Protein Alignment Nmdar1 and Nmdar2

DIOPT Version :10

• Sequence 1: NP_730940.1
• Gene: Nmdar1 / 40665
• FlyBaseID: FBgn0010399
• Length: 997
• Species: Drosophila melanogaster
• Sequence 2: XP_061504088.1
• Gene: Nmdar2 / 1275196
• VectorBaseID: AGAMI1_003064
• Length: 910
• Species: Anopheles gambiae
• Alignment Length: 932
• Identity: 233/932 - (25%)
• Similarity: 417/932 - (44%)
• Gaps: 159/932 - (17%)

  Fly   116 SPAAVSY---TSGFYSIPVIGISSRDAAFSDKNIHVSF-LRTVPPYYHQADVWLEMLSHFAYTKV 176
            |.|:..|   .:|:..||||..::.::....:....:. |:..|...||:...|.:|..:.:.:.
Mosquito    10 STASAQYFLQLAGYLGIPVISWNADNSGLERRASQSALQLQLAPSIEHQSAAMLSILERYKWHQF 74

  Fly   177 IIIHSSDTDGRAILGRFQTTSQTYYDDV--DVRATVELIVEFEPKLESFT----------EHLID 229
            .::.|.      |.|         :||.  .||..|..:..|:     ||          ..|::
Mosquito    75 SVVTSQ------IAG---------HDDFVQAVREQVGAMDHFK-----FTILNSIIVTRPSDLLE 119

  Fly   230 MKTAQSRVYLMYASTEDAQVIFRDAGEYNMTGEGHVWIVTEQALFSNNT----PDGVLGLQLEHA 290
            :..:::||.|:|.:..:|..|...|.|..:|||.:||:||:..:.:..|    |.|:||:   |.
Mosquito   120 LVNSEARVMLLYCTKSEAIEILHAAEELQITGENYVWVVTQSVIENTQTHPQFPIGMLGV---HF 181

  Fly   291 HSDKG----HIRDSVYVLASAIKEMISN--------ETIAEAPKDCGDSAVNWESGKRLFQYLKS 343
            .:..|    .|..::.|.|..::..:::        :|...:.:|.|..  .|:||:..|:||::
Mosquito   182 DTSSGALVNEIATAIRVYAYGVEYYLNDVKNTGRRLDTHQLSCEDQGRG--RWDSGEVFFKYLRN 244

  Fly   344 RNITGETGQ--VAFDDNGDRIYAGYDVINIREQ-QKKHVVGKFSYDSMRAKMRMRINDSEIIWPG 405
            .::..|:.:  :.|..:||...|...::|:|.. ..|.:|.: .....::..:.:::..:|.|||
Mosquito   245 VSLESESNKPNIEFTADGDLKSAELKIMNLRPSVNSKGLVWE-EIGIWKSWQQQKLDIRDIAWPG 308

  Fly   406 KQRRKPEGIMIPTHLRLLTIEEKPFVYVRRMGDDEFRCEPDERP-CPLFNNSDATANEF------ 463
            .....|:|:....||::..:||.|::.:........:|..|... |.:..:.:.|..:.
Mosquito   309 NSHTPPQGVPEKFHLKITFLEEAPYINLSPADPVSGKCLMDRGVLCRVAADHEMTDIDMGQAHKN 373

  Fly   464 -----CCRGYCIDLLIELSKRINFTYDLALSPDGQFGHYILRNNTGAMTLRKEWTGLIGELVNER 523
                 ||.|:|||||.:.::.:.|||:|....||::|  .|.|.        :|.|||.||||.:
Mosquito   374 GSFYQCCSGFCIDLLEKFAEELGFTYELVRVEDGKWG--TLENG--------KWNGLIHELVNRK 428

  Fly   524 ADMIVAPLTINPERAEYIEFSKPFKYQGITILEKKPSRSSTLVSFLQPFSNTLWILV-MVSVHVV 587
            .||::..|.||.||...::||:||...||.|:..|.:...:..:||:||....|:|| :.::...
Mosquito   429 TDMVLTSLMINAEREAVVDFSEPFMETGIAIVVAKRTGIISPTAFLEPFDTASWMLVGIFAIQAA 493

  Fly   588 ALVLYLLDRFSPFG---RFKLSHSDSNEEKALNLSSAVWFAWGVLLNSGIGEGTPRSFSARVLGM 649
            ..:::|.:..||.|   :..|.:..:...: .:|....|..|.||..:.:...:||.|::|.:..
Mosquito   494 TFMIFLFEWLSPSGYDMKTVLQNGQTTPYR-FSLFRTYWLVWAVLFQAAVHVDSPRGFTSRFMTN 557

  Fly   650 VWAGFAMIIVASYTANLAAFLVLERPKTKLSGINDARLRNTMENLTCATVK---------GSSVD 705
            |||.||::.:|.||||||||::......:.:|::|:||.:...:.  .|:|         .|::.
Mosquito   558 VWAMFAVVFLAIYTANLAAFMITREEFHEFTGLDDSRLSHPFSHK--PTIKFGTIPWSHTDSTIS 620

  Fly   706 MYFRRQVELSNMYRTMEANNYATAEQAIQDVKKGKLMAFIWDSSRLEY--EASKDCELVTAGELF 768
            .||:      .|:..|:..|.::....:..|..|:|.|||:|.:.|:|  :..:||.|:|.|:.:
Mosquito   621 KYFK------EMHYYMKQYNRSSVADGVTAVLSGQLDAFIYDGTVLDYLVQQDEDCRLLTVGQWY 679

  Fly   769 GRSGYGIGLQKGSPWTDAVTLAILEFHESGFMEKLDKQWIFHGHVQQNC---ELFEKTPNTLGLK 830
            ..:|||:...:.|.:.......:|||..:|.:|:|.:.|     :...|   :...|:.:.|.|:
Mosquito   680 AMTGYGLAFSRNSKYVGMFNKRLLEFRANGDLERLRRFW-----MTGTCRPGKQEHKSSDPLALE 739

  Fly   831 NMAGVFILVGVGIAGGVGLIIIEVIYKKHQVKKQKRLDIARHAADKWRG--------TIEKRKTI 887
            .....|:|:..||.....|:::|.:|.|:   .:|||      |.|.||        ::.|..|.
Mosquito   740 QFLSAFLLLMAGILLAALLLLLEHLYFKY---FRKRL------AKKDRGGCCALISLSMGKSLTF 795

  Fly   888 RASLAMQRQYNVGLNSTHAPGTISLAVDKRRYPRLGQRLGPERAWP-GDAADVLRIRRPYELGNP 951
            |                   |.:..|.:..|..|....:.....|. ....|:.|:|..:
Mosquito   796 R-------------------GAVYEATEILRRHRCNDPICDTHLWKVKHELDMSRLRNQH----- 836

  Fly   952 GQSPKVMAANQPGMPMPMLGKT 973
              ..|.|..:....|.|.||.|
Mosquito   837 --LEKTMQIHGIKPPQPKLGST 856

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	37..405	CDD:380602	71/323 (22%)
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	122/430 (28%)
		CaM_bdg_C0	854..882	CDD:402271	9/35 (26%)
Nmdar2	XP_061504088.1	None