DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Itpr and Itpr1

DIOPT Version :9

Sequence 1:	NP_730941.1	Gene:	Itpr / 40664	FlyBaseID:	FBgn0010051	Length:	2837	Species:	Drosophila melanogaster
Sequence 2:	XP_006505686.1	Gene:	Itpr1 / 16438	MGIID:	96623	Length:	2758	Species:	Mus musculus

Alignment Length:	2927	Identity:	1661/2927 - (56%)
Similarity:	2051/2927 - (70%)	Gaps:	284/2927 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGDNIIGSASFLHLGDIVSLYAEGSVCGFLSTLGLVDDRTVVCPEAGDLSCPPKKFRDCLIKICP 65
            |.|.:   :||||:|||.|||||||..||:|||||||||.||.||||||:.|||||||||.|:||
Mouse     1 MSDKM---SSFLHIGDICSLYAEGSTNGFISTLGLVDDRCVVQPEAGDLNNPPKKFRDCLFKLCP 62

  Fly    66 MNRYSAQKQFWKAAKQSASSNTDPNLLKRLHHAAEIEKKQNETENKKLLGTSIQYGRAVVQLLHL 130
            |||||||||||||||..|:|.||..||.:|||||::|||||||||:|||||.||||. |:|||||
Mouse    63 MNRYSAQKQFWKAAKPGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGN-VIQLLHL 126

  Fly   131 KSNKYLTVNKRLPSLLEKNAMRVYLDANGNEGSWFYIKPFYKLRSIGDYVVVGDKVILSPVNADQ 195
            |||||||||||||:|||||||||.||..|||||||||:||||||||||.||:||||:|:||||.|
Mouse   127 KSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQPFYKLRSIGDSVVIGDKVVLNPVNAGQ 191

  Fly   196 QNLHVAANYELPDNPGCKEVNVLNSSTSWKISLFMEHKENQEHILKGGDVVRLFHAEQEKFLTMD 260
            . || |::::|.|||||.|||.:|.:|||||.|||:..:|::.||||||||||||||||||||.|
Mouse   192 P-LH-ASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILKGGDVVRLFHAEQEKFLTCD 254

  Fly   261 EYKKQYHVFLRTTGRTSATAATSSKALWEIEVVQHDSCRGGAGDWNSLYRFKHLATGHYLAAEAE 325
            |::|:.|||||||||.|||:|||||||||:||||||.||||||.||||:||||||||||||||.:
Mouse   255 EHRKKQHVFLRTTGRQSATSATSSKALWEVEVVQHDPCRGGAGYWNSLFRFKHLATGHYLAAEVD 319

  Fly   326 IDVSAGAMSATSASGHDLHLGDCSKDSGLSCSTMNSTINDKPKGKQYRLVSVPYSADIASVFVLD 390
            .|.....:....:...|   .|.|:          |.:.:..:...|.|||||...||:|:|.||
Mouse   320 PDFEEECLEFQPSVDPD---QDASR----------SRLRNAQEKMVYSLVSVPEGNDISSIFELD 371

  Fly   391 ATTMARPDSLVPQSSYVRLQHICSNTWVHATSIPIDADDDKPVMSMVCCSPIKEDKEAFALIPVS 455
            .||:...|||||::|||||:|:|:|||||:|:||||.:::||||..:..||:||||||||::|||
Mouse   372 PTTLRGGDSLVPRNSYVRLRHLCTNTWVHSTNIPIDKEEEKPVMLKIGTSPLKEDKEAFAIVPVS 436

  Fly   456 PVEVRDLDFANDACKVLATVTSKLDNGSISINERRALISLLQDIVYFIAGMENEQNKTKALEFTI 520
            |.|||||||||||.|||.::..||:.|:|:.||||::..||:|:|||:.|..|  :....||...
Mouse   437 PAEVRDLDFANDASKVLGSIAGKLEKGTITQNERRSVTKLLEDLVYFVTGGTN--SGQDVLEVVF 499

  Fly   521 KNPIRDRQKLLREQYILKQLFKILQGPFQQHTAGDGPFLRLDELSDPKNSPYKNIFRLCYRILRL 585
            ..|.|:||||:|||.||||:||:||.||..  .||||.|||:||.|.:::|:::|.|||||:||.
Mouse   500 SKPNRERQKLMREQNILKQIFKLLQAPFTD--CGDGPMLRLEELGDQRHAPFRHICRLCYRVLRH 562

