|
Fly 1 MGDNIIGSASFLHLGDIVSLYAEGSVCGFLSTLGLVDDRTVVCPEAGDLSCPPKKFRDCLIKICP 65
|.|.: :||||:|||.|||||||..||:|||||||||.||.||.|||:.|||||||||.|:||
Human 1 MSDKM---SSFLHIGDICSLYAEGSTNGFISTLGLVDDRCVVQPETGDLNNPPKKFRDCLFKLCP 62
Fly 66 MNRYSAQKQFWKAAKQSASSNTDPNLLKRLHHAAEIEKKQNETENKKLLGTSIQYGRAVVQLLHL 130
|||||||||||||||..|:|.||..||.:|||||::|||||||||:|||||.||||. |:|||||
Human 63 MNRYSAQKQFWKAAKPGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGN-VIQLLHL 126
Fly 131 KSNKYLTVNKRLPSLLEKNAMRVYLDANGNEGSWFYIKPFYKLRSIGDYVVVGDKVILSPVNADQ 195
|||||||||||||:|||||||||.||..|||||||||:||||||||||.||:||||:|:||||.|
Human 127 KSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQPFYKLRSIGDSVVIGDKVVLNPVNAGQ 191
Fly 196 QNLHVAANYELPDNPGCKEVNVLNSSTSWKISLFMEHKENQEHILKGGDVVRLFHAEQEKFLTMD 260
. || |::::|.|||||.|||.:|.:|||||.|||:..:|::.||||||||||||||||||||.|
Human 192 P-LH-ASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILKGGDVVRLFHAEQEKFLTCD 254
Fly 261 EYKKQYHVFLRTTGRTSATAATSSKALWEIEVVQHDSCRGGAGDWNSLYRFKHLATGHYLAAEAE 325
|::|:.|||||||||.|||:|||||||||:||||||.||||||.||||:||||||||||||||.:
Human 255 EHRKKQHVFLRTTGRQSATSATSSKALWEVEVVQHDPCRGGAGYWNSLFRFKHLATGHYLAAEVD 319
Fly 326 IDVSAGAMSATSASGHDLHLGDCSKDSGLSCSTMNSTINDKPKGKQYRLVSVPYSADIASVFVLD 390
.|.....:....:...| .|.|: |.:.:..:...|.|||||...||:|:|.||
Human 320 PDFEEECLEFQPSVDPD---QDASR----------SRLRNAQEKMVYSLVSVPEGNDISSIFELD 371
Fly 391 ATTMARPDSLVPQSSYVRLQHICSNTWVHATSIPIDADDDKPVMSMVCCSPIKEDKEAFALIPVS 455
.||:...|||||::|||||:|:|:|||||:|:||||.:::||||..:..||:||||||||::|||
Human 372 PTTLRGGDSLVPRNSYVRLRHLCTNTWVHSTNIPIDKEEEKPVMLKIGTSPVKEDKEAFAIVPVS 436
Fly 456 PVEVRDLDFANDACKVLATVTSKLDNGSISINERRALISLLQDIVYFIAGMENEQNKTKALEFTI 520
|.|||||||||||.|||.::..||:.|:|:.||||::..||:|:|||:.|..| :....||...
Human 437 PAEVRDLDFANDASKVLGSIAGKLEKGTITQNERRSVTKLLEDLVYFVTGGTN--SGQDVLEVVF 499
Fly 521 KNPIRDRQKLLREQYILKQLFKILQGPFQQHTAGDGPFLRLDELSDPKNSPYKNIFRLCYRILRL 585
..|.|:||||:|||.||||:||:||.||.. .||||.|||:||.|.:::|:::|.|||||:||.
Human 500 SKPNRERQKLMREQNILKQIFKLLQAPFTD--CGDGPMLRLEELGDQRHAPFRHICRLCYRVLRH 562
Fly 586 SQQDYRKNQEYIAKHFGLMQKQIGYDILAEDTITALLHNNRKLLEKHITAAEIETFVGLVRKNMH 650
||||||||||||||.||.||||||||:||||||||||||||||||||||||||:|||.|||||.
