|
Fly 9 ASFLHLGDIVSLYAEGSVCGFLSTLGLVDDRTVVCPEAGDLSCPPKKFRDCLIKICPMNRYSAQK 73
:|||::||||||||||||.||:|||||||||.||.||||||:.|||||||||.|:||||||||||
Human 6 SSFLYIGDIVSLYAEGSVNGFISTLGLVDDRCVVHPEAGDLANPPKKFRDCLFKVCPMNRYSAQK 70
Fly 74 QFWKAAKQSASSNTDPNLLKRLHHAAEIEKKQNETENKKLLGTSIQYGRAVVQLLHLKSNKYLTV 138
|:|||.:....::|:..|||:|.||||:|:||||:|||||||..::|.. |:||||:||||||||
Human 71 QYWKAKQAKQGNHTEAALLKKLQHAAELEQKQNESENKKLLGEIVKYSN-VIQLLHIKSNKYLTV 134
Fly 139 NKRLPSLLEKNAMRVYLDANGNEGSWFYIKPFYKLRSIGDYVVVGDKVILSPVNADQQNLHVAAN 203
|||||:|||||||||.|||.|||||||||.||:||||.||.:||||||:|.||||.|. || |:|
Human 135 NKRLPALLEKNAMRVSLDAAGNEGSWFYIHPFWKLRSEGDNIVVGDKVVLMPVNAGQP-LH-ASN 197
Fly 204 YELPDNPGCKEVNVLNSSTSWKISLFMEHKENQEHILKGGDVVRLFHAEQEKFLTMDEYKKQYHV 268
.||.|||||||||.:|.:|||||:|||::...:|.:|||||||||||||||||||.|||:|:.|:
Human 198 IELLDNPGCKEVNAVNCNTSWKITLFMKYSSYREDVLKGGDVVRLFHAEQEKFLTCDEYEKKQHI 262
Fly 269 FLRTTGRTSATAATSSKALWEIEVVQHDSCRGGAGDWNSLYRFKHLATGHYLAAEAEIDVSAGAM 333
|||||.|.|||:|||||||||||||.||.||||||.||||:||||||||:|||||.|
Human 263 FLRTTLRQSATSATSSKALWEIEVVHHDPCRGGAGQWNSLFRFKHLATGNYLAAEME-------- 319
Fly 334 SATSASGHDLHLGDCSKDSGLSCSTMNSTIND-KPKGK--------------------QYRLVSV 377
|....|.||......: :.:|....| :.:|| .|.||||
Human 320 ------GCSCFLIDCGTSMTFT-AQLNPDYRDAQNEGKNVRDGVPPTSKKKRQAGEKIMYTLVSV 377
Fly 378 PYSADIASVFVLDATTMARPDSLVPQSSYVRLQHICSNTWVHATSIPIDADDDKPVMSMVCCSPI 442
|:..||||:|.|||||:.|.|.|||::|||||:|:|:||||.:||||||.|:::|||..:.....
Human 378 PHGNDIASLFELDATTLQRADCLVPRNSYVRLRHLCTNTWVTSTSIPIDTDEERPVMLKIGTCQT 442
Fly 443 KEDKEAFALIPVSPVEVRDLDFANDACKVLATVTSKLDNGSISINERRALISLLQDIVYFIAGME 507
||||||||::.|...|||||||||||.|||||...||:||:|:.||||.:..||:|:::|:|.:.