  Fly   586 SQQDYRKNQEYIAKHFGLMQKQIGYDILAEDTITALLHNNRKLLEKHITAAEIETFVGLVRKNMH 650
            ||||||||||||||.||.||||||||:||||||||||||||||||||||||||:|||.|||||.
Mouse   563 SQQDYRKNQEYIAKQFGFMQKQIGYDVLAEDTITALLHNNRKLLEKHITAAEIDTFVSLVRKNR- 626

  Fly   651 NWDSRFLDYLSDLCVSNRKAIAVTQELICKSVLSDKNKDILIETQVKALRTGSGPVRCYKGNSED 715
              :.||||||||||||..|:|.||||||||:||:..|.||||||::...|.          ..|.
Mouse   627 --EPRFLDYLSDLCVSMNKSIPVTQELICKAVLNPTNADILIETKLVLSRF----------EFEG 679

  Fly   716 VCLATLAEDAGDDEDRSDVQSTSTTTTWDSASLNEDDGTPSTGDKYEIHLKW---TGQPTSRSMA 777
            |.....|.:||:||:                               |:.|.|   ..:..|:|:.
Mouse   680 VSTGENALEAGEDEE-------------------------------EVWLFWRDSNKEIRSKSVR 713

  Fly   778 DLA--SCDGGELEAAILNYYRHQLNLFSNMCLNRQYLALNELSPRLDIDLILKCMSDETMPYELR 840
            :||  :.:|.:.:..||:|||:|||||:.|||:|||||:||:|.:||:||||:|||||.:||:||
Mouse   714 ELAQDAKEGQKEDRDILSYYRYQLNLFARMCLDRQYLAINEISGQLDVDLILRCMSDENLPYDLR 778

  Fly   841 ASFCRLMLHLHVDRDPQEPVTPVKYARLWSEIPSKMSIQDYDGKNQQPDQNKQACRAKFNTTIAF 905
            |||||||||:||||||||.|||||||||||||||:::|.|||......|:.|:    :|..|:.|
Mouse   779 ASFCRLMLHMHVDRDPQEQVTPVKYARLWSEIPSEIAIDDYDSSGTSKDEIKE----RFAQTMEF 839

  Fly   906 VENYLCNVATKVWLFTDQEQNKLTFEVVKLARDLIYFGFYSFSDLLRLTKTLLSILDCV------ 964
            ||.||.:|..:.:.|:|:|:||||||||.|||:|||||||:|||||||||.||:|||||
Mouse   840 VEEYLRDVVCQRFPFSDKEKNKLTFEVVNLARNLIYFGFYNFSDLLRLTKILLAILDCVHVTTIF 904

  Fly   965 --SDTSSGEFASTDIDSVEEETNAEAE----GGVLRSIGDINTVMTSLALGSVG-----QAIAAP 1018
              |..:.||         |.:.|.:.|    ..|:|||..:..:||.:.|...|     ...|||
Mouse   905 PISKMTKGE---------ENKGNNDEEKLKSSNVMRSIHGVGELMTQVVLRGGGFLPMTPMAAAP 960

  Fly  1019 TISLQQRKSVSQLMKEYPLVMDTKLKIIEILQFILDVRLDYRISCLLSIFKREFDESEVAASAAS 1083
            ..:::|    ::..||..:||||||||||||||||:|||||||||||.|||||||||    ::.|
Mouse   961 EGNVKQ----AEPEKEDIMVMDTKLKIIEILQFILNVRLDYRISCLLCIFKREFDES----NSQS 1017

  Fly  1084 NEASQQQSQQQEP-QTPGSSNETDPLDSAESVAAGAAAAAATTARQKNIDLESIGVQAEGIFDCE 1147
            :|.|...|.|:.| ..||:                             :|.|.|..||||||...
Mouse  1018 SETSSGNSSQEGPSNVPGA-----------------------------LDFEHIEEQAEGIFGGS 1053

  Fly  1148 RSDAANLDLDGQGGRTFLRVLLHLIMHDYAPLVSGALHLLFRHFSQRQEVLQAFRQVQLLVSDSD 1212
            ..:.. ||||..||||||||||||.||||.|||||||.||||||||||||||||:||||||:..|
Mouse  1054 EENTP-LDLDDHGGRTFLRVLLHLTMHDYPPLVSGALQLLFRHFSQRQEVLQAFKQVQLLVTSQD 1117

