DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Itpr and Itpr3

DIOPT Version :9

Sequence 1:	NP_730941.1	Gene:	Itpr / 40664	FlyBaseID:	FBgn0010051	Length:	2837	Species:	Drosophila melanogaster
Sequence 2:	XP_006523775.1	Gene:	Itpr3 / 16440	MGIID:	96624	Length:	2797	Species:	Mus musculus

Alignment Length:	2888	Identity:	1494/2888 - (51%)
Similarity:	1941/2888 - (67%)	Gaps:	272/2888 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 ASFLHLGDIVSLYAEGSVCGFLSTLGLVDDRTVVCPEAGDLSCPPKKFRDCLIKICPMNRYSAQK 73
            :||||:||||||||||||.||:|||||||||.||.|.||||..|||||||||.|:||||||||||
Mouse   106 SSFLHIGDIVSLYAEGSVNGFISTLGLVDDRCVVEPAAGDLDNPPKKFRDCLFKVCPMNRYSAQK 170

  Fly    74 QFWKA--AKQSASSNTDPNLLKRLHHAAEIEKKQNETENKKLLGTSIQYGRAVVQLLHLKSNKYL 136
            |:|||  .||......|..||::|.|||::|:|||:|||||:.|..::|| :|:||||:||||||
Mouse   171 QYWKAKQTKQDKEKIADVVLLQKLQHAAQMEQKQNDTENKKVHGDVVKYG-SVIQLLHMKSNKYL 234

  Fly   137 TVNKRLPSLLEKNAMRVYLDANGNEGSWFYIKPFYKLRSIGDYVVVGDKVILSPVNADQQNLHVA 201
            |||||||:|||||||||.|||.||||||.:|:||:||||.||.|||||||||:||||.|. || |
Mouse   235 TVNKRLPALLEKNAMRVTLDATGNEGSWLFIQPFWKLRSNGDNVVVGDKVILNPVNAGQP-LH-A 297

  Fly   202 ANYELPDNPGCKEVNVLNSSTSWKISLFMEHKENQEHILKGGDVVRLFHAEQEKFLTMDEYKKQY 266
            :||||.||.||||||.:|.:|||||:|||:.:::.|.:|||||||||||||||||||.|||:.:.
Mouse   298 SNYELSDNAGCKEVNSVNCNTSWKINLFMQFRDHLEEVLKGGDVVRLFHAEQEKFLTCDEYRGKL 362

  Fly   267 HVFLRTTGRTSATAATSSKALWEIEVVQHDSCRGGAGDWNSLYRFKHLATGHYLAAEAEIDVSAG 331
            .||||||.|.|||:||||.||||:|||.||.||||||.||.||||||||||:|||||.
Mouse   363 QVFLRTTLRQSATSATSSNALWEVEVVHHDPCRGGAGHWNGLYRFKHLATGNYLAAEE------- 420

  Fly   332 AMSATSASGHDLHLGDCS--KDSGLSCSTMNSTINDKPKGKQYRLVSVPYSADIASVFVLDATTM 394
                     :..:.||.|  |.:||.........|...|.| ||||:||:..||||:|.||.||:
Mouse   421 ---------NPSYKGDVSDPKAAGLGAQGRTGRRNAGEKIK-YRLVAVPHGNDIASLFELDPTTL 475

  Fly   395 ARPDSLVPQSSYVRLQHICSNTWVHATSIPIDADDDKPVMSMVCCSPIKEDKEAFALIPVSPVEV 459
            .:.||.||::|||||:|:|:|||:.:|:.|||.::::|:..|:...|.||||||||::.|...|:
Mouse   476 QKTDSFVPRNSYVRLRHLCTNTWIQSTNAPIDVEEERPIRLMLGTCPTKEDKEAFAIVSVPVSEI 540

  Fly   460 RDLDFANDACKVLATVTSKLDNGSISINERRALISLLQDIVYFIAGMENEQNKTKALEFTIKNPI 524
            |||||||||..:||:...||:.|.||.|:||.:|.||:|:|:|::.:.|  |....|:..:..|.
Mouse   541 RDLDFANDASSMLASAVEKLNEGFISQNDRRFVIQLLEDLVFFVSDVPN--NGQNVLDIMVTKPN 603

  Fly   525 RDRQKLLREQYILKQLFKILQGPFQQHTAGDGPFLRLDELSDPKNSPYKNIFRLCYRILRLSQQD 589
            |:||||:|||.||||:|.||:.||:. ..|:||.:||:||||.||:||:.:||||||:||.||:|
Mouse   604 RERQKLMREQNILKQIFGILKAPFRD-KGGEGPLVRLEELSDQKNAPYQYMFRLCYRVLRHSQED 667

