DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NKCC and Slc12a9

DIOPT Version :9

Sequence 1:	NP_730938.1	Gene:	NKCC / 40663	FlyBaseID:	FBgn0051547	Length:	1068	Species:	Drosophila melanogaster
Sequence 2:	NP_001346540.1	Gene:	Slc12a9 / 83704	MGIID:	1933532	Length:	914	Species:	Mus musculus

Alignment Length:	1056	Identity:	272/1056 - (25%)
Similarity:	469/1056 - (44%)	Gaps:	224/1056 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 LTKESLPRLDNYRISMRNLKRPSIGELQGEAVDQSITIPEPEPEATG-----GHIKLGWIVGVLI 144
            :..||.|.| .||:         :|| :|.|.         .|...|     ...||...:||::
Mouse     1 MASESSPLL-AYRL---------LGE-EGAAF---------PPNGAGVSGVPSSRKLSTFLGVVV 45

  Fly   145 PCLLNIWGVMLFLRLSWVVAESGILQSLIIITISAVVCVITTLSLSAISTNGEVKGGGVYFIISR 209
            |.:|:::.:::|||:.:||..:|:||:|.::.::.::..:|.||:.||:|||.|:|||.||:|||
Mouse    46 PTVLSMFSIVVFLRIGFVVGHAGLLQALAMLLVAYIILALTVLSVCAIATNGAVRGGGAYFMISR 110

  Fly   210 SLGPEFGASVGVVFAFANAVSASMNTIGFCES-LNVL----LKNNDLKIVDNGINDIRIVGSITV 269
            :||||.|.|:|::|..||....:::.:|..|| |:|.    ..::.::::..|.....:.||:.:
Mouse   111 TLGPEVGGSIGLMFYLANVCGCAVSLLGLVESILDVFGADATGSSGIQVLPQGYGWNLLYGSLLL 175

  Fly   270 LVLILICCVGMEWETKAQ--NFLIVTIVLA--IFNFLIGAAIGPQG---------NEEQISR--- 318
            .::..:|.:|.....:|.  .||:|:..||  :.:|:   |:||:.         |...:..
Mouse   176 GLVGGVCTLGAGLYARASFLTFLLVSGSLASVLVSFV---AVGPRNIPLAPRPGTNASSVPHRHG 237

  Fly   319 GFVGFSWATLKENFGSDYR--YAEGVNHDFFSVFAIFFPSVTGIQAGANICGDLKDAGAAIPKGT 381
            .|.||:.:||::|.|:.|.  |..|....|.||||:.|...|||.||||:.|:|||...|||.||
Mouse   238 HFTGFNGSTLRDNLGAGYAEDYTTGAMMTFASVFAVLFNGCTGIMAGANMSGELKDPSRAIPLGT 302

  Fly   382 FWSLLISMSSYALFVLFAGGAAVRDASGIPADLVNGTIVSSELPCMATGNCTWGLFNSYEMMQEM 446
            .  :.::.:.:...:||...:...|.:.:..|                          |...:::
Mouse   303 I--IAVAYTFFIYILLFFLSSFTCDRALLQED--------------------------YGFFRDI 339

  Fly   447 SLWGPLIYAGCFAATLSTALTNLLSVPRLVQALGIDQIYPGLIFFSKPYGKHGEPYRGYVLTFFI 511
            |||.||:..|.:|..||.::::|:...|::.||..|.::..::..:|.....|.|:...:.::.:
Mouse   340 SLWPPLVLIGIYATALSASMSSLIGASRILHALAQDDLFGVILAPAKVVSGGGNPWGAVLYSWGL 404

  Fly   512 TTGFLLIGELNLIAPLISTFYLASYALINFCTFHAAFVKPLGWRPTFKYYNAWLSLFGFAMCVAI 576
            ....||.|:||.:|.:::.|||.:||.::.......:.....:||||..::....|.|.|.|:.:
Mouse   405 VQLVLLAGKLNTLAAVVTVFYLVAYAAVDLSCLSLEWASAPNFRPTFSLFSWHTCLLGVASCLLM 469

