|
Fly 9 ASFLHLGDIVSLYAEGSVCGFLSTLGLVDDRTVVCPEAGDLSCPPKKFRDCLIKICPMNRYSAQK 73
:||||:||||||||||||.||:|||||||||.||.|.||||..|||||||||.|:||||||||||
Human 32 SSFLHIGDIVSLYAEGSVNGFISTLGLVDDRCVVEPAAGDLDNPPKKFRDCLFKVCPMNRYSAQK 96
Fly 74 QFWKA--AKQSASSNTDPNLLKRLHHAAEIEKKQNETENKKLLGTSIQYGRAVVQLLHLKSNKYL 136
|:||| .||......|..||::|.|||::|:|||:|||||:.|..::|| :|:||||:||||||
Human 97 QYWKAKQTKQDKEKIADVVLLQKLQHAAQMEQKQNDTENKKVHGDVVKYG-SVIQLLHMKSNKYL 160
Fly 137 TVNKRLPSLLEKNAMRVYLDANGNEGSWFYIKPFYKLRSIGDYVVVGDKVILSPVNADQQNLHVA 201
|||||||:|||||||||.|||.||||||.:|:||:||||.||.|||||||||:||||.|. || |
Human 161 TVNKRLPALLEKNAMRVTLDATGNEGSWLFIQPFWKLRSNGDNVVVGDKVILNPVNAGQP-LH-A 223
Fly 202 ANYELPDNPGCKEVNVLNSSTSWKISLFMEHKENQEHILKGGDVVRLFHAEQEKFLTMDEYKKQY 266
:||||.||.||||||.:|.:|||||:|||:.:::.|.:|||||||||||||||||||.||||.:.
Human 224 SNYELSDNAGCKEVNSVNCNTSWKINLFMQFRDHLEEVLKGGDVVRLFHAEQEKFLTCDEYKGKL 288
Fly 267 HVFLRTTGRTSATAATSSKALWEIEVVQHDSCRGGAGDWNSLYRFKHLATGHYLAAEAEIDVSAG 331
.||||||.|.|||:||||.||||:|||.||.||||||.||.||||||||||:|||||.
Human 289 QVFLRTTLRQSATSATSSNALWEVEVVHHDPCRGGAGHWNGLYRFKHLATGNYLAAEE------- 346
Fly 332 AMSATSASGHDLHLGDCS--KDSGLSCSTMNSTINDKPKGKQYRLVSVPYSADIASVFVLDATTM 394
:..:.||.| |.:|:.........|...|.| |.||:||:..||||:|.||.||:
Human 347 ---------NPSYKGDASDPKAAGMGAQGRTGRRNAGEKIK-YCLVAVPHGNDIASLFELDPTTL 401
Fly 395 ARPDSLVPQSSYVRLQHICSNTWVHATSIPIDADDDKPVMSMVCCSPIKEDKEAFALIPVSPVEV 459
.:.||.||::|||||:|:|:|||:.:|::|||.::::|:..|:...|.||||||||::.|...|:
Human 402 QKTDSFVPRNSYVRLRHLCTNTWIQSTNVPIDIEEERPIRLMLGTCPTKEDKEAFAIVSVPVSEI 466
Fly 460 RDLDFANDACKVLATVTSKLDNGSISINERRALISLLQDIVYFIAGMENEQNKTKALEFTIKNPI 524
|||||||||..:||:...||:.|.||.|:||.:|.||:|:|:|::.:.| |....|:..:..|.
Human 467 RDLDFANDASSMLASAVEKLNEGFISQNDRRFVIQLLEDLVFFVSDVPN--NGQNVLDIMVTKPN 529
Fly 525 RDRQKLLREQYILKQLFKILQGPFQQHTAGDGPFLRLDELSDPKNSPYKNIFRLCYRILRLSQQD 589
|:||||:|||.||||:|.||:.||:: ..|:||.:||:||||.||:||:::||||||:||.||:|
Human 530 RERQKLMREQNILKQVFGILKAPFRE-KGGEGPLVRLEELSDQKNAPYQHMFRLCYRVLRHSQED 593
Fly 590 YRKNQEYIAKHFGLMQKQIGYDILAEDTITALLHNNRKLLEKHITAAEIETFVGLVRKNMHNWDS 654
||||||:|||.||:||.||||||||||||||||||||||||||||..|:||||.|||||. :.