  Fly   590 YRKNQEYIAKHFGLMQKQIGYDILAEDTITALLHNNRKLLEKHITAAEIETFVGLVRKNMHNWDS 654
            ||||||:|||.||:||.||||||||||||||||||||||||||||..|:||||.|||||.   :.
Mouse   668 YRKNQEHIAKQFGMMQSQIGYDILAEDTITALLHNNRKLLEKHITKTEVETFVSLVRKNR---EP 729

  Fly   655 RFLDYLSDLCVSNRKAIAVTQELICKSVLSDKNKDILIETQVKALRTGSGPVRCYKGNSEDVCLA 719
            ||||||||||||||.||.||||||||.||..||.||||:|:::       ||:
Mouse   730 RFLDYLSDLCVSNRIAIPVTQELICKCVLDPKNSDILIQTELR-------PVK------------ 775

  Fly   720 TLAEDAGDDEDRSDVQSTSTTTTWDSASLNEDDGTPSTGDKYEIHLKWTG------QPTSRSMAD 778
               |.|...|             :.|...:|:          |:.|.||.      :.:.|.:|.
Mouse   776 ---EMAQSHE-------------YLSIEYSEE----------EVWLTWTDRNNEHHEKSVRQLAQ 814

  Fly   779 LASCDGGELEAAILNYYRHQLNLFSNMCLNRQYLALNELSPRLDIDLILKCMSDETMPYELRASF 843
            .|.. |...:..:|:|||:||.||:.|||:|||||::|:|.:|.::|:..||:||.:|::|||||
Mouse   815 EARA-GNAHDENVLSYYRYQLKLFARMCLDRQYLAIDEISKQLGVELLFLCMADEMLPFDLRASF 878

  Fly   844 CRLMLHLHVDRDPQEPVTPVKYARLWSEIPSKMSIQDYDGK-NQQPDQNKQACRAKFNTTIAFVE 907
            |.||||:||||||||.|||||:||||:|||:.::|:|||.. |...|..|.    ||.:|:.|||
Mouse   879 CHLMLHVHVDRDPQELVTPVKFARLWTEIPTAITIKDYDSNLNASRDDKKN----KFASTMEFVE 939

  Fly   908 NYLCNVATKVWLFTDQEQNKLTFEVVKLARDLIYFGFYSFSDLLRLTKTLLSILDCVSDTSSGEF 972
            :||.||.::...|.:.|:|.||||||.||.:||||||||||:|||||:|||.|:||:      :.
Mouse   940 DYLNNVVSEAVPFANDEKNILTFEVVSLAHNLIYFGFYSFSELLRLTRTLLGIIDCI------QA 998

  Fly   973 ASTDIDSVEEETNAEAEGG--VLRSIGDINTVMTSLALG---SVGQAIAAPT-ISLQQRKSVSQL 1031
            .:..:.:.||      .||  |.|||..:..:|:::.|.   ||..|.:.|. :.:.::...|:.
Mouse   999 PAAMLQAYEE------PGGKNVRRSIQGVGHMMSTMVLSRKQSVFGASSLPAGVGVPEQLDRSKF 1057

  Fly  1032 M-KEYPLVMDTKLKIIEILQFILDVRLDYRISCLLSIFKREFDESEVAASAASNEASQQQSQQQE 1095
            . .|:.:||:|||||:|||||||:||||||||.|||:||:||
Mouse  1058 EDNEHTVVMETKLKILEILQFILNVRLDYRISYLLSVFKKEF----------------------- 1099

  Fly  1096 PQTPGSSNETDPLDSAESVAAGAAAAAATTARQKNIDLESIGVQAEGIFDCERSDAANLDLDGQG 1160
                   .|..|:.  :|.|.|.|.|..::....|:|  .||.|||.:|...:: ::.|::|.:|
Mouse  1100 -------VEVFPMQ--DSGADGTAPAFDSSTATMNLD--RIGEQAEAMFGVGKT-SSMLEVDDEG 1152

  Fly  1161 GRTFLRVLLHLIMHDYAPLVSGALHLLFRHFSQRQEVLQAFRQVQLLVSDSDVESYKQIKSDLDI 1225
            ||.||||||||.||||..||||||.|||:|||||||.:..|:|||||:|..|||:||.|||:||.
Mouse  1153 GRMFLRVLLHLTMHDYPSLVSGALQLLFKHFSQRQEAMHTFKQVQLLISAQDVENYKVIKSELDR 1217

