Protein Alignment NKCC and ALP1

DIOPT Version :10

• Sequence 1: NP_730938.1
• Gene: NKCC / 40663
• FlyBaseID: FBgn0051547
• Length: 1068
• Species: Drosophila melanogaster
• Sequence 2: NP_014129.1
• Gene: ALP1 / 855451
• SGDID: S000005214
• Length: 573
• Species: Saccharomyces cerevisiae
• Alignment Length: 651
• Identity: 130/651 - (19%)
• Similarity: 221/651 - (33%)
• Gaps: 191/651 - (29%)

  Fly    69 NFLRKSDAERKFSLAQLTKESLPRLDNYRISMRNLKRPSIGELQGEAVDQSITIPEPEPEATGGH 133
            |..:....|||.. ....||:.......|...|.||:..||.:                 |.||.
Yeast    37 NVTKAITTERKVE-DDAAKETESSPQERREVKRKLKQRHIGMI-----------------ALGGT 83

  Fly   134 IKLGWIVGVLIPCLLNIWGVMLFLRLSWVVAESGILQSLIIITISAVVCVITTLSLSAISTNGEV 198
            |..|.|:|:..|                 :|.:|.:.:||.......|....|.||..:.|...|
Yeast    84 IGTGLIIGIGPP-----------------LAHAGPVGALISYLFMGTVIYSVTQSLGEMVTFIPV 131

  Fly   199 KGGGVYFIISRSLGPEFGASVGVV------FAFANAVSASMNTIGFCESLNVLLKNNDLKIVDNG 257
            ......| ..|.|.|..||:.|.:      |.||    ..::.:|              |::...
Yeast   132 TSSFSVF-AQRFLSPALGATNGYMYWLSWCFTFA----LELSVLG--------------KVIQYW 177

  Fly   258 INDIRIVGSITVLVLILICCVGM-------EWETKAQNFLIVTI-VLAIFNFLI---------GA 305
            ...:.:...| |:...|:..:.|       |:|     |.|.:| |:|:..|:|         |.
Yeast   178 TEAVPLAAWI-VIFWCLLTSMNMFPVKYYGEFE-----FCIASIKVIALLGFIIFSFCVVCGAGQ 236

  Fly   306 AIGPQGNEEQISRGFVGFSWATLKENFGSDYRYAEGVNHDFFSVFAIFFPSVTGIQAGANICGDL 370
            :.||.|.....:.|..|....:..:|.|   |:...|:....:.|......:.||.|     |:.
Yeast   237 SDGPIGFRYWRNPGAWGPGIISSDKNEG---RFLGWVSSLINAAFTYQGTELVGITA-----GEA 293

  Fly   371 KDAGAAIPKGTFWSLLISMSSYALFVLFAGGAAVRDASGIPADLVNGTIVSSE------------ 423
            .:...|:|:.....::..:..|.|.:.|.|.....:...:.:|   |..|||.
Yeast   294 ANPRKALPRAIKKVVVRILVFYILSLFFIGLLVPYNDPKLDSD---GIFVSSSPFMISIENSGTK 355

  Fly   424 -LPCMATGNCTWGLFNSYEMMQEMSLWGPLIYAGCFAATLSTALTNLLSVPRLVQALGIDQIYPG 487
             ||         .:||:..::..:|.....:|.|                .|::.:|..:.:.|.
Yeast   356 VLP---------DIFNAVVLITILSAGNSNVYIG----------------SRVLYSLSKNSLAPR 395

  Fly   488 LIFFSKPYGKHGEPYRGYVLTFFITTGFLLIGE------------LNLIAPLISTFYLASYALIN 540
               |.....:.|.||...:.|...  |||...|            ||:..  ::.|:  ::.||:
Yeast   396 ---FLSNVTRGGVPYFSVLSTSVF--GFLAFLEVSAGSGKAFNWLLNITG--VAGFF--AWLLIS 451

  Fly   541 FCTFHAAFVKPLGWR--------------PTFKYYNAW-----LSLFGFAMCVAIMFLINYVAAI 586
            |.  |..|::.:..|              |...||.::     :.:.||.........|::|||.
Yeast   452 FS--HIRFMQAIRKRGISRDDLPYKAQMMPFLAYYASFFIALIVLIQGFTAFAPTFQPIDFVAAY 514

  Fly   587 ITFGIIFALYLVVMYRKPEANWGSTTQAQQYKAALMAVHRLQNVS-DHVKNYHPQVLVLSGDPKT 650
            |:..:..|::|....      |        :|..|:  .:||::. |..:....:::.:..:.||
Yeast   515 ISIFLFLAIWLSFQV------W--------FKCRLL--WKLQDIDIDSDRRQIEELVWIEPECKT 563

  Fly   651 R 651
            |
Yeast   564 R 564

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NKCC	NP_730938.1	AA_permease_2	85..1068	CDD:459263	126/635 (20%)
ALP1	NP_014129.1	2A0310	67..545	CDD:273334	119/599 (20%)