  Fly  1213 VESYKQIKSDLDILRQSVEKSELWVYKAKATDELGATDAGGDAVSLEYNAALSQEQRNE------ 1271
            |::|||||.|||.||..||||||||||.:..|| ....|.|:....:.....|:..::|
Mouse  1118 VDNYKQIKQDLDQLRSIVEKSELWVYKGQGPDE-PMDGASGENEHKKTEEGTSKPLKHESTSSYN 1181

  Fly  1272 YRKVKEILIRMNKFCVTASGPGSVVKPRKHEQRLLRNVGVHTVVLDLLQNPYDEKDDELMKELMC 1336
            ||.|||||||::|.||..|  .||.|.||.:||||||:|.|.|||:|||.||::.:|..|:|:|.
Mouse  1182 YRVVKEILIRLSKLCVQES--ASVRKSRKQQQRLLRNMGAHAVVLELLQIPYEKAEDTKMQEIMR 1244

  Fly  1337 LAHEFLQNFCLGNQQNQVLLHNHLDLFLNPGILEAKTVCAIFKDNLALCNEVTDKVVQHFVHCIE 1401
            ||||||||||.||||||.|||.|::||||||||||.|:..||.:|..||:|:.::||||||||||
Mouse  1245 LAHEFLQNFCAGNQQNQALLHKHINLFLNPGILEAVTMQHIFMNNFQLCSEINERVVQHFVHCIE 1309

  Fly  1402 IHGRHVAYLQFLQTVVRAENQFIRRCQDMVMQELINSGEDVLVFYNDKGSFNHFVQMMQQQMLRM 1466
            .|||:|.|::||||:|:||.:||::||||||.||:||||||||||||:.||...:|||:.:..||
Mouse  1310 THGRNVQYIKFLQTIVKAEGKFIKKCQDMVMAELVNSGEDVLVFYNDRASFQTLIQMMRSERDRM 1374

  Fly  1467 EKLSDDSPLKYHVELVKLLACCTMGKNVYTEIKCNNLLSLDDIVTIICHPLCMPEVKEAYVDFLN 1531
            :   ::|||.||:.||:|||.||.|||||||||||:||.|||||.::.|..|:||||.||::|||
Mouse  1375 D---ENSPLMYHIHLVELLAVCTEGKNVYTEIKCNSLLPLDDIVRVVTHEDCIPEVKIAYINFLN 1436

  Fly  1532 HCYIDTEVEMKEIYASGHMWSLFEKSFLVDINQLITNPA--AASNKTLQAYVLNGVTNLLGSFFA 1594
            |||:||||||||||.|.|||.||| :|||||.:...|.:  ..::..|:.||...|.:::.:||:
Mouse  1437 HCYVDTEVEMKEIYTSNHMWKLFE-NFLVDICRACNNTSDRKHADSILEKYVTEIVMSIVTTFFS 1500

  Fly  1595 SPFSDQSAIVQSRQLIFVQLLQAAHRITQCRWLSLGDRFNVENCIRTLTESAKMRSIALPPELEQ 1659
            |||||||..:|:||.:||||||...|:..|.||....:.:||:|||.|::.||.|:||:|.:|:.
Mouse  1501 SPFSDQSTTLQTRQPVFVQLLQGVFRVYHCNWLMPSQKASVESCIRVLSDVAKSRAIAIPVDLDS 1565

  Fly  1660 QVATMSSKTAMLTRQTT-KWLLASKQ-PKYEAQQAASLMRWDRSIIEGLQDIVSLLEDQLKPVVE 1722
            ||..:..|:..:.::|. .|.|:::. .:.::..|||  |..|:|||.||||||.|||:|:|:|:
Mouse  1566 QVNNLFLKSHNIVQKTALNWRLSARNAARRDSVLAAS--RDYRNIIERLQDIVSALEDRLRPLVQ 1628

  Fly  1723 AELSLLVDILYRSELLFPAGTEARKRCESGGFIRKLIKHTEKLLEEKEERMCVKVLRTLREMMAI 1787
            ||||:|||:|:|.|||||..|:||::|||||||.||||||::||||.||::|:|||:||||||..
Mouse  1629 AELSVLVDVLHRPELLFPENTDARRKCESGGFICKLIKHTKQLLEENEEKLCIKVLQTLREMMTK 1693

  Fly  1788 DVNYGEK----------------------------------------GDALRQTLLLRYFQTKST 1812
            |..||||                                        |:||||.|:.||:.....
Mouse  1694 DRGYGEKQISIDESENAELPQAPEAENSTEQELEPSPPLRQLEDHKRGEALRQILVNRYYGNIRP 1758

