Protein Alignment Nmdar1 and grik5

DIOPT Version :10

• Sequence 1: NP_730940.1
• Gene: Nmdar1 / 40665
• FlyBaseID: FBgn0010399
• Length: 997
• Species: Drosophila melanogaster
• Sequence 2: XP_002936446.1
• Gene: grik5 / 100497490
• XenbaseID: XB-GENE-953974
• Length: 995
• Species: Xenopus tropicalis
• Alignment Length: 1137
• Identity: 266/1137 - (23%)
• Similarity: 434/1137 - (38%)
• Gaps: 322/1137 - (28%)

  Fly     8 FCRPLFGLAIVLLVAPIDAAQRHTASDNPSTYNIGGVLSNSDSEEHFST------------TIKH 60
            |..|...|...|.||.|        .|:.:....|..|:.:.:.||.::            .|..
 Frog    17 FTSPGVSLLSSLRVAAI--------LDDQTVCGRGERLALALAREHINSHTQGSASGRVEVEIFE 73

  Fly    61 LNFDQQYVPRKVTYYDKTIRMDKNPIKTVFNVCDKLIENRVYAVVVSHEQTSGDLSPAAVSYTSG 125
            |..|.||                   :|...:| :::...|.:|:   ..::...|.:.||:..|
 Frog    74 LQKDSQY-------------------ETTDTMC-QILPKGVVSVL---GPSTSPASASTVSHICG 115

  Fly   126 FYSIPVIGISSRDAAFSDKNIHVSFLR--TVPPYYHQADVWLEMLSHFAYTKVIIIHSSDTDGRA 188
            ...||.|.:...:|.      .:.:||  :|..|....|:.| .:||
 Frog   116 EKEIPHIKVGPEEAP------KLQYLRFASVSLYPSNEDISL-AVSH------------------ 155

  Fly   189 ILGRFQTTSQTYYDDVDVRATVELIVEFEPKLESF------------------TEHLIDMKTAQS 235
            ||..|...|.:.     :.|..|.::..|..:..|                  |..|.:::..:.
 Frog   156 ILKSFHNPSTSL-----ICAKAECLLRLEELVRQFLISKDTLSVRMLDESNDPTPLLKEIRDDKV 215

  Fly   236 RVYLMYASTEDAQVIFRDAGEYNMTGEGHVWIVTEQALFSNNTPDGVLGLQLEHAHSDKGHIR-- 298
            ...::.|:...:.:|.:.|.|..||...:.:|:|        |.|..| |.||...||:.:|.
 Frog   216 STIIIDANATVSHLILKKASELGMTSAHYKYILT--------TMDFPL-LSLEGIVSDQSNILGF 271

  Fly   299 -----------------------------------------DSVYVLASAIKEMISNETIAEAPK 322
                                                     |:|:|:.||::|:..::.|.....
 Frog   272 SMYNSSHPFYLEFLRSLNMSWRENCELSTYLGPALSAALMFDAVHVVVSAVRELNRSQEIGVKQL 336

  Fly   323 DCGDSAVNWESGKRLFQYLKSRNITGETGQVAFDDNGDRIYAGYDVINIREQQKKH-VVGKFSYD 386
            .|..|.: |:.|..|..||:.....|.||:|.|:..|.|  ..|.:..:.:....| .:|.: |.
 Frog   337 SCSTSQI-WQHGTSLMNYLRMVEYDGLTGRVEFNSKGQR--TNYTLRILEKAGDGHREIGVW-YS 397

  Fly   387 SMRAKMR---MRINDSEIIWPGKQRRKPEGIMIPTHLRLLTIEEKPFV-----YVRRMGDDEFRC 443
            :....|.   :.::.||.:     ..|.        |.:.||.|.|::     |....|:|::
 Frog   398 NRTLAMNATSLDLSTSETL-----ENKT--------LVVTTILENPYMMRKSNYRSLSGNDQY-- 447

  Fly   444 EPDERPCPLFNNSDATANEFCCRGYCIDLLIELSKRINFTYDLALSPDGQFGHYILRNNTGAMTL 508
                                  .|:|.::|:||:..:.|.|.:.|..||.:         ||...
 Frog   448 ----------------------EGFCAEMLMELAALLRFNYKIKLVEDGLY---------GAPEP 481

