DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Itpr and itpr2

DIOPT Version :9

Sequence 1:NP_730941.1 Gene:Itpr / 40664 FlyBaseID:FBgn0010051 Length:2837 Species:Drosophila melanogaster
Sequence 2:XP_031754312.1 Gene:itpr2 / 100124748 XenbaseID:XB-GENE-877157 Length:2705 Species:Xenopus tropicalis


Alignment Length:2902 Identity:1553/2902 - (53%)
Similarity:1976/2902 - (68%) Gaps:296/2902 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 ASFLHLGDIVSLYAEGSVCGFLSTLGLVDDRTVVCPEAGDLSCPPKKFRDCLIKICPMNRYSAQK 73
            :|||::||||||||||||.||:|||||||||.||.|:||||:.|||||||||.|:||||||||||
 Frog     6 SSFLYIGDIVSLYAEGSVNGFISTLGLVDDRCVVHPDAGDLANPPKKFRDCLFKVCPMNRYSAQK 70

  Fly    74 QFWKAAKQSASSNTDPNLLKRLHHAAEIEKKQNETENKKLLGTSIQYGRAVVQLLHLKSNKYLTV 138
            |||||.:....:||:..|||:|.||||:|:||||:||:||||..::|.. |:||||:||||||||
 Frog    71 QFWKAKQAKQGNNTEAALLKKLQHAAELEQKQNESENRKLLGEIVKYSN-VIQLLHIKSNKYLTV 134

  Fly   139 NKRLPSLLEKNAMRVYLDANGNEGSWFYIKPFYKLRSIGDYVVVGDKVILSPVNADQQNLHVAAN 203
            |||||:|||||||||.||..|||||||||:||:||||.||.|||||||:|.||||.|. || |:|
 Frog   135 NKRLPALLEKNAMRVSLDCAGNEGSWFYIQPFWKLRSEGDNVVVGDKVVLMPVNAGQP-LH-ASN 197

  Fly   204 YELPDNPGCKEVNVLNSSTSWKISLFMEHKENQEHILKGGDVVRLFHAEQEKFLTMDEYKKQYHV 268
            .||.|||||||||.:|.:||||::|||:..:.::.:|||||||||||||||||||.|||:|:.|:
 Frog   198 IELLDNPGCKEVNAVNCNTSWKVNLFMKFSDYRDDVLKGGDVVRLFHAEQEKFLTCDEYEKKQHI 262

  Fly   269 FLRTTGRTSATAATSSKALWEIEVVQHDSCRGGAGDWNSLYRFKHLATGHYLAAEAEIDV-SAGA 332
            |||||.|.|||:|||||||||:|||.||.||||||.||||:||||||||:|||||...|. ..|.
 Frog   263 FLRTTLRQSATSATSSKALWEVEVVHHDPCRGGAGQWNSLFRFKHLATGNYLAAEINPDYRDVGD 327

  Fly   333 MSATSASGHDLHLGDCSKDSGLSCSTMNSTINDKPKGK-----QYRLVSVPYSADIASVFVLDAT 392
            ..||......:|                     |.|.:     .|.|||||:..||||:|.||||
 Frog   328 PRATREGELPVH---------------------KRKWQAGEKIMYTLVSVPHGNDIASLFELDAT 371

  Fly   393 TMARPDSLVPQSSYVRLQHICSNTWVHATSIPIDADDDKPVMSMVCCSPIKEDKEAFALIPVSPV 457
            |:.|.|.|||::|||||:|:|:||||.:||||||.::::|||..:.....||||||||:|.|...
 Frog   372 TLQRADCLVPRNSYVRLRHLCTNTWVTSTSIPIDTEEERPVMLKIGTCQTKEDKEAFAIISVPLS 436

  Fly   458 EVRDLDFANDACKVLATVTSKLDNGSISINERRALISLLQDIVYFIAGMENEQNKTKALEFTIKN 522
            |||||||||||.||||:...||:.|:|:.||||.:..||:|:::|:||:.|  |..:.|:..:..
 Frog   437 EVRDLDFANDANKVLASTVKKLEYGTITQNERRFVTKLLEDLIFFVAGVAN--NGQEVLDVVVTK 499

  Fly   523 PIRDRQKLLREQYILKQLFKILQGPFQQHTAGDGPFLRLDELSDPKNSPYKNIFRLCYRILRLSQ 587
            |.|:||||:|||.||.|:|.||:.||:. .||:|..|||::|.|.:.:|||.|.|||||:||.||
 Frog   500 PNRERQKLMREQNILAQIFGILKAPFKD-KAGEGSMLRLEDLGDQRYAPYKYILRLCYRVLRHSQ 563