Human 443 KEDKEAFAIVSVPLSEVRDLDFANDANKVLATTVKKLENGTITQNERRFVTKLLEDLIFFVADVP 507
Fly 508 NEQNKTKALEFTIKNPIRDRQKLLREQYILKQLFKILQGPFQQHTAGDGPFLRLDELSDPKNSPY 572
| |..:.|:..|..|.|:||||:|||.||.|:|.||:.||:: .||:|..|||::|.|.:.:||
Human 508 N--NGQEVLDVVITKPNRERQKLMREQNILAQVFGILKAPFKE-KAGEGSMLRLEDLGDQRYAPY 569
Fly 573 KNIFRLCYRILRLSQQDYRKNQEYIAKHFGLMQKQIGYDILAEDTITALLHNNRKLLEKHITAAE 637
|.:.|||||:||.||||||||||||||:|.:||.|||||||||||||||||||||||||||||.|
Human 570 KYMLRLCYRVLRHSQQDYRKNQEYIAKNFCVMQSQIGYDILAEDTITALLHNNRKLLEKHITAKE 634
Fly 638 IETFVGLVRKNMHNWDSRFLDYLSDLCVSNRKAIAVTQELICKSVLSDKNKDILIETQVKALRTG 702
|||||.|:|:|. :.|||||||||||||..||.||||||||.:||..|.||||:|:|.::: .
Human 635 IETFVSLLRRNR---EPRFLDYLSDLCVSNTTAIPVTQELICKFMLSPGNADILIQTKVVSMQ-A 695
Fly 703 SGPVRCYKGNSEDVCLATLAEDAGDDEDRSDVQSTSTTTTWDSASLNEDDGTPSTGDKYEIHLKW 767
..|:. :::..|..||| |:.|.|
Human 696 DNPME-----------SSILSDDIDDE--------------------------------EVWLYW 717
Fly 768 ---TGQPTSRSMADLA--SCDGGELEAAILNYYRHQLNLFSNMCLNRQYLALNELSPRLDIDLIL 827
..:|..:::..|| :.:|.:.:..:|.|||:|||||:.|||:|||||:|::|.:|.:||||
Human 718 IDSNKEPHGKAIRHLAQEAKEGTKADLEVLTYYRYQLNLFARMCLDRQYLAINQISTQLSVDLIL 782
Fly 828 KCMSDETMPYELRASFCRLMLHLHVDRDPQEPVTPVKYARLWSEIPSKMSIQDYDGKNQQPDQNK 892
:|:|||::|::|||||||||||:||||||||.|.||:|||||:|||:|::|.:||... |.::
Human 783 RCVSDESLPFDLRASFCRLMLHMHVDRDPQESVVPVRYARLWTEIPTKITIHEYDSIT---DSSR 844
Fly 893 QACRAKFNTTIAFVENYLCNVATKVWLFTDQEQNKLTFEVVKLARDLIYFGFYSFSDLLRLTKTL 957
...:.||..|:.|||.||..|..:.:.|.|:|:||||||||.|||:||||||||||:|||||:||
Human 845 NDMKRKFALTMEFVEEYLKEVVNQPFPFGDKEKNKLTFEVVHLARNLIYFGFYSFSELLRLTRTL 909
Fly 958 LSILDCVSDTSSGEFASTDIDSVEEETNAEAEGG--VLRSIGDINTVMTSLAL--GSVGQAIAAP 1018
|:|||.|....|..| |..:...:|| |:|:|..:..:||.:.| ||: ..::.|
Human 910 LAILDIVQAPMSSYF---------ERLSKFQDGGNNVMRTIHGVGEMMTQMVLSRGSI-FPMSVP 964
Fly 1019 TI--SLQQRKSVSQLMKEYPLVMDTKLKIIEILQFILDVRLDYRISCLLSIFKREFDESEVAASA 1081
.: |:...|..|....|...||||||||||||||||.||||||||.:|||:|:||.|..
Human 965 DVPPSIHPSKQGSPTEHEDVTVMDTKLKIIEILQFILSVRLDYRISYMLSIYKKEFGEDN----- 1024
Fly 1082 ASNEASQQQSQQQEPQTPGSSNETDPLDSAESVAAGAAAAAATTARQKNIDLESIGVQAEGIFDC 1146
|:||:.|:|:......:|...:|| .|..|||.:| .
Human 1025 ---------------------------DNAETSASGSPDTLLPSAIVPDID--EIAAQAETMF-A 1059
Fly 1147 ERSDAANLDLDGQGGRTFLRVLLHLIMHDYAPLVSGALHLLFRHFSQRQEVLQAFRQVQLLVSDS 1211
.|.:...:.||.:|||||||||:|||||||.||:||||.|||:|||||.||||||:|||||||:.
