|
Fly 1 MGDNIIGSASFLHLGDIVSLYAEGSVCGFLSTLGLVDDRTVVCPEAGDLSCPPKKFRDCLIKICP 65
|.|.: :|||::||||||||||||.||:|||||||||.||.||||||:.|||||||||.|:||
Mouse 1 MSDKM---SSFLYIGDIVSLYAEGSVNGFISTLGLVDDRCVVHPEAGDLANPPKKFRDCLFKVCP 62
Fly 66 MNRYSAQKQFWKAAKQSASSNTDPNLLKRLHHAAEIEKKQNETENKKLLGTSIQYGRAVVQLLHL 130
|||||||||:|||.:....::|:..|||:|.||||:|:||||:||:||||..::|.. |:||||:
Mouse 63 MNRYSAQKQYWKAKQAKQGNHTEAALLKKLQHAAELEQKQNESENRKLLGEIVKYSN-VIQLLHI 126
Fly 131 KSNKYLTVNKRLPSLLEKNAMRVYLDANGNEGSWFYIKPFYKLRSIGDYVVVGDKVILSPVNADQ 195
|||||||||||||:|||||||||.|||.|||||||||.||:||||.||.:||||||:|.||||.|
Mouse 127 KSNKYLTVNKRLPALLEKNAMRVSLDAAGNEGSWFYIHPFWKLRSEGDNIVVGDKVVLMPVNAGQ 191
Fly 196 QNLHVAANYELPDNPGCKEVNVLNSSTSWKISLFMEHKENQEHILKGGDVVRLFHAEQEKFLTMD 260
. || |:|.||.|||||||||.:|.:|||||:|||:....:|.:|||||||||||||||||||.|
Mouse 192 P-LH-ASNVELLDNPGCKEVNAVNCNTSWKITLFMKFSSYREDVLKGGDVVRLFHAEQEKFLTCD 254
Fly 261 EYKKQYHVFLRTTGRTSATAATSSKALWEIEVVQHDSCRGGAGDWNSLYRFKHLATGHYLAAEAE 325
:|:|:.|:|||||.|.|||:|||||||||||||.||.||||||.||||:||||||||:|||||..
Mouse 255 DYEKKQHIFLRTTLRQSATSATSSKALWEIEVVHHDPCRGGAGQWNSLFRFKHLATGNYLAAELN 319
Fly 326 IDVSAGAMSATSASGHDLHLGDCSKDSGLSCSTMNSTINDKPKGKQ-------YRLVSVPYSADI 383
.|..... :.|...||..: ..||.|: |.|||||:..||
Mouse 320 PDYRDAQ-----------NEGKNVKDGEI----------PTPKKKRQAGEKIMYTLVSVPHGNDI 363
Fly 384 ASVFVLDATTMARPDSLVPQSSYVRLQHICSNTWVHATSIPIDADDDKPVMSMVCCSPIKEDKEA 448
||:|.|||||:.|.|.|||::|||||:|:|:||||.:|:||||.::::|||..:.....||||||
Mouse 364 ASLFELDATTLQRADCLVPRNSYVRLRHLCTNTWVTSTTIPIDTEEERPVMLKIGTCQTKEDKEA 428
Fly 449 FALIPVSPVEVRDLDFANDACKVLATVTSKLDNGSISINERRALISLLQDIVYFIAGMENEQNKT 513
||::.|...|||||||||||.|||||...||:||||:.||||.:..||:|:::|:|.:.| |..
Mouse 429 FAIVCVPLSEVRDLDFANDANKVLATTVKKLENGSITQNERRFVTKLLEDLIFFVADVTN--NGQ 491
Fly 514 KALEFTIKNPIRDRQKLLREQYILKQLFKILQGPFQQHTAGDGPFLRLDELSDPKNSPYKNIFRL 578
..|:..|..|.|:||||:|||.||.|:|.||:.||:: .||:|..|||::|.|.:.:|||.:.||
Mouse 492 DVLDVVITKPNRERQKLMREQNILAQVFGILKAPFKE-KAGEGSMLRLEDLGDQRYAPYKYVLRL 555
Fly 579 CYRILRLSQQDYRKNQEYIAKHFGLMQKQIGYDILAEDTITALLHNNRKLLEKHITAAEIETFVG 643
|||:||.||||||||||||||:|.:||.|||||||||||||||||||||||||||||.||||||.