  Fly   588 QDYRKNQEYIAKHFGLMQKQIGYDILAEDTITALLHNNRKLLEKHITAAEIETFVGLVRKNMHNW 652
            ||||||||||||||.:||.|||||||||||||||||||||||||||||.||||||.|:|:|.   
 Frog   564 QDYRKNQEYIAKHFCVMQSQIGYDILAEDTITALLHNNRKLLEKHITAKEIETFVNLLRRNR--- 625

  Fly   653 DSRFLDYLSDLCVSNRKAIAVTQELICKSVLSDKNKDILIETQVKALRTGSGPVRCYKGNSEDVC 717
            :.|||||||||||||..||.||||||||.:||..|.||||:|::.:::. ..|:.|         
 Frog   626 EPRFLDYLSDLCVSNTTAIPVTQELICKFMLSPGNADILIQTKLVSMQM-DNPLEC--------- 680

  Fly   718 LATLAEDAGDDEDRSDVQSTSTTTTWDSASLNEDDGTPSTGDKYEIHLKW---TGQPTSRSMADL 779
                                         |:.:||     .|:.|:.|.|   ..:|..:::..|
 Frog   681 -----------------------------SVLQDD-----MDEEEVWLYWIDSNKEPHGKAIRHL 711

  Fly   780 A--SCDGGELEAAILNYYRHQLNLFSNMCLNRQYLALNELSPRLDIDLILKCMSDETMPYELRAS 842
            |  :.:|.:.:..:|.|||:|||||:.|||:|||||:|::|.:|.:||||:|||||::|::||||
 Frog   712 AQEAKEGTKADLEVLTYYRYQLNLFARMCLDRQYLAINQISTQLSVDLILRCMSDESLPFDLRAS 776

  Fly   843 FCRLMLHLHVDRDPQEPVTPVKYARLWSEIPSKMSIQDYDGKNQQPDQNKQACRAKFNTTIAFVE 907
            |||||||:||||||||.|.||||||||:|||:|:||.|||...   |.::...:.||..|:.|||
 Frog   777 FCRLMLHIHVDRDPQETVVPVKYARLWTEIPTKISIHDYDSFT---DSSRDEMKRKFALTMEFVE 838

  Fly   908 NYLCNVATKVWLFTDQEQNKLTFEVVKLARDLIYFGFYSFSDLLRLTKTLLSILDCVSDTSSGEF 972
            .||..|..:.:.|.|:|:||||||||.|||:|||||||||::|||||:|||:|||.|....|   
 Frog   839 EYLKEVVNQPFPFGDKEKNKLTFEVVHLARNLIYFGFYSFTELLRLTRTLLAILDIVQSPMS--- 900

  Fly   973 ASTDIDSVEEETNAEAEGG--VLRSIGDINTVMTSLAL--GSVGQAIAAPTI--SLQQRKSVSQL 1031
                  |..|..:...:||  |:|:|..:..:||.:.|  ||: ..||.|.:  .|...|....:
 Frog   901 ------SYLERLSRFQDGGNNVMRTIHGVGEMMTQMVLSRGSI-LPIAIPDVPAGLHSSKQGGAI 958

  Fly  1032 MKEYPLVMDTKLKIIEILQFILDVRLDYRISCLLSIFKREFDESEVAASAASNEASQQQSQQQEP 1096
            ..|...||||||||||||||||.||||||||.:|||:||||.:.                     
 Frog   959 DNEDITVMDTKLKIIEILQFILSVRLDYRISYMLSIYKREFGDQ--------------------- 1002

  Fly  1097 QTPGSSNETDPLDSAESVAAGAAAAAATTARQKNIDLESIGVQAEGIFDCERSDAANLDLDGQGG 1161
               |:|.|...:...|.:.....|.          |::.|..|||.:| ....:...::||.:||
 Frog  1003 ---GNSIENSTVSPPELLPPSVGAP----------DIDEIAAQAETMF-AGSKEKNPVELDDEGG 1053

  Fly  1162 RTFLRVLLHLIMHDYAPLVSGALHLLFRHFSQRQEVLQAFRQVQLLVSDSDVESYKQIKSDLDIL 1226
            |||||||:|||||||.||:||||.|||:|||||.||||||:|||||||:.||::|||||:|||.|
 Frog  1054 RTFLRVLIHLIMHDYPPLLSGALQLLFKHFSQRAEVLQAFKQVQLLVSNQDVDNYKQIKADLDQL 1118