Human 1060 GRKEKNPVQLDDEGGRTFLRVLIHLIMHDYPPLLSGALQLLFKHFSQRAEVLQAFKQVQLLVSNQ 1124
Fly 1212 DVESYKQIKSDLDILRQSVEKSELWVYKAK--ATDELGATDAGGDAVSLEYNAALSQEQ------ 1268
||::|||||:|||.||.:||||||||.|:. ...|:|.:...|....:|.:..||..|
Human 1125 DVDNYKQIKADLDQLRLTVEKSELWVEKSSNYENGEIGESQVKGGEEPIEESNILSPVQDGTKKP 1189
Fly 1269 ------RNEYRKVKEILIRMNKFCVTASGPGSVVKPRKHEQRLLRNVGVHTVVLDLLQNPYDEKD 1327
.|.||.|||||||::|.||... |.|...||||:|:|.|:|||||||.|| ||:
Human 1190 QIDSNKSNNYRIVKEILIRLSKLCVQNK------KCRNQHQRLLKNMGAHSVVLDLLQIPY-EKN 1247
Fly 1328 DELMKELMCLAHEFLQNFCLGNQQNQVLLHNHLDLFLNPGILEAKTVCAIFKDNLALCNEVTDKV 1392
||.|.|:|.|||.||||||.||.|||||||.||:|||.||:|||:|:..||.:|..||||::::|
Human 1248 DEKMNEVMNLAHTFLQNFCRGNPQNQVLLHKHLNLFLTPGLLEAETMRHIFMNNYHLCNEISERV 1312
Fly 1393 VQHFVHCIEIHGRHVAYLQFLQTVVRAENQFIRRCQDMVMQELINSGEDVLVFYNDKGSFNHFVQ 1457
|||||||||.|||||.||:||||:|:|:.:::::||||||.||||.|||||:||||:.||...:.
Human 1313 VQHFVHCIETHGRHVEYLRFLQTIVKADGKYVKKCQDMVMTELINGGEDVLIFYNDRASFPILLH 1377
Fly 1458 MMQQQMLRMEKLSDDS-PLKYHVELVKLLACCTMGKNVYTEIKCNNLLSLDDIVTIICHPLCMPE 1521
||..:..| .|:| ||.||:.||:|||.||.|||||||||||:||.|||||.::.|..|:||
Human 1378 MMCSERDR----GDESGPLAYHITLVELLAACTEGKNVYTEIKCNSLLPLDDIVRVVTHDDCIPE 1438
Fly 1522 VKEAYVDFLNHCYIDTEVEMKEIYASGHMWSLFEKSFLVDINQL--ITNPAAASNKTLQAYVLNG 1584
||.|||:|:||||:||||||||||.|.|:|.||| :||||:.:: .|.....::..|:..|...