Human 594 YRKNQEHIAKQFGMMQSQIGYDILAEDTITALLHNNRKLLEKHITKTEVETFVSLVRKNR---EP 655
Fly 655 RFLDYLSDLCVSNRKAIAVTQELICKSVLSDKNKDILIETQVKALRTGSGPVRCYKGNSEDVCLA 719
|||||||||||||..||.||||||||.||..||.||||.|::: ||:
Human 656 RFLDYLSDLCVSNHIAIPVTQELICKCVLDPKNSDILIRTELR-------PVK------------ 701
Fly 720 TLAEDAGDDEDRSDVQSTSTTTTWDSASLNEDDGTPSTGDKYEIHLKWTG------QPTSRSMAD 778
|.|...| :.|...:|: |:.|.||. :.:.|.:|.
Human 702 ---EMAQSHE-------------YLSIEYSEE----------EVWLTWTDKNNEHHEKSVRQLAQ 740
Fly 779 LASCDGGELEAAILNYYRHQLNLFSNMCLNRQYLALNELSPRLDIDLILKCMSDETMPYELRASF 843
.|.. |...:..:|:|||:||.||:.|||:|||||::|:|.:|.:|||..||:||.:|::|||||
Human 741 EARA-GNAHDENVLSYYRYQLKLFARMCLDRQYLAIDEISQQLGVDLIFLCMADEMLPFDLRASF 804
Fly 844 CRLMLHLHVDRDPQEPVTPVKYARLWSEIPSKMSIQDYDGK-NQQPDQNKQACRAKFNTTIAFVE 907
|.||||:||||||||.|||||:||||:|||:.::|:|||.. |...|..|. ||..|:.|||
Human 805 CHLMLHVHVDRDPQELVTPVKFARLWTEIPTAITIKDYDSNLNASRDDKKN----KFANTMEFVE 865
Fly 908 NYLCNVATKVWLFTDQEQNKLTFEVVKLARDLIYFGFYSFSDLLRLTKTLLSILDCVSDTSSGEF 972
:||.||.::...|.::|:||||||||.||.:||||||||||:|||||:|||.|:|||....:...
Human 866 DYLNNVVSEAVPFANEEKNKLTFEVVSLAHNLIYFGFYSFSELLRLTRTLLGIIDCVQGPPAMLQ 930
Fly 973 ASTDIDSVEEETNAEAEGG--VLRSIGDINTVMTSLALGSVGQAIAAPTIS--------LQQRKS 1027
|..| .|| |.|||..:..:|:::.|.......:||::| |.:.|.
Human 931 AYED------------PGGKNVRRSIQGVGHMMSTMVLSRKQSVFSAPSLSAGASAAEPLDRSKF 983
Fly 1028 VSQLMKEYPLVMDTKLKIIEILQFILDVRLDYRISCLLSIFKREFDESEVAASAASNEASQQQSQ 1092
.. .|..:||:|||||:|||||||:||||||||.|||:||:||
Human 984 EE---NEDIVVMETKLKILEILQFILNVRLDYRISYLLSVFKKEF-------------------- 1025
Fly 1093 QQEPQTPGSSNETDPLDSAESVAAGAAAA-AATTARQKNIDLESIGVQAEGIFDCERSDAANLDL 1156
.|..|:. :|.|.|.|.| .:||| |::|:.||.|||.:|...:: ::.|::
Human 1026 ----------VEVFPMQ--DSGADGTAPAFDSTTA---NMNLDRIGEQAEAMFGVGKT-SSMLEV 1074
Fly 1157 DGQGGRTFLRVLLHLIMHDYAPLVSGALHLLFRHFSQRQEVLQAFRQVQLLVSDSDVESYKQIKS 1221
|.:|||.|||||:||.||||||||||||.|||:|||||||.:..|:|||||:|..|||:||.|||
Human 1075 DDEGGRMFLRVLIHLTMHDYAPLVSGALQLLFKHFSQRQEAMHTFKQVQLLISAQDVENYKVIKS 1139
Fly 1222 DLDILRQSVEKSELWVYKAKATDELGATDAGGDAVSLEYNAALSQEQR----------------N 1270
:||.||..|||||||| |:.|: |....:|..||..:::| .
