|
Fly 1 MGDNIIGSASFLHLGDIVSLYAEGSVCGFLSTLGLVDDRTVVCPEAGDLSCPPKKFRDCLIKICP 65
|.|.: :||||:|||.|||||||..||:|||||||||.||.||||||:.|||||||||.|:||
Mouse 1 MSDKM---SSFLHIGDICSLYAEGSTNGFISTLGLVDDRCVVQPEAGDLNNPPKKFRDCLFKLCP 62
Fly 66 MNRYSAQKQFWKAAKQSASSNTDPNLLKRLHHAAEIEKKQNETENKKLLGTSIQYGRAVVQLLHL 130
|||||||||||||||..|:|.||..||.:|||||::|||||||||:|||||.||||. |:|||||
Mouse 63 MNRYSAQKQFWKAAKPGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGN-VIQLLHL 126
Fly 131 KSNKYLTVNKRLPSLLEKNAMRVYLDANGNEGSWFYIKPFYKLRSIGDYVVVGDKVILSPVNADQ 195
|||||||||||||:|||||||||.||..|||||||||:||||||||||.||:||||:|:||||.|
Mouse 127 KSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQPFYKLRSIGDSVVIGDKVVLNPVNAGQ 191
Fly 196 QNLHVAANYELPDNPGCKEVNVLNSSTSWKISLFMEHKENQEHILKGGDVVRLFHAEQEKFLTMD 260
. || |::::|.|||||.|||.:|.:|||||.|||:..:|::.||||||||||||||||||||.|
Mouse 192 P-LH-ASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILKGGDVVRLFHAEQEKFLTCD 254
Fly 261 EYKKQYHVFLRTTGRTSATAATSSKALWEIEVVQHDSCRGGAGDWNSLYRFKHLATGHYLAAEAE 325
|::|:.|||||||||.|||:|||||||||:||||||.||||||.||||:||||||||||||||.:
Mouse 255 EHRKKQHVFLRTTGRQSATSATSSKALWEVEVVQHDPCRGGAGYWNSLFRFKHLATGHYLAAEVD 319
Fly 326 IDVSAGAMSATSASGHDLHLGDCSKDSGLSCSTMNSTINDKPKGKQYRLVSVPYSADIASVFVLD 390
.|.....:....:...| .|.|: |.:.:..:...|.|||||...||:|:|.||
Mouse 320 PDFEEECLEFQPSVDPD---QDASR----------SRLRNAQEKMVYSLVSVPEGNDISSIFELD 371
Fly 391 ATTMARPDSLVPQSSYVRLQHICSNTWVHATSIPIDADDDKPVMSMVCCSPIKEDKEAFALIPVS 455
.||:...|||||::|||||:|:|:|||||:|:||||.:::||||..:..||:||||||||::|||
Mouse 372 PTTLRGGDSLVPRNSYVRLRHLCTNTWVHSTNIPIDKEEEKPVMLKIGTSPLKEDKEAFAIVPVS 436
Fly 456 PVEVRDLDFANDACKVLATVTSKLDNGSISINERRALISLLQDIVYFIAGMENEQNKTKALEFTI 520
|.|||||||||||.|||.::..||:.|:|:.||||::..||:|:|||:.|..| :....||...
Mouse 437 PAEVRDLDFANDASKVLGSIAGKLEKGTITQNERRSVTKLLEDLVYFVTGGTN--SGQDVLEVVF 499
Fly 521 KNPIRDRQKLLREQYILKQLFKILQGPFQQHTAGDGPFLRLDELSDPKNSPYKNIFRLCYRILRL 585
..|.|:||||:|||.||||:||:||.||.. .||||.|||:||.|.:::|:::|.|||||:||.
Mouse 500 SKPNRERQKLMREQNILKQIFKLLQAPFTD--CGDGPMLRLEELGDQRHAPFRHICRLCYRVLRH 562
Fly 586 SQQDYRKNQEYIAKHFGLMQKQIGYDILAEDTITALLHNNRKLLEKHITAAEIETFVGLVRKNMH 650
||||||||||||||.||.||||||||:||||||||||||||||||||||||||:|||.|||||.
