DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Itpr and Itpr1

DIOPT Version :9

Sequence 1:	NP_730941.1	Gene:	Itpr / 40664	FlyBaseID:	FBgn0010051	Length:	2837	Species:	Drosophila melanogaster
Sequence 2:	XP_006237049.1	Gene:	Itpr1 / 25262	RGDID:	2933	Length:	2758	Species:	Rattus norvegicus

Alignment Length:	2910	Identity:	1658/2910 - (56%)
Similarity:	2051/2910 - (70%)	Gaps:	250/2910 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGDNIIGSASFLHLGDIVSLYAEGSVCGFLSTLGLVDDRTVVCPEAGDLSCPPKKFRDCLIKICP 65
            |.|.:   :||||:|||.|||||||..||:|||||||||.||.||||||:.|||||||||.|:||
  Rat     1 MSDKM---SSFLHIGDICSLYAEGSTNGFISTLGLVDDRCVVQPEAGDLNNPPKKFRDCLFKLCP 62

  Fly    66 MNRYSAQKQFWKAAKQSASSNTDPNLLKRLHHAAEIEKKQNETENKKLLGTSIQYGRAVVQLLHL 130
            |||||||||||||||..|:|.||..||.:|||||::|||||||||:|||||.||||. |:|||||
  Rat    63 MNRYSAQKQFWKAAKPGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGN-VIQLLHL 126

  Fly   131 KSNKYLTVNKRLPSLLEKNAMRVYLDANGNEGSWFYIKPFYKLRSIGDYVVVGDKVILSPVNADQ 195
            |||||||||||||:|||||||||.||..|||||||||:||||||||||.||:||||:|:||||.|
  Rat   127 KSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQPFYKLRSIGDSVVIGDKVVLNPVNAGQ 191

  Fly   196 QNLHVAANYELPDNPGCKEVNVLNSSTSWKISLFMEHKENQEHILKGGDVVRLFHAEQEKFLTMD 260
            . || |::::|.|||||.|||.:|.:|||||.|||:..:|::.||||||||||||||||||||.|
  Rat   192 P-LH-ASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILKGGDVVRLFHAEQEKFLTCD 254

  Fly   261 EYKKQYHVFLRTTGRTSATAATSSKALWEIEVVQHDSCRGGAGDWNSLYRFKHLATGHYLAAEAE 325
            |::|:.|||||||||.|||:|||||||||:||||||.||||||.||||:||||||||||||||.:
  Rat   255 EHRKKQHVFLRTTGRQSATSATSSKALWEVEVVQHDPCRGGAGYWNSLFRFKHLATGHYLAAEVD 319

  Fly   326 IDVSAGAMSATSASGHDLHLGDCSKDSGLSCSTMNSTINDKPKGKQYRLVSVPYSADIASVFVLD 390
            .|.....:....:...|   .|.|:          |.:.:..:...|.|||||...||:|:|.||
  Rat   320 PDFEEECLEFQPSVDPD---QDASR----------SRLRNAQEKMVYSLVSVPEGNDISSIFELD 371

  Fly   391 ATTMARPDSLVPQSSYVRLQHICSNTWVHATSIPIDADDDKPVMSMVCCSPIKEDKEAFALIPVS 455
            .||:...|||||::|||||:|:|:|||||:|:||||.:::||||..:..||:||||||||::|||
  Rat   372 PTTLRGGDSLVPRNSYVRLRHLCTNTWVHSTNIPIDKEEEKPVMLKIGTSPLKEDKEAFAIVPVS 436

  Fly   456 PVEVRDLDFANDACKVLATVTSKLDNGSISINERRALISLLQDIVYFIAGMENEQNKTKALEFTI 520
            |.|||||||||||.|||.::..||:.|:|:.||||::..||:|:|||:.|..|  :....||...
  Rat   437 PAEVRDLDFANDASKVLGSIAGKLEKGTITQNERRSVTKLLEDLVYFVTGGTN--SGQDVLEVVF 499

  Fly   521 KNPIRDRQKLLREQYILKQLFKILQGPFQQHTAGDGPFLRLDELSDPKNSPYKNIFRLCYRILRL 585
            ..|.|:||||:|||.||||:||:||.||..  .||||.|||:||.|.:::|:::|.|||||:||.
  Rat   500 SKPNRERQKLMREQNILKQIFKLLQAPFTD--CGDGPMLRLEELGDQRHAPFRHICRLCYRVLRH 562

