Protein Alignment Nmdar1 and grid1

DIOPT Version :10

• Sequence 1: NP_730940.1
• Gene: Nmdar1 / 40665
• FlyBaseID: FBgn0010399
• Length: 997
• Species: Drosophila melanogaster
• Sequence 2: NP_001096470.1
• Gene: grid1 / 100125089
• XenbaseID: XB-GENE-990290
• Length: 1009
• Species: Xenopus tropicalis
• Alignment Length: 1071
• Identity: 254/1071 - (23%)
• Similarity: 446/1071 - (41%)
• Gaps: 231/1071 - (21%)

  Fly    37 STYNIGGVLSNS--DSEEHFSTTIKHLNFDQQYV-PRKVTYYDKTIRMDKNPIKTVFNVCDKLIE 98
            |..:||.:...:  ..:|.|...:..|:.:...: ..|:||..|.|..: ||.:.|...|| |:.
 Frog    22 SIIHIGAIFEENAVKDDEVFQLAVSDLSLNDDILQSEKITYSIKFIEAN-NPFQAVQEACD-LMT 84

  Fly    99 NRVYAVVVSHEQTSGDLSPAAVSYTSGFYSIPVIGISSRDAAFSDKNI--------HVSFLRTVP 155
            ..:.|:|.|    :|..|..|:...:....||.|.: .|::..|.:.:        ...:.....
 Frog    85 QGILALVTS----TGCASANALQSLTDAMHIPHIFV-QRNSGGSPRTVCQFNPSPEGEEYTLAAR 144

  Fly   156 PYYHQADVWLEMLSHFAYTKVIIIHSSDTDGRAILGRFQTTSQTYYD----DVD-----VRATV- 210
            |.....||.|::::...:.|.|:.:.||.|.|.:.|.....|:...|    .||     |.||:
 Frog   145 PPVRLNDVMLKLVTELRWQKFIVFYDSDYDIRGLQGFLDQASRLGLDVSLQKVDRNISRVFATLF 209

  Fly   211 ------EL----------IVEFEPK-LESFTEHLIDMKTAQSRVYLMYASTE--DAQVIFRDAGE 256
                  ||          |:...|: .:||....::...|....:.:|.:.|  ||:::     |
 Frog   210 TSMKTEELNRYRDTLRRAILLLSPRGAQSFISEAVETNLASKDSHWVYVNEEINDAEIV-----E 269

  Fly   257 YNMTGEGHVWIVTE--QALFSNN----------------TPDGVLG-LQLEHAHSDKGHIRDSVY 302
            ...:..|.:.::.:  .:|..||                ..:|.|. ||:.:.     ::.|||.
 Frog   270 LVHSALGRITVIRQIFPSLKDNNIRCVRNNHRIASLPCDPQEGYLQMLQVSNL-----YLYDSVL 329

  Fly   303 VLASAI-KEMISNETIAEAPKDC-GDSAVNWESGKRLFQYLKSRNITGETGQVAFDDNGDRIYAG 365
            :||:|. :::...:..:.|..:| ..|...|..|:.:...:|...|||.||.:.|.:.|...:..
 Frog   330 MLANAFHRKLEDRKWHSMASLNCMRKSTKPWNGGRSMLDTIKKGRITGLTGIMEFKEAGANPHVQ 394

  Fly   366 YDVI--NIREQQKKHVVGKFSYDSMRAKMRMRINDSEIIWPGKQRRKP-----EGIMIPTHLRLL 423
            ::::  :..|...|.|....::|||:.            :.|..:.||     :|:.    |:::
 Frog   395 FEILGTSYSETFGKDVRRLATWDSMKG------------FNGSLQEKPLNNDLQGLT----LKVV 443

  Fly   424 TIEEKPFVYVRRMGDDEFRCEPDERPCPLFNNSDATANEFCCRGYCIDLLIELSKRINFTYDLAL 488
            |:.|:|||.|.    :....:|..                 .:|:.|::|.|||.|:.|.|::..
 Frog   444 TVLEEPFVMVA----ENILGQPKR-----------------YKGFSIEILDELSNRLGFKYEIYQ 487