Human 563 SQQDYRKNQEYIAKQFGFMQKQIGYDVLAEDTITALLHNNRKLLEKHITAAEIDTFVSLVRKNR- 626
Fly 651 NWDSRFLDYLSDLCVSNRKAIAVTQELICKSVLSDKNKDILIETQVKALR--------TGSGPVR 707
:.||||||||||||..|:|.||||||||:||:..|.||||||::...| ||..
Human 627 --EPRFLDYLSDLCVSMNKSIPVTQELICKAVLNPTNADILIETKLVLSRFEFEGVSSTGEN--- 686
Fly 708 CYKGNSEDVCLATLAEDAGDDEDRSDVQSTSTTTTWDSASLNEDDGTPSTGDKYEIHLKW---TG 769
|.:||:||: |:.|.| ..
Human 687 --------------ALEAGEDEE-------------------------------EVWLFWRDSNK 706
Fly 770 QPTSRSMADLA--SCDGGELEAAILNYYRHQLNLFSNMCLNRQYLALNELSPRLDIDLILKCMSD 832
:..|:|:.:|| :.:|.:.:..:|:|||:|||||:.|||:|||||:||:|.:||:||||:||||
Human 707 EIRSKSVRELAQDAKEGQKEDRDVLSYYRYQLNLFARMCLDRQYLAINEISGQLDVDLILRCMSD 771
Fly 833 ETMPYELRASFCRLMLHLHVDRDPQEPVTPVKYARLWSEIPSKMSIQDYDGKNQQPDQNKQACRA 897
|.:||:|||||||||||:||||||||.|||||||||||||||:::|.|||......|:.|:
Human 772 ENLPYDLRASFCRLMLHMHVDRDPQEQVTPVKYARLWSEIPSEIAIDDYDSSGASKDEIKE---- 832
Fly 898 KFNTTIAFVENYLCNVATKVWLFTDQEQNKLTFEVVKLARDLIYFGFYSFSDLLRLTKTLLSILD 962
:|..|:.|||.||.:|..:.:.|:|:|:||||||||.|||:|||||||:|||||||||.||:|||
Human 833 RFAQTMEFVEEYLRDVVCQRFPFSDKEKNKLTFEVVNLARNLIYFGFYNFSDLLRLTKILLAILD 897
Fly 963 CV--------SDTSSGEFASTDIDSVEEETNAEAE----GGVLRSIGDINTVMTSLALGSVG--- 1012
|| |..:.|| |.:.|.:.| ..|:|||..:..:||.:.|...|
Human 898 CVHVTTIFPISKMAKGE---------ENKGNNDVEKLKSSNVMRSIHGVGELMTQVVLRGGGFLP 953
Fly 1013 --QAIAAPTISLQQRKSVSQLMKEYPLVMDTKLKIIEILQFILDVRLDYRISCLLSIFKREFDES 1075
...|||..:::| ::..||..:||||||||||||||||:|||||||||||.|||||||||
Human 954 MTPMAAAPEGNVKQ----AEPEKEDIMVMDTKLKIIEILQFILNVRLDYRISCLLCIFKREFDES 1014
Fly 1076 EVAASAASNEASQQQSQQQEPQTPGSSNETDPLDSAESVAAGAAAAAATTARQKNIDLESIGVQA 1140
. |..|..:|...||:.....||: :|.|.|..||
Human 1015 N---SQTSETSSGNSSQEGPSNVPGA-----------------------------LDFEHIEEQA 1047
Fly 1141 EGIFDCERSDAANLDLDGQGGRTFLRVLLHLIMHDYAPLVSGALHLLFRHFSQRQEVLQAFRQVQ 1205
||||.....:.. ||||..||||||||||||.||||.|||||||.||||||||||||||||:|||
Human 1048 EGIFGGSEENTP-LDLDDHGGRTFLRVLLHLTMHDYPPLVSGALQLLFRHFSQRQEVLQAFKQVQ 1111
Fly 1206 LLVSDSDVESYKQIKSDLDILRQSVEKSELWVYKAKATDEL--GATDAGGDAVSLEYNAALSQEQ 1268