  Fly   586 SQQDYRKNQEYIAKHFGLMQKQIGYDILAEDTITALLHNNRKLLEKHITAAEIETFVGLVRKNMH 650
            ||||||||||||||.||.||||||||:||||||||||||||||||||||||||:|||.|||||.
  Rat   563 SQQDYRKNQEYIAKQFGFMQKQIGYDVLAEDTITALLHNNRKLLEKHITAAEIDTFVSLVRKNR- 626

  Fly   651 NWDSRFLDYLSDLCVSNRKAIAVTQELICKSVLSDKNKDILIETQVKALRTGSGPVRCYKGNSED 715
              :.||||||||||||..|:|.||||||||:||:..|.||||||::...|.          ..|.
  Rat   627 --EPRFLDYLSDLCVSMNKSIPVTQELICKAVLNPTNADILIETKLVLSRF----------EFEG 679

  Fly   716 VCLATLAEDAGDDEDRSDVQSTSTTTTWDSASLNEDDGTPSTGDKYEIHLKW---TGQPTSRSMA 777
            |.....|.:||:||:                               |:.|.|   ..:..|:|:.
  Rat   680 VSTGENALEAGEDEE-------------------------------EVWLFWRDSNKEIRSKSVR 713

  Fly   778 DLA--SCDGGELEAAILNYYRHQLNLFSNMCLNRQYLALNELSPRLDIDLILKCMSDETMPYELR 840
            :||  :.:|.:.:..:|:|||:|||||:.|||:|||||:||:|.:||:||||:|||||.:||:||
  Rat   714 ELAQDAKEGQKEDRDVLSYYRYQLNLFARMCLDRQYLAINEISGQLDVDLILRCMSDENLPYDLR 778

  Fly   841 ASFCRLMLHLHVDRDPQEPVTPVKYARLWSEIPSKMSIQDYDGKNQQPDQNKQACRAKFNTTIAF 905
            |||||||||:||||||||.|||||||||||||||:::|.|||......|:.|:    :|..|:.|
  Rat   779 ASFCRLMLHMHVDRDPQEQVTPVKYARLWSEIPSEIAIDDYDSSGASKDEIKE----RFAQTMEF 839

  Fly   906 VENYLCNVATKVWLFTDQEQNKLTFEVVKLARDLIYFGFYSFSDLLRLTKTLLSILDCVSDTSSG 970
            ||.||.:|..:.:.|:|:|:||||||||.|||:|||||||:|||||||||.||:|||||..|:.
  Rat   840 VEEYLRDVVCQRFPFSDKEKNKLTFEVVNLARNLIYFGFYNFSDLLRLTKILLAILDCVHVTTI- 903

  Fly   971 EFASTDIDSVEEETNAEAE-----GGVLRSIGDINTVMTSLALGSVG-----QAIAAPTISLQQR 1025
             |..:.:...||.....||     ..|:|||..:..:||.:.|...|     ...|||..:::|
  Rat   904 -FPISKMTKGEENKGNNAEEKLKSSNVMRSIHGVGELMTQVVLRGGGFLPMTPMAAAPEGNVKQ- 966

  Fly  1026 KSVSQLMKEYPLVMDTKLKIIEILQFILDVRLDYRISCLLSIFKREFDESEVAASAASNEASQQQ 1090
               ::..||..:||||||||||||||||:|||||||||||.|||||||||    ::.|:|.|...
  Rat   967 ---AEPEKEDIMVMDTKLKIIEILQFILNVRLDYRISCLLCIFKREFDES----NSQSSETSSGN 1024

  Fly  1091 SQQQEP-QTPGSSNETDPLDSAESVAAGAAAAAATTARQKNIDLESIGVQAEGIFDCERSDAANL 1154
            |.|:.| ..||:                             :|.|.|..||||||.....:.. |
  Rat  1025 SSQEGPSNVPGA-----------------------------LDFEHIEEQAEGIFGGSEENTP-L 1059

  Fly  1155 DLDGQGGRTFLRVLLHLIMHDYAPLVSGALHLLFRHFSQRQEVLQAFRQVQLLVSDSDVESYKQI 1219
            |||..||||||||||||.||||.|||||||.||||||||||||||||:||||||:..||::||||
  Rat  1060 DLDDHGGRTFLRVLLHLTMHDYPPLVSGALQLLFRHFSQRQEVLQAFKQVQLLVTSQDVDNYKQI 1124

