DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Itpr and itpr3

DIOPT Version :9

Sequence 1:	NP_730941.1	Gene:	Itpr / 40664	FlyBaseID:	FBgn0010051	Length:	2837	Species:	Drosophila melanogaster
Sequence 2:	XP_017947060.1	Gene:	itpr3 / 100124749	XenbaseID:	XB-GENE-1012312	Length:	2673	Species:	Xenopus tropicalis

Alignment Length:	2905	Identity:	1502/2905 - (51%)
Similarity:	1941/2905 - (66%)	Gaps:	323/2905 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 ASFLHLGDIVSLYAEGSVCGFLSTLGLVDDRTVVCPEAGDLSCPPKKFRDCLIKICPMNRYSAQK 73
            :||||:||||||||||:||||:|||||||||.||.|.||||..|||||||||.::||||||||||
Frog     5 SSFLHIGDIVSLYAEGTVCGFISTLGLVDDRCVVEPAAGDLDNPPKKFRDCLFRVCPMNRYSAQK 69

  Fly    74 QFWKA--AKQSASSNTDPNLLKRLHHAAEIEKKQNETENKKLLGTSIQYGRAVVQLLHLKSNKYL 136
            |:|||  |||.....:|..||::|.|||.:|:|||||||||:.|..::|| :|:||||:||||||
Frog    70 QYWKAKQAKQDKEKISDVLLLQKLQHAANLEQKQNETENKKVHGEVVKYG-SVIQLLHMKSNKYL 133

  Fly   137 TVNKRLPSLLEKNAMRVYLDANGNEGSWFYIKPFYKLRSIGDYVVVGDKVILSPVNADQQNLHVA 201
            |||||||:|||||||||.||..|||||||:|:||:||||.||.|||||||.|:||||.|. || |
Frog   134 TVNKRLPALLEKNAMRVTLDVTGNEGSWFFIQPFWKLRSNGDNVVVGDKVNLNPVNAGQP-LH-A 196

  Fly   202 ANYELPDNPGCKEVNVLNSSTSWKISLFMEHKENQEHILKGGDVVRLFHAEQEKFLTMDEYKKQY 266
            :||||.|||||||||.|||:|||||:|||::::..|.:|||||||||||||||||||.||||.:.
Frog   197 SNYELTDNPGCKEVNSLNSNTSWKINLFMQYRDYMEDVLKGGDVVRLFHAEQEKFLTCDEYKSRL 261

  Fly   267 HVFLRTTGRTSATAATSSKALWEIEVVQHDSCRGGAGDWNSLYRFKHLATGHYLAAEAEIDVSAG 331
            |||||||.|.|||:||||.||||:|||.||.||||||.|||||||||||||||||||.
Frog   262 HVFLRTTLRQSATSATSSNALWEVEVVHHDPCRGGAGHWNSLYRFKHLATGHYLAAEE------- 319

  Fly   332 AMSATSASGHDLHLGDCSK-DSGLSCSTMNSTINDKPKGK------QYRLVSVPYSADIASVFVL 389
                     :..:.||..: .||.|    |:.::.:|..|      ::|||:||:..||||:|.|
Frog   320 ---------NPAYKGDAPEFKSGSS----NAVVSTRPSRKNAGEKIKFRLVAVPHGNDIASLFEL 371

  Fly   390 DATTMARPDSLVPQSSYVRLQHICSNTWVHATSIPIDADDDKPVMSMVCCSPIKEDKEAFALIPV 454
            |.||:.:.|||||::|:|||:|:|:|||:.:|::|||.|:::|:..|:...|.||||||||::.|
Frog   372 DPTTLQKTDSLVPRNSFVRLRHLCTNTWIQSTNVPIDVDEERPIRLMLGTCPTKEDKEAFAIVSV 436

  Fly   455 SPVEVRDLDFANDACKVLATVTSKLDNGSISINERRALISLLQDIVYFIAGMENEQNKTKALEFT 519
            ...|:|||||||||..:||....:|:.|.||.|:||..|.||:|:|:|:..:.|  |....|:..
Frog   437 PVSEIRDLDFANDASSMLANFVERLNEGFISQNDRRFAIKLLEDLVFFVVDVSN--NGQNVLDIM 499

  Fly   520 IKNPIRDRQKLLREQYILKQLFKILQGPFQQHTAGDGPFLRLDELSDPKNSPYKNIFRLCYRILR 584
            |..|.|:||||:|||.||||:|.||:.||:: ...|||.|||:||||.|||||:.:||||||:||
Frog   500 ITKPNRERQKLMREQNILKQIFGILKAPFKE-KGTDGPLLRLEELSDQKNSPYQYMFRLCYRVLR 563