  Fly  1226 LRQSVEKSELWVYKAKATD----ELGATDAGGDAVSLE--YNAALSQEQRNEYRKVKEILIRMNK 1284
            ||..||||||||.|..:..    |.|||....:..|.|  :.....::....|:.||.||.|:||
Mouse  1218 LRTMVEKSELWVDKKGSVKGEEVEAGATKDKKERPSDEEGFLQPHGEKSSENYQIVKGILERLNK 1282

  Fly  1285 FCVTASGPGSVVKPRKHEQRLLRNVGVHTVVLDLLQNPYDEKDDELMKELMCLAHEFLQNFCLGN 1349
            .|    |.|.  :.||.:||||:|:..|.|:|||||.|||:.|:::: |::...|:|||.||.||
Mouse  1283 MC----GVGE--QMRKKQQRLLKNMDAHKVMLDLLQIPYDKSDNKML-EILRYTHQFLQKFCAGN 1340

  Fly  1350 QQNQVLLHNHLDLFLNPGILEAKTVCAIFKDNLALCNEVTDKVVQHFVHCIEIHGRHVAYLQFLQ 1414
            ..||.|||.||.|||.||:|||:|:..||.:|..||:|:::.|:|||||.:..|||||.||.||.
Mouse  1341 PGNQALLHKHLQLFLTPGLLEAETMQHIFLNNYQLCSEISEPVLQHFVHLLATHGRHVQYLDFLH 1405

  Fly  1415 TVVRAENQFIRRCQDMVMQELINSGEDVLVFYNDKGSFNHFVQMMQQQMLRMEKLSDDSPLKYHV 1479
            ||::||.:::::||||:|.||.|:|:||:||||||.|..|.:.||:   ...:.:.|.|||.||:
Mouse  1406 TVIKAEGKYVKKCQDMIMTELTNAGDDVVVFYNDKASLAHLLDMMK---AARDGVEDHSPLMYHI 1467

  Fly  1480 ELVKLLACCTMGKNVYTEIKCNNLLSLDDIVTIICHPLCMPEVKEAYVDFLNHCYIDTEVEMKEI 1544
            .||.|||.|..||||||||||.:||.|:|:||::.|..|:.|||.|||:|:||||:|||||||||
Mouse  1468 SLVDLLAACAEGKNVYTEIKCTSLLPLEDVVTVVTHEDCITEVKMAYVNFVNHCYVDTEVEMKEI 1532

  Fly  1545 YASGHMWSLFEKSFLVDINQLITN--PAAASNKTLQAYVLNGVTNLLGSFFASPFSDQSAIVQSR 1607
            |.|.|:|:||| :|.:|: .|:.|  ....|:.||:.|||..|.:.:.:||:||||:.|..:|:.
Mouse  1533 YTSNHIWTLFE-NFTLDM-ALVCNKREKRLSDPTLEKYVLTVVLDTISAFFSSPFSENSTSLQTH 1595

  Fly  1608 QLIFVQLLQAAHRITQCRWLSLGDRFNVENCIRTLTESAKMRSIALPPELEQQVATMSSK----T 1668
            |.|.|||||:..|:.:|.||....:.:||.|:|||...||.|:|.||.:|:..::.:.|.    :
Mouse  1596 QTIVVQLLQSTTRLLECPWLQQQHKGSVEACVRTLAMVAKSRAILLPMDLDAHMSALLSSGGSCS 1660

  Fly  1669 AMLTRQTTKWLLASKQ-PKYEAQQAASLMRWD-RSIIEGLQDIVSLLEDQLKPVVEAELSLLVDI 1731
            |...|....:..|::. |:.    ..:..:|| ::|||.||||:..||::|||:|:||||:|||:
Mouse  1661 AAAQRSAANYKTATRTFPRV----IPTANQWDYKNIIEKLQDIIMALEERLKPLVQAELSVLVDM 1721

  Fly  1732 LYRSELLFPAGTEARKRCESGGFIRKLIKHTEKLLEEKEERMCVKVLRTLREMMAIDVNYGEKGD 1796
            |:..|||||.|:||.:|||||||:.|||:||:.|: |.||::||||||||::|:.....:|::|:
Mouse  1722 LHWPELLFPEGSEAYQRCESGGFLSKLIRHTKGLM-ESEEKLCVKVLRTLQQMLLKKSKFGDRGN 1785

