DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nmdar1 and grin1b

DIOPT Version :9

Sequence 1:	NP_730940.1	Gene:	Nmdar1 / 40665	FlyBaseID:	FBgn0010399	Length:	997	Species:	Drosophila melanogaster
Sequence 2:	NP_001137603.1	Gene:	grin1b / 100005675	ZFINID:	ZDB-GENE-051202-2	Length:	937	Species:	Danio rerio

Alignment Length:	966	Identity:	438/966 - (45%)
Similarity:	596/966 - (61%)	Gaps:	111/966 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 PSTYNIGGVLSNSDSEEHFSTTIKHLNFDQQYVPRKVTYYDKTIRMDKNPIKTVFNVCDKLIENR 100
            |.|.|||.|||....|:.|...:...|  ..|...|......::....|.|:...:||:.||.|:
Zfish    21 PKTVNIGAVLSQKRYEQVFKDAVTQAN--NIYGKDKFKMNAISVTHKPNAIQMALSVCEDLISNQ 83

  Fly   101 VYAVVVSHEQTSGD-LSPAAVSYTSGFYSIPVIGISSRDAAFSDKNIHVSFLRTVPPYYHQADVW 164
            |||::|||...|.| |:|..||||:|||.|||:|:::|.:.:|||:||:|||||||||.|||.||
Zfish    84 VYAILVSHPPQSNDHLTPTPVSYTAGFYRIPVVGLTTRMSIYSDKSIHLSFLRTVPPYSHQAQVW 148

  Fly   165 LEMLSHFAYTKVIIIHSSDTDGRAILGRFQT--------TSQTYYDDVDVRATVELIVEFE---- 217
            .:|:..|.:..:|:|.|.|.:|||...|.:|        :....|:::|.       :.|:
Zfish   149 FDMMREFQWNHIILIVSDDHEGRAAQKRLETLLEERETKSKNRNYENLDQ-------LSFDNKRG 206

  Fly   218 PKLE---------SFTEHLIDMKTAQSRVYLMYASTEDAQVIFRDAGEYNMTGEGHVWIVTEQAL 273
            ||.|         :.|..|.:.|..::||.::.||.::|..|::.|.:.||||.|:||:|.|:.:
Zfish   207 PKAEKVLLFSQDTNLTALLQEAKELEARVIILSASEDEAAAIYKVARQLNMTGSGYVWLVGEREM 271

  Fly   274 FS---NNTPDGVLGLQLEHAHSDKGHIRDSVYVLASAIKEMISNETIAEAPKDCGDSAVNWESG- 334
            ..   :..|||:|||||.:..::..||.|:|.|:|.:|:|:...|.|.|.|:.|..:...|::|
Zfish   272 SGKALSEAPDGLLGLQLINGKNESAHIYDAVAVVAQSIQELFEKENITEPPRGCVGNTNIWKTGP 336

  Fly   335 --KRLFQYLKSRNITGETGQVAFDDNGDRIYAGYDVINIREQQKKHVVGKFSYDSMRAKMRMRIN 397
              ||:.  :.|:...|.||:|.|:|:|||.:|.|.::|   .||..:|....|:..:..|..:
Zfish   337 LFKRVL--MSSKYPDGLTGRVEFNDDGDRRFAHYSILN---YQKTRLVQVGVYNGSQVVMNAQ-- 394

  Fly   398 DSEIIWPGKQRRKPEGIMIPTHLRLLTIEEKPFVYVRRMGDDEFRCEPDERPCPLFNNSDATANE 462
             .:|||||.:..||:|..:.|.|:::||.::|||||:          |..|        |.|..|
Zfish   395 -RKIIWPGGETEKPKGYQMSTRLKIVTIHQEPFVYVK----------PTLR--------DGTCKE 440

  Fly   463 ----------------------------FCCRGYCIDLLIELSKRINFTYDLALSPDGQFGHYIL 499
                                        .||.|:||||||:|:..:||||::.|..||:||....
Zfish   441 EHTVNGVKIKKVICTGPNETIPGRPIVPQCCYGFCIDLLIKLAFTMNFTYEVHLVADGKFGTQER 505