|||:..||::|||||.|||.||..||||||||||.:..||. ||:.......:.|.| ::.|
Human 1112 LLVTSQDVDNYKQIKQDLDQLRSIVEKSELWVYKGQGPDETMDGASGENEHKKTEEGN---NKPQ 1173
Fly 1269 RNE------YRKVKEILIRMNKFCVTASGPGSVVKPRKHEQRLLRNVGVHTVVLDLLQNPYDEKD 1327
::| ||.|||||||::|.||..| .||.|.||.:||||||:|.|.|||:|||.||::.:
Human 1174 KHESTSSYNYRVVKEILIRLSKLCVQES--ASVRKSRKQQQRLLRNMGAHAVVLELLQIPYEKAE 1236
Fly 1328 DELMKELMCLAHEFLQNFCLGNQQNQVLLHNHLDLFLNPGILEAKTVCAIFKDNLALCNEVTDKV 1392
|..|:|:|.||||||||||.||||||.|||.|::||||||||||.|:..||.:|..||:|:.::|
Human 1237 DTKMQEIMRLAHEFLQNFCAGNQQNQALLHKHINLFLNPGILEAVTMQHIFMNNFQLCSEINERV 1301
Fly 1393 VQHFVHCIEIHGRHVAYLQFLQTVVRAENQFIRRCQDMVMQELINSGEDVLVFYNDKGSFNHFVQ 1457
|||||||||.|||:|.|::||||:|:||.:||::||||||.||:||||||||||||:.||...:|
Human 1302 VQHFVHCIETHGRNVQYIKFLQTIVKAEGKFIKKCQDMVMAELVNSGEDVLVFYNDRASFQTLIQ 1366
Fly 1458 MMQQQMLRMEKLSDDSPLKYHVELVKLLACCTMGKNVYTEIKCNNLLSLDDIVTIICHPLCMPEV 1522
||:.:..||: ::|||.||:.||:|||.||.|||||||||||:||.|||||.::.|..|:|||
Human 1367 MMRSERDRMD---ENSPLMYHIHLVELLAVCTEGKNVYTEIKCNSLLPLDDIVRVVTHEDCIPEV 1428
Fly 1523 KEAYVDFLNHCYIDTEVEMKEIYASGHMWSLFEKSFLVDINQLITNPA--AASNKTLQAYVLNGV 1585
|.||::||||||:||||||||||.|.|||.||| :|||||.:...|.: ..::..|:.||...|
Human 1429 KIAYINFLNHCYVDTEVEMKEIYTSNHMWKLFE-NFLVDICRACNNTSDRKHADSILEKYVTEIV 1492
Fly 1586 TNLLGSFFASPFSDQSAIVQSRQLIFVQLLQAAHRITQCRWLSLGDRFNVENCIRTLTESAKMRS 1650
.:::.:||:|||||||..:|:||.:||||||...|:..|.||....:.:||:|||.|::.||.|:
Human 1493 MSIVTTFFSSPFSDQSTTLQTRQPVFVQLLQGVFRVYHCNWLMPSQKASVESCIRVLSDVAKSRA 1557
Fly 1651 IALPPELEQQVATMSSKTAMLTRQTT-KWLLASKQ-PKYEAQQAASLMRWDRSIIEGLQDIVSLL 1713
||:|.:|:.||..:..|:..:.::|. .|.|:::. .:.::..||| |..|:|||.||||||.|
Human 1558 IAIPVDLDSQVNNLFLKSHSIVQKTAMNWRLSARNAARRDSVLAAS--RDYRNIIERLQDIVSAL 1620
Fly 1714 EDQLKPVVEAELSLLVDILYRSELLFPAGTEARKRCESGGFIRKLIKHTEKLLEEKEERMCVKVL 1778
||:|:|:|:||||:|||:|:|.|||||..|:||::|||||||.||||||::||||.||::|:|||
Human 1621 EDRLRPLVQAELSVLVDVLHRPELLFPENTDARRKCESGGFICKLIKHTKQLLEENEEKLCIKVL 1685
Fly 1779 RTLREMMAIDVNYGEK---------------------------------------GDALRQTLLL 1804
:||||||..|..|||| |:||||.|:.