  Fly   585 LSQQDYRKNQEYIAKHFGLMQKQIGYDILAEDTITALLHNNRKLLEKHITAAEIETFVGLVRKNM 649
            .||:|||||||:|||.||:||.||||||||||||||||||||||||||||..|:||||.|||||.
Frog   564 HSQEDYRKNQEHIAKQFGVMQSQIGYDILAEDTITALLHNNRKLLEKHITKTEVETFVNLVRKNR 628

  Fly   650 HNWDSRFLDYLSDLCVSNRKAIAVTQELICKSVLSDKNKDILIETQVKALRTGSGPVRCYKGNSE 714
               :.|||||||||||||..||.||||||||.||..||.||||:|:::.|:..|......:...|
Frog   629 ---EPRFLDYLSDLCVSNHIAIPVTQELICKCVLDPKNSDILIKTELRPLKEMSPEYMSLEYCDE 690

  Fly   715 DVCLATLAEDAGDDEDRSDVQSTSTTTTWDSASLNEDDGTPSTGDKYEIHLKWTGQPTSRSMADL 779
            :|.|                       ||          |....|.:|..::...|....
Frog   691 EVWL-----------------------TW----------TDKNNDSHEKSIRQLSQEARA----- 717

  Fly   780 ASCDGGELEAAILNYYRHQLNLFSNMCLNRQYLALNELSPRLDIDLILKCMSDETMPYELRASFC 844
                |...:..:|.|||:||.||:.|||:|||||::|:|.:|.:|||..||:||.:|||:|||||
Frog   718 ----GNAHDENVLTYYRYQLKLFARMCLDRQYLAIHEISKQLSVDLIFLCMADEMLPYEIRASFC 778

  Fly   845 RLMLHLHVDRDPQEPVTPVKYARLWSEIPSKMSIQDYDGKNQQPDQNKQACRAKFNTTIAFVENY 909
            .||||:||||||||.|||||:||||:|||..::|:|||........||   :.||.:|:.|||:|
Frog   779 HLMLHVHVDRDPQELVTPVKFARLWTEIPMAITIKDYDSNLNDSRDNK---KNKFTSTMEFVEDY 840

  Fly   910 LCNVATKVWLFTDQEQNKLTFEVVKLARDLIYFGFYSFSDLLRLTKTLLSILDCVSDTSSGEFAS 974
            |.||.::...|:.:::||||||||.|||.||||||||||:|||||:|||.|:|||.:..     |
Frog   841 LNNVVSESMPFSHEDKNKLTFEVVSLARHLIYFGFYSFSELLRLTRTLLGIIDCVQNPQ-----S 900

  Fly   975 TDIDSVEEETNAEAEG-GVLRSIGDINTVMTSLALG------SVGQAIAAPTISLQ---QRKSVS 1029
            ..:.::..|   :..| .|.|||..:..:::::.|.      |..|:::: .::.:   :||:|.
Frog   901 ILLQAIYSE---DGTGKNVRRSIHGVGQMVSTMVLNRKQTGYSSSQSLSS-VVNHETPIKRKNVD 961

  Fly  1030 QLMKEYPLVMDTKLKIIEILQFILDVRLDYRISCLLSIFKREFDESEVAASAASNEASQQQSQQQ 1094
            .   |..:||:|||||:|||||||:||||||||.|||:||:||
Frog   962 M---ENIIVMETKLKILEILQFILNVRLDYRISYLLSVFKKEF---------------------- 1001

  Fly  1095 EPQTPGSSNETDPLDSAESVAAGAAAAAATTARQKNIDLESIGVQAEGIFDCERSDAANLDLDGQ 1159
                    .|..|:.  ::.|.|.|.|..:|  ..:::|:.||..||.:|...:| .:.|::|.:
Frog  1002 --------VEVFPMQ--DNAADGTAPAFDST--NASLNLDRIGELAEAMFGVGKS-TSMLEVDDE 1053

  Fly  1160 GGRTFLRVLLHLIMHDYAPLVSGALHLLFRHFSQRQEVLQAFRQVQLLVSDSDVESYKQIKSDLD 1224
            |||.|||||:.|.|:||..|:||:|.|||:|||||||||..|:|||||:|..||::||.|||:||
Frog  1054 GGRMFLRVLIQLTMNDYPSLISGSLQLLFKHFSQRQEVLHTFKQVQLLISTQDVDNYKVIKSELD 1118

