DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Itpr and itpr2

DIOPT Version :9

Sequence 1:NP_730941.1 Gene:Itpr / 40664 FlyBaseID:FBgn0010051 Length:2837 Species:Drosophila melanogaster
Sequence 2:XP_021323455.1 Gene:itpr2 / 562585 ZFINID:ZDB-GENE-050419-192 Length:2665 Species:Danio rerio


Alignment Length:2873 Identity:1496/2873 - (52%)
Similarity:1924/2873 - (66%) Gaps:281/2873 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 ASFLHLGDIVSLYAEGSVCGFLSTLGLVDDRTVVCPEAGDLSCPPKKFRDCLIKICPMNRYSAQK 73
            :||||:||||||||||:|.||:|||||||||.||.||.|||:.|||||||||.|:|||||||||:
Zfish     6 SSFLHIGDIVSLYAEGTVNGFISTLGLVDDRCVVQPETGDLTNPPKKFRDCLFKVCPMNRYSAQR 70

  Fly    74 QFWKAAKQSASSNTDPNLLKRLHHAAEIEKKQNETENKKLLGTSIQYGRAVVQLLHLKSNKYLTV 138
            |||||.:....:||..:|.|:|.||||:|:|||::|||||||..::|.| |:||||:||||||||
Zfish    71 QFWKAKQGKHGNNTQADLFKKLQHAAELEQKQNDSENKKLLGEVVKYSR-VIQLLHIKSNKYLTV 134

  Fly   139 NKRLPSLLEKNAMRVYLDANGNEGSWFYIKPFYKLRSIGDYVVVGDKVILSPVNADQQNLHVAAN 203
            |||||:|||||||||.||.:|||||||||:||:||||.||.|||||||:|.||||.|. || |:|
Zfish   135 NKRLPALLEKNAMRVSLDPSGNEGSWFYIQPFWKLRSEGDNVVVGDKVVLMPVNAGQP-LH-ASN 197

  Fly   204 YELPDNPGCKEVNVLNSSTSWKISLFMEHKENQEHILKGGDVVRLFHAEQEKFLTMDEYKKQYHV 268
            .||.||.||||||.||.:||||::|||:..|.::.||||||||||||||||||||.||||||.:|
Zfish   198 IELLDNRGCKEVNALNCNTSWKVTLFMKFSEYRDDILKGGDVVRLFHAEQEKFLTCDEYKKQQYV 262

  Fly   269 FLRTTGRTSATAATSSKALWEIEVVQHDSCRGGAGDWNSLYRFKHLATGHYLAAEAEIDVSAGAM 333
            |||||.|.|||:|||||||||:|||.:|.||||||.||||:||||||||||||||...|.     
Zfish   263 FLRTTLRQSATSATSSKALWEVEVVHYDPCRGGAGQWNSLFRFKHLATGHYLAAEVNPDF----- 322

  Fly   334 SATSASGHDLHLGDCSKDSGLSCSTMNSTINDKPKGKQ--------YRLVSVPYSADIASVFVLD 390
                            ||...|.:|.|.|..:....|:        |.||:||:..||||:|.||
Zfish   323 ----------------KDRTDSITTKNETNTESLYSKKKWQADKIPYTLVAVPHGNDIASLFELD 371

  Fly   391 ATTMARPDSLVPQSSYVRLQHICSNTWVHATSIPIDADDDKPVMSMVCCSPIKEDKEAFALIPVS 455
            |||:.|.|.|||::|||||:::|:||||.:|:||||.::::|||..:....:|||||||::..|.
Zfish   372 ATTLQRADCLVPRNSYVRLRNLCTNTWVTSTNIPIDVEEERPVMLKIGTCHMKEDKEAFSINSVP 436

  Fly   456 PVEVRDLDFANDACKVLATVTSKLD-NGSISINERRALISLLQDIVYFIAGMENEQNKTKALEFT 519
            ..|||||||||||.|||.:....|. :...:.||||..|.||:|:::|:..:.|  |....|...
Zfish   437 LSEVRDLDFANDANKVLESFVRILGISNYAAANERRFTIKLLEDLIFFVGDVPN--NGQDVLSVV 499

  Fly   520 IKNPIRDRQKLLREQYILKQLFKILQGPFQQHTAGDGPFLRLDELSDPKNSPYKNIFRLCYRILR 584
            |.||.|:||||:|||.||.|:|.||:.||.:  ..|.|..:|:::.:.:||.:|.:.:||||.||
Zfish   500 ISNPNRERQKLMREQNILAQIFGILKAPFSE--IKDSPMPKLEDVGEQRNSAFKYMLQLCYRTLR 562