  Fly  1220 KSDLDILRQSVEKSELWVYKAKATDELGATDAGGDAVSLEYNAALSQEQRNE------YRKVKEI 1278
            |.|||.||..||||||||||.:..|| ....|.|:....:.....|:..::|      ||.||||
  Rat  1125 KQDLDQLRSIVEKSELWVYKGQGPDE-PMDGASGENEHKKTEEGTSKPLKHESTSSYNYRVVKEI 1188

  Fly  1279 LIRMNKFCVTASGPGSVVKPRKHEQRLLRNVGVHTVVLDLLQNPYDEKDDELMKELMCLAHEFLQ 1343
            |||::|.||..|  .||.|.||.:||||||:|.|.|||:|||.||::.:|..|:|:|.|||||||
  Rat  1189 LIRLSKLCVQES--ASVRKSRKQQQRLLRNMGAHAVVLELLQIPYEKAEDTKMQEIMRLAHEFLQ 1251

  Fly  1344 NFCLGNQQNQVLLHNHLDLFLNPGILEAKTVCAIFKDNLALCNEVTDKVVQHFVHCIEIHGRHVA 1408
            |||.||||||.|||.|::||||||||||.|:..||.:|..||:|:.::||||||||||.|||:|.
  Rat  1252 NFCAGNQQNQALLHKHINLFLNPGILEAVTMQHIFMNNFQLCSEINERVVQHFVHCIETHGRNVQ 1316

  Fly  1409 YLQFLQTVVRAENQFIRRCQDMVMQELINSGEDVLVFYNDKGSFNHFVQMMQQQMLRMEKLSDDS 1473
            |::||||:|:||.:||::||||||.||:||||||||||||:.||...:|||:.:..||:   ::|
  Rat  1317 YIKFLQTIVKAEGKFIKKCQDMVMAELVNSGEDVLVFYNDRASFQTLIQMMRSERDRMD---ENS 1378

  Fly  1474 PLKYHVELVKLLACCTMGKNVYTEIKCNNLLSLDDIVTIICHPLCMPEVKEAYVDFLNHCYIDTE 1538
            ||.||:.||:|||.||.|||||||||||:||.|||||.::.|..|:||||.||::||||||:|||
  Rat  1379 PLMYHIHLVELLAVCTEGKNVYTEIKCNSLLPLDDIVRVVTHEDCIPEVKIAYINFLNHCYVDTE 1443

  Fly  1539 VEMKEIYASGHMWSLFEKSFLVDINQLITNPA--AASNKTLQAYVLNGVTNLLGSFFASPFSDQS 1601
            |||||||.|.|||.||| :|||||.:...|.:  ..::..|:.||...|.:::.:||:|||||||
  Rat  1444 VEMKEIYTSNHMWKLFE-NFLVDICRACNNTSDRKHADSVLEKYVTEIVMSIVTTFFSSPFSDQS 1507

  Fly  1602 AIVQSRQLIFVQLLQAAHRITQCRWLSLGDRFNVENCIRTLTESAKMRSIALPPELEQQVATMSS 1666
            ..:|:||.:||||||...|:..|.||....:.:||:|||.|::.||.|:||:|.:|:.||..:..
  Rat  1508 TTLQTRQPVFVQLLQGVFRVYHCNWLMPSQKASVESCIRVLSDVAKSRAIAIPVDLDSQVNNLFL 1572

  Fly  1667 KTAMLTRQTT-KWLLASKQ-PKYEAQQAASLMRWDRSIIEGLQDIVSLLEDQLKPVVEAELSLLV 1729
            |:..:.::|. .|.|:::. .:.::..|||  |..|:|||.||||||.|||:|:|:|:||||:||
  Rat  1573 KSHNIVQKTAMNWRLSARNAARRDSVLAAS--RDYRNIIERLQDIVSALEDRLRPLVQAELSVLV 1635

  Fly  1730 DILYRSELLFPAGTEARKRCESGGFIRKLIKHTEKLLEEKEERMCVKVLRTLREMMAIDVNYGEK 1794
            |:|:|.|||||..|:||::|||||||.||||||::||||.||::|:|||:||||||..|..||||
  Rat  1636 DVLHRPELLFPENTDARRKCESGGFICKLIKHTKQLLEENEEKLCIKVLQTLREMMTKDRGYGEK 1700

  Fly  1795 ----------------------------------------GDALRQTLLLRYFQTKSTPRLPEDE 1819
                                                    |:||||.|:.||:.........|..
  Rat  1701 QISIDELENAELPQPPEAENSTEQELEPSPPLRQLEDHKRGEALRQILVNRYYGNIRPSGRRESL 1765