  Fly  1797 ALRQTLLLRYFQTKSTPRLPEDEVPLLAAPLMDPAKQNHLVTHGPGAKYLQRAGKTLHEMQNHLD 1861
            .||:.||..|.|.:.:....|         |.||.        |.|   |.:....:...|..||
Mouse  1786 QLRKMLLQNYLQNRKSGARGE---------LTDPT--------GSG---LDQDWSAIAATQCRLD 1830

  Fly  1862 REGASDLVVELVIKSVHSPNIFVEAVELGIALLEGGNPIIQKGMFQKFLSDDLNQAFFKVFFEKM 1926
            :|||:.||.:| |.|..:..||.|::.|.|.||:|||..|||..:....||..::.||||..::|
Mouse  1831 KEGATKLVCDL-ITSTKNEKIFQESIGLAIRLLDGGNTEIQKSFYNLMTSDKKSERFFKVLHDRM 1894

  Fly  1927 KDAQQEIKSTVTVNTTDIAAKAHEHKQDTNLELDKIARKHGLKSNGVVITEELKRELHNAGLATA 1991
            |.||||.||||.||.:|:.::..|.::..:     .|.|.|...          |.:...|..|
Mouse  1895 KRAQQETKSTVAVNMSDLGSQPREDREPAD-----PATKGGAPG----------RYIQGMGYLT- 1943

  Fly  1992 RAYGN---ARNIHSGEESSAISVNSPLEDILAEKLEKHKD--SRDQRNQLSNKVLVMQPILRFLQ 2051
               |:   .:.:.:|..|| .|:.|....:|...|.:..|  .|.|.|::...||:|:|||||||
Mouse  1944 ---GDPDLIKALPTGRVSS-FSMPSSSRYLLGLGLHRGHDMSERAQNNEMGTSVLIMRPILRFLQ 2004

  Fly  2052 LLCENHNPDMQNLLRNQNNKTNNNLVSETLMFLDCICGSTTGGLGLLGLYINEHNVALINQTLEA 2116
            |||||||.|:||.||.||||||.|||.|||.|||.:|||||||||||||||||.||.|:.||||.
Mouse  2005 LLCENHNRDLQNFLRCQNNKTNYNLVCETLQFLDIMCGSTTGGLGLLGLYINEDNVGLVIQTLET 2069

  Fly  2117 LTEYCQGPCHENQNCIATHESNGLDIITALILNNINPLGENRMDLVLELKNNASKLLLAIMESRG 2181
            |||||||||||||.||.||||||:|||||||||:|:||.:.||||||:||:||||||||:||||.
Mouse  2070 LTEYCQGPCHENQTCIVTHESNGIDIITALILNDISPLCKYRMDLVLQLKDNASKLLLALMESRH 2134

  Fly  2182 DSENAERILYNMNPKQLVEVACKAYHQEELIDEQDDGDEPDAGSDDDDATVSPREVGHNIYILCH 2246
            |||||||||.::.|::||:|..|||.|||               :.:::.|||||||||||||..
Mouse  2135 DSENAERILISLRPQELVDVIKKAYLQEE---------------ERENSEVSPREVGHNIYILAL 2184

  Fly  2247 QLAQHNKELAGLLK-----ASEDPQ-------------------SASFDAKTSQALMYYATHTAQ 2287
            ||::|||:|..|||     ..|:.:                   ||....:....|.||..||:|
Mouse  2185 QLSRHNKQLQHLLKPVRRIQEEEAEGISSMLSLNNKQLSQMLKSSAPAQEEEEDPLAYYENHTSQ 2249

  Fly  2288 IEIVRNDRTLEQIVFPIPEICEYLTTDTKIKILNTAERDDQGSKVADFFDKAEEMFNEMKWQKKL 2352
            |||||.||::||||||:|.||::||.:||.::..|.|:|:|||||:||||::..:.|||:||::|
Mouse  2250 IEIVRQDRSMEQIVFPVPAICQFLTEETKHRLFTTTEQDEQGSKVSDFFDQSSFLHNEMEWQRRL 2314

  Fly  2353 RSQPLLFWISSYMSLWSNILFNCVVVINMIVAFFYPF---DNTVPELSSHISLLFWIITIFSLVI 2414
            ||.||::|.|..|:||.:|.||..|.||:|:|||||:   .:|....|..|||||||:..||:..
Mouse  2315 RSMPLIYWFSRRMTLWGSISFNLAVFINIIIAFFYPYVEGASTGVLGSPLISLLFWILICFSIAA 2379