  Fly   585 LSQQDYRKNQEYIAKHFGLMQKQIGYDILAEDTITALLHNNRKLLEKHITAAEIETFVGLVRKNM 649
            .||||||||||||||:|.:||.||||:||||||||||||||||||||||||.||||||.|:|:|.
Zfish   563 HSQQDYRKNQEYIAKNFSIMQAQIGYEILAEDTITALLHNNRKLLEKHITAREIETFVKLLRRNR 627

  Fly   650 HNWDSRFLDYLSDLCVSNRKAIAVTQELICKSVLSDKNKDILIETQVKALRTGSGPVRCYKGNSE 714
               :.|||||||||||||:.||.||||||||.:|:..|.||||:|::                  
Zfish   628 ---EPRFLDYLSDLCVSNKTAIPVTQELICKFMLNPTNADILIQTKL------------------ 671

  Fly   715 DVCLATLAEDAGDDEDRSDVQSTSTTTTWDSASLNEDDGTPSTGDKYEIHLKWTG---QPTSRSM 776
                               :|.|.|:.   .:||..||     .:..|:.|.|..   :|..:|:
Zfish   672 -------------------IQHTETSL---ESSLLHDD-----VEDEEVWLYWIDHHKEPHGKSI 709

  Fly   777 ADLA--SCDGGELEAAILNYYRHQLNLFSNMCLNRQYLALNELSPRLDIDLILKCMSDETMPYEL 839
            ..||  :.||.:|:..|:.|||.|||||:.|||:|||||:|::|..|.:||||:||.|:.:||.|
Zfish   710 RHLAQDAKDGQKLDTDIITYYRCQLNLFAKMCLDRQYLAINQISIPLPVDLILRCMFDDCLPYNL 774

  Fly   840 RASFCRLMLHLHVDRDPQEPVTPVKYARLWSEIPSKMSIQDYDGKNQQPDQNKQACRAKFNTTIA 904
            ||||||||||:||||||||.|.||:|||||:|||||:|:.:||.:.:  |.:::..:.||..|:.
Zfish   775 RASFCRLMLHMHVDRDPQEAVVPVRYARLWTEIPSKISVNEYDYEFR--DTSREEMKRKFAPTMH 837

  Fly   905 FVENYLCNVATKVWLFTDQEQNKLTFEVVKLARDLIYFGFYSFSDLLRLTKTLLSILDCVSDTSS 969
            ||:.||.:|.::...|.|:|:|:||.|||.|||:|:|||||||::||.||:|||:|||.|..|.:
Zfish   838 FVDEYLKDVVSQPDPFGDREKNELTLEVVHLARNLVYFGFYSFNELLSLTRTLLAILDIVQPTYT 902

  Fly   970 GEFASTDIDSVEEETNAEAEGG--VLRSIGDINTVMTSLALGSVG----------QAIAAPTISL 1022
              |.|        :.|...|||  |:|:|..:..::|.:.| |.|          |.|....|.|
Zfish   903 --FMS--------KLNKGPEGGNNVMRTIHGVGEMVTQMVL-SRGLMMPHCLPDAQPIHGKQICL 956

  Fly  1023 QQRKSVSQLMKEYPLVMDTKLKIIEILQFILDVRLDYRISCLLSIFKREFDESEVAASAASNEAS 1087
            ...::|        :||||||:|||||||||:|||||||:.||||:|:||.:..:.|||:..|. 
Zfish   957 PDNENV--------MVMDTKLRIIEILQFILNVRLDYRITYLLSIYKKEFGDHTLDASASVAEV- 1012

  Fly  1088 QQQSQQQEPQTPGSSNETDPLDSAESVAAGAAAAAATTARQKNIDLESIGVQAEGIFDCERSDAA 1152
               ....||                                   ::|.|..:||.:|.....:.:
Zfish  1013 ---PVMAEP-----------------------------------NIEDIAEKAENMFSGSAKERS 1039

  Fly  1153 NLDLDGQGGRTFLRVLLHLIMHDYAPLVSGALHLLFRHFSQRQEVLQAFRQVQLLVSDSDVESYK 1217
            .:|||.:||:||||||:||||.||.|||||:|.|:|:|||||.||||||:|||||||:.|||:||
Zfish  1040 PVDLDDEGGQTFLRVLIHLIMQDYPPLVSGSLQLIFKHFSQRSEVLQAFKQVQLLVSEEDVENYK 1104