Mouse 563 SQQDYRKNQEYIAKQFGFMQKQIGYDVLAEDTITALLHNNRKLLEKHITAAEIDTFVSLVRKNR- 626
Fly 651 NWDSRFLDYLSDLCVSNRKAIAVTQELICKSVLSDKNKDILIETQVKALRTGSGPVRCYKGNSED 715
:.||||||||||||..|:|.||||||||:||:..|.||||||::...|. ..|.
Mouse 627 --EPRFLDYLSDLCVSMNKSIPVTQELICKAVLNPTNADILIETKLVLSRF----------EFEG 679
Fly 716 VCLATLAEDAGDDEDRSDVQSTSTTTTWDSASLNEDDGTPSTGDKYEIHLKW---TGQPTSRSMA 777
|.....|.:||:||: |:.|.| ..:..|:|:.
Mouse 680 VSTGENALEAGEDEE-------------------------------EVWLFWRDSNKEIRSKSVR 713
Fly 778 DLA--SCDGGELEAAILNYYRHQLNLFSNMCLNRQYLALNELSPRLDIDLILKCMSDETMPYELR 840
:|| :.:|.:.:..||:|||:|||||:.|||:|||||:||:|.:||:||||:|||||.:||:||
Mouse 714 ELAQDAKEGQKEDRDILSYYRYQLNLFARMCLDRQYLAINEISGQLDVDLILRCMSDENLPYDLR 778
Fly 841 ASFCRLMLHLHVDRDPQEPVTPVKYARLWSEIPSKMSIQDYDGKNQQPDQNKQACRAKFNTTIAF 905
|||||||||:||||||||.|||||||||||||||:::|.|||......|:.|: :|..|:.|
Mouse 779 ASFCRLMLHMHVDRDPQEQVTPVKYARLWSEIPSEIAIDDYDSSGTSKDEIKE----RFAQTMEF 839
Fly 906 VENYLCNVATKVWLFTDQEQNKLTFEVVKLARDLIYFGFYSFSDLLRLTKTLLSILDCV------ 964
||.||.:|..:.:.|:|:|:||||||||.|||:|||||||:|||||||||.||:|||||
Mouse 840 VEEYLRDVVCQRFPFSDKEKNKLTFEVVNLARNLIYFGFYNFSDLLRLTKILLAILDCVHVTTIF 904
Fly 965 --SDTSSGEFASTDIDSVEEETNAEAE----GGVLRSIGDINTVMTSLALGSVG-----QAIAAP 1018
|..:.|| |.:.|.:.| ..|:|||..:..:||.:.|...| ...|||
Mouse 905 PISKMTKGE---------ENKGNNDEEKLKSSNVMRSIHGVGELMTQVVLRGGGFLPMTPMAAAP 960
Fly 1019 TISLQQRKSVSQLMKEYPLVMDTKLKIIEILQFILDVRLDYRISCLLSIFKREFDESEVAASAAS 1083
..:::| ::..||..:||||||||||||||||:|||||||||||.||||||||| ::.|
Mouse 961 EGNVKQ----AEPEKEDIMVMDTKLKIIEILQFILNVRLDYRISCLLCIFKREFDES----NSQS 1017
Fly 1084 NEASQQQSQQQEP-QTPGSSNETDPLDSAESVAAGAAAAAATTARQKNIDLESIGVQAEGIFDCE 1147
:|.|...|.|:.| ..||: :|.|.|..||||||...
