DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NKCC and SLC12A8

DIOPT Version :9

Sequence 1:	NP_730938.1	Gene:	NKCC / 40663	FlyBaseID:	FBgn0051547	Length:	1068	Species:	Drosophila melanogaster
Sequence 2:	NP_001182412.2	Gene:	SLC12A8 / 84561	HGNCID:	15595	Length:	714	Species:	Homo sapiens

Alignment Length:	452	Identity:	123/452 - (27%)
Similarity:	225/452 - (49%)	Gaps:	70/452 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 IGELQGEAVDQ-SITIPEP---------EPEATGGHIKLGWIVGVLIPCLLNIWGVMLFLRLSWV 162
            :.||..||..| ::..|:|         ||      :..|...||...|::||:||:||||..|:
Human     7 VQELFHEAAQQDALAQPQPWWKTQLFMWEP------VLFGTWDGVFTSCMINIFGVVLFLRTGWL 65

  Fly   163 VAESGILQSLIIITISAVVCVITTLSLSAISTNGEVKGGGVYFIISRSLGPEFGASVGVVFAFAN 227
            |..:|:|..:.:::...:|.::|.||...:.....:..||||.:||..||.:.|.::|:::.|..
Human    66 VGNTGVLLGMFLVSFVILVALVTVLSGIGVGERSSIGSGGVYSMISSVLGGQTGGTIGLLYVFGQ 130

  Fly   228 AVSASMNTIGFCESLNVLLKNNDLKIVDNGINDIRIVGSITVLVLILICCV---GMEWETKAQNF 289
            .|:.:|...||.||::.||          |:.:|..|..|:|.||:.:..:   |::|..:.|..
Human   131 CVAGAMYITGFAESISDLL----------GLGNIWAVRGISVAVLLALLGINLAGVKWIIRLQLL 185

  Fly   290 LIVTIVLAIFNFLIGA--AIGPQGNEEQISRGFVGFSWATLKENFGSDYRYAEGVNHDFFSVFAI 352
            |:..:.::..:|::|:  .:.|:       .||:|:|...|:.|...||...|    .||:||.:
Human   186 LLFLLAVSTLDFVVGSFTHLDPE-------HGFIGYSPELLQNNTLPDYSPGE----SFFTVFGV 239

  Fly   353 FFPSVTGIQAGANICGDLKDAGAAIPKGTFWSLLISMSSYALFVLFAGGAAVRDASGIPADLVNG 417
            |||:.||:.||.|:.|||::..|:||.|:..::.||...|.:||...|....|:|
Human   240 FFPAATGVMAGFNMGGDLREPAASIPLGSLAAVGISWFLYIIFVFLLGAICTREA---------- 294

  Fly   418 TIVSSELPCMATGNCTWGLFNSYEMMQEMSLWGPLIYAGCFAATLSTALTNLLSVPRLVQALGID 482
                              |...:.:.:::||.|.|...|.:.::|::.:..|...||::|.:..:
Human   295 ------------------LRYDFLIAEKVSLMGFLFLLGLYISSLASCMGGLYGAPRILQCIAQE 341

  Fly   483 QIYPGLIFFSKPYGKHGEPYRGYVLTFFITTGFLLIGELNLIAPLISTFYLASYALINFCTF 544
            ::.|.|....:..|.:..|.....||..:|..|:.:|::|::||:::..::.:|..:::..|
Human   342 KVIPALACLGQGKGPNKTPVAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTYVAVDYSYF 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NKCC	NP_730938.1	2a30	85..1068	CDD:273347	123/452 (27%)
		DUF502	507..>643	CDD:294696	10/38 (26%)
		SLC12	651..1068	CDD:281515
SLC12A8	NP_001182412.2	2a30	35..>407	CDD:273347	116/424 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	471..503
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	530..550
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2083
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810