  Fly  1820 VPLLAAPLM--DPAKQNHLVTHGPGAKYLQRAGKTLHEMQNHLDREGASDLVVELVIKSVHSPNI 1882
            ......||.  .|:|... ...|||:....|...:|.|:|.|||:||||:||::|:: :..|..:
  Rat  1766 TSFGNGPLSPGGPSKPGG-GGGGPGSGSTSRGEMSLAEVQCHLDKEGASNLVIDLIM-NASSDRV 1828

  Fly  1883 FVEAVELGIALLEGGNPIIQKGMFQKFLSDDLNQAFFKVFFEKMKDAQQEIKSTVTVNTTDIAAK 1947
            |.|::.|.||||||||..||...|.:...|..::.|||||:::||.||||||:||||||:|:..|
  Rat  1829 FHESILLAIALLEGGNTTIQHSFFCRLTEDKKSEKFFKVFYDRMKVAQQEIKATVTVNTSDLGNK 1893

  Fly  1948 AHEHKQDTNLELDKIARKHGLKSNGVVITEELKRELHNAGLATARAYGNAR-------NIHSGEE 2005
                |:|..::.|..:||.. |.....||||::.:|..|..||.:|:...|       :..|||.
  Rat  1894 ----KKDDEVDRDAPSRKKA-KEPTTQITEEVRDQLLEASAATRKAFTTFRREADPDDHYQSGEG 1953

  Fly  2006 SSAISVNSPLEDILAEKLEKHKDSRDQRNQLSNKVLVMQPILRFLQLLCENHNPDMQNLLRNQNN 2070
            :.|.:             :|.||..    ::|..:.:||||||||||||||||.|:||.||.|||
  Rat  1954 TQATT-------------DKAKDDL----EMSAVITIMQPILRFLQLLCENHNRDLQNFLRCQNN 2001

  Fly  2071 KTNNNLVSETLMFLDCICGSTTGGLGLLGLYINEHNVALINQTLEALTEYCQGPCHENQNCIATH 2135
            |||.|||.|||.||||||||||||||||||||||.||||||||||:|||||||||||||||||||
  Rat  2002 KTNYNLVCETLQFLDCICGSTTGGLGLLGLYINEKNVALINQTLESLTEYCQGPCHENQNCIATH 2066

  Fly  2136 ESNGLDIITALILNNINPLGENRMDLVLELKNNASKLLLAIMESRGDSENAERILYNMNPKQLVE 2200
            ||||:|||||||||:|||||:.|||||||||||||||||||||||.||||||||||||.||:|||
  Rat  2067 ESNGIDIITALILNDINPLGKKRMDLVLELKNNASKLLLAIMESRHDSENAERILYNMRPKELVE 2131

  Fly  2201 VACKAYHQEELIDEQDDGDEPDAGSDDDDATVSPREVGHNIYILCHQLAQHNKELAGLLKASEDP 2265
            |..|||.|.|:  |.:||:      :.:|...|||.||||||||.||||:|||||..:||.....
  Rat  2132 VIKKAYMQGEV--EFEDGE------NGEDGAASPRNVGHNIYILAHQLARHNKELQTMLKPGGQV 2188

  Fly  2266 QSASFDAKTSQALMYYATHTAQIEIVRNDRTLEQIVFPIPEICEYLTTDTKIKILNTAERDDQGS 2330
            ..       .:||.:||.|||||||||.|||:||||||:|.|||:||.::|::|..|.|||:|||
  Rat  2189 DG-------DEALEFYAKHTAQIEIVRLDRTMEQIVFPVPSICEFLTKESKLRIYYTTERDEQGS 2246

  Fly  2331 KVADFFDKAEEMFNEMKWQKKLRSQPLLFWISSYMSLWSNILFNCVVVINMIVAFFYPFDNT-VP 2394
            |:.|||.::|::||||.||||||:||:|:|.:..||.||:|.||..|::|::|||||||... ..
  Rat  2247 KINDFFLRSEDLFNEMNWQKKLRAQPVLYWCARNMSFWSSISFNLAVLMNLLVAFFYPFKGVRGG 2311

  Fly  2395 ELSSHISLLFWIITIFSLVIVLALPRESGIRTFIGSVILRFIFLLGPESTLCLLGVVTVTLKSVH 2459
            .|..|.|.|.|...:.||.||:|||:..|||..|.|.|||.||.:|.:.||.|||...|..|.:.
  Rat  2312 TLEPHWSGLLWTAMLISLAIVIALPKPHGIRALIASTILRLIFSVGLQPTLFLLGAFNVCNKIIF 2376

