Protein Alignment NKCC and GAP1

DIOPT Version :10

• Sequence 1: NP_730938.1
• Gene: NKCC / 40663
• FlyBaseID: FBgn0051547
• Length: 1068
• Species: Drosophila melanogaster
• Sequence 2: NP_012965.3
• Gene: GAP1 / 853912
• SGDID: S000001747
• Length: 602
• Species: Saccharomyces cerevisiae
• Alignment Length: 613
• Identity: 127/613 - (20%)
• Similarity: 208/613 - (33%)
• Gaps: 205/613 - (33%)

  Fly    87 KESLPRLDNYRISMRNLKRPSIGELQGEAVDQSITIPEP----------EPEATGGHIKLGWIVG 141
            |:|..|:....:.      |::.|.:..|:   ||...|          :..|.||.|..|.:||
Yeast    56 KDSFKRVKPIEVD------PNLSEAEKVAI---ITAQTPLKHHLKNRHLQMIAIGGAIGTGLLVG 111

  Fly   142 VLIPCLLNIWGVML------FLRLSWVVAESGILQSLIIITISAV--VCVITTLSLSAISTNGEV 198
            .         |..|      .|.:.|     |...::|...:.|:  :.||..:|
Yeast   112 S---------GTALRTGGPASLLIGW-----GSTGTMIYAMVMALGELAVIFPIS---------- 152

  Fly   199 KGGGVYFIISRSLGPEFGASVGVVFAFAN---------------AVSASMNTIGFCESLNVLLKN 248
              ||.....:|.:...||        :||               .||||: |:.|.        .
Yeast   153 --GGFTTYATRFIDESFG--------YANNFNYMLQWLVVLPLEIVSASI-TVNFW--------G 198

  Fly   249 NDLKIVDNGINDIRIVGSITVLVLILICCVGMEWETKAQ---NFL-IVTIV-LAIFNFLIGAAIG 308
            .|.|..|..:       ::..|.:::|...|::...:|:   :|: ::|:| ..|...::....|
Yeast   199 TDPKYRDGFV-------ALFWLAIVIINMFGVKGYGEAEFVFSFIKVITVVGFIILGIILNCGGG 256

  Fly   309 PQGNEEQISRGFVGFSWATLKENFGSDYRYAEGVNHDFFSVFAIFFPSVTGIQAGANICG----D 369
            |.|       |::|..:......|..|...|:     |..|.::|..:.... ||:.:.|    :
Yeast   257 PTG-------GYIGGKYWHDPGAFAGDTPGAK-----FKGVCSVFVTAAFSF-AGSELVGLAASE 308

  Fly   370 LKDAGAAIPKG---TFWSLLISMSSYALFVLFAG-----------GAAVRDASGIPADLVNGTIV 420
            ..:...::||.   .||.:.:   .|.|.:|..|           ||:..||:..|..:...|..
Yeast   309 SVEPRKSVPKAAKQVFWRITL---FYILSLLMIGLLVPYNDKSLIGASSVDAAASPFVIAIKTHG 370

  Fly   421 SSELPCMATGNCTWGLFNSYEMMQEMSLWGPLIYAGCFAATLSTALTNLLSVPRLVQALGIDQIY 485
            ...||         .:.|...::..:|:....||| |               .|.:.||...:..
Yeast   371 IKGLP---------SVVNVVILIAVLSVGNSAIYA-C---------------SRTMVALAEQRFL 410

  Fly   486 PGLIFFSKPYGKHGEPYRGYVLTFFITTGFLLI---------GEL-NLIAPLISTFYLASYALIN 540
            |.:..:   ..:.|.|..|..    :|:.|.||         ||: |.:..|.....|.::.  .
Yeast   411 PEIFSY---VDRKGRPLVGIA----VTSAFGLIAFVAASKKEGEVFNWLLALSGLSSLFTWG--G 466

  Fly   541 FCTFHAAFVKPLGWR-----------PTFKYYNAWLSLFGFAMCVAIMFLINYVAAIITFGI--- 591
            .|..|..|.|.|..:           ||    ..|.|.:|..| |.|||:..:..|:...|.
Yeast   467 ICICHIRFRKALAAQGRGLDELSFKSPT----GVWGSYWGLFM-VIIMFIAQFYVAVFPVGDSPS 526

  Fly   592 ---IFALYL-----VVMY---RKPEANW 608
               .|..||     :|||   :..:.||
Yeast   527 AEGFFEAYLSFPLVMVMYIGHKIYKRNW 554

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NKCC	NP_730938.1	AA_permease_2	85..1068	CDD:459263	127/613 (21%)
GAP1	NP_012965.3	2A0310	87..566	CDD:273334	118/573 (21%)