Human 1140 ELDRLRTMVEKSELWV------DKKGS----GKGEEVEAGAAKDKKERPTDEEGFLHPPGEKSSE 1194
Fly 1271 EYRKVKEILIRMNKFCVTASGPGSVVKPRKHEQRLLRNVGVHTVVLDLLQNPYDEKDDELMKELM 1335
.|:.||.||.|:||.| |.|. :.||.:||||:|:..|.|:|||||.||| |.|..|.|::
Human 1195 NYQIVKGILERLNKMC----GVGE--QMRKKQQRLLKNMDAHKVMLDLLQIPYD-KGDAKMMEIL 1252
Fly 1336 CLAHEFLQNFCLGNQQNQVLLHNHLDLFLNPGILEAKTVCAIFKDNLALCNEVTDKVVQHFVHCI 1400
...|:|||.||.||..||.|||.||.|||.||:|||:|:..||.:|..||:|:::.|:|||||.:
Human 1253 RYTHQFLQKFCAGNPGNQALLHKHLHLFLTPGLLEAETMQHIFLNNYQLCSEISEPVLQHFVHLL 1317
Fly 1401 EIHGRHVAYLQFLQTVVRAENQFIRRCQDMVMQELINSGEDVLVFYNDKGSFNHFVQMMQQQMLR 1465
..|||||.||.||.||::||.:::::||||:|.||.|:|:||:||||||.|..|.:.||: ..
Human 1318 ATHGRHVQYLDFLHTVIKAEGKYVKKCQDMIMTELTNAGDDVVVFYNDKASLAHLLDMMK---AA 1379
Fly 1466 MEKLSDDSPLKYHVELVKLLACCTMGKNVYTEIKCNNLLSLDDIVTIICHPLCMPEVKEAYVDFL 1530
.:.:.|.|||.||:.||.|||.|..||||||||||.:||.|:|:|:::.|..|:.|||.|||:|:
Human 1380 RDGVEDHSPLMYHISLVDLLAACAEGKNVYTEIKCTSLLPLEDVVSVVTHEDCITEVKMAYVNFV 1444
Fly 1531 NHCYIDTEVEMKEIYASGHMWSLFEKSFLVDINQLIT-NPAAASNKTLQAYVLNGVTNLLGSFFA 1594
||||:||||||||||.|.|:|:||| :|.:|:.::.: .....::.||:.|||:.|.:.:.:||:
Human 1445 NHCYVDTEVEMKEIYTSNHIWTLFE-NFTLDMARVCSKREKRVADPTLEKYVLSVVLDTINAFFS 1508
Fly 1595 SPFSDQSAIVQSRQLIFVQLLQAAHRITQCRWLSLGDRFNVENCIRTLTESAKMRSIALPPELEQ 1659
||||:.|..:|:.|.|.|||||:..|:.:|.||....:.:||.|||||...||.|:|.||.:|:.