Human 1686 QTLREMMTKDRGYGEKLISIDELDNAELPPAPDSENATEELEPSPPLRQLEDHKRGEALRQVLVN 1750
Fly 1805 RYFQTKSTPRLPEDEVPLLAAPLM--DPAKQNHLVTHGPGAKYLQRAGKTLHEMQNHLDREGASD 1867
||:.........|........||. .|.|... ...|.|:..:.|...:|.|:|.|||:||||:
Human 1751 RYYGNVRPSGRRESLTSFGNGPLSAGGPGKPGG-GGGGSGSSSMSRGEMSLAEVQCHLDKEGASN 1814
Fly 1868 LVVELVIKSVHSPNIFVEAVELGIALLEGGNPIIQKGMFQKFLSDDLNQAFFKVFFEKMKDAQQE 1932
||::|:: :..|..:|.|::.|.||||||||..||...|.:...|..::.|||||:::||.||||
Human 1815 LVIDLIM-NASSDRVFHESILLAIALLEGGNTTIQHSFFCRLTEDKKSEKFFKVFYDRMKVAQQE 1878
Fly 1933 IKSTVTVNTTDIAAKAHEHKQDTNLELDKIARKHGLKSNGVVITEELKRELHNAGLATARAYGNA 1997
||:||||||:|:..| |:|..::.|..:||.. |.....||||::.:|..|..||.:|:...
Human 1879 IKATVTVNTSDLGNK----KKDDEVDRDAPSRKKA-KEPTTQITEEVRDQLLEASAATRKAFTTF 1938
Fly 1998 R-------NIHSGEESSAISVNSPLEDILAEKLEKHKDSRDQRNQLSNKVLVMQPILRFLQLLCE 2055
| :...||.:.|.: :|.||.. ::|..:.:|||||||||||||
Human 1939 RREADPDDHYQPGEGTQATA-------------DKAKDDL----EMSAVITIMQPILRFLQLLCE 1986
Fly 2056 NHNPDMQNLLRNQNNKTNNNLVSETLMFLDCICGSTTGGLGLLGLYINEHNVALINQTLEALTEY 2120
|||.|:||.||.||||||.|||.|||.||||||||||||||||||||||.||||||||||:||||
Human 1987 NHNRDLQNFLRCQNNKTNYNLVCETLQFLDCICGSTTGGLGLLGLYINEKNVALINQTLESLTEY 2051
Fly 2121 CQGPCHENQNCIATHESNGLDIITALILNNINPLGENRMDLVLELKNNASKLLLAIMESRGDSEN 2185
|||||||||||||||||||:|||||||||:|||||:.|||||||||||||||||||||||.||||
Human 2052 CQGPCHENQNCIATHESNGIDIITALILNDINPLGKKRMDLVLELKNNASKLLLAIMESRHDSEN 2116
Fly 2186 AERILYNMNPKQLVEVACKAYHQEELIDEQDDGDEPDAGSDDDDATVSPREVGHNIYILCHQLAQ 2250
||||||||.||:||||..|||.|.|: |.:||: :.:|...|||.||||||||.||||:
Human 2117 AERILYNMRPKELVEVIKKAYMQGEV--EFEDGE------NGEDGAASPRNVGHNIYILAHQLAR 2173
Fly 2251 HNKELAGLLKASEDPQSASFDAKTSQALMYYATHTAQIEIVRNDRTLEQIVFPIPEICEYLTTDT 2315
|||||..:||....... .:||.:||.|||||||||.|||:||||||:|.|||:||.::
Human 2174 HNKELQSMLKPGGQVDG-------DEALEFYAKHTAQIEIVRLDRTMEQIVFPVPSICEFLTKES 2231