  Fly  1225 ILRQSVEKSELWVYKAKATDELGATDAG----GDAVSLEYNAA--LSQEQRNEYRKVKEILIRMN 1283
            .||..||||||||.|...|..:|:||..    .:.|..:.|:.  :.::....|:.||.||..:|
Frog  1119 RLRTMVEKSELWVDKKGNTGIIGSTDGNKKDKKEHVENQDNSGKPVMEKSSENYQIVKGILETLN 1183

  Fly  1284 KFCVTASGPGSVVKPRKHEQRLLRNVGVHTVVLDLLQNPYDEKDDELMKELMCLAHEFLQNFCLG 1348
            |.|   :||..|   ||.:||||:|:..|.|:|||||.|| ||:|..|||::...|:|||.||..
Frog  1184 KMC---NGPEQV---RKKQQRLLKNMDAHKVMLDLLQVPY-EKEDTKMKEILKYTHQFLQKFCAT 1241

  Fly  1349 NQQNQVLLHNHLDLFLNPGILEAKTVCAIFKDNLALCNEVTDKVVQHFVHCIEIHGRHVAYLQFL 1413
            |.:||.|||.||.|||.||:.||:|:..||.:|..||:|:.:.|:|||:||:..|||||.||.||
Frog  1242 NPENQALLHKHLSLFLTPGLQEAETMQHIFLNNYQLCSEIHEAVLQHFIHCLATHGRHVQYLDFL 1306

  Fly  1414 QTVVRAENQFIRRCQDMVMQELINSGEDVLVFYNDKGSFNHFVQMMQQQMLRMEKLSDDSPLKYH 1478
            .|:::||.::|::||||:|.||.|:|:||:||||||.||...::||   ....|.:.::||||||
Frog  1307 HTIIKAEGKYIKKCQDMIMTELTNAGDDVVVFYNDKASFASMLEMM---ATAREAIEENSPLKYH 1368

  Fly  1479 VELVKLLACCTMGKNVYTEIKCNNLLSLDDIVTIICHPLCMPEVKEAYVDFLNHCYIDTEVEMKE 1543
            :.||.|||.|..||||||||||.:||.|:|:|.::.|..|:.|||.:||:|:||||:||||||||
Frog  1369 ISLVDLLAACAEGKNVYTEIKCTSLLPLEDVVRVVTHEDCITEVKISYVNFVNHCYVDTEVEMKE 1433

  Fly  1544 IYASGHMWSLFEKSFLVDINQLITNPAAASNK--------TLQAYVLNGVTNLLGSFFASPFSDQ 1600
            ||.|.|:|:||| :|::|:       |...||        ||:.|||..|...:.|||.||||:.
Frog  1434 IYTSNHIWTLFE-NFILDM-------ARVCNKREKRIVDSTLEKYVLTVVLETIRSFFNSPFSEN 1490

  Fly  1601 SAIVQSRQLIFVQLLQAAHRITQCRWLSLGDRFNVENCIRTLTESAKMRSIALPPELEQQVATM- 1664
            |..:|:.|.|.|||||:..|:.:|.||....:.:||.|||.|...||.|||:||.:|:..|:::
Frog  1491 STSLQTHQTIVVQLLQSTTRLLECPWLLQQYKVSVEACIRALAMLAKSRSISLPMDLDTHVSSLL 1555

  Fly  1665 -SSKTAMLTRQTTKWLLASKQPKYEAQQAASLMRWD-RSIIEGLQDIVSLLEDQLKPVVEAELSL 1727
             ||.:|:...|:|   ..:...:..|:.:|:..:|| ::|:|.||||:::||::|||:||||||:
Frog  1556 NSSSSALQRNQST---YKTTSTRSFARGSATQNQWDYKNIVEKLQDIINILEERLKPLVEAELSV 1617

  Fly  1728 LVDILYRSELLFPAGTEARKRCESGGFIRKLIKHTEKLLEEKEERMCVKVLRTLREMMAIDVNYG 1792
            |||:|...||||..||:||.||||||||.|||:||:.|: ..||::|:||||||::|:....|||
Frog  1618 LVDVLQHPELLFAEGTDARLRCESGGFISKLIQHTKNLM-SSEEKLCIKVLRTLQQMLMKKRNYG 1681

