DRSC/TRiP Functional Genomics Resources

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Protein Alignment NKCC and SLC12A2

DIOPT Version :9

Sequence 1:NP_730938.1 Gene:NKCC / 40663 FlyBaseID:FBgn0051547 Length:1068 Species:Drosophila melanogaster
Sequence 2:NP_001037.1 Gene:SLC12A2 / 6558 HGNCID:10911 Length:1212 Species:Homo sapiens


Alignment Length:1151 Identity:457/1151 - (39%)
Similarity:664/1151 - (57%) Gaps:162/1151 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 RFQISKVNGTANAGYDGEARSAESDQTDAAH---PLPPTSNEN----------HLHPKASGETGE 55
            ||:::.|:..|::       |||...:|||.   ..|..|.:|          .||....|.:|.
Human   138 RFRVNFVDPAASS-------SAEDSLSDAAGVGVDGPNVSFQNGGDTVLSEGSSLHSGGGGGSGH 195

  Fly    56 NR------RSSRLSFRGFGNFLRKSDAERKFSLAQLTKESLPRLDNYRISM----RNLKRPSIGE 110
            ::      .::....|.||:               .|.:::||:|:||.:.    ..|.|||:.|
Human   196 HQHYYYDTHTNTYYLRTFGH---------------NTMDAVPRIDHYRHTAAQLGEKLLRPSLAE 245

  Fly   111 LQGEAVDQSITIPEPEPEATG----------------------GHIKLGWIVGVLIPCLLNIWGV 153
            |..|.        |.||...|                      |.:|.|||.|||:.|:||||||
Human   246 LHDEL--------EKEPFEDGFANGEESTPTRDAVVTYTAESKGVVKFGWIKGVLVRCMLNIWGV 302

  Fly   154 MLFLRLSWVVAESGILQSLIIITISAVVCVITTLSLSAISTNGEVKGGGVYFIISRSLGPEFGAS 218
            |||:||||:|.::||..|:::|.::.||..||.||.|||:|||.|:|||.|::||||||||||.:
Human   303 MLFIRLSWIVGQAGIGLSVLVIMMATVVTTITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGA 367

  Fly   219 VGVVFAFANAVSASMNTIGFCESLNVLLKNNDLKIVDNGINDIRIVGSITVLVLILICCVGMEWE 283
            :|::|||||||:.:|..:||.|::..|||.:.:.::|. ||||||:|:|||::|:.|...|||||
Human   368 IGLIFAFANAVAVAMYVVGFAETVVELLKEHSILMIDE-INDIRIIGAITVVILLGISVAGMEWE 431

  Fly   284 TKAQNFLIVTIVLAIFNFLIGAAIGPQGNEEQISRGFVGFSWATLKENFGSDYRYAEGVNHDFFS 348
            .|||..|:|.::|||.:|:||..| |.  |.:..:||.|:......||||.|:|..|    .|||
Human   432 AKAQIVLLVILLLAIGDFVIGTFI-PL--ESKKPKGFFGYKSEIFNENFGPDFREEE----TFFS 489

  Fly   349 VFAIFFPSVTGIQAGANICGDLKDAGAAIPKGTFWSLLISMSSYALFVLFAGGAAVRDASGIPAD 413
            |||||||:.|||.|||||.|||.|..:||||||..::||:...|....:..|...||||:|    
Human   490 VFAIFFPAATGILAGANISGDLADPQSAIPKGTLLAILITTLVYVGIAVSVGSCVVRDATG---- 550

  Fly   414 LVNGTIVSSELPCMA-------------TGNCTWGLFNSYEMMQEMSLWGPLIYAGCFAATLSTA 465
            .||.|||:....|.:             :..|::||.|::::|..:|.:.|||.||.|:||||:|
Human   551 NVNDTIVTELTNCTSAACKLNFDFSSCESSPCSYGLMNNFQVMSMVSGFTPLISAGIFSATLSSA 615

  Fly   466 LTNLLSVPRLVQALGIDQIYPGLIFFSKPYGKHGEPYRGYVLTFFITTGFLLIGELNLIAPLIST 530
            |.:|:|.|::.|||..|.|||....|:|.|||:.||.|||:|||.|..||:||.|||:|||:||.
Human   616 LASLVSAPKIFQALCKDNIYPAFQMFAKGYGKNNEPLRGYILTFLIALGFILIAELNVIAPIISN 680

