-NPFQAVQEACD-LMT 84

  Fly    99 NRVYAVVVSHEQTSGDLSPAAVSYTSGFYSIPVIGISSRDAAFSDKNIHVS--------FLRTVP 155
            ..:.|:|.|    :|..|..|:...:....||.:.:............|::        .|.:.|
Mouse    85 QGILALVTS----TGCASANALQSLTDAMHIPHLFVQRNPGGSPRTACHLNPSPDGEAYTLASRP 145

  Fly   156 PYYHQADVWLEMLSHFAYTKVIIIHSSDTDGRAILGRFQTTSQTYYDDVDVRATVELIVEFEPKL 220
            | ....||.|.:::...:.|.::.:.|:.|.|.:        |::.|... |..:::.::...|.
Mouse   146 P-VRLNDVMLRLVTELRWQKFVMFYDSEYDIRGL--------QSFLDQAS-RLGLDVSLQKVDKN 200

  Fly   221 ES--FTEHLIDMKTAQSRVY-------LMYASTEDAQVIFRDAGEYNMTGEGHVWIVTEQALFSN 276
            .|  ||.....|||.:...|       ::..|.:.|.....:|.|.|:..:...|:...:.:...
Mouse   201 ISHVFTSLFTTMKTEELNRYRDTLRRAILLLSPQGAHSFINEAVETNLASKDSHWVFVNEEISDP 265

  Fly   277 NTPD---GVLG------------------LQLEHAHS------DKGHIR----------DSVYVL 304
            ...|   ..||                  ::..|..|      .:|:::          |||.:|
Mouse   266 EILDLVHSALGRMTVVRQIFPSAKDNQKCMRNNHRISSLLCDPQEGYLQMLQISNLYLYDSVLML 330

  Fly   305 ASAI-KEMISNETIAEAPKDC-GDSAVNWESGKRLFQYLKSRNITGETGQVAFDDNGDRIYAGYD 367
            |:|. :::...:..:.|..:| ..|...|..|:.:...:|..:|||.||.:.|.::....|..::
Mouse   331 ANAFHRKLEDRKWHSMASLNCIRKSTKPWNGGRSMLDTIKKGHITGLTGVMEFREDSSNPYVQFE 395

  Fly   368 VINIREQQKKHVVGKFSYDSMRAKMRMRINDSEIIWPGKQRRKPEGIMIP-THLRLLTIEEKPFV 431
            ::.....:   ..||    .||   ::...|||....|..:.:|.|..:. ..|:::|:.|:|||
Mouse   396 ILGTTYSE---TFGK----DMR---KLATWDSEKGLNGSLQERPMGSRLQGLTLKVVTVLEEPFV 450

  Fly   432 YVRRMGDDEFRCEPDERPCPLFNNSDATANEFCCRGYCIDLLIELSKRINFTYDLALSPDGQFGH 496
            .|.    :....:|..                 .:|:.||:|..|:|.:.|.|::..:|||::||
Mouse   451 MVA----ENILGQPKR-----------------YKGFSIDVLDALAKALGFKYEIYQAPDGRYGH 494

  Fly   497 YILRNNTGAMTLRKEWTGLIGELVNERADMIVAPLTINPERAEYIEFSKPFKYQGITILEKKPSR 561
            .:  :||       .|.|:||||:::|||:.::.:||.|||...::|||.:....:.||.|||..
Mouse   495 QL--HNT-------SWNGMIGELISKRADLAISAITITPERESVVDFSKRYMDYSVGILIKKPEE 550

  Fly   562 SSTLVSFLQPFSNTLWILVMVSVHVVALVLYLLDRFSPFGRFKLSHSDSNEEKALNLSSAVWFAW 626
            ..::.|...||...:|..:..::.||.:::::|:|.....  ..|.:......:..|.||:|..:
Mouse   551 KISIFSLFAPFDFAVWACIAAAIPVVGVLIFVLNRIQAVR--SQSATQPRPSASATLHSAIWIVY 613

  Fly   627 GVLLNSGIGEGTPRSFSARVLGMVWAGFAMIIVASYTANLAAFLVLERPKTKLSGINDARLRNTM 691
            |..:..| ||.:..|.:.|::...|..|.:|:.:||||||||||.:.|....:....|  |...:
Mouse   614 GAFVQQG-GESSVNSVAMRIVMGSWWLFTLIVCSSYTANLAAFLTVSRMDNPIRTFQD--LSKQL 675

  Fly   692 ENLTCATVKGSSVDMYFR--------RQVELSNMYRTMEANNYA-----TAEQAIQDVKKGKLMA 743
            | ::..||:.|:|..|||        :....:.::||:..|..|     ...:.|:..|||. .|
Mouse   676 E-MSYGTVRDSAVYEYFRAKGTNPLEQDSTFAELWRTISKNGGADNCVSNPSEGIRKAKKGN-YA 738

  Fly   744 FIWDSSRLEYEA--SKDCELVTAGELFGRSGYGIGLQKGSPWTDAVTLAILEFHESGFMEKLDKQ 806
            |:||.:.:||.|  ..||.:...|......||||.||.|||:.|..:..|||..::|.::.|.::
Mouse   739 FLWDVAVVEYAALTDDDCSVTVIGNSISSKGYGIALQHGSPYRDLFSQRILELQDTGDLDVLKQK 803

  Fly   807 WIFHGHVQQNCELFEKTP-----NTLGLKNMAGVFILVGVGIAGGVGLIIIEVIYKKHQVKKQKR 866
            |..|   ...|:|...:.     .:|.|.:.||||.::.:|:.....:..:|:.:..::..::
Mouse   804 WWPH---TGRCDLTSHSSTQTEGKSLKLHSFAGVFCILAIGLLLACLVAALELWWNSNRCHQE-- 863

  Fly   867 LDIARHAADKWRGTIEKRKTIRASLAMQRQYNVGLNS------TH---APGTISLAVDKRRYPRL 922
                         |.::.|.:......:|     :||      .|   :|.:|.|:..:......
Mouse   864 -------------TPKEDKEVNLEQVHRR-----INSLMDEDIAHKQISPASIELSALEMGGLAP 910

  Fly   923 GQRLGPERAWPGDAADVLRIRRPYELGNPGQSPKVMAANQPGMPMPM------------------ 969
            .|.|.|.|.:......|.....  |..:.|.|..:.:.....:|:|:
Mouse   911 SQALEPTREYQNTQLSVSTFLP--EQSSHGTSRTLSSGPSSNLPLPLSSSATMPSIQCKHRSPNG 973

  Fly   970 -LGKTRPQQSVLPPRYSP 986
             |.:..|.::.:|..:.|
Mouse   974 GLFRQSPVKTPIPMSFQP 991

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	37..405	CDD:380602	84/426 (20%)
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	123/416 (30%)
		CaM_bdg_C0	854..882	CDD:402271	1/27 (4%)
Grid1	NP_032192.2	Interaction with CBLN1. /evidence=ECO:0000269|PubMed:27418511	21..436		87/439 (20%)
		PBP1_iGluR_delta_1	25..425	CDD:380615	84/425 (20%)
		PBP2_iGluR_delta_1	436..806	CDD:270448	122/406 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	931..960		5/30 (17%)