  Fly  1793 EKGDALRQTLLLRYFQTKSTPRLPEDEVPLLAAPLMDPAKQNHLVTHGPGAKYLQRAGKTLHEMQ 1857
            |:|:.||:|||..|...|......|.......|...|.|                    .:..:|
Frog  1682 EQGNMLRRTLLNIYLHNKKLNPKGETSDSFAIAQDQDWA--------------------MIASIQ 1726

  Fly  1858 NHLDREGASDLVVELVIKSVHSPNIFVEAVELGIALLEGGNPIIQKGMFQKFLSDDLNQAFFKVF 1922
            ..||||||:.||.:|::.| .:..||.|::.|.|.||:|||..||...:.....|:.::.||||.
Frog  1727 CKLDREGATKLVSDLIMSS-KNEKIFQESILLAIRLLDGGNTEIQNSFYNLMKGDNKSEKFFKVL 1790

  Fly  1923 FEKMKDAQQEIKSTVTVNTTDIAAKAHEHKQDTNLELDKIARKHGLKSNGVVITEELKRELHNAG 1987
            .|:||.||||||||::||..|:.  ||| ..|.|.|.....|     :|..||         :|.
Frog  1791 NERMKCAQQEIKSTMSVNMNDLG--AHE-PDDENAEYPPKGR-----NNQYVI---------HAS 1838

  Fly  1988 LATARAYGNARNIHSGEESSAISVNSPLEDILAEKLEKHKDSRDQRNQLSNKVLVMQPILRFLQL 2052
            .:.|...|:.|..|...::.                        :.|::...||:|:||||||||
Frog  1839 TSRAITGGSFRKGHDVADNG------------------------ESNEVGPAVLIMEPILRFLQL 1879

  Fly  2053 LCENHNPDMQNLLRNQNNKTNNNLVSETLMFLDCICGSTTGGLGLLGLYINEHNVALINQTLEAL 2117
            ||||||.|:||.||||.||||.|||.|||.|||.:|||||||||||||||||.|||||.||||.|
Frog  1880 LCENHNSDLQNFLRNQTNKTNYNLVCETLQFLDIMCGSTTGGLGLLGLYINEKNVALIIQTLETL 1944

  Fly  2118 TEYCQGPCHENQNCIATHESNGLDIITALILNNINPLGENRMDLVLELKNNASKLLLAIMESRGD 2182
            ||||||||||||:||.||||||:||||||:||:|:||.:.||||||:||:||||||||:||||.|
Frog  1945 TEYCQGPCHENQSCIVTHESNGIDIITALVLNDISPLCKYRMDLVLQLKDNASKLLLALMESRHD 2009

  Fly  2183 SENAERILYNMNPKQLVEVACKAYHQEELIDEQDDGDEPDAGSDDDDATVSPREVGHNIYILCHQ 2247
            ||||||||.::.|::||.|..|||.|||      :||..|         |||:|||||||||..|
Frog  2010 SENAERILISLRPQELVSVIKKAYMQEE------EGDSSD---------VSPQEVGHNIYILALQ 2059

  Fly  2248 LAQHNKELAGLLK----ASEDPQS--------------------ASFDAKTSQALMYYATHTAQI 2288
            |::|||.|..|||    ..|:.:|                    |....:....|.|||.|||||
Frog  2060 LSRHNKHLQHLLKPVKRIQEEEESISTMLSLNNKQLTQMLKSTTAPVQEEEEDPLAYYAKHTAQI 2124

  Fly  2289 EIVRNDRTLEQIVFPIPEICEYLTTDTKIKILNTAERDDQGSKVADFFDKAEEMFNEMKWQKKLR 2353
            ||||.||::|||||.:|.||::||.:||.::..|.|:|||||||:||||::..:.|||:||:|||
Frog  2125 EIVRMDRSMEQIVFSVPSICKFLTEETKHRVFTTTEQDDQGSKVSDFFDQSSFLHNEMEWQRKLR 2189

  Fly  2354 SQPLLFWISSYMSLWSNILFNCVVVINMIVAFFYPF--DNTVPELSSH-ISLLFWIITIFSLVIV 2415
            |.||::|.|..|:||..|.||..|.||:|:|||||:  ..::..|.|. ||||||.:..||::.:
Frog  2190 SMPLIYWFSRRMTLWGTISFNLAVFINLIIAFFYPYVEGTSIGILDSPLISLLFWGMVCFSVMSL 2254