  Fly  1227 RQSVEKSELWVYKAKA--TDELGATDAGGDAVSLEYNAALSQE-------------------QRN 1270
            |.:||||||||.|:.:  ::||      ||..:.|....:::|                   :.|
 Frog  1119 RLTVEKSELWVEKSNSYESEEL------GDGQTKERKEQMNEEASILSPLQDGIKKPQIDSNKAN 1177

  Fly  1271 EYRKVKEILIRMNKFCVTASGPGSVVKPRKHEQRLLRNVGVHTVVLDLLQNPYDEKDDELMKELM 1335
            .|:.|:|||||:::.|..:.      |.|..:||||:|:|.|:|||||||.|| ||.|:.|.::|
 Frog  1178 NYKIVREILIRLSRLCTQSK------KGRNQQQRLLKNMGAHSVVLDLLQIPY-EKTDDKMNDIM 1235

  Fly  1336 CLAHEFLQNFCLGNQQNQVLLHNHLDLFLNPGILEAKTVCAIFKDNLALCNEVTDKVVQHFVHCI 1400
            .|||.||||||.||.|||:|||..|:|||.||:|||:|:..||.:|..||||::|:||||||||:
 Frog  1236 TLAHTFLQNFCRGNPQNQILLHKKLNLFLTPGLLEAETMRNIFMNNYHLCNEISDRVVQHFVHCV 1300

  Fly  1401 EIHGRHVAYLQFLQTVVRAENQFIRRCQDMVMQELINSGEDVLVFYNDKGSFNHFVQMMQQQMLR 1465
            |.|||||.||:||||:|:|:.:::::|||:||.||:|.|||||:||||:.||...:|||..:   
 Frog  1301 ETHGRHVEYLRFLQTIVKADGKYVKKCQDVVMTELVNGGEDVLIFYNDRASFPVLLQMMSSE--- 1362

  Fly  1466 MEKLSDDSPLKYHVELVKLLACCTMGKNVYTEIKCNNLLSLDDIVTIICHPLCMPEVKEAYVDFL 1530
            .::..:..||.||:.||:|||.||.|||||||||||:||.|||||.::.|..|:||||.|||:|:
 Frog  1363 RDRADESGPLAYHITLVELLAACTEGKNVYTEIKCNSLLPLDDIVRVVTHEDCIPEVKIAYVNFV 1427

  Fly  1531 NHCYIDTEVEMKEIYASGHMWSLFEKSFLVDINQL--ITNPAAASNKTLQAYVLNGVTNLLGSFF 1593
            ||||:||||||||||.|.|:|.||| :||||:.::  .|.....::..|:.||...|.|::..||
 Frog  1428 NHCYVDTEVEMKEIYTSNHIWKLFE-NFLVDMARVCNTTTDRKHADTALEKYVTESVMNIVSGFF 1491

  Fly  1594 ASPFSDQSAIVQSRQLIFVQLLQAAHRITQCRWLSLGDRFNVENCIRTLTESAKMRSIALPPELE 1658
            .|||||.|..:|:.|.:|:||||:|.||..|.|.:...:.:||:||:||.|.||.|.:|:|.:|:
 Frog  1492 NSPFSDNSTNLQTHQPVFIQLLQSAFRIYNCTWPNQTQKASVESCIKTLAEVAKNRGMAIPVDLD 1556

  Fly  1659 QQVATMSSK--TAMLTRQTTKWLLASKQ-PKY-EAQQAASLMRWD-RSIIEGLQDIVSLLEDQLK 1718
            .||.|:..|  :.|:.|....|.:.::. ||| ||..:.||   | ::|||.|||:|:.||:|..
 Frog  1557 SQVNTLFLKAHSNMVQRAAMGWRITARNGPKYKEALGSPSL---DYKTIIEKLQDVVASLENQFS 1618

  Fly  1719 PVVEAELSLLVDILYRSELLFPAGTEARKRCESGGFIRKLIKHTEKLLEEKEERMCVKVLRTLRE 1783
            |::.||.|:|||:|:..|.|||.|::||.||  |.|:.|||.||:||: ||||::|:|:|:||||
 Frog  1619 PMLLAEFSVLVDVLHSPERLFPDGSDARIRC--GAFMSKLINHTKKLM-EKEEKLCMKILQTLRE 1680