Human 1439 VKIAYVNFVNHCYVDTEVEMKEIYTSNHIWKLFE-NFLVDMARVCNTTTDRKHADIFLEKCVTES 1502
Fly 1585 VTNLLGSFFASPFSDQSAIVQSRQLIFVQLLQAAHRITQCRWLSLGDRFNVENCIRTLTESAKMR 1649
:.|::..||.|||||.|..:|:.|.:|:||||:|.||..|.|.:...:.:||:|||||.|.||.|
Human 1503 IMNIVSGFFNSPFSDNSTSLQTHQPVFIQLLQSAFRIYNCTWPNPAQKASVESCIRTLAEVAKNR 1567
Fly 1650 SIALPPELEQQVAT--MSSKTAMLTRQTTKWLLASKQ-PKYEAQQAASLMRWD-RSIIEGLQDIV 1710
.||:|.:|:.||.| |.|.:.|:.|....|.|:::. |:: ::|.....|| |:|||.|||:|
Human 1568 GIAIPVDLDSQVNTLFMKSHSNMVQRAAMGWRLSARSGPRF--KEALGGPAWDYRNIIEKLQDVV 1630
Fly 1711 SLLEDQLKPVVEAELSLLVDILYRSELLFPAGTEARKRCESGGFIRKLIKHTEKLLEEKEERMCV 1775
:.||.|..|:::||.|:|||:||..|||||.|::||.|| |.|:.|||.||:||: ||||::|:
Human 1631 ASLEHQFSPMMQAEFSVLVDVLYSPELLFPEGSDARIRC--GAFMSKLINHTKKLM-EKEEKLCI 1692
Fly 1776 KVLRTLREMMAIDVNYGEKGDALRQTLLLRYFQTKSTPRLPEDEVPLLAAPLMDPAKQNHLVTHG 1840
|:|:|||||:....::.|:|:.||:.||.|||:...:..: ..|| .|
Human 1693 KILQTLREMLEKKDSFVEEGNTLRKILLNRYFKGDYSIGV-----------------NGHL--SG 1738
Fly 1841 PGAKYLQ-----------RAGKTLHEMQNHLDREGASDLVVELVIKSVHSPNIFVEAVELGIALL 1894
..:|..| :.|.::.::|..||:||||:||::::: :..:..||.|.:.||||||
Human 1739 AYSKTAQVGGSFSGQDSDKMGISMSDIQCLLDKEGASELVIDVIV-NTKNDRIFSEGIFLGIALL 1802
Fly 1895 EGGNPIIQKGMFQKFLSDDLNQAFFKVFFEKMKDAQQEIKSTVTVNTTDIAAKAHEHKQDTNLEL 1959
||||...|...:|:......::.||||.:::||.||:||:|||||||.|:..| |:|.:.||
Human 1803 EGGNTQTQYSFYQQLHEQKKSEKFFKVLYDRMKAAQKEIRSTVTVNTIDLGNK----KRDDDNEL 1863
Fly 1960 DKIARKHGLKSNGVVITEELKRELHNAGLATARAY--------------------GNARNIHSGE 2004
.....:..::.:.:.:.|.:|.:|..|..||::|| ||. |
Human 1864 MTSGPRMRVRDSTLHLKEGMKGQLTEASSATSKAYCVYRREMDPEIDIMCTGPEAGNT------E 1922
Fly 2005 ESSAISVNSPLEDILAEKLEKHKDSRDQRNQLSNKVLVMQPILRFLQLLCENHNPDMQNLLRNQN 2069
|.||..|. :|..:.:||||||||||||||||.::||.|||||
Human 1923 EKSAEEVT-----------------------MSPAIAIMQPILRFLQLLCENHNRELQNFLRNQN 1964
Fly 2070 NKTNNNLVSETLMFLDCICGSTTGGLGLLGLYINEHNVALINQTLEALTEYCQGPCHENQNCIAT 2134
||||.|||.|||.||||||||||||||||||||||.||||:||.||:|||||||||||||.||||
Human 1965 NKTNYNLVCETLQFLDCICGSTTGGLGLLGLYINEKNVALVNQNLESLTEYCQGPCHENQTCIAT 2029
Fly 2135 HESNGLDIITALILNNINPLGENRMDLVLELKNNASKLLLAIMESRGDSENAERILYNMNPKQLV 2199
|||||:|||.|||||:|||||:.||||||:||||||||||||||||.|||||||||:||.|::||
Human 2030 HESNGIDIIIALILNDINPLGKYRMDLVLQLKNNASKLLLAIMESRHDSENAERILFNMRPRELV 2094
Fly 2200 EVACKAYHQEELIDEQDDGDEPDAGSDDDDATVSPREVGHNIYILCHQLAQHNKELAGLLKASED 2264
:|...||:|.. |.|.|| |.|.||. |||::||||||||.||||:|||.|..:||...|
Human 2095 DVMKNAYNQGL---ECDHGD--DEGGDDG---VSPKDVGHNIYILAHQLARHNKLLQQMLKPGSD 2151
Fly 2265 PQSASFDAKTSQALMYYATHTAQIEIVRNDRTLEQIVFPIPEICEYLTTDTKIKILNTAERDDQG 2329
|... .:||.|||.|||||||||:|||:||||||:|.||||||.::|.::.||.|||:||
Human 2152 PDEG------DEALKYYANHTAQIEIVRHDRTMEQIVFPVPNICEYLTRESKCRVFNTTERDEQG 2210
Fly 2330 SKVADFFDKAEEMFNEMKWQKKLRSQPLLFWISSYMSLWSNILFNCVVVINMIVAFFYPF--DNT 2392
|||.|||.:.|:::||||||||:|:.|.|||.|.::|||.:|.||..|.||:.||.|||| |..