  Fly  1813 PRLPEDEVPLLAAPLM--DPAKQNHLVTHGPGAKYLQRAGKTLHEMQNHLDREGASDLVVELVIK 1875
            ....|........||.  .|:|... ...|||:....|...:|.|:|.|||:||||:||::|::
Mouse  1759 SGRRESLTSFGNGPLSPGGPSKPGG-GGGGPGSSSTSRGEMSLAEVQCHLDKEGASNLVIDLIM- 1821

  Fly  1876 SVHSPNIFVEAVELGIALLEGGNPIIQKGMFQKFLSDDLNQAFFKVFFEKMKDAQQEIKSTVTVN 1940
            :..|..:|.|::.|.||||||||..||...|.:...|..::.|||||:::||.||||||:|||||
Mouse  1822 NASSDRVFHESILLAIALLEGGNTTIQHSFFCRLTEDKKSEKFFKVFYDRMKVAQQEIKATVTVN 1886

  Fly  1941 TTDIAAKAHEHKQDTNLELDKIARKHGLKSNGVVITEELKRELHNAGLATARAYGNAR------- 1998
            |:|:..|    |:|..::.|..:||.. |.....||||::.:|..|..||.:|:...|
Mouse  1887 TSDLGNK----KKDDEVDRDAPSRKKA-KEPTTQITEEVRDQLLEASAATRKAFTTFRREADPDD 1946

  Fly  1999 NIHSGEESSAISVNSPLEDILAEKLEKHKDSRDQRNQLSNKVLVMQPILRFLQLLCENHNPDMQN 2063
            :..|||.:.|.:             :|.||..    ::|..:.:||||||||||||||||.|:||
Mouse  1947 HYQSGEGTQATT-------------DKAKDDL----EMSAVITIMQPILRFLQLLCENHNRDLQN 1994

  Fly  2064 LLRNQNNKTNNNLVSETLMFLDCICGSTTGGLGLLGLYINEHNVALINQTLEALTEYCQGPCHEN 2128
            .||.||||||.|||.|||.||||||||||||||||||||||.||||||||||:||||||||||||
Mouse  1995 FLRCQNNKTNYNLVCETLQFLDCICGSTTGGLGLLGLYINEKNVALINQTLESLTEYCQGPCHEN 2059

  Fly  2129 QNCIATHESNGLDIITALILNNINPLGENRMDLVLELKNNASKLLLAIMESRGDSENAERILYNM 2193
            |||||||||||:|||||||||:|||||:.|||||||||||||||||||||||.||||||||||||
Mouse  2060 QNCIATHESNGIDIITALILNDINPLGKKRMDLVLELKNNASKLLLAIMESRHDSENAERILYNM 2124

  Fly  2194 NPKQLVEVACKAYHQEELIDEQDDGDEPDAGSDDDDATVSPREVGHNIYILCHQLAQHNKELAGL 2258
            .||:||||..|||.|.|:  |.:||:      :.:|...|||.||||||||.||||:|||||..:
Mouse  2125 RPKELVEVIKKAYMQGEV--EFEDGE------NGEDGAASPRNVGHNIYILAHQLARHNKELQTM 2181

  Fly  2259 LKASEDPQSASFDAKTSQALMYYATHTAQIEIVRNDRTLEQIVFPIPEICEYLTTDTKIKILNTA 2323
            ||.......       .:||.:||.|||||||||.|||:||||||:|.|||:||.::|::|..|.
Mouse  2182 LKPGGQVDG-------DEALEFYAKHTAQIEIVRLDRTMEQIVFPVPSICEFLTKESKLRIYYTT 2239

  Fly  2324 ERDDQGSKVADFFDKAEEMFNEMKWQKKLRSQPLLFWISSYMSLWSNILFNCVVVINMIVAFFYP 2388
            |||:||||:.|||.::|::||||.||||||:||:|:|.:..||.||:|.||..|::|::||||||
Mouse  2240 ERDEQGSKINDFFLRSEDLFNEMNWQKKLRAQPVLYWCARNMSFWSSISFNLAVLMNLLVAFFYP 2304

  Fly  2389 FDNT-VPELSSHISLLFWIITIFSLVIVLALPRESGIRTFIGSVILRFIFLLGPESTLCLLGVVT 2452
            |... ...|..|.|.|.|...:.||.||:|||:..|||..|.|.|||.||.:|.:.||.|||...
Mouse  2305 FKGVRGGTLEPHWSGLLWTAMLISLAIVIALPKPHGIRALIASTILRLIFSVGLQPTLFLLGAFN 2369