Mouse 556 CYRVLRHSQQDYRKNQEYIAKNFCVMQSQIGYDILAEDTITALLHNNRKLLEKHITAKEIETFVS 620
Fly 644 LVRKNMHNWDSRFLDYLSDLCVSNRKAIAVTQELICKSVLSDKNKDILIETQVKALRTGSGPVRC 708
|:|:|. :.|||||||||||||..||.||||||||.:||..|.||||:|::.:::.
Mouse 621 LLRRNR---EPRFLDYLSDLCVSNSTAIPVTQELICKFMLSPGNADILIQTKLVSMQV------- 675
Fly 709 YKGNSEDVCLATLAEDAGDDEDRSDVQSTSTTTTWDSASLNEDDGTPSTGDKYEIHLKW---TGQ 770
|:...:::..|..||| |:.|.| ..:
Mouse 676 -----ENPMESSILPDDIDDE--------------------------------EVWLYWIDSNKE 703
Fly 771 PTSRSMADLA--SCDGGELEAAILNYYRHQLNLFSNMCLNRQYLALNELSPRLDIDLILKCMSDE 833
|..:::..|| :.:|.:.:..:|.|||:|||||:.|||:|||||:|::|.:|.:||||:|:|||
Mouse 704 PHGKAIRHLAQEAREGTKADLEVLTYYRYQLNLFARMCLDRQYLAINQISTQLSVDLILRCVSDE 768
Fly 834 TMPYELRASFCRLMLHLHVDRDPQEPVTPVKYARLWSEIPSKMSIQDYDGKNQQPDQNKQACRAK 898
::|::|||||||||||:||||||||.|.||:|||||:|||:|::|.:||... |.::...:.|
Mouse 769 SLPFDLRASFCRLMLHMHVDRDPQESVVPVRYARLWTEIPTKITIHEYDSIT---DSSRNDMKRK 830
Fly 899 FNTTIAFVENYLCNVATKVWLFTDQEQNKLTFEVVKLARDLIYFGFYSFSDLLRLTKTLLSILDC 963
|..|:.|||.||..|..:.:.|.|:|:||||||||.|||:||||||||||:|||||:|||:|||.
Mouse 831 FALTMEFVEEYLKEVVNQPFPFGDKEKNKLTFEVVHLARNLIYFGFYSFSELLRLTRTLLAILDI 895
Fly 964 VSDTSSGEFASTDIDSVEEETNAEAEGGVLRSIGDINTVMTSLAL--GSV-------GQAIAAPT 1019
|....|..|.. :...::.:| .|:|:|..:..:||.:.| ||: .|.|..|:
Mouse 896 VQAPMSSYFER--LSKFQDGSN-----NVMRTIHGVGEMMTQMVLSRGSIFPVSVPDAQPIVHPS 953
Fly 1020 ISLQQRKSVSQLMKEYPLVMDTKLKIIEILQFILDVRLDYRISCLLSIFKREFDESEVAASAASN 1084
|..|...:|...|||||||:||||||||.||||||||.:|||:|:||
Mouse 954 ------KQASPGEQEDVTVMDTKLKVIEILQFILSVRLDYRISYMLSIYKKEF------------ 1000
Fly 1085 EASQQQSQQQEPQTPGSSNETDPLDSAESVAAGAAAAAATTARQKNIDLESIGVQAEGIFDCERS 1149
|.:| |:.:..|:|.......:|...:|| .|..|||.:| ..|.
