DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nmdar1 and LOC100149482

DIOPT Version :9

Sequence 1:	NP_730940.1	Gene:	Nmdar1 / 40665	FlyBaseID:	FBgn0010399	Length:	997	Species:	Drosophila melanogaster
Sequence 2:	XP_009290417.1	Gene:	LOC100149482 / 100149482	-ID:	-	Length:	1959	Species:	Danio rerio

Alignment Length:	972	Identity:	254/972 - (26%)
Similarity:	439/972 - (45%)	Gaps:	163/972 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 DKNPIKTVFNVCDKLIENRVYAVVVSHEQ----TSGDLSPAAVSYTSGFYSIPVIGISSRDAAF- 141
            |.:|...:..:||.|....:..:|...|:    .:|.|:| .:.:.|....:|::.:.. .||.
Zfish   100 DSSPRTLLSQLCDLLAARPLQGLVYEDERPLPLATGPLAP-MLEFVSAQTGLPIVAVGG-GAALG 162

  Fly   142 ----SDKNIHVSFLRTVPPYYHQADVWLEMLSHFAYTKVIIIHSSDTDGRAILGRFQTTSQTYYD 202
                ...:|.:.|..:..   .|.:|..|:|..:.:|...::.:.....:..|...:..:...:.
Zfish   163 RVPQESGSIFLQFSSSTA---LQLEVIFEVLEEYDWTAFSVVSTRHHGYQDFLSVVEGLTDGSFI 224

  Fly   203 DVDVRATVELIVEFEPKLESFTEHLIDMKTAQSRVYLMYASTEDAQVIFRDAGEYNMTGEGHVWI 267
            ..:.::.|.|.:..:|. ...|:.|  :|..:::|.|:|.|.|:|:.:|..|......|..|:|.
Zfish   225 GWEKKSIVMLNLTDDPG-GVRTQRL--LKENEAQVRLLYCSQEEAEQVFLAAWAAGQAGASHIWF 286

  Fly   268 VTEQALFSNNTPDGVLGLQLE-HAHSDKGHIRDSVYVLASAIKEMISNETIAEAPKDCGDS---- 327
            ....||    :..|:.||... .|...:|...:....:|..: .::::..:| ..||.|.:
Zfish   287 AVGPAL----SELGLTGLPKRLFAVRPQGWRDEPRRRIARGV-SILTHGAVA-LRKDYGATGGPH 345

  Fly   328 -AVNWESGKRLFQYLKSR-----NITGETGQVAFDDNGDRIYAGYDVINIREQQKKHVVGKFSYD 386
             ..|.::.....|.::.|     |||......:|.:.|.......|||:.........||.:...
Zfish   346 FVTNCQTDGNRTQRIRGRMRYFSNITLGGRDYSFSNEGYLANPFLDVISYTPGSGWEDVGWWENG 410

  Fly   387 SMRAKMRMRINDSEIIWPGKQRRKPEGIMIP----THLRLLTIEEKPFVYVRRMGDDEFRCEPDE 447
            .:|.:           :|...|..|  .:.|    .|||::|:||:|||.|.........|..|.
Zfish   411 VLRLR-----------YPAWSRYGP--FLQPPDDAQHLRVVTLEERPFVIVELADAASGTCIRDS 462

  Fly   448 RPC--PLFNNSDATAN-----EFCCRGYCIDLLIELSKRINFTYDLALSPDGQFGHYILRNNTGA 505
            .||  ||  |:.|...     :.||:|:|||:|..|::.:.|||||.|..:|:.|..|    .|.
Zfish   463 VPCRRPL--NASALQEGVAPVKQCCKGFCIDILKRLARIVGFTYDLYLVTNGKHGKKI----DGV 521

  Fly   506 MTLRKEWTGLIGELVNERADMIVAPLTINPERAEYIEFSKPFKYQGITILEKKPSRSSTLVS--- 567
                  |.|::||:|.:||||.:..||||.||:|.::||.||...||:::   .|||:..||
Zfish   522 ------WNGMVGEVVYKRADMAIGSLTINEERSEVVDFSVPFVETGISVM---VSRSNGTVSPSA 577