  Fly  1784 MMAIDVNYGEKGDALRQTLLLRYFQTKSTPRLPEDEVPLLAAPLMDPAKQNHLVTHG---PGAKY 1845
            |:....::||:|..||:.||.|||:        .:....|..||.        |.:|   |...:
 Frog  1681 MLDKKESFGEQGSTLRKILLNRYFK--------GEHGSSLNGPLS--------VAYGKSVPAGAF 1729

  Fly  1846 ----LQRAGKTLHEMQNHLDREGASDLVVELVIKSVHSPNIFVEAVELGIALLEGGNPIIQKGMF 1906
                ..::|.::.|:|..||:||||:||::::: |..:..||.|.:.||||||||||..||...:
 Frog  1730 SGQDSDKSGVSISEIQCLLDKEGASELVIDVIV-STKNDRIFSEGILLGIALLEGGNTQIQNSFY 1793

  Fly  1907 QKFLSDDLNQAFFKVFFEKMKDAQQEIKSTVTVNTTDIAAKAHEHKQDTNLELDKIARKHGLKSN 1971
            ::......::.||||.:::||.|||||::||:|||.|:..|..|...| :|.|.    |..::.:
 Frog  1794 KQLDMQKKSEKFFKVLYDRMKTAQQEIRATVSVNTVDLGTKKKEEDYD-SLSLP----KRRVRDS 1853

  Fly  1972 GVVITEELKRELHNAGLATARAY--------------GNARNIHSGEESSAISVNSPLEDILAEK 2022
            ...:.|.:|.:|..|..||::||              |:..:..:|||.||              
 Frog  1854 QYHLKEGMKGQLAEASSATSKAYCVYRKEIDPDIDMVGSGVDNGTGEEKSA-------------- 1904

  Fly  2023 LEKHKDSRDQRNQLSNKVLVMQPILRFLQLLCENHNPDMQNLLRNQNNKTNNNLVSETLMFLDCI 2087
                    ::...:|..:.:|:||||||||||||||.::||.|||||||||.|||.|||.|||||
 Frog  1905 --------EESAAMSPVIAIMEPILRFLQLLCENHNRELQNFLRNQNNKTNYNLVCETLQFLDCI 1961

  Fly  2088 CGSTTGGLGLLGLYINEHNVALINQTLEALTEYCQGPCHENQNCIATHESNGLDIITALILNNIN 2152
            |||||||||||||||||.||||:|||||:|||||||||||||.|||||||||:|||.|||||:||
 Frog  1962 CGSTTGGLGLLGLYINERNVALVNQTLESLTEYCQGPCHENQTCIATHESNGIDIIIALILNDIN 2026

  Fly  2153 PLGENRMDLVLELKNNASKLLLAIMESRGDSENAERILYNMNPKQLVEVACKAYHQEELIDEQDD 2217
            |||:.||||||:||||||||||||||||.||||||||||||.|.:||:|...|::|..      :
 Frog  2027 PLGKYRMDLVLQLKNNASKLLLAIMESRHDSENAERILYNMRPAELVDVIKTAFNQGL------E 2085

  Fly  2218 GDEPDAGSDDDDATVSPREVGHNIYILCHQLAQHNKELAGLLKASEDPQSASFDAKTSQALMYYA 2282
            ||..:.|.:|.   |||:.||||||||.||||:|||.|..:||...||:..      .:||.|||
 Frog  2086 GDNEEHGPEDQ---VSPKAVGHNIYILAHQLARHNKALQHMLKPGLDPEEG------DEALKYYA 2141

  Fly  2283 THTAQIEIVRNDRTLEQIVFPIPEICEYLTTDTKIKILNTAERDDQGSKVADFFDKAEEMFNEMK 2347
            .|||||||||:|||:||||||:|.|||:||.::..::.|:.|||:|||||..||.:.|:::||||
 Frog  2142 NHTAQIEIVRHDRTMEQIVFPVPNICEFLTKESMWRVFNSTERDEQGSKVNHFFQQTEDLYNEMK 2206

  Fly  2348 WQKKLRSQPLLFWISSYMSLWSNILFNCVVVINMIVAFFYPFDNTVPE---------LSSHISLL 2403
            ||||:|:.|.|||.|.::|||.:|.||..|.||:.||.||||.:...|         ||...|:|
 Frog  2207 WQKKIRNNPALFWFSRHISLWGSISFNLAVFINLAVALFYPFGDDGDEGKLIVMRGTLSPLFSVL 2271