  Fly  1218 QIKSDLDILRQSVEKSELWVYKA---------------KATDELGATDAGGDAVSLEYNAALSQE 1267
            :||:.||.||.:||||||||.|:               :.::|.|......|..|   ...:...
Zfish  1105 KIKASLDQLRLTVEKSELWVEKSGGYGSEDLTENQNKEQNSEEAGILSPVQDGNS---KPQIDSN 1166

  Fly  1268 QRNEYRKVKEILIRMNKFCVTASGPGSVVKPRKHEQRLLRNVGVHTVVLDLLQNPYDEKDDELMK 1332
            :.|.|:.|||||:.::|.|..|.      |.|..:||||:|:|.|||||||||.|| ||.||.|.
Zfish  1167 KANNYKIVKEILLSLSKLCSPAK------KTRVQQQRLLKNMGAHTVVLDLLQIPY-EKGDEKMD 1224

  Fly  1333 ELMCLAHEFLQNFCLGNQQNQVLLHNHLDLFLNPGILEAKTVCAIFKDNLALCNEVTDKVVQHFV 1397
            |:|.|||.|||.||..|.|||.|||.||:|||.||:|||||:|.||.:|..||||::|:||.|||
Zfish  1225 EIMTLAHTFLQYFCKDNVQNQALLHKHLNLFLTPGLLEAKTMCYIFMNNYHLCNEISDRVVHHFV 1289

  Fly  1398 HCIEIHGRHVAYLQFLQTVVRAENQFIRRCQDMVMQELINSGEDVLVFYNDKGSFNHFVQMMQQQ 1462
            ||||.|||||.||:||||:|:|:.::::.||..||.||:|.||||||||||:.||.....||   
Zfish  1290 HCIETHGRHVQYLRFLQTIVKADGKYVKECQCKVMNELVNGGEDVLVFYNDRASFPALQSMM--- 1351

  Fly  1463 MLRMEKLSDDSPLKYHVELVKLLACCTMGKNVYTEIKCNNLLSLDDIVTIICHPLCMPEVKEAYV 1527
               ...|.:...|.||:.||:|||.||.||||.||:|||:||.|||||.::.:..|.||||.|||
Zfish  1352 ---CSGLDETGALMYHITLVELLAACTEGKNVDTELKCNSLLPLDDIVNVVTYDGCTPEVKIAYV 1413

  Fly  1528 DFLNHCYIDTEVEMKEIYASGHMWSLFEKSFLVDINQLITNPAAASN--KTLQAYVLNGVTNLLG 1590
            :|:||||:||||||||||.|.|:|:||: |||||:..:...|....|  .:|:.||.:.:..::.
Zfish  1414 NFVNHCYVDTEVEMKEIYTSDHIWNLFD-SFLVDMATVSIGPTDRKNADTSLEKYVTDTIMAIVK 1477

  Fly  1591 SFFASPFSDQSAIVQSRQLIFVQLLQAAHRITQCRWLSLGDRFNVENCIRTLTESAKMRSIALPP 1655
            .||.|.||..::.:|:.|..|::|||:|.|:..|.||:...:.|:|.||:||.:.||.|:|.:|.
Zfish  1478 GFFGSQFSVSNSKLQAHQATFIKLLQSACRLYNCTWLNSLQKTNIEGCIKTLADVAKSRAIPIPV 1542

  Fly  1656 ELEQQVATMSSK--TAMLTRQTTKWLLASK-QPKYEAQQAASLMRWDRSIIEGLQDIVSLLEDQL 1717
            :|:.||..:|.|  |:|:.|....|.|::: :|:.|...|     .|..|||.||.:||.||:|.
Zfish  1543 DLDGQVNALSLKTHTSMVQRAVKDWRLSARGRPRKEPFGA-----HDYKIIEKLQGVVSYLEEQF 1602

  Fly  1718 KPVVEAELSLLVDILYRSELLFPAGTEARKRCESGGFIRKLIKHTEKLLEEKEERMCVKVLRTLR 1782
            .|.|:||.|:|||:|:..|:|||  ..|:.|.|.|.|:.||||||:||: ||||::|:|:|:|||
Zfish  1603 NPRVQAEFSVLVDVLHSPEMLFP--ESAQLRTEDGAFLSKLIKHTKKLM-EKEEKLCIKILQTLR 1664