  Fly  2460 IVSIMGNKGTLEKQLIKIITDFQLLYHCIYIAFCFCGLIFHPFFYSLLLFDVVYREETLVNVIRS 2524
            ::|.:||.||..:....::.|.:.|||.:|:..|..||..|.|||||||||:|||||||:|||:|
  Rat  2377 LMSFVGNCGTFTRGYRAMVLDVEFLYHLLYLLICAMGLFVHEFFYSLLLFDLVYREETLLNVIKS 2441

  Fly  2525 VTRNGRSIVLTAVLALILVYLFSIIGYMFFKDDFLVSVDFEEQDNAPPPS--------VPLTLSV 2581
            ||||||||:|||||||||||||||:||:||||||::.||....:.|.|.:        :...:..
  Rat  2442 VTRNGRSIILTAVLALILVYLFSIVGYLFFKDDFILEVDRLPNETAGPETGESLANDFLYSDVCR 2506

  Fly  2582 PVSGDSCSAPDDLGNCQAAKEVAPPSAGGGEVKERSCDSLVMCIVTTLNQGLRNGGGIGDILRAP 2646
            ..:|::|::|       |.||...|.....:.||.:|::|:|||||.|:.|||:|||:||:||.|
  Rat  2507 VETGENCTSP-------APKEELLPVEETEQDKEHTCETLLMCIVTVLSHGLRSGGGVGDVLRKP 2564

  Fly  2647 SSKEGLFVARVIYDLLFFFIVIIIVLNLIFGVIIDTFADLRSEKQQKEAILKTTCFICSLNRSAF 2711
            |.:|.||.|||||||||||:|||||||||||||||||||||||||:||.|||||||||.|.|..|
  Rat  2565 SKEEPLFAARVIYDLLFFFMVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKF 2629

  Fly  2712 DNKTVSFEEHIKSEHNMWHYLYFIVLVKVKDPTEFTGPESYVYAMVKAGILEWFPRLRAMSLAAV 2776
            |||||:||||||.||||||||.|||||||||.||:|||||||..|::...|:||||:|||||.:.
  Rat  2630 DNKTVTFEEHIKEEHNMWHYLCFIVLVKVKDSTEYTGPESYVAEMIRERNLDWFPRMRAMSLVSS 2694

  Fly  2777 DADGEQIELRSMQAQLLDTQLLIKNLSTQLHELKDHMTEQRKQKQRLGLL 2826
            |::|||.|||::|.:|..|..|:.|||.||.||||.||||||||||:|||
  Rat  2695 DSEGEQNELRNLQEKLESTMKLVTNLSGQLSELKDQMTEQRKQKQRIGLL 2744

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Itpr	NP_730941.1	Ins145_P3_rec	7..231	CDD:285871	170/223 (76%)
		MIR	237..293	CDD:197746	45/55 (82%)
		MIR	238..452	CDD:280906	129/213 (61%)
		RYDR_ITPR	495..691	CDD:279676	132/195 (68%)
		RYDR_ITPR	1294..1413	CDD:279676	77/118 (65%)
		RIH_assoc	2042..2147	CDD:285630	93/104 (89%)
		Ion_trans	2433..2691	CDD:278921	147/265 (55%)
		Sec2p	<2782..2819	CDD:283965	22/36 (61%)
Itpr1	XP_006237049.1	Ins145_P3_rec	4..225	CDD:285871	170/226 (75%)
		MIR	231..287	CDD:197746	45/55 (82%)
		MIR	232..433	CDD:280906	129/213 (61%)
		MIR	294..>321	CDD:197746	22/26 (85%)
		RYDR_ITPR	476..665	CDD:279676	132/195 (68%)
		RYDR_ITPR	1208..1339	CDD:279676	85/130 (65%)
		RIH_assoc	1973..2078	CDD:285630	93/104 (89%)
		Ion_trans	2350..2609	CDD:278921	147/265 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	482	1.000	Domainoid score	I389
eggNOG	1	0.900	-	-		E1_KOG3533
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1673
Inparanoid	1	1.050	2989	1.000	Inparanoid score	I14
OMA	1	1.010	-	-		QHG58623
OrthoDB	1	1.010	-	-		D58374at33208
OrthoFinder	1	1.000	-	-		FOG0001660
OrthoInspector	1	1.000	-	-		otm45685
orthoMCL	1	0.900	-	-		OOG6_102308
Panther	1	1.100	-	-	LDO	PTHR13715
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1057
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.880