  Fly   489 SPDGQFGHYILRNNTGAMTLRKEWTGLIGELVNERADMIVAPLTINPERAEYIEFSKPFKYQGIT 553
            :|||::||.:...:         |.|:||||:|:|||:.::.:||.|||...::|:|.:....:.
 Frog   488 APDGKYGHQLSNGS---------WNGMIGELINKRADIAISAITITPERENVVDFTKRYLDYSVG 543

  Fly   554 ILEKKPSRSSTLVSFLQPFSNTLWILVMVSVHVVALVLYLLDRFSPFGRFKLSHSDSNEEKALNL 618
            ||.|||.....:.|...||...:|..:...:.||.:::::|:|.... |.:.| |.:::..:..|
 Frog   544 ILIKKPEERINIFSLFAPFDFAVWACIAAVIPVVGVLIFVLNRIQAV-RAQNS-SQTSQSTSSTL 606

  Fly   619 SSAVWFAWGVLLNSGIGEGTPRSFSARVLGMVWAGFAMIIVASYTANLAAFLVLERPKTKLSGIN 683
            .||:|..:|..:..| ||....|.:.|::...|..|.:|:.:||||||||||.:.|....:....
 Frog   607 HSAIWIVYGAFVQQG-GESAANSVAMRIVMGSWWLFTLIVCSSYTANLAAFLTVSRMDNPIRTFQ 670

  Fly   684 DARLRNTMENLTCATVKGSSVDMYFR--------RQVELSNMYRTMEANN-----YATAEQAIQD 735
            |..   ...:|...|||.|||..||:        :....:.::||:..||     .::..:.|:.
 Frog   671 DLA---KQVDLPYGTVKDSSVYEYFKSKGTNTLVQDRTFAELWRTIGKNNGSDNCVSSPSEGIRK 732

  Fly   736 VKKGKLMAFIWDSSRLEYEASKD--CELVTAGELFGRSGYGIGLQKGSPWTDAVTLAILEFHESG 798
            .|:|. .||:||.:.:||.|..|  |.:...|......||||.||.|||:.|..:..||||.:||
 Frog   733 AKRGN-YAFLWDVTVVEYAALTDDECSVAVTGNTISSKGYGIALQHGSPYRDIFSQRILEFQDSG 796

  Fly   799 FMEKLDKQW---------IFHGHVQQNCELFEKTPNTLGLKNMAGVFILVGVGIAGGVGLIIIEV 854
            .::.|.::|         ..|.:.|.:       ...|.|.:.||||.::.:|:.....:..:|:
 Frog   797 RLDVLKEKWWPRTGRCDLNSHNNAQND-------GKALKLHSFAGVFCILAIGLLLACLVAALEL 854

  Fly   855 IYKKHQV-----KKQKRLDIARHAADKWRGTIEKRKTIRASLAMQRQYNVGLNSTHAPGTISLAV 914
            .:..::.     |:.|.:::.:                     :.|:.|..::...|...||.|.
 Frog   855 WWNSNRCRQDSPKEDKEVNLEQ---------------------VHRRLNSLIDEDMAHKQISTAS 898

  Fly   915 DKRRYPRLG----QRLGPERAWPGDAADVLRIRRPYELGNPG------------QSPKVMAANQP 963
            .:.....:|    |.|.|.|.:......|... .|.:.|:.|            ..|...:|..|
 Frog   899 IEISALEIGGMPSQTLEPLREYQSTQLSVTTF-LPEQTGHSGGRTLTSIPSSNLPLPLSSSATMP 962

  Fly   964 GM-------------------PMPMLGKTRP 975
            .|                   |||:..::.|
 Frog   963 SMQCKHRSPNGGLFRQSPVKTPMPLSFQSMP 993

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	37..405	CDD:380602	91/430 (21%)
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	126/424 (30%)
		CaM_bdg_C0	854..882	CDD:402271	2/32 (6%)
grid1	NP_001096470.1	PBP1_iGluR_delta_1	25..426	CDD:380615	91/429 (21%)
		PBP2_iGluR_delta_1	437..807	CDD:270448	125/410 (30%)