Protein Alignment Nmdar1 and gria4

DIOPT Version :10

• Sequence 1: NP_730940.1
• Gene: Nmdar1 / 40665
• FlyBaseID: FBgn0010399
• Length: 997
• Species: Drosophila melanogaster
• Sequence 2: XP_031751480.1
• Gene: gria4 / 100125052
• XenbaseID: XB-GENE-5838893
• Length: 902
• Species: Xenopus tropicalis
• Alignment Length: 983
• Identity: 251/983 - (25%)
• Similarity: 426/983 - (43%)
• Gaps: 215/983 - (21%)

  Fly    36 PSTYNIGGVLSNSDSEEHFSTTIKHLNFDQQYVP-RKVTYYDKTIRMDKNPIKTVFNV---CDKL 96
            ||:..|||:...              |.||:|.. |...:...|   ..|..:.:||:   .|.:
 Frog    24 PSSVQIGGLFIR--------------NTDQEYTAFRLAIFLHNT---SPNESEALFNLVPHVDNI 71

  Fly    97 IENRVYAVVVSHEQTSGDLSPAAVSYTSGFYSIPVIGISSRDAAFSDKN----IHVSFLRTVPPY 157
            ..:..:||      |:...|    .|:.|.::|  .|:..:.:..:..:    :|:|.:  .|.:
 Frog    72 ETSNSFAV------TNAFCS----QYSRGVFAI--FGLYDKRSVHTLTSFCSALHISLI--TPSF 122

  Fly   158 YHQAD-------------VWLEMLSHFAYTKVIIIHSSDTD-GRAIL------------------ 190
            ..:.:             ..|.:|.|:.:...:.::  ||| |.:||
 Frog   123 PTEGESQFVLQLRPSLRGALLSLLDHYGWNHYVFLY--DTDRGYSILQAIMEKAGQNGWQVSAIC 185

  Fly   191 -GRFQTTS-QTYYDDVDVRATVELIVEFE-PKLESFTEHLIDM-KTAQSRVYLMYASTEDAQVIF 251
             ..|...| :...:|:|.|...:.:::.| .:|::..|.::.: |..:...|::      |.:.|
 Frog   186 VENFNDASYRRLLEDLDRRQENKFVIDCEVERLQNILEQIVSVGKHVKGYHYII------ANLGF 244

  Fly   252 RDA-------GEYNMTG----EGHVWIVTEQALFSN-NTPDGVLGLQLEHAHSD------KGHIR 298
            :|.       |..|:||    :.:..||||  |... .|.|     |.|:..|:      .....
 Frog   245 KDISLDRFMHGGANVTGFQLVDFNTPIVTE--LMQRWKTLD-----QREYPGSESPPKYTSALTY 302

  Fly   299 DSVYVLASAIKEMISNETIAEAPKDCGDSAVN----WESGKRLFQYLKSRNITGETGQVAFDDNG 359
            |.|.|:|.|.:.:...:.......:.||...|    |..|..:.:.||...|.|.||.:.||..|
 Frog   303 DGVLVMAEAFRILRRQKIDLSRRGNAGDCLANPAAPWGQGIDMERTLKQVRIQGLTGNIQFDHYG 367

  Fly   360 DRIYAGYDVINIREQQKKHVVGKFSYDSMRAKMRMRINDSEIIWPGKQRRKPEGIMIPTHLRLLT 424
            .|:....||:.:    |.:.:.|..|.:...|:.:..::...      :....||...|.: :.|
 Frog   368 RRVNYTMDVLEL----KSNGLRKIGYWNDMDKLVLLQHEPAF------KNDSSGIENRTVI-VTT 421

  Fly   425 IEEKPFVYVRR-----MGDDEFRCEPDERPCPLFNNSDATANEFCCRGYCIDLLIELSKRINFTY 484
            |.|.|:|..::     .|:|:|                        .|||:||..|::|.|...|
 Frog   422 ILEAPYVMYKKNHELLEGNDKF------------------------EGYCVDLAYEIAKHIGIKY 462

  Fly   485 DLALSPDGQFGHYILRNNTGAMTLRKEWTGLIGELVNERADMIVAPLTINPERAEYIEFSKPFKY 549
            .:|:.|||::|   .|::.     .|.|.|::||||..:|::.||||||...|.|.|:|||||..
 Frog   463 KIAIVPDGKYG---ARDSE-----TKIWNGMVGELVYGKAEIAVAPLTITLVREEVIDFSKPFMS 519

  Fly   550 QGITILEKKPSRSST-LVSFLQPFSNTLWILVMVSVHVVALVLYLLDRFSPF---------GRFK 604
            .||:|:.|||.:|.. :.|||.|.:..:|:.::.:...|::||:|:.||||:         |:..
 Frog   520 LGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEPEDGKEG 584

  Fly   605 LSHSDSNEEKALNLSSAVWFAWGVLLNSGIGEGTPRSFSARVLGMVWAGFAMIIVASYTANLAAF 669
            .|....||   ..:.:::||:.|..:..|. :.:|||.|.|::|.||..|.:||::|||||||||
 Frog   585 PSDQPPNE---FGIFNSLWFSLGAFMQQGC-DISPRSLSGRIVGGVWWFFTLIIISSYTANLAAF 645

  Fly   670 LVLERPKTKLSGINDARLRNTMENLTCATVKGSSVDMYFRRQ--VELSNMYRTMEANNYA----T 728
            |.:||   .:|.|..|........:...|:...|...:|:|.  .....|:..|::...:    |
 Frog   646 LTVER---MVSPIESAEDLAKQTEIAYGTLDAGSTKEFFKRSKIAVYEKMWTYMKSAEPSVFTKT 707

  Fly   729 AEQAIQDVKKGK-LMAFIWDSSRLEY-EASKDCELVTAGELFGRSGYGIGLQKGSPWTDAVTLAI 791
            ..:.:..|:|.| ..||:.:|:..|| |..|.|:.:..|......|||:...|.|...:||.||:
 Frog   708 TAEGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKHSQLRNAVNLAV 772

  Fly   792 LEFHESGFMEKLDKQWIFHGHVQQNC-----ELFEKTPNTLGLKNMAGVFILVGVGIAGGVGL-- 849
            |:.:|.|.::||..:|.:.   :..|     :..:|| :.|.|.|:||||.:    :.||:||
 Frog   773 LKLNEQGLLDKLKNKWWYD---KGECGSGGGDSKDKT-SALSLSNVAGVFYI----LVGGLGLAM 829

  Fly   850 --IIIEVIYKKHQVKKQKRLDIARHAADKWR----GTIEKR---------KTIRASLAMQRQYNV 899
              .:||..||.....|:.:|..:....:|.|    |:|.:.         |.:....|:::...:
 Frog   830 LVALIEFCYKSRAEAKRMKLTFSEAIRNKARLSITGSIGENGRVLTPDCPKAVHTGTALRQSSGL 894

  Fly   900 GLNSTHAP 907
            .:.::..|
 Frog   895 AVIASDLP 902

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	37..405	CDD:380602	87/433 (20%)
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	135/428 (32%)
		CaM_bdg_C0	854..882	CDD:402271	7/31 (23%)
gria4	XP_031751480.1	PBP1_iGluR_AMPA_GluR4	28..400	CDD:380611	86/421 (20%)
		PBP2_iGluR_AMPA_GluR4	414..795	CDD:270445	134/423 (32%)