  Fly   500 RNNTGAMTLRKEWTGLIGELVNERADMIVAPLTINPERAEYIEFSKPFKYQGITILEKKPSRSST 564
            .||:.    :|||.|::|||::..|||||||||||.|||:||||||||||||:|||.||....||
Zfish   506 VNNSN----KKEWNGMMGELLSGLADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRST 566

  Fly   565 LVSFLQPFSNTLWILVMVSVHVVALVLYLLDRFSPFGRFKLSHSDSNEEKALNLSSAVWFAWGVL 629
            |.||:|||.:|||:||.:||||||::||||||||||||||: :|:..||.||.||||:||:||||
Zfish   567 LDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKV-NSEEEEEDALTLSSAMWFSWGVL 630

  Fly   630 LNSGIGEGTPRSFSARVLGMVWAGFAMIIVASYTANLAAFLVLERPKTKLSGINDARLRNTMENL 694
            ||||||||.|||||||:||||||||||||||||||||||||||:||:.:::||||.||||..:..
Zfish   631 LNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDKF 695

  Fly   695 TCATVKGSSVDMYFRRQVELSNMYRTMEANNYATAEQAIQDVKKGKLMAFIWDSSRLEYEASKDC 759
            ..||||.||||:|||||||||.|||.||.:||.:|.:|||.|:..||.||||||:.||:|||:.|
Zfish   696 IYATVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEASQKC 760

  Fly   760 ELVTAGELFGRSGYGIGLQKGSPWTDAVTLAILEFHESGFMEKLDKQWIFHGHVQQNCELFEKTP 824
            :|||.||||.|||:|||::|.|||...|:||||..||:||||.|||.|:.:    |.|:.....|
Zfish   761 DLVTTGELFFRSGFGIGMRKDSPWKQNVSLAILSSHENGFMEDLDKTWVRY----QECDSRSNAP 821

  Fly   825 NTLGLKNMAGVFILVGVGIAGGVGLIIIEVIYKKHQVKKQKRLDIARHAADKWRGTIEKRKTIRA 889
            .||..:||||||:||..||..|:.||.||:.||:|:..::|::.:|..|.:.||..::.||:.||
Zfish   822 ATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRHKDARRKQMQLAFAAVNVWRKNLQDRKSGRA 886

  Fly   890 SLAMQRQYNVGLNSTHAPGTISLAVDKRRYPRLGQRLGPERAWPGDAADVLRIRRP 945
            ....:::.:....||:....|     |||      |...:..:|.|....|.:..|
Zfish   887 EPDPKKKASFRSISTNLASNI-----KRR------RSSKDTPYPTDITGQLNLSDP 931

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	12..405	CDD:107374	143/396 (36%)
		ANF_receptor	58..371	CDD:279440	124/340 (36%)
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	248/428 (58%)
		HisJ	451..>558	CDD:223904	60/134 (45%)
		Periplasmic_Binding_Protein_Type_2	<516..651	CDD:304360	100/134 (75%)
		Lig_chan	575..838	CDD:278489	177/262 (68%)
		CaM_bdg_C0	854..882	CDD:287524	8/27 (30%)
grin1b	NP_001137603.1	PBP1_iGluR_NMDA_NR1	5..401	CDD:107374	143/396 (36%)
		ANF_receptor	36..372	CDD:279440	126/346 (36%)
		PBP2_iGluR_NMDA_Nr1	413..815	CDD:270437	248/428 (58%)
		Lig_chan	577..840	CDD:278489	179/267 (67%)
		CaM_bdg_C0	851..879	CDD:287524	8/27 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574587
Domainoid	1	1.000	356	1.000	Domainoid score	I941
eggNOG	1	0.900	-	-		E1_KOG4440
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7187
Inparanoid	1	1.050	763	1.000	Inparanoid score	I528
OMA	1	1.010	-	-		QHG49285
OrthoDB	1	1.010	-	-		D108757at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		otm26608
orthoMCL	1	0.900	-	-		OOG6_107231
Panther	1	1.100	-	-	LDO	PTHR18966
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4690
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	15	14.840