  Fly  2404 FWIITIFSLVIVLALPRESGIRTFIGSVILRFIFLLGPESTLCLLGVVTVTLKSVHIVSIMGNKG 2468
            .||.......::..||:..|||.|:.||:||.|:.:|...||.|||...:..|.|.:||.:||:|
 Frog  2272 LWIAVAVCTAMLFLLPKPFGIRPFLVSVMLRSIYTIGLGPTLILLGAGNLWNKVVFLVSFVGNRG 2336

  Fly  2469 TLEKQLIKIITDFQLLYHCIYIAFCFCGLIFHPFFYSLLLFDVVYREETLVNVIRSVTRNGRSIV 2533
            |..:....:|.|...|||.:|:..|..||..|.||||.||||:|||||||:|||:|||||||||:
 Frog  2337 TFTRGYRAVIMDMAFLYHVLYVIVCMLGLFVHEFFYSFLLFDLVYREETLLNVIKSVTRNGRSII 2401

  Fly  2534 LTAVLALILVYLFSIIGYMFFKDDFLVSVDFEEQDNAPPP-------SVPLTLSVPVSGDSCSAP 2591
            |||||||||||||||||::|.||||::.||  ...|..|.       :.|||..:    |:|...
 Frog  2402 LTAVLALILVYLFSIIGFLFLKDDFIMEVD--RLKNRTPDLGHGEIRTSPLTTMM----DTCHTE 2460

  Fly  2592 DDLGNCQAAKEVAPPSAGGGEVKERSCDSLVMCIVTTLNQGLRNGGGIGDILRAPSSKEGLFVAR 2656
                ||.....:...........||:||:|:|||||.||||||||||:||:||.||..|.||.||
 Frog  2461 ----NCSMTVSIPDEDDDDDADVERACDTLLMCIVTVLNQGLRNGGGVGDVLRKPSKDEPLFAAR 2521

  Fly  2657 VIYDLLFFFIVIIIVLNLIFGVIIDTFADLRSEKQQKEAILKTTCFICSLNRSAFDNKTVSFEEH 2721
            |:|||||:|||||||||||||||||||||||||||:||.|||||||||.|.|..|||||||||||
 Frog  2522 VVYDLLFYFIVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSFEEH 2586

  Fly  2722 IKSEHNMWHYLYFIVLVKVKDPTEFTGPESYVYAMVKAGILEWFPRLRAMSLAAVDADGEQIELR 2786
            |.|||.||||||||||||||||||:|||||||..|:....|:||||:|||||.:.:.:.||.|:|
 Frog  2587 IMSEHCMWHYLYFIVLVKVKDPTEYTGPESYVAQMIVEKNLDWFPRMRAMSLVSSEGENEQNEIR 2651

  Fly  2787 SMQAQLLDTQLLIKNLSTQLHELKDHMTEQRKQKQRLGLLNT 2828
            ::|.:|..|..|:|.||.||.|||:.||||||.|||||.|.:
 Frog  2652 NLQDKLECTMSLVKQLSGQLAELKEQMTEQRKNKQRLGFLGS 2693

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ItprNP_730941.1 Ins145_P3_rec 7..231 CDD:285871 161/221 (73%)
MIR 237..293 CDD:197746 43/55 (78%)
MIR 238..452 CDD:280906 126/219 (58%)
RYDR_ITPR 495..691 CDD:279676 128/195 (66%)
RYDR_ITPR 1294..1413 CDD:279676 74/118 (63%)
RIH_assoc 2042..2147 CDD:285630 89/104 (86%)
Ion_trans 2433..2691 CDD:278921 149/264 (56%)
Sec2p <2782..2819 CDD:283965 20/36 (56%)
itpr2XP_031754312.1 Ins145_P3_rec 4..228 CDD:400861 162/224 (72%)
MIR 232..431 CDD:397103 126/219 (58%)
RYDR_ITPR 472..669 CDD:396093 132/202 (65%)
RYDR_ITPR 1202..1344 CDD:396093 90/142 (63%)
RIH_assoc 1914..2021 CDD:400656 89/106 (84%)
Ion_trans 2311..2556 CDD:395416 145/254 (57%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 483 1.000 Domainoid score I403
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 2959 1.000 Inparanoid score I18
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D58374at33208
OrthoFinder 1 1.000 - - FOG0001660
OrthoInspector 1 1.000 - - otm48773
Panther 1 1.100 - - O PTHR13715
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1057
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
77.160

Return to query results.
Submit another query.