  Fly  1783 EMMAIDVNYGEKGDALRQTLLLRYF--QTKSTPRLPEDEVPLLAAPLMDPAKQNHLVTHG--PGA 1843
            ||:.....:.|||:|||::||..||  .||:                ::.:..|...:.|  || 
Zfish  1665 EMLDRREMFDEKGNALRKSLLAHYFGNHTKA----------------LEYSSSNSSSSGGGSPG- 1712

  Fly  1844 KYLQRAGKTLHEMQNHLDREGASDLVVELVIKSVHSPNIFVEAVELGIALLEGGNPIIQKGMFQK 1908
            :...:.|.:|.::|..||..|||:|||:|:: |..:..||.|::.||||||.|||..||.....:
Zfish  1713 QDSDKPGTSLADIQCVLDNVGASELVVDLIV-STKNDRIFEESILLGIALLRGGNTQIQNSFHNQ 1776

  Fly  1909 FLSDDLNQAFFKVFFEKMKDAQQEIKSTVTVNTTDIAAKAHEHKQDTNLELDKIARKHGLKSNGV 1973
            ......::.||:||:|:|:.||:||:|:|:||..:::.:..|.:.:.:      ..:|....:.:
Zfish  1777 LHKQKKSEKFFRVFYERMEQAQKEIRSSVSVNMFELSCRKREEESEGS------GIRHKKVRDSL 1835

  Fly  1974 VITEELKRELHNAGLATARAYGNARNIHSGEESSAISVNSPLEDILAEKLEKHKDSRDQRNQLSN 2038
            .:.||::.:|.:|...|::||...|.....:..:..:.....|:::.|            .|:|.
Zfish  1836 HLREEMRGQLKDASSVTSKAYSTFRREWDPDIEAVGTTGDATEEVVEE------------IQMSQ 1888

  Fly  2039 KVLVMQPILRFLQLLCENHNPDMQNLLRNQNNKTNNNLVSETLMFLDCICGSTTGGLGLLGLYIN 2103
            .:.:|:||||||||||||||.|:||.||:||||||.|||.|||.|||||||||||||||||||||
Zfish  1889 AITIMKPILRFLQLLCENHNRDLQNFLRDQNNKTNYNLVCETLQFLDCICGSTTGGLGLLGLYIN 1953

  Fly  2104 EHNVALINQTLEALTEYCQGPCHENQNCIATHESNGLDIITALILNNINPLGENRMDLVLELKNN 2168
            |.||.|:.||||.:||||||||||||:|||.|||||:|||.|||:|.|:|||:||:|||||||||
Zfish  1954 ERNVYLVIQTLETITEYCQGPCHENQSCIARHESNGIDIIIALIVNPIDPLGKNRLDLVLELKNN 2018

  Fly  2169 ASKLLLAIMESRGDSENAERILYNMNPKQLVEVACKAYHQEELIDEQDDGDEPDAGSDDDDATVS 2233
            ||||||||||||.||||||:|||.|.|.:||:|..:||.|         |:|.....|:....:.
Zfish  2019 ASKLLLAIMESRQDSENAEKILYKMRPNELVDVIKEAYVQ---------GEEECEIDDETLDLIR 2074

  Fly  2234 PREVGHNIYILCHQLAQHNKELAGLLKASEDPQSASFDAKTSQALMYYATHTAQIEIVRNDRTLE 2298
            .::||||||||.||||:|.|.|...||...||   :.|.:.  ||.||..|||||||||:|||:|
Zfish  2075 SKDVGHNIYILAHQLAKHRKNLQQSLKPGPDP---TIDGEA--ALTYYTNHTAQIEIVRHDRTME 2134

  Fly  2299 QIVFPIPEICEYLTTDTKIKILNTAERDDQGSKVADFFDKAEEMFNEMKWQKKLRSQPLLFWISS 2363
            |||||:|.||||||.::|:::..|.|||||||||.|||.:.::::|||:||||:|:...|||:|.
Zfish  2135 QIVFPVPNICEYLTEESKVRVFTTTERDDQGSKVNDFFQQFDDLYNEMRWQKKIRNNAPLFWVSK 2199

  Fly  2364 YMSLWSNILFNCVVVINMIVAFFYPFDNTVPE--LSSHISLLFWIITIFSLVIVLALPRESGIRT 2426
            ::|||.:|.||..|:||:.||.||||.:...|  |...:|:|.|...:.|...:..||...||..
Zfish  2200 HISLWGSISFNMAVLINLAVALFYPFGDDGDEGVLPPFLSVLLWGAVVVSTFTLFILPPRGGILA 2264