Mouse 1018 SETSSGNSSQEGPSNVPGA-----------------------------LDFEHIEEQAEGIFGGS 1053
Fly 1148 RSDAANLDLDGQGGRTFLRVLLHLIMHDYAPLVSGALHLLFRHFSQRQEVLQAFRQVQLLVSDSD 1212
..:.. ||||..||||||||||||.||||.|||||||.||||||||||||||||:||||||:..|
Mouse 1054 EENTP-LDLDDHGGRTFLRVLLHLTMHDYPPLVSGALQLLFRHFSQRQEVLQAFKQVQLLVTSQD 1117
Fly 1213 VESYKQIKSDLDILRQSVEKSELWVYKAKATDELGATDAGGDAVSLEYNAALSQEQRNE------ 1271
|::|||||.|||.||..||||||||||.:..|| ....|.|:....:.....|:..::|
Mouse 1118 VDNYKQIKQDLDQLRSIVEKSELWVYKGQGPDE-PMDGASGENEHKKTEEGTSKPLKHESTSSYN 1181
Fly 1272 YRKVKEILIRMNKFCVTASGPGSVVKPRKHEQRLLRNVGVHTVVLDLLQNPYDEKDDELMKELMC 1336
||.|||||||::|.||..| .||.|.||.:||||||:|.|.|||:|||.||::.:|..|:|:|.
Mouse 1182 YRVVKEILIRLSKLCVQES--ASVRKSRKQQQRLLRNMGAHAVVLELLQIPYEKAEDTKMQEIMR 1244
Fly 1337 LAHEFLQNFCLGNQQNQVLLHNHLDLFLNPGILEAKTVCAIFKDNLALCNEVTDKVVQHFVHCIE 1401
||||||||||.||||||.|||.|::||||||||||.|:..||.:|..||:|:.::||||||||||
Mouse 1245 LAHEFLQNFCAGNQQNQALLHKHINLFLNPGILEAVTMQHIFMNNFQLCSEINERVVQHFVHCIE 1309
Fly 1402 IHGRHVAYLQFLQTVVRAENQFIRRCQDMVMQELINSGEDVLVFYNDKGSFNHFVQMMQQQMLRM 1466
.|||:|.|::||||:|:||.:||::||||||.||:||||||||||||:.||...:|||:.:..||
Mouse 1310 THGRNVQYIKFLQTIVKAEGKFIKKCQDMVMAELVNSGEDVLVFYNDRASFQTLIQMMRSERDRM 1374
Fly 1467 EKLSDDSPLKYHVELVKLLACCTMGKNVYTEIKCNNLLSLDDIVTIICHPLCMPEVKEAYVDFLN 1531
: ::|||.||:.||:|||.||.|||||||||||:||.|||||.::.|..|:||||.||::|||
Mouse 1375 D---ENSPLMYHIHLVELLAVCTEGKNVYTEIKCNSLLPLDDIVRVVTHEDCIPEVKIAYINFLN 1436
Fly 1532 HCYIDTEVEMKEIYASGHMWSLFEKSFLVDINQLITNPA--AASNKTLQAYVLNGVTNLLGSFFA 1594
|||:||||||||||.|.|||.||| :|||||.:...|.: ..::..|:.||...|.:::.:||:
Mouse 1437 HCYVDTEVEMKEIYTSNHMWKLFE-NFLVDICRACNNTSDRKHADSILEKYVTEIVMSIVTTFFS 1500
Fly 1595 SPFSDQSAIVQSRQLIFVQLLQAAHRITQCRWLSLGDRFNVENCIRTLTESAKMRSIALPPELEQ 1659
|||||||..:|:||.:||||||...|:..|.||....:.:||:|||.|::.||.|:||:|.:|:.
Mouse 1501 SPFSDQSTTLQTRQPVFVQLLQGVFRVYHCNWLMPSQKASVESCIRVLSDVAKSRAIAIPVDLDS 1565
Fly 1660 QVATMSSKTAMLTRQTT-KWLLASKQ-PKYEAQQAASLMRWDRSIIEGLQDIVSLLEDQLKPVVE 1722
||..:..|:..:.::|. .|.|:::. .:.::..||| |..|:|||.||||||.|||:|:|:|:
Mouse 1566 QVNNLFLKSHNIVQKTALNWRLSARNAARRDSVLAAS--RDYRNIIERLQDIVSALEDRLRPLVQ 1628
Fly 1723 AELSLLVDILYRSELLFPAGTEARKRCESGGFIRKLIKHTEKLLEEKEERMCVKVLRTLREMMAI 1787
||||:|||:|:|.|||||..|:||::|||||||.||||||::||||.||::|:|||:||||||..
