DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nmdar1 and si:dkey-183j2.10

DIOPT Version :9

Sequence 1:	NP_730940.1	Gene:	Nmdar1 / 40665	FlyBaseID:	FBgn0010399	Length:	997	Species:	Drosophila melanogaster
Sequence 2:	XP_001923977.1	Gene:	si:dkey-183j2.10 / 100151589	ZFINID:	ZDB-GENE-130530-729	Length:	465	Species:	Danio rerio

Alignment Length:	437	Identity:	124/437 - (28%)
Similarity:	207/437 - (47%)	Gaps:	51/437 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   467 GYCIDLLIELSKRINFTYDLALSPDGQFGHYILRNNTGAMTLRKEWTGLIGELVNERADMIVAPL 531
            |||:|||.||:|::.|.|.:.|..||.:|......|         |.|:|||:|...||:.||||
Zfish    51 GYCMDLLTELAKKLGFKYKVHLVKDGSYGRQDENGN---------WNGMIGEVVRGEADLAVAPL 106

  Fly   532 TINPERAEYIEFSKPFKYQGITILEKKP--SRSSTLVSFLQPFSNTLWILVMVSVHVVALVLYLL 594
            |:...|.:.:..:||:...||:||.:|.  |..:....||.|||...|..::::..|.|:.:.::
Zfish   107 TLTAAREKAVGMTKPYMQTGISILLRKDIVSEEAGFFDFLSPFSGETWFGILIAYFVTAVCICIV 171

  Fly   595 DRFSPF---------GRFKLSHSDSNEEKALNLSSAVWFAWGVLLNSGIGEGTPRSFSARVLGMV 650
            .|.||.         ..|.|.||             :|:..|.|...|.|. .|::.|.||:...
Zfish   172 GRLSPCEWSQPETEPNHFTLLHS-------------LWYTAGALSLQGAGP-HPKAVSGRVISCT 222

  Fly   651 WAGFAMIIVASYTANLAAFLVLERPKTKLSGINDARLRNTMENLTCATVKGSSVDMYFRRQVELS 715
            |..||::::|.|.::|::....:.....:.|..|...::.:|   ..|:.|||...:|:.....|
Zfish   223 WWLFAVVLLACYFSSLSSTQGSDSAPLMIKGFEDLANQDVIE---YGTLAGSSTLAFFKNSNNPS 284

  Fly   716 --NMYRTMEANN--YATAEQAIQDVKKGKLMAFIWDSSRLEYEASKDCELVTAGELFGRSGYGIG 776
              .:|..||...  .::.::.:|..|:|. .|||.:|..|:...::.||||.|.|:.|..||.|.
Zfish   285 YRRIYEHMERRKSFVSSMDEGVQKAKEGN-YAFIGESVSLDLAVARHCELVRAHEVIGMRGYSIV 348

  Fly   777 LQKGSPWTDAVTLAILEFHESGFMEKLDKQWIFHGHVQQNCELFEKTPNTLGLKNMAGVFILVGV 841
            ...||.....:::|||:..|:|.:..|..:|.....:..|.:     .::|...:|.|:|:::.:
Zfish   349 TPLGSAMLKNLSVAILQLSEAGELAYLRTKWWASSCLPDNAK-----ASSLRAHSMKGIFLVLAI 408

  Fly   842 GIAGGVGLIIIEVIYKKH----QVKKQKRLDIARHAADKWRGTIEKR 884
            |:..||.|.:.|:..|..    :.||.....:.:..:.:.|.|..||
Zfish   409 GLGIGVLLSLFELTTKSRSAAGEQKKSCCTVLTQELSQRLRMTNTKR 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	12..405	CDD:107374
		ANF_receptor	58..371	CDD:279440
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	108/365 (30%)
		HisJ	451..>558	CDD:223904	36/90 (40%)
		Periplasmic_Binding_Protein_Type_2	<516..651	CDD:304360	44/145 (30%)
		Lig_chan	575..838	CDD:278489	69/275 (25%)
		CaM_bdg_C0	854..882	CDD:287524	5/31 (16%)
si:dkey-183j2.10	XP_001923977.1	PBP2_iGluR_non_NMDA_like	28..381	CDD:270403	107/356 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910