  Fly  2427 FIGSVILRFIFLLGPESTLCLLGVVTVTLKSVHIVSIMGNKGTLEKQLIKIITDFQLLYHCIYIA 2491
            |:.:||.|.|:.||...||.|||...:..|.|.:||.:||:||..:....:|.|...|.|..|:.
Zfish  2265 FLVTVIFRSIYTLGLGPTLLLLGAANLLNKIVFLVSFVGNQGTFTRGYKAVIMDVFFLLHVSYVI 2329

  Fly  2492 FCFCGLIFHPFFYSLLLFDVVYREETLVNVIRSVTRNGRSIVLTAVLALILVYLFSIIGYMFFKD 2556
            .|..||..|.||||:||||:|.|||||:||:||||:|||||.||||||:||||||||:|::||||
Zfish  2330 VCMLGLFVHEFFYSILLFDLVRREETLLNVMRSVTKNGRSIFLTAVLAIILVYLFSIVGFLFFKD 2394

  Fly  2557 DFLVSVDFEEQDNAPPPSVPLTLSVP-VSGD--SCSAPDDLGNCQAAKEVAPPSAGGGEVKERSC 2618
            |||:.||.            |.|..| |:|.  ||.:.|...:..:...|......|   .||.|
Zfish  2395 DFLMEVDH------------LPLKRPNVNGKSMSCVSADCAESMFSRNHVEEEDEDG---SERVC 2444

  Fly  2619 DSLVMCIVTTLNQGLRNGGGIGDILRAPSSKEGLFVARVIYDLLFFFIVIIIVLNLIFGVIIDTF 2683
            |:|:|||:|.||.||||||||.|:||..|.:|.:|.|||:|||||||||||||||||||||||||
Zfish  2445 DTLLMCIITVLNHGLRNGGGIADVLRKLSKEEPMFPARVVYDLLFFFIVIIIVLNLIFGVIIDTF 2509

  Fly  2684 ADLRSEKQQKEAILKTTCFICSLNRSAFDNKTVSFEEHIKSEHNMWHYLYFIVLVKVKDPTEFTG 2748
            ||||||||:||.|||||||||.|.|..||||||||||||||||||||||||:||||||||||:||
Zfish  2510 ADLRSEKQRKEEILKTTCFICGLERDKFDNKTVSFEEHIKSEHNMWHYLYFLVLVKVKDPTEYTG 2574

  Fly  2749 PESYVYAMVKAGILEWFPRLRAMSLAAVDADGEQIELRSMQAQLLDTQLLIKNLSTQLHELKDHM 2813
            |||||..|:|...|:||||:|||||.:.:.:.||.|:||:|.:|..|..|:..||:||.|||:.|
Zfish  2575 PESYVAQMIKEKNLDWFPRMRAMSLVSSEGESEQNEIRSLQERLDTTVSLVAQLSSQLSELKEQM 2639

  Fly  2814 TEQRKQKQRLGLL 2826
            |||||.|||||.|
Zfish  2640 TEQRKNKQRLGFL 2652

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ItprNP_730941.1 Ins145_P3_rec 7..231 CDD:285871 160/221 (72%)
MIR 237..293 CDD:197746 46/55 (84%)
MIR 238..452 CDD:280906 126/221 (57%)
RYDR_ITPR 495..691 CDD:279676 118/195 (61%)
RYDR_ITPR 1294..1413 CDD:279676 78/118 (66%)
RIH_assoc 2042..2147 CDD:285630 85/104 (82%)
Ion_trans 2433..2691 CDD:278921 144/260 (55%)
Sec2p <2782..2819 CDD:283965 20/36 (56%)
itpr2XP_021323455.1 Ins145_P3_rec 6..225 CDD:312293 160/221 (72%)
MIR 232..432 CDD:308455 126/220 (57%)
RYDR_ITPR 475..671 CDD:307497 123/202 (61%)
RYDR_ITPR 1194..1320 CDD:307497 82/126 (65%)
RIH_assoc 1892..1997 CDD:312080 85/104 (82%)
Ion_trans <2316..2517 CDD:306908 127/215 (59%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 482 1.000 Domainoid score I393
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG58623
OrthoDB 1 1.010 - - D58374at33208
OrthoFinder 1 1.000 - - FOG0001660
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_102308
Panther 1 1.100 - - O PTHR13715
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1057
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
98.930

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