Mouse 1629 AELSVLVDVLHRPELLFPENTDARRKCESGGFICKLIKHTKQLLEENEEKLCIKVLQTLREMMTK 1693
Fly 1788 DVNYGEK----------------------------------------GDALRQTLLLRYFQTKST 1812
|..|||| |:||||.|:.||:.....
Mouse 1694 DRGYGEKQISIDESENAELPQAPEAENSTEQELEPSPPLRQLEDHKRGEALRQILVNRYYGNIRP 1758
Fly 1813 PRLPEDEVPLLAAPLM--DPAKQNHLVTHGPGAKYLQRAGKTLHEMQNHLDREGASDLVVELVIK 1875
....|........||. .|:|... ...|||:....|...:|.|:|.|||:||||:||::|::
Mouse 1759 SGRRESLTSFGNGPLSPGGPSKPGG-GGGGPGSSSTSRGEMSLAEVQCHLDKEGASNLVIDLIM- 1821
Fly 1876 SVHSPNIFVEAVELGIALLEGGNPIIQKGMFQKFLSDDLNQAFFKVFFEKMKDAQQEIKSTVTVN 1940
:..|..:|.|::.|.||||||||..||...|.:...|..::.|||||:::||.||||||:|||||
Mouse 1822 NASSDRVFHESILLAIALLEGGNTTIQHSFFCRLTEDKKSEKFFKVFYDRMKVAQQEIKATVTVN 1886
Fly 1941 TTDIAAKAHEHKQDTNLELDKIARKHGLKSNGVVITEELKRELHNAGLATARAYGNAR------- 1998
|:|:..| |:|..::.|..:||.. |.....||||::.:|..|..||.:|:...|
Mouse 1887 TSDLGNK----KKDDEVDRDAPSRKKA-KEPTTQITEEVRDQLLEASAATRKAFTTFRREADPDD 1946
Fly 1999 NIHSGEESSAISVNSPLEDILAEKLEKHKDSRDQRNQLSNKVLVMQPILRFLQLLCENHNPDMQN 2063
:..|||.:.|.: :|.||.. ::|..:.:||||||||||||||||.|:||
Mouse 1947 HYQSGEGTQATT-------------DKAKDDL----EMSAVITIMQPILRFLQLLCENHNRDLQN 1994
Fly 2064 LLRNQNNKTNNNLVSETLMFLDCICGSTTGGLGLLGLYINEHNVALINQTLEALTEYCQGPCHEN 2128
.||.||||||.|||.|||.||||||||||||||||||||||.||||||||||:||||||||||||
Mouse 1995 FLRCQNNKTNYNLVCETLQFLDCICGSTTGGLGLLGLYINEKNVALINQTLESLTEYCQGPCHEN 2059
Fly 2129 QNCIATHESNGLDIITALILNNINPLGENRMDLVLELKNNASKLLLAIMESRGDSENAERILYNM 2193
|||||||||||:|||||||||:|||||:.|||||||||||||||||||||||.||||||||||||
Mouse 2060 QNCIATHESNGIDIITALILNDINPLGKKRMDLVLELKNNASKLLLAIMESRHDSENAERILYNM 2124
Fly 2194 NPKQLVEVACKAYHQEELIDEQDDGDEPDAGSDDDDATVSPREVGHNIYILCHQLAQHNKELAGL 2258
.||:||||..|||.|.|: |.:||: :.:|...|||.||||||||.||||:|||||..:
Mouse 2125 RPKELVEVIKKAYMQGEV--EFEDGE------NGEDGAASPRNVGHNIYILAHQLARHNKELQTM 2181
Fly 2259 LKASEDPQSASFDAKTSQALMYYATHTAQIEIVRNDRTLEQIVFPIPEICEYLTTDTKIKILNTA 2323
||....... .:||.:||.|||||||||.|||:||||||:|.|||:||.::|::|..|.
