DRSC/TRiP Functional Genomics Resources

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Protein Alignment NKCC and SLC12A6

DIOPT Version :9

Sequence 1:NP_730938.1 Gene:NKCC / 40663 FlyBaseID:FBgn0051547 Length:1068 Species:Drosophila melanogaster
Sequence 2:NP_001352017.1 Gene:SLC12A6 / 9990 HGNCID:10914 Length:1150 Species:Homo sapiens


Alignment Length:1285 Identity:317/1285 - (24%)
Similarity:522/1285 - (40%) Gaps:377/1285 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 QISKVNGTANAGYDGEARSAESDQTDAAHPLPPTSNENHL-----------------------HP 47
            :|..:.|.::...|..:||:...:..:...:|.||....:                       ||
Human    21 KIDDIPGLSDTSPDLSSRSSSRVRFSSRESVPETSRSEPMSEMSGATTSLATVALDPPSDRTSHP 85

  Fly    48 K-------ASGETGEN-------RRSSRLSFRGFGNFLRKSDA--ERKFSLAQLTKESLPRLDNY 96
            :       .:..|||:       .:.:|.::....|: .:.|.  ::..:|.:...::.|::.:.
Human    86 QDVIEDLSQNSITGEHSQLLDDGHKKARNAYLNNSNY-EEGDEYFDKNLALFEEEMDTRPKVSSL 149

  Fly    97 RISMRNLKRPSIGELQGEAVDQSITIPEPEPEATGGHIKLGWIVGVLIPCLLNIWGVMLFLRLSW 161
            ...|.|....:.|..:.|.. ::||..:.:|..|.   ::|..:||.:|||.||:||:|||||:|
Human   150 LNRMANYTNLTQGAKEHEEA-ENITEGKKKPTKTP---QMGTFMGVYLPCLQNIFGVILFLRLTW 210

  Fly   162 VVAESGILQSLIIITISAVVCVITTLSLSAISTNGEVKGGGVYFIISRSLGPEFGASVGVVFAFA 226
            ||..:|:||:..|:.|.....::|.:|:|||:|||.|..||.||:|||:||||||.:||:.|...
Human   211 VVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLG 275

  Fly   227 NAVSASMNTIGFCESLNVLL--------KNNDLKIVDNGINDIRIVGSITVLVLILICCVGMEWE 283
            ...:|:|..:|..|...|.:        .::.||.....:|::|:.|:..:::::|:..:|:.:.
Human   276 TTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYV 340

  Fly   284 TK-AQNFL--IVTIVLAIFNFLIGAAIGPQ-------GNEEQISR-------------------- 318
            .| |..||  ::..:|||:...|.::..|.       ||....||                    
Human   341 NKFASLFLACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKL 405

  Fly   319 ----------------------------GFVGFSWATLKENFGSDYRYAEG-------------- 341
                                        |..|.:...:.||..|:| ..:|              
Human   406 WGFFCNSSQFFNATCDEYFVHNNVTSIQGIPGLASGIITENLWSNY-LPKGEIIEKPSAKSSDVL 469

  Fly   342 --VNHDFFSV---------FAIFFPSVTGIQAGANICGDLKDAGAAIPKGTFWSLL----ISMSS 391
              :||::..|         ..|||||||||.||:|..||||||..:||.||..::|    :.:|:
Human   470 GSLNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSN 534

  Fly   392 YALFVLFAGGAAVRDASGIPADLVNGTIVSSELPCMATGNCTWGLFNSYEMMQEMSLWGPLIYAG 456
            ..||.....|..:||..|   |.|.|.:|        .|..:|           .|.|  :|..|
Human   535 VVLFGACIEGVVLRDKFG---DAVKGNLV--------VGTLSW-----------PSPW--VIVIG 575

