DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nmdar1 and grin2cb

DIOPT Version :9

Sequence 1:	NP_730940.1	Gene:	Nmdar1 / 40665	FlyBaseID:	FBgn0010399	Length:	997	Species:	Drosophila melanogaster
Sequence 2:	XP_009305071.2	Gene:	grin2cb / 100333648	ZFINID:	ZDB-GENE-100308-2	Length:	1328	Species:	Danio rerio

Alignment Length:	902	Identity:	250/902 - (27%)
Similarity:	423/902 - (46%)	Gaps:	113/902 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 RPLFGLAIVLLVAPIDAAQRHTASDNPSTYNIGGVLSNSDSEEHFSTTIKHLNF-DQQYVPRKVT 73
            ||.||                     |.:.|:..|.|.|.........:...|| |.......:|
Zfish    31 RPFFG---------------------PPSVNVAVVFSGSAHHSEIKGRLSPENFLDMPLEVNPIT 74

  Fly    74 YYDKTIRMDKNPIKTVFNVCDKLIENRVYAVVVSHEQTSGDLSPAAVS----YTSGFYSIPVIGI 134
                .:..|.||...:..:|..:....::.||.     ..|:...||:    :.|...|||::||
Zfish    75 ----VLVNDTNPRALLTRLCQTMAAESLHGVVF-----EDDVDSEAVAQILDFVSSQTSIPIVGI 130

  Fly   135 SSRDA-AFSDKNIHVSFLRTVPPYYHQADVWLEMLSHFAYTKVIIIHSSDTDGRAILGRFQTTSQ 198
            |...| ....|....:||:.......|.:...:::..:.:...::|.|........:...::.:.
Zfish   131 SGGSAVVIPHKADGSTFLQMGASIDQQINAMFKVMEEYNWGNFVVITSLYPGYETFVDYIRSFTD 195

  Fly   199 TYY-----DDVDVRATVELIVEFEPKL---ESFTEHLIDMKTAQSRVYLMYASTEDAQVIFRDAG 255
            |.|     .||         :.||..:   :..|..|  ::...|:|||:|.|.|:||.:||.|.
Zfish   196 TSYFLWELQDV---------LSFEMSVGANDIRTRRL--LQQVDSQVYLVYCSHEEAQYLFRMAS 249

  Fly   256 EYNMTGEGHVWIVTEQALFSNNT------PDGVLGLQLEHAHSD-KGHIRDSVYVLASAIKEMIS 313
            :..:.|.|::|||...|:.:...      |.||:.:..:..... :..:|:.|.::...:.....
Zfish   250 DVGLLGPGYIWIVPSLAVGNPEAAPPASFPVGVISIITDRWRKTLRQRVREGVAIIVKGVHSFHK 314

  Fly   314 NE-TIAEAPKDCGDSAVNWESGKRLFQYLKSRNITGETGQVAFDDNGDRIYAGYDVINIREQQKK 377
            :. .|.|...|| .|.|...:...||:::  .|::.|...::|:.:|........:|.:..:...
Zfish   315 HRGFIPEGHSDC-SSPVKSYANNSLFRHM--LNVSWEHKDLSFNSDGYLTNPSMVIIALDRENHW 376

  Fly   378 HVVGKFSYDSMRAKMRMRINDSEIIWPGKQRRKPEGIMIPTHLRLLTIEEKPFVYVRRMGDDEFR 442
            ..||  ||:....:||..      :|| :.....|.:....||.:.|:||:|||.|..:......
Zfish   377 DKVG--SYEGGILQMRYP------VWP-RYGSFLEPVSDNRHLTVATLEERPFVIVESVDPATGT 432

  Fly   443 CEPDERPCPLFNNSDATA-------NEFCCRGYCIDLLIELSKRINFTYDLALSPDGQFGHYILR 500
            |..:..||...:|...:.       .:.||:|:|||:|.:||:.|.|:|||.|..:|:.|..:
Zfish   433 CVRNTVPCRRQSNRTESIIGHTEPYTKLCCKGFCIDILKKLSRTIKFSYDLYLVTNGKHGKMV-- 495

  Fly   501 NNTGAMTLRKEWTGLIGELVNERADMIVAPLTINPERAEYIEFSKPFKYQGITILEKKPSRSSTL 565
                    |..|.|:|||:..:||||.:..||||.||:|.::||.||...||:::..:.:.:.:.
Zfish   496 --------RGVWNGMIGEVFYKRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSNGTVSP 552

  Fly   566 VSFLQPFSNTLWILVMV-SVHVVALVLYLLDRFSPFG-RFKLSHSDSNEEKALNLSSAVWFAWGV 628
            .:||:|:|..:|:::.| .:.|||:.:::.:.|||.| ...|..:.:.......:..:||..||:
Zfish   553 SAFLEPYSPAVWVMMFVMCLTVVAVTVFVFEYFSPVGYNRSLVSAKAPGGPTFTIGKSVWLLWGI 617

  Fly   629 LLNSGIGEGTPRSFSARVLGMVWAGFAMIIVASYTANLAAFLVLERPKTKLSGINDARLRNTMEN 693
            :.|:.:....|:..:::::.:|||.||:|.:||||||||||::.|:....:||::|.:.:...|:
Zfish   618 VFNNSVPIENPKGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDKKFQKPQEH 682

  Fly   694 ---LTCATVKGSSVDMYFRRQVELSNMYRTMEANNYATAEQAIQDVKKGKLMAFIWDSSRLEYEA 755
               ....||...|.:...|.  ...:|:..|...|....|:|:..:|.|||.|||:|::.|.|.|
Zfish   683 YPPFRFGTVPNGSTERNIRS--NYPDMHTHMIKYNQKGVEEALNSLKTGKLDAFIYDAAVLNYMA 745

  Fly   756 SKD--CELVT--AGELFGRSGYGIGLQKGSPWTDAVTLAILEFHESGFMEKLDKQWIFHGHVQQN 816
            .||  |:|||  :|::|..:||||.|||.|.|...:.||:|:|...|..::|:..|:  ..:.||
Zfish   746 GKDEGCKLVTIGSGKVFATTGYGIALQKDSRWKRPIDLALLQFLGDGDTQRLETVWL--SGICQN 808

  Fly   817 CELFEKTPNTLGLKNMAGVFILVGVGIAGGVGLIII---EVIYKK--HQVKKQKRLD 868
             |..|...:.|.:.||||||.::.|  |.|:.|::.   .::|.|  |.|.|..|||
Zfish   809 -EKNEVMSSKLDIDNMAGVFYMLLV--AMGLSLLVFAWEHLLYWKLRHSVHKSDRLD 862

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	12..405	CDD:107374	85/414 (21%)
		ANF_receptor	58..371	CDD:279440	71/334 (21%)
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	140/416 (34%)
		HisJ	451..>558	CDD:223904	41/113 (36%)
		Periplasmic_Binding_Protein_Type_2	<516..651	CDD:304360	40/136 (29%)
		Lig_chan	575..838	CDD:278489	92/271 (34%)
		CaM_bdg_C0	854..882	CDD:287524	8/17 (47%)
grin2cb	XP_009305071.2	PBP1_iGluR_NMDA_NR2	37..396	CDD:107373	83/390 (21%)
		PBP2_iGluR_NMDA_Nr2	407..808	CDD:270436	138/414 (33%)
		NMDAR2_C	845..>932	CDD:313729	8/18 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910