Mouse 2182 LKPGGQVDG-------DEALEFYAKHTAQIEIVRLDRTMEQIVFPVPSICEFLTKESKLRIYYTT 2239
Fly 2324 ERDDQGSKVADFFDKAEEMFNEMKWQKKLRSQPLLFWISSYMSLWSNILFNCVVVINMIVAFFYP 2388
|||:||||:.|||.::|::||||.||||||:||:|:|.:..||.||:|.||..|::|::||||||
Mouse 2240 ERDEQGSKINDFFLRSEDLFNEMNWQKKLRAQPVLYWCARNMSFWSSISFNLAVLMNLLVAFFYP 2304
Fly 2389 FDNT-VPELSSHISLLFWIITIFSLVIVLALPRESGIRTFIGSVILRFIFLLGPESTLCLLGVVT 2452
|... ...|..|.|.|.|...:.||.||:|||:..|||..|.|.|||.||.:|.:.||.|||...
Mouse 2305 FKGVRGGTLEPHWSGLLWTAMLISLAIVIALPKPHGIRALIASTILRLIFSVGLQPTLFLLGAFN 2369
Fly 2453 VTLKSVHIVSIMGNKGTLEKQLIKIITDFQLLYHCIYIAFCFCGLIFHPFFYSLLLFDVVYREET 2517
|..|.:.::|.:||.||..:....::.|.:.|||.:|:..|..||..|.|||||||||:||||||
Mouse 2370 VCNKIIFLMSFVGNCGTFTRGYRAMVLDVEFLYHLLYLLICAMGLFVHEFFYSLLLFDLVYREET 2434
Fly 2518 LVNVIRSVTRNGRSIVLTAVLALILVYLFSIIGYMFFKDDFLVSVDFEEQDNAPPPSVPLTLSVP 2582
|:|||:|||||||||:|||||||||||||||:||:||||||::.|| .:|...:||
Mouse 2435 LLNVIKSVTRNGRSIILTAVLALILVYLFSIVGYLFFKDDFILEVD----------RLPNETAVP 2489
Fly 2583 VSGDS------------------CSAPDDLGNCQAAKEVAPPSAGGGEVKERSCDSLVMCIVTTL 2629
.:|:| |::| |.||...|:....:.||.:|::|:|||||.|
Mouse 2490 ETGESLANDFLYSDVCRVETGENCTSP-------APKEELLPAEETEQDKEHTCETLLMCIVTVL 2547
Fly 2630 NQGLRNGGGIGDILRAPSSKEGLFVARVIYDLLFFFIVIIIVLNLIFGVIIDTFADLRSEKQQKE 2694
:.|||:|||:||:||.||.:|.||.|||||||||||:|||||||||||||||||||||||||:||
Mouse 2548 SHGLRSGGGVGDVLRKPSKEEPLFAARVIYDLLFFFMVIIIVLNLIFGVIIDTFADLRSEKQKKE 2612
Fly 2695 AILKTTCFICSLNRSAFDNKTVSFEEHIKSEHNMWHYLYFIVLVKVKDPTEFTGPESYVYAMVKA 2759
.|||||||||.|.|..||||||:||||||.||||||||.|||||||||.||:|||||||..|::.
Mouse 2613 EILKTTCFICGLERDKFDNKTVTFEEHIKEEHNMWHYLCFIVLVKVKDSTEYTGPESYVAEMIRE 2677
Fly 2760 GILEWFPRLRAMSLAAVDADGEQIELRSMQAQLLDTQLLIKNLSTQLHELKDHMTEQRKQKQRLG 2824
..|:||||:|||||.:.|::|||.|||::|.:|..|..|:.|||.||.||||.||||||||||:|
Mouse 2678 RNLDWFPRMRAMSLVSSDSEGEQNELRNLQEKLESTMKLVTNLSGQLSELKDQMTEQRKQKQRIG 2742
Fly 2825 LL 2826
||
Mouse 2743 LL 2744
| 