  Fly   531 FYLASYALINFCTFHAAFVKPLGWRPTFKYYNAWLSLFGFAMCVAIMFLINYVAAIITFGIIFAL 595
            |:|||||||||..|||:..|..||||.|||||.|:||.|..:|..:||:||:.||::|:.|:..|
Human   681 FFLASYALINFSVFHASLAKSPGWRPAFKYYNMWISLLGAILCCIVMFVINWWAALLTYVIVLGL 745

  Fly   596 YLVVMYRKPEANWGSTTQAQQYKAALMAVHRLQNVSDHVKNYHPQVLVLSGDPKTRPPLVDFGYL 660
            |:.|.|:||:.||||:|||..|..||....||..|.|||||:.||.||::|.|.:||.|:...:.
Human   746 YIYVTYKKPDVNWGSSTQALTYLNALQHSIRLSGVEDHVKNFRPQCLVMTGAPNSRPALLHLVHD 810

  Fly   661 LTKNNSLMFVANII--PVRVGYKNRQHLVKDGQKYLDARKIKAFYNVIDGFSLEDGINALTKSTG 723
            .|||..||...::.  |.|...|.........|::|...|:||||..:....|.:|...|.::.|
Human   811 FTKNVGLMICGHVHMGPRRQAMKEMSIDQAKYQRWLIKNKMKAFYAPVHADDLREGAQYLMQAAG 875

  Fly   724 FGKMSPNIVLVGYKPDWNRCRKEEVESYFSILYNAFSQRMGVALLRLPNGLDFSELSSEVTLPAN 788
            .|:|.||.:::|:|.||.:....:|:.|.::.::||..:.||.::||..|||.|.|..:..|.: 
Human   876 LGRMKPNTLVLGFKKDWLQADMRDVDMYINLFHDAFDIQYGVVVIRLKEGLDISHLQGQEELLS- 939

  Fly   789 GMGHMHTANAHGFTNELMPAANAASELLHIDSNLNLASMD-SPNSSFTMPQPAPMPNMQRNSRSY 852
                         :.|..|.....           :.|:: |..|.....:|     :.....::
Human   940 -------------SQEKSPGTKDV-----------VVSVEYSKKSDLDTSKP-----LSEKPITH 975

  Fly   853 KVTSSD-----EPAVTYHTKGGSDIP-----QNLLDAMTIFTRKQPKGTIDVFWLYDDGGLTILL 907
            ||...|     :|.:...:| |..:|     |.||:|.|.|.:||.|.||||:||:||||||:|:
Human   976 KVEEEDGKTATQPLLKKESK-GPIVPLNVADQKLLEASTQFQKKQGKNTIDVWWLFDDGGLTLLI 1039

  Fly   908 PYIISMRSHWQNSKLRVFAMCHGKDE--EQEEKSMASLLTKFRIKYSELIMLKGVSEQPRADTVL 970
            ||:::.:..|::.|:|||  ..||..  :.:.::||:||:||||.:|::::|..::.:|:.:.::
Human  1040 PYLLTTKKKWKDCKIRVF--IGGKINRIDHDRRAMATLLSKFRIDFSDIMVLGDINTKPKKENII 1102

  Fly   971 KHKRLIEPFRRGARNE-------------FGITDDELQSMSEKTNRQLRIHELVVKHSSNASLVV 1022
            ..:.:|||:|....::             :.|||:||:....||.||:|::||:.:|||.|:::|
Human  1103 AFEEIIEPYRLHEDDKEQDIADKMKEDEPWRITDNELELYKTKTYRQIRLNELLKEHSSTANIIV 1167

  Fly  1023 MSLPMPRKEAISAPLYMSWLEMLTSDMKCPVALARGNQTPVLTLYS 1068
            ||||:.||.|:|:.|||:|||.|:.|:. |:.|.|||...|||.||
Human  1168 MSLPVARKGAVSSALYMAWLEALSKDLP-PILLVRGNHQSVLTFYS 1212

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NKCCNP_730938.1 2a30 85..1068 CDD:273347 435/1049 (41%)
DUF502 507..>643 CDD:294696 78/135 (58%)
SLC12 651..1068 CDD:281515 144/444 (32%)
SLC12A2NP_001037.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 36..81
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 112..138 457/1151 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 150..193 12/49 (24%)
2a30 216..1212 CDD:273347 435/1049 (41%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 962..989 4/31 (13%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG2083
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG57166
OrthoDB 1 1.010 - - D135130at33208
OrthoFinder 1 1.000 - - FOG0001536
OrthoInspector 1 1.000 - - mtm8484
orthoMCL 1 0.900 - - OOG6_101360
Panther 1 1.100 - - O PTHR11827
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
109.790

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