  Fly   509 RKEWTGLIGELVNERADMIVAPLTINPERAEYIEFSKPFKYQGITILEK-KPSRSSTLVSFLQPF 572
            ...|||::|||:|.:||:.||..||..||.:.|:|||||...||:||.: :..|.....|||.||
 Frog   482 NGSWTGMVGELINRKADLAVAAFTITAEREKVIDFSKPFMTLGISILYRVQMGRKPGYFSFLDPF 546

  Fly   573 SNTLWILVMVSVHVVALVLYLLDRFSPFGRFKLSHSDSNE-----EKALNLSSAVWFAWGVLLNS 632
            |..:|:.::::...|:.||:|..|.||:..:. .|....|     |....|.:::||..|..:..
 Frog   547 SPAVWLFMLLAYLAVSCVLFLAARLSPYEWYN-PHPCLRERHHILENQYTLGNSLWFPVGGFMQQ 610

  Fly   633 GIGEGTPRSFSARVLGMVWAGFAMIIVASYTANLAAFLVLERPKTKLSGINDARLRNTMENLTCA 697
            | .|..||:.|.|.:..||..|.:||::||||||||||.::|.:..:...:|..   ...|:...
 Frog   611 G-SEVMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPIESADDLA---DQTNIEYG 671

  Fly   698 TVKGSSVDMYFRRQVELSNMYRTMEAN-NYATAEQA---IQDVKKG------KLMAFIWDSSRLE 752
            |:.|.|...:|:     ::.|:|.:.. ||..::|.   ::..::|      ...||:.:|:..|
 Frog   672 TIHGGSTMTFFQ-----NSRYQTYQRMWNYMNSKQPSVFVKSTEEGIARVLNSRYAFLLESTMNE 731

  Fly   753 YEASKDCELVTAGELFGRSGYGIGLQKGSPWTDAVTLAILEFHESGFMEKLDKQWIFHGHVQQNC 817
            |....:|.|...|.|....|||||:..|||:.|.:|||||:..|:..:|.|.::|...|
 Frog   732 YHRRLNCNLTQIGGLLDTKGYGIGMPLGSPYRDEITLAILQLQENNRLEILKRKWWEGG------ 790

  Fly   818 ELFEKTPNT-------LGLKNMAGVFILVGVGIAGGVGLIIIEVIYKKHQVKKQKRLDIARHAAD 875
                |.|..       ||::|:.|:|:::..|:...|.:.|:|.::...:....:.:.:.:....
 Frog   791 ----KCPKEEDHRAKGLGMENIGGIFVVLICGLIIAVFVAIMEFVWSTRRSVDNEEISVCQEMLS 851

  Fly   876 KWRGTIEKRKTIRA-----------------------SLAMQRQYNVGLNSTH-----------A 906
            :.|..:..:||.|:                       |....|..|..|..||           |
 Frog   852 ELRSAVSCKKTSRSRHRRRPPRHLHGRTLLSLSRPPRSTRETRLCNGRLYQTHQHPPAPPHPPPA 916

  Fly   907 PGTISLAVDKRRYPRLGQRLGPERAWPGDAAD---------VLRIRRPYELGNPGQSPKVMAANQ 962
            ||...|..|.           |..:..|..|.         :..:|.|..|..|.||||
 Frog   917 PGAQRLHEDP-----------PSSSTRGGCAHFRICQECRRIQTLRGPPPLPRPPQSPK------ 964

  Fly   963 PGMPMPMLGKTRPQQSVLPPRYSPGYTSDVSH 994
               |.|            ||..:|...:..||
 Frog   965 ---PPP------------PPPPAPENVTPHSH 981

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	37..405	CDD:380602	84/446 (19%)
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	129/421 (31%)
		CaM_bdg_C0	854..882	CDD:402271	1/27 (4%)
grik5	XP_002936446.1	PBP1_iGluR_Kainate_KA1_2	27..405	CDD:380616	87/451 (19%)
		Periplasmic_Binding_Protein_Type_2	418..788	CDD:473866	129/420 (31%)