Protein Alignment NKCC and VHC1

DIOPT Version :10

• Sequence 1: NP_730938.1
• Gene: NKCC / 40663
• FlyBaseID: FBgn0051547
• Length: 1068
• Species: Drosophila melanogaster
• Sequence 2: NP_009794.3
• Gene: VHC1 / 852537
• SGDID: S000000439
• Length: 1120
• Species: Saccharomyces cerevisiae
• Alignment Length: 1221
• Identity: 286/1221 - (23%)
• Similarity: 462/1221 - (37%)
• Gaps: 333/1221 - (27%)

  Fly    70 FLRKSDAERKFSLAQLTKESLPRLDNYRISMRNLKRPSIGELQGEAVDQSITIPEPEPEATGGHI 134
            |.:.....|..|....:.||...|...|||.......:..|.|  .|........|..:
Yeast     5 FYQIPGTHRPSSAISSSNESSSLLSARRISQTYFNYQATPECQ--KVSSKYDPDNPNKD------ 61

  Fly   135 KLGWIVGVLIPCLLNIWGVMLFLRLSWVVAESGILQSLIIITISAVVCVITTLSLSAISTNGEVK 199
            |||...||.:|..||:..:::|||..:::.:.||:.::.::.:|..:.::||||:|||||||.|:
Yeast    62 KLGTYDGVFVPTALNVLSILMFLRFGFILGQLGIICTIGLLLLSYTINLLTTLSISAISTNGTVR 126

  Fly   200 GGGVYFIISRSLGPEFGASVGVVFAFANAVSASMNTIGFCESLNVLLKNNDLKIVDNGINDIRIV 264
            |||.|::||||||||||.|:|:||......:|.||.:|..|.|...|..:........:.::...
Yeast   127 GGGAYYMISRSLGPEFGGSIGLVFFLGQVFNAGMNAVGIIEPLLYNLGYSAQGEPPAALGELLPR 191

  Fly   265 G---SITVLVLILICC-----VGMEWETKAQNFLIVTIVLAIFNFLIGAAIGPQGNEEQISRGFV 321
            |   ..|...:||..|     ||.:..::|.|.|.:.:..:||:..:.|.|.....|..||  :.
Yeast   192 GHWHEFTYATVILFLCFSVAFVGSQTVSRAGNILFLVLAASIFSIPLSALIRSPFTEGGIS--YT 254

  Fly   322 GFSWATLKENF------GSDYRYAEGVNHDFFSVFAIFFPSVTGIQAGANICGDLKDAGAAIPKG 380
            |.||.|..:|.      |:.....:| ...|..:|.:|||:..||.|||.:..:|:....:||||
Yeast   255 GPSWQTFHDNLLPHLTKGAAGSLLKG-KETFNDLFGVFFPATAGIFAGAGMSSELRKPSKSIPKG 318

  Fly   381 TFWSLLISMSSYALFVLFAGGAAVRDASGIPADLVNGTIVSSELPCMATGNCTWGLFNSYEMMQE 445
            |.|.||.:...||: |:|:.|.::...|                           |::..:::|.
Yeast   319 TLWGLLFTFICYAV-VVFSMGCSIPRRS---------------------------LYDEVQIIQT 355

  Fly   446 MSLWGPLIYAGCFAATLSTALTNLLSVPRLVQALGIDQIYPGL-IFFSKPYGKHGEPYRGYVLTF 509
            :|....:|:.|..|.:|.:.:..:|....:::|:..|.|.||| ||...|.         |.|.|
Yeast   356 ISSVQWVIFMGEMATSLFSIIVGMLGAAYVLEAIAKDNIIPGLEIFAHSPL---------YSLIF 411

  Fly   510 -FITTGFLLIGELNLIAPLISTFYLASYALINFCTFHAAFVKPLGWRPTFKYYNAWLSLFGFAMC 573
             :|.|...|..::|.||..|:..:|.::.::|...|.........:||:|||:|.:.:..|..:.
Yeast   412 TWILTQLCLFSDVNKIATFITMTFLMTFVVMNLACFLLGISSAPNFRPSFKYFNRYTTAIGALLS 476