Mouse 1001 ---------------GDNN-----DNGDPSASGTPDTLLPSALVPDID--EIAAQAETMF-AGRK 1042
Fly 1150 DAANLDLDGQGGRTFLRVLLHLIMHDYAPLVSGALHLLFRHFSQRQEVLQAFRQVQLLVSDSDVE 1214
:...:.||.:|||||||||:||||||||||:||||.|||:|||||.||||||:|||||||:.||:
Mouse 1043 EKTPVQLDDEGGRTFLRVLIHLIMHDYAPLLSGALQLLFKHFSQRAEVLQAFKQVQLLVSNQDVD 1107
Fly 1215 SYKQIKSDLDILRQSVEKSELWVYKAKATD--ELGATDA-GGDAVSLEYN-----------AALS 1265
:|||||:|||.||.:||||||||.|:.:.: ::|...| ||:..:.|.| ..:.
Mouse 1108 NYKQIKADLDQLRLTVEKSELWVEKSGSYENGDVGEGQAKGGEEANEESNLLSPVQDGAKTPQID 1172
Fly 1266 QEQRNEYRKVKEILIRMNKFCVTASGPGSVVKPRKHEQRLLRNVGVHTVVLDLLQNPYDEKDDEL 1330
..:.|.||.|||||||::|.||... |.|...||||:|:|.|:|||||||.|| ||.||.
Mouse 1173 SNKGNNYRIVKEILIRLSKLCVQNK------KCRNQHQRLLKNMGAHSVVLDLLQIPY-EKTDEK 1230
Fly 1331 MKELMCLAHEFLQNFCLGNQQNQVLLHNHLDLFLNPGILEAKTVCAIFKDNLALCNEVTDKVVQH 1395
|.|:|.|||.||||||.||.|||||||.||:|||.||:|||:|:..||.:|..||||::::||||
Mouse 1231 MNEVMDLAHTFLQNFCRGNPQNQVLLHKHLNLFLTPGLLEAETMRHIFMNNYHLCNEISERVVQH 1295
Fly 1396 FVHCIEIHGRHVAYLQFLQTVVRAENQFIRRCQDMVMQELINSGEDVLVFYNDKGSFNHFVQMMQ 1460
||||||.|||||.||:||||:|:|:.:::::||||||.||||.|||||:||||:.||...:.||.
Mouse 1296 FVHCIETHGRHVEYLRFLQTIVKADGKYVKKCQDMVMTELINGGEDVLIFYNDRASFPILLNMMC 1360
Fly 1461 QQMLRMEKLSDDS-PLKYHVELVKLLACCTMGKNVYTEIKCNNLLSLDDIVTIICHPLCMPEVKE 1524
.:..| .|:| ||.||:.||:|||.||.|||||||||||:||.|||||.::.|..|:||||.
Mouse 1361 SERAR----GDESGPLAYHITLVELLAACTEGKNVYTEIKCNSLLPLDDIVRVVTHDDCIPEVKI 1421
Fly 1525 AYVDFLNHCYIDTEVEMKEIYASGHMWSLFEKSFLVDINQL--ITNPAAASNKTLQAYVLNGVTN 1587
|||:|:||||:||||||||||.|.|:|.||| :||||:.:: .|.....::..|:..|...|.|
Mouse 1422 AYVNFVNHCYVDTEVEMKEIYTSNHIWKLFE-NFLVDMARVCNTTTDRKHADTFLERCVTESVMN 1485
Fly 1588 LLGSFFASPFSDQSAIVQSRQLIFVQLLQAAHRITQCRWLSLGDRFNVENCIRTLTESAKMRSIA 1652
::..||.|||||.|..:|:.|.:|:||||:|.||..|.|.:...:.:||:|||.|.|.||.|.||
Mouse 1486 IVSGFFNSPFSDNSTSLQTHQPVFIQLLQSAFRIYNCTWPNPAQKASVESCIRALAEVAKNRGIA 1550
Fly 1653 LPPELEQQVAT--MSSKTAMLTRQTTKWLLASKQ-PKYEAQQAASLMRWD-RSIIEGLQDIVSLL 1713
:|.:|:.||.| |.:.::.:.|....|.|:::. |:: ::|.....|| |:|||.|||:|:.|
Mouse 1551 IPVDLDSQVNTLFMKNHSSTVQRAAMGWRLSARSGPRF--KEALGGPAWDYRNIIEKLQDVVASL 1613
Fly 1714 EDQLKPVVEAELSLLVDILYRSELLFPAGTEARKRCESGGFIRKLIKHTEKLLEEKEERMCVKVL 1778
|.|..|:::||.|:|||:||..|||||.|::||.|| |.|:.|||.||:||: ||||::|:|:|