  Fly  2453 VTLKSVHIVSIMGNKGTLEKQLIKIITDFQLLYHCIYIAFCFCGLIFHPFFYSLLLFDVVYREET 2517
            |..|.:.::|.:||.||..:....::.|.:.|||.:|:..|..||..|.|||||||||:||||||
Mouse  2370 VCNKIIFLMSFVGNCGTFTRGYRAMVLDVEFLYHLLYLLICAMGLFVHEFFYSLLLFDLVYREET 2434

  Fly  2518 LVNVIRSVTRNGRSIVLTAVLALILVYLFSIIGYMFFKDDFLVSVDFEEQDNAPPPSVPLTLSVP 2582
            |:|||:|||||||||:|||||||||||||||:||:||||||::.||          .:|...:||
Mouse  2435 LLNVIKSVTRNGRSIILTAVLALILVYLFSIVGYLFFKDDFILEVD----------RLPNETAVP 2489

  Fly  2583 VSGDS------------------CSAPDDLGNCQAAKEVAPPSAGGGEVKERSCDSLVMCIVTTL 2629
            .:|:|                  |::|       |.||...|:....:.||.:|::|:|||||.|
Mouse  2490 ETGESLANDFLYSDVCRVETGENCTSP-------APKEELLPAEETEQDKEHTCETLLMCIVTVL 2547

  Fly  2630 NQGLRNGGGIGDILRAPSSKEGLFVARVIYDLLFFFIVIIIVLNLIFGVIIDTFADLRSEKQQKE 2694
            :.|||:|||:||:||.||.:|.||.|||||||||||:|||||||||||||||||||||||||:||
Mouse  2548 SHGLRSGGGVGDVLRKPSKEEPLFAARVIYDLLFFFMVIIIVLNLIFGVIIDTFADLRSEKQKKE 2612

  Fly  2695 AILKTTCFICSLNRSAFDNKTVSFEEHIKSEHNMWHYLYFIVLVKVKDPTEFTGPESYVYAMVKA 2759
            .|||||||||.|.|..||||||:||||||.||||||||.|||||||||.||:|||||||..|::.
Mouse  2613 EILKTTCFICGLERDKFDNKTVTFEEHIKEEHNMWHYLCFIVLVKVKDSTEYTGPESYVAEMIRE 2677

  Fly  2760 GILEWFPRLRAMSLAAVDADGEQIELRSMQAQLLDTQLLIKNLSTQLHELKDHMTEQRKQKQRLG 2824
            ..|:||||:|||||.:.|::|||.|||::|.:|..|..|:.|||.||.||||.||||||||||:|
Mouse  2678 RNLDWFPRMRAMSLVSSDSEGEQNELRNLQEKLESTMKLVTNLSGQLSELKDQMTEQRKQKQRIG 2742

  Fly  2825 LL 2826
            ||
Mouse  2743 LL 2744

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Itpr	NP_730941.1	Ins145_P3_rec	7..231	CDD:285871	170/223 (76%)
		MIR	237..293	CDD:197746	45/55 (82%)
		MIR	238..452	CDD:280906	129/213 (61%)
		RYDR_ITPR	495..691	CDD:279676	132/195 (68%)
		RYDR_ITPR	1294..1413	CDD:279676	77/118 (65%)
		RIH_assoc	2042..2147	CDD:285630	93/104 (89%)
		Ion_trans	2433..2691	CDD:278921	149/275 (54%)
		Sec2p	<2782..2819	CDD:283965	22/36 (61%)
Itpr1	XP_006505686.1	Ins145_P3_rec	4..225	CDD:370078	170/226 (75%)
		MIR	232..433	CDD:367197	129/213 (61%)
		RYDR_ITPR	474..670	CDD:366595	137/202 (68%)
		RYDR_ITPR	1205..1321	CDD:366595	75/115 (65%)
		RIH_assoc	1973..2078	CDD:369886	93/104 (89%)
		Ion_trans	2322..2609	CDD:366146	163/303 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	483	1.000	Domainoid score	I401
eggNOG	1	0.900	-	-		E1_KOG3533
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1673
Inparanoid	1	1.050	2967	1.000	Inparanoid score	I17
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58623
OrthoDB	1	1.010	-	-		D58374at33208
OrthoFinder	1	1.000	-	-		FOG0001660
OrthoInspector	1	1.000	-	-		otm43612
orthoMCL	1	0.900	-	-		OOG6_102308
Panther	1	1.100	-	-	LDO	PTHR13715
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3112
SonicParanoid	1	1.000	-	-		X1057
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.870