Human 1509 SPFSENSTSLQTHQTIVVQLLQSTTRLLECPWLQQQHKGSVEACIRTLAMVAKGRAILLPMDLDA 1573
Fly 1660 QVATMSSKTAMLTRQTTKWLLASKQPKYEAQQAA------SLMRWD-RSIIEGLQDIVSLLEDQL 1717
.:::|.|..|.......: ....|:|...| :..:|| ::|||.||||::.||::|
Human 1574 HISSMLSSGASCAAAAQR-----NASSYKATTRAFPRVTPTANQWDYKNIIEKLQDIITALEERL 1633
Fly 1718 KPVVEAELSLLVDILYRSELLFPAGTEARKRCESGGFIRKLIKHTEKLLEEKEERMCVKVLRTLR 1782
||:|:||||:|||:|:..||||..|:||.:|||||||:.|||:||:.|: |.||::|:||||||:
Human 1634 KPLVQAELSVLVDVLHWPELLFLEGSEAYQRCESGGFLSKLIQHTKDLM-ESEEKLCIKVLRTLQ 1697
Fly 1783 EMMAIDVNYGEKGDALRQTLLLRYFQT-KSTPRLPEDEVPLLAAPLMDPAKQNHLVTHGPGAKYL 1846
:|:.....||::|:.||:.||..|.|. |||.| ..|.||. |.| |
Human 1698 QMLLKKTKYGDRGNQLRKMLLQNYLQNRKSTSR----------GDLPDPI--------GTG---L 1741
Fly 1847 QRAGKTLHEMQNHLDREGASDLVVELVIKSVHSPNIFVEAVELGIALLEGGNPIIQKGMFQKFLS 1911
......:...|..||:|||:.||.:| |.|..:..||.|::.|.|.||:|||..|||......:|
Human 1742 DPDWSAIAATQCRLDKEGATKLVCDL-ITSTKNEKIFQESIGLAIHLLDGGNTEIQKSFHNLMMS 1805
Fly 1912 DDLNQAFFKVFFEKMKDAQQEIKSTVTVNTTDIAAKAHEHKQDTNLELDKIARKHGLKSNGVVIT 1976
|..::.||||..::||.||||.||||.||..|:.::.||.::..: ..:.|.|.:
Human 1806 DKKSERFFKVLHDRMKRAQQETKSTVAVNMNDLGSQPHEDREPVD-----------PTTKGRVAS 1859
Fly 1977 EELKRELHNAGLATARAYGNARNIHSGEESSAISVNSPLEDILAEKLEKHKDSRDQRNQLSNKVL 2041
..:. .::..|....::..|.|.| .|.|.:::...||
Human 1860 FSIP--------GSSSRYSLGPSLRQGHEVS---------------------ERVQSSEMGTSVL 1895
Fly 2042 VMQPILRFLQLLCENHNPDMQNLLRNQNNKTNNNLVSETLMFLDCICGSTTGGLGLLGLYINEHN 2106
:||||||||||||||||.|:||.||.||||||.|||.|||.|||.:|||||||||||||||||.|
Human 1896 IMQPILRFLQLLCENHNRDLQNFLRCQNNKTNYNLVCETLQFLDIMCGSTTGGLGLLGLYINEDN 1960
Fly 2107 VALINQTLEALTEYCQGPCHENQNCIATHESNGLDIITALILNNINPLGENRMDLVLELKNNASK 2171
|.|:.||||.|||||||||||||.||.||||||:|||||||||:|:||.:.||||||:||:||||
Human 1961 VGLVIQTLETLTEYCQGPCHENQTCIVTHESNGIDIITALILNDISPLCKYRMDLVLQLKDNASK 2025
Fly 2172 LLLAIMESRGDSENAERILYNMNPKQLVEVACKAYHQEELIDEQDDGDEPDAGSDDDDATVSPRE 2236
||||:||||.|||||||||.::.|::||:|..|||.||| :.:::.|||||
Human 2026 LLLALMESRHDSENAERILISLRPQELVDVIKKAYLQEE---------------ERENSEVSPRE 2075
Fly 2237 VGHNIYILCHQLAQHNKELAGLLKASEDPQ------------------------SASFDAKTSQA 2277
||||||||..||::|||:|..|||..:..| ||....:....