  Fly   457 CFAATLSTALTNLLSVPRLVQALGIDQIYPGLIFF--SKPYGKHGEPYRGYVLTFFITTGFLLIG 519
            .|.:|....|.:|...|||:||:..|.|.|.|..|  ||   .:|||....:||..|....:||.
Human   576 SFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSK---ANGEPTWALLLTAAIAELGILIA 637

  Fly   520 ELNLIAPLISTFYLASYALINFCTFHAAFVKPLGWRPTFKYYNAWLSLFGFAMCVAIMFLINYVA 584
            .|:|:||::|.|:|..|..:|........::...|||.|:||:..||..|.::|:|:||:.::..
Human   638 SLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYY 702

  Fly   585 AIITFGIIFALYLVVMYRKPEANWGSTTQAQQYKAALMAVHRLQNVSDHVKNYHPQVLV---LSG 646
            ||:...|...:|..:.|:..|..||...:.....||..|:.||:....|.||:.||:||   |..
Human   703 AIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDE 767

  Fly   647 DPKTR-PPLVDFGYLLTKNNSLMFVANIIPVRVG------------YKNRQHLVKDGQKYLDARK 698
            |...: |.|:.|...|.....|..|.::|   ||            .:..:||       ::|.|
Human   768 DLHVKHPRLLTFASQLKAGKGLTIVGSVI---VGNFLENYGEALAAEQTIKHL-------MEAEK 822

  Fly   699 IKAFYNVIDGFSLEDGINALTKSTGFGKMSPNIVLVGYKPDWNRCRKEEVESYFSILYNAFSQRM 763
            :|.|..::....|.:||:.|.:|.|.|.|..|.|::|:...|   |:.|         :|.:.:.
Human   823 VKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGW---RQSE---------DARAWKT 875

  Fly   764 GVALLRLPNGLDFSELSSEVTLPANGMGHMHTANAHGFTNELMPAANAASELLHIDSNLNLASMD 828
            .:..:|:                        |..||                        ||.:.
Human   876 FIGTVRV------------------------TTAAH------------------------LALLV 892

  Fly   829 SPNSSFTMPQPAPMPNMQRNSRSYKVTSSDEPAVTYHTKGGSDIPQNLLDAMTIFTRKQPKGTID 893
            :.|.||                                     .|.|:        .:..:|.||
Human   893 AKNISF-------------------------------------FPSNV--------EQFSEGNID 912

  Fly   894 VFWLYDDGGLTILLPYIISMRSHWQNSKLRVFAMCHGKDEE-QEEKSMASLLTKFRIK------- 950
            |:|:..|||:.:|||:::.....|:...:|:|.:...:|.. |.:|.:|:.|...||:       
Human   913 VWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVE 977

  Fly   951 ----------YSELIMLKGVSEQPRADTVLKHKRLIEPFR-RGA-----RNEF-------GITDD 992
                      |...:|::..|:      :|:|.||.:..| |.|     ||..       ...|:
Human   978 MHDSDISAYTYERTLMMEQRSQ------MLRHMRLSKTERDREAQLVKDRNSMLRLTSIGSDEDE 1036

  Fly   993 ELQSMSEKT---------------------------------------NRQLRIHELVVKHSSNA 1018
            |.::..||.                                       :..::::|::|..|..|
Human  1037 ETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEA 1101

  Fly  1019 SLVVMSLPMPRKEAISAPLYMSWLEMLTSDMKCPVALARGNQTPVLTLYS 1068
            .||::::|.|.:.......||.:||:||..:: .|.|.||..:.|:|:||
Human  1102 KLVLLNMPGPPRNPEGDENYMEFLEVLTEGLE-RVLLVRGGGSEVITIYS 1150

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NKCCNP_730938.1 2a30 85..1068 CDD:273347 298/1165 (26%)
DUF502 507..>643 CDD:294696 45/135 (33%)
SLC12 651..1068 CDD:281515 98/499 (20%)
SLC12A6NP_001352017.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 20..66 8/44 (18%)
2a30 109..1150 CDD:273347 302/1195 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 161..181 5/20 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG57166
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

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