  Fly  2416 LALPRESGIRTFIGSVILRFIFLLGPESTLCLLGVVTVTLKSVHIVSIMGNKGTLEKQLIKIITD 2480
            ..  :..|.|..|.::|||.::.||...||.:||.:.:|.|.|.:||.:||:||..:....::.|
Frog  2255 FT--KRYGFRPLIVALILRSVYYLGIGPTLYILGALNLTNKIVFVVSFVGNRGTFIRGYKAMVMD 2317

  Fly  2481 FQLLYHCIYIAFCFCGLIFHPFFYSLLLFDVVYREETLVNVIRSVTRNGRSIVLTAVLALILVYL 2545
            .:.|||..||.....||..|..|||:||||::||||||.|||:|||||||||:|||:||||||||
Frog  2318 VEFLYHVAYILTSVLGLFIHELFYSILLFDLIYREETLFNVIKSVTRNGRSILLTALLALILVYL 2382

  Fly  2546 FSIIGYMFFKDDFLVSVDFEEQDNAPPPSVPLTLSVPVSGDSCSAPDDLGN-CQAAKEVAPPSAG 2609
            |||:|::|.||||::.|     |..|..:.|:            ||::... |:  |:....:.|
Frog  2383 FSIVGFLFLKDDFIMEV-----DRLPKATSPM------------APNNFAEFCE--KDQTDCTVG 2428

  Fly  2610 ----------GGEVKERSCDSLVMCIVTTLNQGLRNGGGIGDILRAPSSKEGLFVARVIYDLLFF 2664
                      .|:| ||:||:|:|||:|.||.|||||||:|||||.||..|.||.||::||||||
Frog  2429 VTTLDEIEDEEGDV-ERACDTLLMCIITVLNHGLRNGGGVGDILRKPSKDETLFPARIVYDLLFF 2492

  Fly  2665 FIVIIIVLNLIFGVIIDTFADLRSEKQQKEAILKTTCFICSLNRSAFDNKTVSFEEHIKSEHNMW 2729
            |||||||||||||||||||||||||||:||.:||||||||.|.|..|||||||||||||.|||:|
Frog  2493 FIVIIIVLNLIFGVIIDTFADLRSEKQKKEEVLKTTCFICGLERDKFDNKTVSFEEHIKEEHNIW 2557

  Fly  2730 HYLYFIVLVKVKDPTEFTGPESYVYAMVKAGILEWFPRLRAMSLAAVDADGEQIELRSMQAQLLD 2794
            :||||||||:||:.|::|||||||..|:|...|:||||:|||||.:.:.:|||.|:|.:|.:|..
Frog  2558 NYLYFIVLVRVKNKTDYTGPESYVAQMIKNKNLDWFPRMRAMSLVSNEGEGEQNEIRILQDKLGS 2622

  Fly  2795 TQLLIKNLSTQLHELKDHMTEQRKQKQRLGLL-------NTTANS 2832
            |..|:.:|:.||.|||:.||||||::||:|.:       |||.||
Frog  2623 TMRLVSHLTMQLSELKEQMTEQRKRRQRMGFVDVQNNVGNTTTNS 2667

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Itpr	NP_730941.1	Ins145_P3_rec	7..231	CDD:285871	164/223 (74%)
		MIR	237..293	CDD:197746	44/55 (80%)
		MIR	238..452	CDD:280906	124/220 (56%)
		RYDR_ITPR	495..691	CDD:279676	132/195 (68%)
		RYDR_ITPR	1294..1413	CDD:279676	64/118 (54%)
		RIH_assoc	2042..2147	CDD:285630	87/104 (84%)
		Ion_trans	2433..2691	CDD:278921	143/268 (53%)
		Sec2p	<2782..2819	CDD:283965	18/36 (50%)
itpr3	XP_017947060.1	Ins145_P3_rec	3..226	CDD:370078	164/223 (74%)
		MIR	233..434	CDD:367197	124/220 (56%)
		RYDR_ITPR	475..672	CDD:366595	137/202 (68%)
		RYDR_ITPR	1164..1306	CDD:366595	74/148 (50%)
		RIH_assoc	1869..1974	CDD:369886	87/104 (84%)
		PAP2_like	2193..2288	CDD:382032	40/96 (42%)
		Ion_trans	2264..2519	CDD:366146	145/274 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	471	1.000	Domainoid score	I442
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	2959	1.000	Inparanoid score	I18
OMA	1	1.010	-	-		QHG58623
OrthoDB	1	1.010	-	-		D58374at33208
OrthoFinder	1	1.000	-	-		FOG0001660
OrthoInspector	1	1.000	-	-		otm48773
Panther	1	1.100	-	-	O	PTHR13715
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1057
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.080