  Fly  2415 VLALPRESGIRTFIGSVILRFIFLLGPESTLCLLGVVTVTLKSVHIVSIMGNKGTLEKQLIKIIT 2479
            :..  :...:|..|.::|||.|:.||...||.:||.:.:|.|.|.:||.:||:||..:....::.
Mouse  2380 LFT--KRYSVRPLIVALILRSIYYLGIGPTLNILGALNLTNKIVFVVSFVGNRGTFIRGYKAMVM 2442

  Fly  2480 DFQLLYHCIYIAFCFCGLIFHPFFYSLLLFDVVYREETLVNVIRSVTRNGRSIVLTAVLALILVY 2544
            |.:.|||..||.....||..|..|||:||||::||||||.|||:|||||||||:|||:|||||||
Mouse  2443 DMEFLYHVGYILTSVLGLFAHELFYSILLFDLIYREETLFNVIKSVTRNGRSILLTALLALILVY 2507

  Fly  2545 LFSIIGYMFFKDDFLVSVDF--EEQDNAPPPSVP---LTLSVPVSGDSCSAPDDLGNCQAAKEVA 2604
            ||||:|::|.||||::.||.  .....|.|..:|   .|.....|||......::...:..:|..
Mouse  2508 LFSIVGFLFLKDDFILEVDRLPGNHSRASPLGMPHGAATFMGTCSGDKMDCVSEVSVPEILEEDE 2572

  Fly  2605 PPSAGGGEVKERSCDSLVMCIVTTLNQGLRNGGGIGDILRAPSSKEGLFVARVIYDLLFFFIVII 2669
            .|.:     .||:||:|:|||||.:|.|||||||:|||||.||..|.||.|||:|||||||||||
Mouse  2573 EPDS-----TERACDTLLMCIVTVMNHGLRNGGGVGDILRKPSKDESLFPARVVYDLLFFFIVII 2632

  Fly  2670 IVLNLIFGVIIDTFADLRSEKQQKEAILKTTCFICSLNRSAFDNKTVSFEEHIKSEHNMWHYLYF 2734
            ||||||||||||||||||||||:||.|||||||||.|.|..|||||||||||||.|||||:||||
Mouse  2633 IVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSFEEHIKLEHNMWNYLYF 2697

  Fly  2735 IVLVKVKDPTEFTGPESYVYAMVKAGILEWFPRLRAMSLAAVDADGEQIELRSMQAQLLDTQLLI 2799
            ||||:||:.|::|||||||..|:|...|:||||:|||||.:.:.:|||.|:|.:|.:|..|..|:
Mouse  2698 IVLVRVKNKTDYTGPESYVAQMIKNKNLDWFPRMRAMSLVSGEGEGEQNEIRILQEKLGSTMKLV 2762

  Fly  2800 KNLSTQLHELKDHMTEQRKQKQRLGLLN 2827
            .:|::||:|||:.||||||::||||.::
Mouse  2763 SHLTSQLNELKEQMTEQRKRRQRLGFVD 2790

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Itpr	NP_730941.1	Ins145_P3_rec	7..231	CDD:285871	161/223 (72%)
		MIR	237..293	CDD:197746	42/55 (76%)
		MIR	238..452	CDD:280906	121/215 (56%)
		RYDR_ITPR	495..691	CDD:279676	130/195 (67%)
		RYDR_ITPR	1294..1413	CDD:279676	62/118 (53%)
		RIH_assoc	2042..2147	CDD:285630	85/104 (82%)
		Ion_trans	2433..2691	CDD:278921	145/262 (55%)
		Sec2p	<2782..2819	CDD:283965	18/36 (50%)
Itpr3	XP_006523775.1	Ins145_P3_rec	104..327	CDD:370078	161/223 (72%)
		MIR	335..533	CDD:367197	121/214 (57%)
		RYDR_ITPR	574..771	CDD:366595	135/202 (67%)
		RYDR_ITPR	1292..1404	CDD:366595	61/112 (54%)
		RIH_assoc	1995..2100	CDD:369886	85/104 (82%)
		Ion_trans	2390..2654	CDD:366146	147/268 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	483	1.000	Domainoid score	I401
eggNOG	1	0.900	-	-		E1_KOG3533
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	2967	1.000	Inparanoid score	I17
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58623
OrthoDB	1	1.010	-	-		D58374at33208
OrthoFinder	1	1.000	-	-		FOG0001660
OrthoInspector	1	1.000	-	-		otm43612
orthoMCL	1	0.900	-	-		OOG6_102308
Panther	1	1.100	-	-	O	PTHR13715
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1057
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.840