Human 2076 VGHNIYILALQLSRHNKQLQHLLKPVKRIQEEEAEGISSMLSLNNKQLSQMLKSSAPAQEEEEDP 2140
Fly 2278 LMYYATHTAQIEIVRNDRTLEQIVFPIPEICEYLTTDTKIKILNTAERDDQGSKVADFFDKAEEM 2342
|.||..||:||||||.||::||||||:|.||::||.:||.::..|.|:|:|||||:||||::..:
Human 2141 LAYYENHTSQIEIVRQDRSMEQIVFPVPGICQFLTEETKHRLFTTTEQDEQGSKVSDFFDQSSFL 2205
Fly 2343 FNEMKWQKKLRSQPLLFWISSYMSLWSNILFNCVVVINMIVAFFYPF---DNTVPELSSHISLLF 2404
.|||:||:||||.||::|.|..|:||.:|.||..|.||:|:|||||: .:|....|..|||||
Human 2206 HNEMEWQRKLRSMPLIYWFSRRMTLWGSISFNLAVFINIIIAFFYPYMEGASTGVLDSPLISLLF 2270
Fly 2405 WIITIFSLVIVLALPRESGIRTFIGSVILRFIFLLGPESTLCLLGVVTVTLKSVHIVSIMGNKGT 2469
||:..||:..:.. :...||..|.::|||.|:.||...||.:||.:.:|.|.|.:||.:||:||
Human 2271 WILICFSIAALFT--KRYSIRPLIVALILRSIYYLGIGPTLNILGALNLTNKIVFVVSFVGNRGT 2333
Fly 2470 LEKQLIKIITDFQLLYHCIYIAFCFCGLIFHPFFYSLLLFDVVYREETLVNVIRSVTRNGRSIVL 2534
..:....::.|.:.|||..||.....||..|..|||:||||::||||||.|||:|||||||||:|
Human 2334 FIRGYKAMVMDMEFLYHVGYILTSVLGLFAHELFYSILLFDLIYREETLFNVIKSVTRNGRSILL 2398
Fly 2535 TAVLALILVYLFSIIGYMFFKDDFLVSVDF--EEQDNAPPPSVPLTLSVPVSGDSCSAPDDLGNC 2597
||:|||||||||||:|::|.||||::.||. .....|.|..:|...:..| |:||. |..:|
Human 2399 TALLALILVYLFSIVGFLFLKDDFILEVDRLPNNHSTASPLGMPHGAAAFV--DTCSG--DKMDC 2459
Fly 2598 QAAKEVAPPSAGGGEV--KERSCDSLVMCIVTTLNQGLRNGGGIGDILRAPSSKEGLFVARVIYD 2660
.:...|........|: .||:||:|:|||||.:|.|||||||:|||||.||..|.||.|||:||
Human 2460 VSGLSVPEVLEEDRELDSTERACDTLLMCIVTVMNHGLRNGGGVGDILRKPSKDESLFPARVVYD 2524
Fly 2661 LLFFFIVIIIVLNLIFGVIIDTFADLRSEKQQKEAILKTTCFICSLNRSAFDNKTVSFEEHIKSE 2725
|||||||||||||||||||||||||||||||:||.|||||||||.|.|..|||||||||||||.|
Human 2525 LLFFFIVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSFEEHIKLE 2589
Fly 2726 HNMWHYLYFIVLVKVKDPTEFTGPESYVYAMVKAGILEWFPRLRAMSLAAVDADGEQIELRSMQA 2790
||||:||||||||:||:.|::|||||||..|:|...|:||||:|||||.:.:.:|||.|:|.:|.
Human 2590 HNMWNYLYFIVLVRVKNKTDYTGPESYVAQMIKNKNLDWFPRMRAMSLVSNEGEGEQNEIRILQD 2654
Fly 2791 QLLDTQLLIKNLSTQLHELKDHMTEQRKQKQRLGLLN 2827
:|..|..|:.:|:.||:|||:.||||||::||||.::
Human 2655 KLNSTMKLVSHLTAQLNELKEQMTEQRKRRQRLGFVD 2691
| 
