Protein Alignment Nmdar1 and Ir25a

DIOPT Version :10

• Sequence 1: NP_730940.1
• Gene: Nmdar1 / 40665
• FlyBaseID: FBgn0010399
• Length: 997
• Species: Drosophila melanogaster
• Sequence 2: XP_319463.5
• Gene: Ir25a / 1279695
• VectorBaseID: AGAMI1_004282
• Length: 946
• Species: Anopheles gambiae
• Alignment Length: 908
• Identity: 209/908 - (23%)
• Similarity: 359/908 - (39%)
• Gaps: 260/908 - (28%)

  Fly    75 YDKTIRMD------------KNPIKTVFNVCDKL----------IENRVYAVVVSHEQTSGDLSP 117
            ||.|..||            ::.|.|:.:..|:.          |.|  :.::.|.......|..
Mosquito   182 YDNTFVMDHKYKALLQNIPTRHVITTIADDRDRASQIEKLRNLDINN--FFILGSLASIKQVLES 244

  Fly   118 AAVSYTSGFYSIPVIGISSRDAAFSDKNIHVSFLRTVPPYYHQADVWLEMLSHFAYTKVIIIHSS 182
            |...|....::..||....:|...:.:|..:.|||.:                           |
Mosquito   245 AKNEYFERNFAWHVITQEQKDLTCNVENATIMFLRPM---------------------------S 282

  Fly   183 DTDGRAILGRFQTT---------SQTYYDDVDVRATVELIVEFEPKLESFTEHLIDMKTAQSRVY 238
            |:..:..||..:||         :..:|.|:.:||.:.:            ::::...:..|.
Mosquito   283 DSSSKDRLGSIRTTYNLKQEPQITGFFYFDLTLRALIAI------------KNILQSGSWPSN-- 333

  Fly   239 LMYASTEDAQVIFRDAGEYNMTGEGHVWIVTEQALFSNNTPDGVLGLQLEHAHSDKGHIRDSVYV 303
            :.|.:.||          |:.|                |||:..:.|:
Mosquito   334 MKYITCED----------YDGT----------------NTPNHTIDLK----------------- 355

  Fly   304 LASAIKEMISNETIA--EAPKDCGDSAVNWESGKRLFQ---YLKSRNITGETGQVAFDDNGDRIY 363
              :|..|:....|..  |.||          .||..|.   |:|          ...|.|...|.
Mosquito   356 --TAFIEVTEPTTFGPFEIPK----------GGKMQFNGNTYMK----------FDMDINAVSIR 398

  Fly   364 AGYDVINIREQQKKHVVGKFSYDSMRAKMRMRI---NDSEIIWPGKQRRKPEGIMIPTHLRLLTI 425
            :|..| |.|           |..:..|.:...|   |::||          :.:......|:.|:
Mosquito   399 SGASV-NTR-----------SLGTWEASLNAPINVANEAEI----------KNLTADVVYRVYTV 441

  Fly   426 EEKPFVYVRRMGDDEFRCEPDERPCPLFNNSDATANE-FCCRGYCIDLLIELSKRINFTYDLALS 489
            .:.||:.                       .|.||.: |  :|||||||.::::.:.|.|::...
Mosquito   442 VQAPFIM-----------------------RDPTAPKGF--KGYCIDLLNKIAEIVEFDYEIREV 481

  Fly   490 PDGQFGHYILRNNTGAMTLRKEWTGLIGELVNERADMIVAPLTINPERAEYIEFSKPFKYQ--GI 552
            .||:||:   .|..|      ||.|::.:|::::||:.:..:::..||...|:|:.|: |.  ||
Mosquito   482 EDGKFGN---MNENG------EWNGIVRKLIDKQADIGLGSMSVMAERETVIDFTVPY-YDLVGI 536

  Fly   553 TILEKKPSRSSTLVSFLQPFSNTLWILVMVSVHVVALVLYLLDRFSPF----GRFKLSHSDSNEE 613
            :|:.:.||..|:|..||......:|:.::.:....:.::::.||:||:    .|.|..:.|  |:
Mosquito   537 SIMMQLPSTPSSLFKFLTVLETNVWLCILAAYFFTSFLMWIFDRYSPYSYQNNREKYKNDD--EK 599

  Fly   614 KALNLSSAVWFAWGVLLNSGIGEGTPRSFSARVLGMVWAGFAMIIVASYTANLAAFLVLERPKTK 678
            :..|:...:||....|...|.|| .|::.|.|::...|..|..||:|||||||||||.:.|..|.
Mosquito   600 REFNIKECLWFCMTSLTPQGGGE-APKNLSGRLVAATWWLFGFIIIASYTANLAAFLTVSRLDTP 663

  Fly   679 LSGINDARLRNTMENLTCATVKGSSVDMYFRRQVELS----NMYRTMEANNYATA---------- 729
            :..::|.   :....:..|.:.|||...||:|..::.    .:::.|..|:..||
Mosquito   664 VESLDDL---SKQYKILYAPLNGSSAMTYFQRMADIEAKFYEIWKEMSLNDSLTAVERSKLAVWD 725

  Fly   730 -----------------------EQAIQDVKKGKL---MAFIWDSSRLEYEASKDCELVTAGELF 768
                                   |:|:|.::....   .||:.|::.:.|:...:|:|...||.|
Mosquito   726 YPVSDKYTKMWQAMLEAGLPNSLEEAVQRIRNSTSASGFAFLGDATDIRYQVLTNCDLQMVGEEF 790

  Fly   769 GRSGYGIGLQKGSPWTDAVTLAILEFHESGFMEKLDKQWIFHGHVQQNCELFEKTPNTLGLKNMA 833
            .|..|.|.:|:|||..|....|||.......:|||.:||..:..||..||..:...:.:.::|:.
Mosquito   791 SRKPYAIAVQQGSPLKDQFNNAILMLLNRRELEKLKEQWWKNDDVQNKCEKPDDQSDGISIQNIG 855

  Fly   834 GVFILVGVGIAGGVGLIIIEVIYKKHQVKKQKRLDIARHAADKWRGTIEKRKTIRASLAMQRQ 896
            ||||::.|||......::.|..|.|:: ...|.:|:|.....:..|||.  |.:|.:..:.:|
Mosquito   856 GVFIVIFVGIGMACITLLFEFWYYKYR-NNSKVIDVAESTDQQHGGTIV--KNVRPAGKLMKQ 915

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	37..405	CDD:380602	65/368 (18%)
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	122/447 (27%)
		CaM_bdg_C0	854..882	CDD:402271	7/27 (26%)
Ir25a	XP_319463.5	None