Mouse 1614 EQQFSPMMQAEFSVLVDVLYSPELLFPEGSDARIRC--GAFMSKLINHTKKLM-EKEEKLCIKIL 1675
Fly 1779 RTLREMMAIDVNYGEKGDALRQTLLLRYFQTKSTPRLPEDEVPLLAAPLMDPAKQNHLVT-HGP- 1841
:|||||:....::.|:|..||:.||.||| |.:|.:: :||
Mouse 1676 QTLREMLEKKDSFMEEGSTLRRILLNRYF------------------------KGDHSISVNGPL 1716
Fly 1842 -GAKYLQRA--------------GKTLHEMQNHLDREGASDLVVELVIKSVHSPNIFVEAVELGI 1891
|| |.:.| |.::.::|..||:||||:||::::: :..:..||.|.:.|||
Mouse 1717 SGA-YAKTAQVGGSFSGQDSDKKGISMSDIQCLLDKEGASELVIDVIV-NTKNDRIFSEGILLGI 1779
Fly 1892 ALLEGGNPIIQKGMFQKFLSDDLNQAFFKVFFEKMKDAQQEIKSTVTVNTTDIAAKAHEHKQDTN 1956
|||||||...|...:|:......::.||||.:::||.||:||:|||||||.|:.:|..|...|
Mouse 1780 ALLEGGNTQTQYSFYQQLHEQKKSEKFFKVLYDRMKAAQKEIRSTVTVNTIDLGSKKREEDSD-- 1842
Fly 1957 LELDKIARKHGLKSNGVVITEELKRELHNAGLATARAYGNARNIHSGEESSAISVNSPLEDILAE 2021
:..:..:..::.:.:.:.|.:|.:|..|..||::|| .::..|....|....| .:
Mouse 1843 --VMALGPRMRVRDSSLHLREGMKGQLTEASSATSKAY----CVYRREMDPEIDTMCP-----GQ 1896
Fly 2022 KLEKHKDSRDQRNQLSNKVLVMQPILRFLQLLCENHNPDMQNLLRNQNNKTNNNLVSETLMFLDC 2086
:....::...:...:|..:.:|:||||||||||||||.::||.|||||||||.|||.|||.||||
Mouse 1897 EAGSAEEKSAEEVTMSPAITIMRPILRFLQLLCENHNRELQNFLRNQNNKTNYNLVCETLQFLDC 1961
Fly 2087 ICGSTTGGLGLLGLYINEHNVALINQTLEALTEYCQGPCHENQNCIATHESNGLDIITALILNNI 2151
||||||||||||||||||.||||:|||||:|||||||||||||.|||||||||:|||.|||||:|
Mouse 1962 ICGSTTGGLGLLGLYINERNVALVNQTLESLTEYCQGPCHENQTCIATHESNGIDIIIALILNDI 2026
Fly 2152 NPLGENRMDLVLELKNNASKLLLAIMESRGDSENAERILYNMNPKQLVEVACKAYHQEELIDEQD 2216
||||:.||||||:||||||||||||||||.|||||||||:||.|::||:|...||:|.. |.|
Mouse 2027 NPLGKYRMDLVLQLKNNASKLLLAIMESRHDSENAERILFNMRPRELVDVMKNAYNQGL---ECD 2088
Fly 2217 DGDEPDAGSDDDDATVSPREVGHNIYILCHQLAQHNKELAGLLKASEDPQSASFDAKTSQALMYY 2281
.||| .|.||. |||::||||||||.||||:|||.|..:||...||:.. .:||.||
Mouse 2089 HGDE--EGGDDG---VSPKDVGHNIYILAHQLARHNKLLQQMLKPGSDPEEG------DEALKYY 2142
Fly 2282 ATHTAQIEIVRNDRTLEQIVFPIPEICEYLTTDTKIKILNTAERDDQGSKVADFFDKAEEMFNEM 2346
|.|||||||||:|||:||||||:|.|||:||.::|.::.||.|||:|||||.|||.:.|:::|||
Mouse 2143 ANHTAQIEIVRHDRTMEQIVFPVPNICEFLTRESKYRVFNTTERDEQGSKVNDFFQQTEDLYNEM 2207
Fly 2347 KWQKKLRSQPLLFWISSYMSLWSNILFNCVVVINMIVAFFYPF--DNTVPELSSHISLLFWIITI 2409
|||||:|:.|.|||.|.::|||.:|.||..|.||:.||.|||| |.....||...|:|.|:...