  Fly   574 VAIMFLINYVAAIITFGIIFALYLVVMYRKPEANWGSTTQAQQYKAALMAVHRLQNVSDHVKNYH 638
            |..|.:::.::|.:.|..:..|:|.:.|..|..:||..:|:..|......:.||:  .|::|.:.
Yeast   477 VVAMLIVDGISASVLFLAMILLFLFIHYFSPPKSWGDVSQSLIYHQVRKYLLRLR--QDNIKYWR 539

  Fly   639 PQVLVLSGDPKTRPPLVDFGYLLTKNNSLMFVANIIPVRVGYKNRQHLVKDGQ----KYLDARKI 699
            ||:|:...:|:|...|:.|...|.|..  :::...:.|...:..:.:.:|..|    |..|...|
Yeast   540 PQILLFVDNPRTSWNLIRFCNHLKKGG--LYILGHVAVTADFPKQLNELKTQQKAWMKIRDMAAI 602

  Fly   700 KAFYNVIDGFSLEDGINALTKSTGFGKMSPNIVLVGYKPDWNRCRKEEVESYFSILYNAFSQRMG 764
            |||..|..|.||..||..:...:|.|.|.|||.:||:         .::|||          |..
Yeast   603 KAFVQVGTGPSLIWGIRNVFIGSGLGGMKPNITVVGF---------FDLESY----------RKH 648

  Fly   765 VALLRLPNGLD-------------FSELSSEVTLPAN--------------------GMGHMHTA 796
            :...|..|.|.             .|::...|.||.:                    .:...:.|
Yeast   649 IPQSRSQNNLQKQVEIKATVPRSTCSDVKINVPLPTDECKNETKVNVQQWVQIVEDLSLMQSNIA 713

  Fly   797 NAHGFTN-EL-----------------------------MPAANAAS------------------ 813
            .||||.| |:                             .|||...:
Yeast   714 IAHGFKNLEIPNKRDSCFPKKTIDLYPIQMCGKVEAKGDQPAAITTNFDTYTLILQLAAILVTVP 778

  Fly   814 -------------------------------ELLHIDSNLNLASMD------------------- 828
                                           ::|.||:.:.:.|:|
Yeast   779 EWKRTHSLRVILFVEQEYHRTNETQRMKKLLQVLRIDAEVLVVSLDQFRVYNTIVKGDPIVFDYV 843

  Fly   829 --------------------SPNSSFTMPQPAPMPNMQRNSRSYKVTSSDEPAVTYHTKGGSDIP 873
                                .|...|:..:|..:......||.|             |.|    .
Yeast   844 NSKLADNEWWKDLVEARDTLKPKRRFSTIEPQTIAKQFTQSRKY-------------TSG----V 891

  Fly   874 QNLLDAMTIFTRKQPKGTIDVFWLYDDGGLTILLPYIISMRSHWQNSKLRVFAMCHGKDEEQEEK 938
            |.|..:.|:.|| .|...||.....:|..|...|..|....|...|..:       |||...:.|
Yeast   892 QKLGVSFTMNTR-MPTNRIDTPCESEDSDLDTDLTSIRDAFSASTNISV-------GKDLTTKSK 948

  Fly   939 S---MASLLTK----------FRIKYSE------LIMLKGVSEQPRADTVLKHKRLIEP-FRRGA 983
            :   ..:||.|          .|..:|.      .::..|..|||   |::.   :.|| ...|.
Yeast   949 TGSDRTNLLVKNLQSDVSTQSLRPVFSSNTLPRTRVVEDGTGEQP---TLIP---IAEPDLSNGN 1007

  Fly   984 RNEFGI------------------TDDELQSMSE--------KTNRQLRIHELVVKHSSNASLVV 1022
            ....||                  :.|.|.:..:        .|.:.|.:::::.:.|.::.|:.
Yeast  1008 GTGSGIGNGNKLKKPVLPELSPCCSKDSLVTAMQNLGFNDLPSTAQHLVLNDVMTQMSKSSDLIF 1072

  Fly  1023 MSLPMP---RKEAISAPL-YMS----WLEMLTSDMKCPVALARGNQTPVLT 1065
            .:||:|   ..|...|.| |:.    |||.|      |..:...:||..:|
Yeast  1073 STLPVPALGTHEDHDASLQYVEDLDIWLEGL------PPCMLINSQTMTVT 1117

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NKCC	NP_730938.1	AA_permease_2	85..1068	CDD:459263	283/1206 (23%)
VHC1	NP_009794.3	AA_permease_2	45..824	CDD:459263	214/849 (25%)