  Fly   577 MFLINYVAA---IITFGIIFALYLVVMYRKPEANWGSTTQAQQYKAALMAVHRLQNVSDHVKNYH 638
            ||||:..||   ::..|::.||   :..|...::||..:||..:......:.||....:|||.:.
Mouse   470 MFLISPGAAGGSLLLMGLLSAL---LTARGGPSSWGYVSQALLFHQVRKYLLRLDVRKEHVKFWR 531

  Fly   639 PQVLVLSGDPKTRPPLVDFGYLLTKNNSLMFVANII----------PVRVGYKNRQHLVKDGQKY 693
            ||:|:|.|:|:...||:.....| |...|..:.::.          ||:..|.....||
Mouse   532 PQLLLLVGNPRGALPLLRLANQL-KKGGLYVLGHVTLGDLDSLPSDPVQPQYGAWLSLV------ 589

  Fly   694 LDARKIKAFYNVIDGFSLEDGINALTKSTGFGKMSPNIVLVGYKPDWNRCRKEEVESYFSILYNA 758
             |..::|||.::....|:..|...|.:.:|.|.|.||.:::|:..|      ...:.:| :...|
Mouse   590 -DLAQVKAFVDLTLSPSVRQGAQHLLRISGLGGMKPNTLVLGFYDD------APPQDHF-LTDPA 646

  Fly   759 FSQRMGVALLRLPNGLDFSELSSEVTLPANGMGH---------MHTANAHGFTNELMPAANAA-- 812
            ||:                        ||.|...         .....|.|....|.|....|
Mouse   647 FSE------------------------PAEGTREGGSPALSTLFPPPRAPGSPRALSPQDYVATV 687

  Fly   813 SELLHIDSNLNLASMDSPNSSFTMPQPAPMPNMQRNSRSYKVTSSDEPAVTYHTKGGSDI-PQNL 876
            ::.|.::.|:.||     .:...:|.       :|.||     .|...|..:|.    |: |.||
Mouse   688 ADALKMNKNVVLA-----RACGALPP-------ERLSR-----GSSSSAQLHHV----DVWPLNL 731

  Fly   877 LDAMTIFTRKQPK---GTIDVFWLYDDGGLTILLPYIISMRSHWQNSKLRVFAMCHGKDEE--QE 936
            |         :|:   |.:||..|:     .:.:..|:||...|.:::||:| :|.|..|.  ..
Mouse   732 L---------RPRGGPGYVDVCGLF-----LLQMATILSMVPAWHSARLRIF-LCLGPREAPGAA 781

  Fly   937 EKSMASLLTKFRIK--YSELIMLKGVS----EQPRADTVLKHKRLIEPFRRGARNEFGITDDELQ 995
            |..:.:||::.||:  ..|::..:|..    |:...|           |..|.|.     |:|.:
Mouse   782 EGRLRALLSQLRIRAEVQEVVWGEGAETGEPEEEEGD-----------FVNGGRG-----DEEAE 830

  Fly   996 SMSEKTNRQLRIHE-------------LVVKHSSNASLVVMSLPMPRKEAISAPLYMSWLEMLTS 1047
            :::...|..:|..:             ...:.....:|..:.||.|..:....|.|::.||.|:.
Mouse   831 ALACSANALVRAQQGRGTVGGPGGPEGRDGEEGPTTALTFLYLPRPPADPARYPRYLALLETLSR 895

  Fly  1048 DMKCPVALARGNQTPV 1063
            |:. |..|..| .|||
Mouse   896 DLG-PTLLIHG-VTPV 909

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NKCC	NP_730938.1	2a30	85..1068	CDD:273347	272/1056 (26%)
		DUF502	507..>643	CDD:294696	40/138 (29%)
		SLC12	651..1068	CDD:281515	99/459 (22%)
Slc12a9	NP_001346540.1	2a30	36..905	CDD:273347	256/994 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	645..678		8/56 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	844..864		0/19 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910