Protein Alignment Nmdar1 and grin2cb

DIOPT Version :10

• Sequence 1: NP_730940.1
• Gene: Nmdar1 / 40665
• FlyBaseID: FBgn0010399
• Length: 997
• Species: Drosophila melanogaster
• Sequence 2: XP_009305071.3
• Gene: grin2cb / 100333648
• ZFINID: ZDB-GENE-100308-2
• Length: 1328
• Species: Danio rerio
• Alignment Length: 902
• Identity: 250/902 - (27%)
• Similarity: 423/902 - (46%)
• Gaps: 113/902 - (12%)

  Fly    10 RPLFGLAIVLLVAPIDAAQRHTASDNPSTYNIGGVLSNSDSEEHFSTTIKHLNF-DQQYVPRKVT 73
            ||.||                     |.:.|:..|.|.|.........:...|| |.......:|
Zfish    31 RPFFG---------------------PPSVNVAVVFSGSAHHSEIKGRLSPENFLDMPLEVNPIT 74

  Fly    74 YYDKTIRMDKNPIKTVFNVCDKLIENRVYAVVVSHEQTSGDLSPAAVS----YTSGFYSIPVIGI 134
                .:..|.||...:..:|..:....::.||.     ..|:...||:    :.|...|||::||
Zfish    75 ----VLVNDTNPRALLTRLCQTMAAESLHGVVF-----EDDVDSEAVAQILDFVSSQTSIPIVGI 130

  Fly   135 SSRDA-AFSDKNIHVSFLRTVPPYYHQADVWLEMLSHFAYTKVIIIHSSDTDGRAILGRFQTTSQ 198
            |...| ....|....:||:.......|.:...:::..:.:...::|.|........:...::.:.
Zfish   131 SGGSAVVIPHKADGSTFLQMGASIDQQINAMFKVMEEYNWGNFVVITSLYPGYETFVDYIRSFTD 195

  Fly   199 TYY-----DDVDVRATVELIVEFEPKL---ESFTEHLIDMKTAQSRVYLMYASTEDAQVIFRDAG 255
            |.|     .||         :.||..:   :..|..|  ::...|:|||:|.|.|:||.:||.|.
Zfish   196 TSYFLWELQDV---------LSFEMSVGANDIRTRRL--LQQVDSQVYLVYCSHEEAQYLFRMAS 249

  Fly   256 EYNMTGEGHVWIVTEQALFSNNT------PDGVLGLQLEHAHSD-KGHIRDSVYVLASAIKEMIS 313
            :..:.|.|::|||...|:.:...      |.||:.:..:..... :..:|:.|.::...:.....
Zfish   250 DVGLLGPGYIWIVPSLAVGNPEAAPPASFPVGVISIITDRWRKTLRQRVREGVAIIVKGVHSFHK 314

  Fly   314 NE-TIAEAPKDCGDSAVNWESGKRLFQYLKSRNITGETGQVAFDDNGDRIYAGYDVINIREQQKK 377
            :. .|.|...|| .|.|...:...||:::  .|::.|...::|:.:|........:|.:..:...
Zfish   315 HRGFIPEGHSDC-SSPVKSYANNSLFRHM--LNVSWEHKDLSFNSDGYLTNPSMVIIALDRENHW 376

  Fly   378 HVVGKFSYDSMRAKMRMRINDSEIIWPGKQRRKPEGIMIPTHLRLLTIEEKPFVYVRRMGDDEFR 442
            ..||  ||:....:||..      :|| :.....|.:....||.:.|:||:|||.|..:......
Zfish   377 DKVG--SYEGGILQMRYP------VWP-RYGSFLEPVSDNRHLTVATLEERPFVIVESVDPATGT 432

  Fly   443 CEPDERPCPLFNNSDATA-------NEFCCRGYCIDLLIELSKRINFTYDLALSPDGQFGHYILR 500
            |..:..||...:|...:.       .:.||:|:|||:|.:||:.|.|:|||.|..:|:.|..:
Zfish   433 CVRNTVPCRRQSNRTESIIGHTEPYTKLCCKGFCIDILKKLSRTIKFSYDLYLVTNGKHGKMV-- 495

  Fly   501 NNTGAMTLRKEWTGLIGELVNERADMIVAPLTINPERAEYIEFSKPFKYQGITILEKKPSRSSTL 565
                    |..|.|:|||:..:||||.:..||||.||:|.::||.||...||:::..:.:.:.:.
Zfish   496 --------RGVWNGMIGEVFYKRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSNGTVSP 552

  Fly   566 VSFLQPFSNTLWILVMV-SVHVVALVLYLLDRFSPFG-RFKLSHSDSNEEKALNLSSAVWFAWGV 628
            .:||:|:|..:|:::.| .:.|||:.:::.:.|||.| ...|..:.:.......:..:||..||:
Zfish   553 SAFLEPYSPAVWVMMFVMCLTVVAVTVFVFEYFSPVGYNRSLVSAKAPGGPTFTIGKSVWLLWGI 617

  Fly   629 LLNSGIGEGTPRSFSARVLGMVWAGFAMIIVASYTANLAAFLVLERPKTKLSGINDARLRNTMEN 693
            :.|:.:....|:..:::::.:|||.||:|.:||||||||||::.|:....:||::|.:.:...|:
Zfish   618 VFNNSVPIENPKGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDKKFQKPQEH 682

  Fly   694 ---LTCATVKGSSVDMYFRRQVELSNMYRTMEANNYATAEQAIQDVKKGKLMAFIWDSSRLEYEA 755
               ....||...|.:...|.  ...:|:..|...|....|:|:..:|.|||.|||:|::.|.|.|
Zfish   683 YPPFRFGTVPNGSTERNIRS--NYPDMHTHMIKYNQKGVEEALNSLKTGKLDAFIYDAAVLNYMA 745

  Fly   756 SKD--CELVT--AGELFGRSGYGIGLQKGSPWTDAVTLAILEFHESGFMEKLDKQWIFHGHVQQN 816
            .||  |:|||  :|::|..:||||.|||.|.|...:.||:|:|...|..::|:..|:  ..:.||
Zfish   746 GKDEGCKLVTIGSGKVFATTGYGIALQKDSRWKRPIDLALLQFLGDGDTQRLETVWL--SGICQN 808

  Fly   817 CELFEKTPNTLGLKNMAGVFILVGVGIAGGVGLIII---EVIYKK--HQVKKQKRLD 868
             |..|...:.|.:.||||||.::.|  |.|:.|::.   .::|.|  |.|.|..|||
Zfish   809 -EKNEVMSSKLDIDNMAGVFYMLLV--AMGLSLLVFAWEHLLYWKLRHSVHKSDRLD 862

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	37..405	CDD:380602	82/389 (21%)
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	140/416 (34%)
		CaM_bdg_C0	854..882	CDD:402271	8/17 (47%)
grin2cb	XP_009305071.3	None