Fly 2316 KIKILNTAERDDQGSKVADFFDKAEEMFNEMKWQKKLRSQPLLFWISSYMSLWSNILFNCVVVIN 2380
|::|..|.|||:||||:.|||.::|::||||.||||||:||:|:|.:..||.||:|.||..|::|
Human 2232 KLRIYYTTERDEQGSKINDFFLRSEDLFNEMNWQKKLRAQPVLYWCARNMSFWSSISFNLAVLMN 2296
Fly 2381 MIVAFFYPFDNT-VPELSSHISLLFWIITIFSLVIVLALPRESGIRTFIGSVILRFIFLLGPEST 2444
::|||||||... ...|..|.|.|.|...:.||.||:|||:..|||..|.|.|||.||.:|.:.|
Human 2297 LLVAFFYPFKGVRGGTLEPHWSGLLWTAMLISLAIVIALPKPHGIRALIASTILRLIFSVGLQPT 2361
Fly 2445 LCLLGVVTVTLKSVHIVSIMGNKGTLEKQLIKIITDFQLLYHCIYIAFCFCGLIFHPFFYSLLLF 2509
|.|||...|..|.:.::|.:||.||..:....::.|.:.|||.:|:..|..||..|.||||||||
Human 2362 LFLLGAFNVCNKIIFLMSFVGNCGTFTRGYRAMVLDVEFLYHLLYLVICAMGLFVHEFFYSLLLF 2426
Fly 2510 DVVYREETLVNVIRSVTRNGRSIVLTAVLALILVYLFSIIGYMFFKDDFLVSVDFEEQDNAPPPS 2574
|:|||||||:|||:|||||||||:|||||||||||||||:||:||||||::.||....:.|.|.:
Human 2427 DLVYREETLLNVIKSVTRNGRSIILTAVLALILVYLFSIVGYLFFKDDFILEVDRLPNETAVPET 2491
Fly 2575 VPLTLSVPV--------SGDSCSAPDDLGNCQAAKEVAPPSAGGGEVKERSCDSLVMCIVTTLNQ 2631
.....|..: ||::||:| |.:|...|:....:.||.:|::|:|||||.|:.
Human 2492 GESLASEFLFSDVCRVESGENCSSP-------APREELVPAEETEQDKEHTCETLLMCIVTVLSH 2549
Fly 2632 GLRNGGGIGDILRAPSSKEGLFVARVIYDLLFFFIVIIIVLNLIFGVIIDTFADLRSEKQQKEAI 2696
|||:|||:||:||.||.:|.||.|||||||||||:|||||||||||||||||||||||||:||.|
Human 2550 GLRSGGGVGDVLRKPSKEEPLFAARVIYDLLFFFMVIIIVLNLIFGVIIDTFADLRSEKQKKEEI 2614
Fly 2697 LKTTCFICSLNRSAFDNKTVSFEEHIKSEHNMWHYLYFIVLVKVKDPTEFTGPESYVYAMVKAGI 2761
||||||||.|.|..||||||:||||||.||||||||.|||||||||.||:|||||||..|:|...
Human 2615 LKTTCFICGLERDKFDNKTVTFEEHIKEEHNMWHYLCFIVLVKVKDSTEYTGPESYVAEMIKERN 2679
Fly 2762 LEWFPRLRAMSLAAVDADGEQIELRSMQAQLLDTQLLIKNLSTQLHELKDHMTEQRKQKQRLGLL 2826
|:||||:|||||.:.|::|||.|||::|.:|..|..|:.|||.||.||||.||||||||||:|||
Human 2680 LDWFPRMRAMSLVSSDSEGEQNELRNLQEKLESTMKLVTNLSGQLSELKDQMTEQRKQKQRIGLL 2744
Fly 2827 2826
Human 2745 2744
| 