  Fly   568 FLQPFSNTLWILVMV-SVHVVALVLYLLDRFSPFGRFKLSHSDSNEEKA----LNLSSAVWFAWG 627
            ||:|:|..:|:::.| .:.|||:.:::.:.|||.|   .:.|..:.:||    ..:..::|..|.
Zfish   578 FLEPYSPAVWVMMFVMCLTVVAVTVFIFEFFSPVG---YNRSLQSGKKAGGSKFTIGKSIWLLWA 639

  Fly   628 VLLNSGIGEGTPRSFSARVLGMVWAGFAMIIVASYTANLAAFLVLERPKTKLSGINDARLRNTME 692
            ::.|:.:....|:..:::::.:|||.||:|.:||||||||||::.|.....:||::|.:.::..|
Zfish   640 LVFNNSVPVENPKGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEEYIDTVSGLSDKKFQHPTE 704

  Fly   693 N---LTCATVKGSSVDMYFRRQVELSNMYRTMEANNYATAEQAIQDVKKGKLMAFIWDSSRLEYE 754
            .   |...||...|.:...|.  ...:|::.|...|..:.|.||..:|.|||.|||:|::.|.|.
Zfish   705 QYPPLKFGTVPNGSTEKNIRS--NYPDMHQYMVKYNQKSVEDAISHLKTGKLDAFIYDAAVLNYM 767

  Fly   755 ASKD--CELVT--AGELFGRSGYGIGLQKGSPWTDAVTLAILEFHESGFMEKLDKQW---IFHGH 812
            |.||  |:::|  :|::|..:||||.|.|.|.|...:.||:|:......:|.|::.|   |.|.
Zfish   768 ARKDEGCKVMTIGSGKVFATTGYGIALIKNSRWKRPLDLALLQLVGDDEIEMLERLWLSGICHN- 831

  Fly   813 VQQNCELFEKTPNTLGLKNMAGVFILVGVGIAGGVGLIII---EVIYKKHQVKKQKRLDIARHAA 874
                 :..|...:.|.:.||||||.::.|  |.|:.|::.   .::|.:           .||..
Zfish   832 -----DKIEVMSSKLDIDNMAGVFYMLLV--AMGLSLLVFAWEHLVYWR-----------LRHCM 878

  Fly   875 DKW-------------RGTIE----KRKTIR--ASLAMQRQYNVGLNSTHAPGTISLAVDKRRYP 920
            .|.             ||...    :.:|.:  |.:.:...::..:..|.:...::.||..   |
Zfish   879 SKMGQSGKLDFLLAFSRGMYSCCSFEDETAQGGAKVTVSGHHHTAMVPTSSSHVVTSAVSN---P 940

  Fly   921 RLG-----QRLGPERAWPGDAADVLRIRRPYELGNPGQSPKVM---AANQP------GMPMP 968
            .:.     |:..|::..|..:         |:...||..|.::   ||..|      |.|:|
Zfish   941 AIAMVQQQQQQQPQQPQPPQS---------YKTPLPGSPPPIVHSGAALGPANTQLIGAPLP 993

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	12..405	CDD:107374	65/342 (19%)
		ANF_receptor	58..371	CDD:279440	62/308 (20%)
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	149/429 (35%)
		HisJ	451..>558	CDD:223904	44/111 (40%)
		Periplasmic_Binding_Protein_Type_2	<516..651	CDD:304360	45/142 (32%)
		Lig_chan	575..838	CDD:278489	89/277 (32%)
		CaM_bdg_C0	854..882	CDD:287524	6/40 (15%)
LOC100149482	XP_009290417.1	PBP1_iGluR_NMDA_NR2	44..421	CDD:107373	66/345 (19%)
		PBP2_iGluR_NMDA_Nr2	433..831	CDD:270436	147/417 (35%)
		HisJ	<487..>570	CDD:223904	40/95 (42%)
		Lig_chan	585..857	CDD:278489	90/284 (32%)
		NMDAR2_C	868..>900	CDD:287527	6/42 (14%)
		FAM76	<1763..>1856	CDD:292665
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910