Mouse 2208 KWQKKIRNNPALFWFSRHISLWGSISFNLAVFINLAVALFYPFGDDGDEGTLSPMFSVLLWVAVA 2272
Fly 2410 FSLVIVLALPRESGIRTFIGSVILRFIFLLGPESTLCLLGVVTVTLKSVHIVSIMGNKGTLEKQL 2474
....::....:..|||.|:.||:||.|:.:|...||.|||...:..|.|.:||.:||:||..:..
Mouse 2273 ICTSMLFFFSKPVGIRPFLVSVMLRSIYTIGLGPTLILLGAANLCNKIVFLVSFVGNRGTFTRGY 2337
Fly 2475 IKIITDFQLLYHCIYIAFCFCGLIFHPFFYSLLLFDVVYREETLVNVIRSVTRNGRSIVLTAVLA 2539
..:|.|...|||..|:..|..||..|.||||.||||:|||||||:|||:|||||||||:||||||
Mouse 2338 RAVILDMAFLYHVAYVLVCMLGLFVHEFFYSFLLFDLVYREETLLNVIKSVTRNGRSIILTAVLA 2402
Fly 2540 LILVYLFSIIGYMFFKDDFLVSVDFEEQDNAPPPS----VPLTLSVPVSGDSCSAPDDLGNCQAA 2600
|||||||||||::|.||||.:.|| ...|..|.: || |:::....::|... ||
Mouse 2403 LILVYLFSIIGFLFLKDDFTMEVD--RLKNRTPVTGNHGVP-TMTLSSMMETCQKE----NC--- 2457
Fly 2601 KEVAPPSAGGGEVK----ERSCDSLVMCIVTTLNQGLRNGGGIGDILRAPSSKEGLFVARVIYDL 2661
....|.|...||.. ||:||:|:|||||.||||||||||:||:||.||..|.||.|||:|||
Mouse 2458 SPTIPSSNTAGEEGEDGIERTCDTLLMCIVTVLNQGLRNGGGVGDVLRRPSKDEPLFAARVVYDL 2522
Fly 2662 LFFFIVIIIVLNLIFGVIIDTFADLRSEKQQKEAILKTTCFICSLNRSAFDNKTVSFEEHIKSEH 2726
||||||||||||||||||||||||||||||:||.|||||||||.|.|..||||||||||||||||
Mouse 2523 LFFFIVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSFEEHIKSEH 2587
Fly 2727 NMWHYLYFIVLVKVKDPTEFTGPESYVYAMVKAGILEWFPRLRAMSLAAVDADGEQIELRSMQAQ 2791
|||||||||||||||||||:|||||||..|:....|:||||:|||||.:.:.|.||.|:|::|.:
Mouse 2588 NMWHYLYFIVLVKVKDPTEYTGPESYVAQMITEKNLDWFPRMRAMSLVSNEGDSEQNEIRNLQEK 2652
Fly 2792 LLDTQLLIKNLSTQLHELKDHMTEQRKQKQRLGLLNT 2828
|..|..|:|.||.||.|||:.||||||.|||||.|.:
Mouse 2653 LESTMSLVKQLSGQLAELKEQMTEQRKNKQRLGFLGS 2689
| 
