DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nmdar1 and Grik4

DIOPT Version :9

Sequence 1:	NP_730940.1	Gene:	Nmdar1 / 40665	FlyBaseID:	FBgn0010399	Length:	997	Species:	Drosophila melanogaster
Sequence 2:	NP_780690.2	Gene:	Grik4 / 110637	MGIID:	95817	Length:	956	Species:	Mus musculus

Alignment Length:	910	Identity:	229/910 - (25%)
Similarity:	383/910 - (42%)	Gaps:	198/910 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 IPVIGISSRDAAFS-DKNI----HVSFLRTVPPYYHQADVWLEMLSHFAYTKVIIIHSSDTD--- 185
            :.|:|.||..|:.| ..||    .|...:..|..:.:.     .|..|.   .:.:|.|:||
Mouse    92 VAVLGPSSSPASSSIISNICGEKEVPHFKVAPEEFVRF-----QLQRFT---TLNLHPSNTDISV 148

  Fly   186 -GRAILGRFQTTSQTYYDDVDVRATVELIVEFEPKLESF------------------TEHLIDMK 231
             ...||..|..|:...     :.|..|.::..|..|..|                  |..|.:::
Mouse   149 AVAGILNFFNCTTACL-----ICAKAECLLNLEKLLRQFLISKDTLSVRMLDDTRDPTPLLKEIR 208

  Fly   232 TAQSRVYLMYASTEDAQVIFRDAGEYNMTGEGHVWIVTEQALFSNNTPD-------GVLGLQL-- 287
            ..::...:::|:...:..|...|.|..|....:.:|.|... ||....|       .:||..:
Mouse   209 DDKTATIIIHANASMSHTILLKAAELGMVSAYYTYIFTNLE-FSLQRMDSLVDDRVNILGFSIFN 272

  Fly   288 -EHA-------------HSDKGHIR------------DSVYVLASAIKEMISNETIAEAPKDCGD 326
             .||             ..:..|:.            |:||.:.:|::|:..::.|...|..||
Mouse   273 QSHAFFQEFSQSLNQSWQENCDHVPFTGPALSSALLFDAVYAVVTAVQELNRSQEIGVKPLSCG- 336

  Fly   327 SAVNWESGKRLFQYLKSRNITGETGQVAFDDNGDRIYAGYDVINIRE---QQ--KKHVVGKFSYD 386
            ||..|:.|..|..||:...:.|.||.:.|:..|.|......::....   ||  :.||....|.|
Mouse   337 SAQIWQHGTSLMNYLRMVELEGLTGHIEFNSKGQRSNYALKILQFTRNGFQQIGQWHVAEGLSMD 401

  Fly   387 SMRAKMRM---RINDSEIIWPGKQRRKPEGIMIPTHLRLLTIEEKPFVYVRRMGDDEFRCEPDER 448
            |     |:   .|:||               :..|.|.:.||.|.|::.::.
Mouse   402 S-----RLYASNISDS---------------LFNTTLVVTTILENPYLMLKG------------- 433

  Fly   449 PCPLFNNSDATANEFCCRGYCIDLLIELSKRINFTYDLALSPDGQFGHYILRNNTGAMTLRKEWT 513
                 |:.:...|: ...|:|:|:|.||::.:.|.|.:.|..||.:|   :....|.      ||
Mouse   434 -----NHQEMEGND-RYEGFCVDMLKELAEILRFNYKIRLVGDGVYG---VPEANGT------WT 483

  Fly   514 GLIGELVNERADMIVAPLTINPERAEYIEFSKPFKYQGITILEK-KPSRSSTLVSFLQPFSNTLW 577
            |::|||:..:||:.||.|||..||.:.|:|||||...||:||.: ...|.....|||.|||..:|
Mouse   484 GMVGELIARKADLAVAGLTITAEREKVIDFSKPFMTLGISILYRVHMGRRPGYFSFLDPFSPGVW 548

  Fly   578 ILVMVSVHVVALVLYLLDRFSPF----------GRFKLSHSDSNEEKALNLSSAVWFAWGVLLNS 632
            :.::::...|:.||:|:.|.:|:          ||..|..:.      .:|.:::||..|..:..
Mouse   549 LFMLLAYLAVSCVLFLVARLTPYEWYSPHPCAQGRCNLLVNQ------YSLGNSLWFPVGGFMQQ 607

  Fly   633 GIGEGTPRSFSARVLGMVWAGFAMIIVASYTANLAAFLVLERPKTKLSGINDARLRNTMENLTCA 697
            | ....||:.|.|.:..||..|.:||::||||||||||.::|.:..:..::|...:..:|   ..
Mouse   608 G-STIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPIESVDDLADQTAIE---YG 668

  Fly   698 TVKGSSVDMYFRRQVELSNMYRTMEAN-NYATAEQA---IQDVKKG------KLMAFIWDSSRLE 752
            |:.|.|...:|:     ::.|:|.:.. ||..::|.   ::..::|      ...||:.:|:..|
Mouse   669 TIHGGSSMTFFQ-----NSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVLNSNYAFLLESTMNE 728

  Fly   753 YEASKDCELVTAGELFGRSGYGIGLQKGSPWTDAVTLAILEFHESGFMEKLDKQWIFHGHVQQNC 817
            |...::|.|...|.|....|||||:..||.:.|...||||:..|:..:|.|.::|...|
Mouse   729 YYRQRNCNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQLQENNRLEILKRKWWEGG------ 787

  Fly   818 ELFEKTPNT-------LGLKNMAGVFILVGVGIAGGVGLIIIEVIYK-KHQVKKQKRLDIARHAA 874
                |.|..       ||::|:.|:|:::..|:...:.:.::|.::. :|  .:...:.:.:...
Mouse   788 ----KCPKEEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLEFLWTLRH--SEASEVSVCQEMV 846

  Fly   875 DKWRGTIEKRKTI----RASLAMQRQYNVGLNSTHAPGTISLAVDK----RRYPRLGQRLGPERA 931
            .:.|..|..:..|    |.|..:..|..| |......||.:|:..|    ....:|.|||..|.|
Mouse   847 TELRNIILCQDNIHPRRRRSGGLPPQPPV-LEERRPRGTATLSNGKLCGAGEPDQLAQRLAQEAA 910

Fly 932 931
Mouse 911 910

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	12..405	CDD:107374	75/345 (22%)
		ANF_receptor	58..371	CDD:279440	64/303 (21%)
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	126/421 (30%)
		HisJ	451..>558	CDD:223904	40/107 (37%)
		Periplasmic_Binding_Protein_Type_2	<516..651	CDD:304360	48/145 (33%)
		Lig_chan	575..838	CDD:278489	80/289 (28%)
		CaM_bdg_C0	854..882	CDD:287524	2/28 (7%)
Grik4	NP_780690.2	Periplasmic_Binding_Protein_type1	24..402	CDD:385651	69/324 (21%)
		PBP2_iGluR_kainate_KA1	415..785	CDD:270442	125/412 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..956
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910