Human 2211 SKVNDFFQQTEDLYNEMKWQKKIRNNPALFWFSRHISLWGSISFNLAVFINLAVALFYPFGDDGD 2275
Fly 2393 VPELSSHISLLFWIITIFSLVIVLALPRESGIRTFIGSVILRFIFLLGPESTLCLLGVVTVTLKS 2457
...||...|:|.||.......::....:..|||.|:.|::||.|:.:|...||.|||...:..|.
Human 2276 EGTLSPLFSVLLWIAVAICTSMLFFFSKPVGIRPFLVSIMLRSIYTIGLGPTLILLGAANLCNKI 2340
Fly 2458 VHIVSIMGNKGTLEKQLIKIITDFQLLYHCIYIAFCFCGLIFHPFFYSLLLFDVVYREETLVNVI 2522
|.:||.:||:||..:....:|.|...|||..|:..|..||..|.||||.||||:|||||||:|||
Human 2341 VFLVSFVGNRGTFTRGYRAVILDMAFLYHVAYVLVCMLGLFVHEFFYSFLLFDLVYREETLLNVI 2405
Fly 2523 RSVTRNGRSIVLTAVLALILVYLFSIIGYMFFKDDFLVSVDFEEQDNAPPPS----VPLTLSVPV 2583
:|||||||||:|||||||||||||||||::|.||||.:.|| ...|..|.: || |:::..
Human 2406 KSVTRNGRSIILTAVLALILVYLFSIIGFLFLKDDFTMEVD--RLKNRTPVTGSHQVP-TMTLTT 2467
Fly 2584 SGDSCSAPDDLGNCQAAKEVAPPSAGGGEVK--------ERSCDSLVMCIVTTLNQGLRNGGGIG 2640
..::| |||...|:....... ||:||:|:|||||.||||||||||:|
Human 2468 MMEAC-----------AKENCSPTIPASNTADEEYEDGIERTCDTLLMCIVTVLNQGLRNGGGVG 2521
Fly 2641 DILRAPSSKEGLFVARVIYDLLFFFIVIIIVLNLIFGVIIDTFADLRSEKQQKEAILKTTCFICS 2705
|:||.||..|.||.|||:|||||:|||||||||||||||||||||||||||:||.|||||||||.
Human 2522 DVLRRPSKDEPLFAARVVYDLLFYFIVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICG 2586
Fly 2706 LNRSAFDNKTVSFEEHIKSEHNMWHYLYFIVLVKVKDPTEFTGPESYVYAMVKAGILEWFPRLRA 2770
|.|..|||||||||||||||||||||||||||||||||||:|||||||..|:....|:||||:||
Human 2587 LERDKFDNKTVSFEEHIKSEHNMWHYLYFIVLVKVKDPTEYTGPESYVAQMIVEKNLDWFPRMRA 2651
Fly 2771 MSLAAVDADGEQIELRSMQAQLLDTQLLIKNLSTQLHELKDHMTEQRKQKQRLGLLNT 2828
|||.:.:.|.||.|:||:|.:|..|..|:|.||.||.|||:.||||||.|||||.|.:
Human 2652 MSLVSNEGDSEQNEIRSLQEKLESTMSLVKQLSGQLAELKEQMTEQRKNKQRLGFLGS 2709
| 
