DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NKCC and slc12a10.1

DIOPT Version :9

Sequence 1:	NP_730938.1	Gene:	NKCC / 40663	FlyBaseID:	FBgn0051547	Length:	1068	Species:	Drosophila melanogaster
Sequence 2:	NP_001154850.2	Gene:	slc12a10.1 / 570849	ZFINID:	ZDB-GENE-060503-330	Length:	1033	Species:	Danio rerio

Alignment Length:	1132	Identity:	419/1132 - (37%)
Similarity:	624/1132 - (55%)	Gaps:	166/1132 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MADRFQISKVNGTANAGYDGEARSAESDQTDAAHPLPP--TSNENHLHPKASGETGENRRSSRLS 63
            |..||....::.|.|         ..|.|...:...||  :|..|.:....:.::...|.|..|:
Zfish     1 MGHRFSKRGLSSTDN---------LPSGQFSGSEEAPPHYSSYSNGIDTAITVDSPTRRSSEVLN 56

  Fly    64 FRGFGNFLRKSDAERKFSLAQLTKESLPRLDNY------------RISMRNLKR----------- 105
            .|        .|:.|....:  |.:::|.|:.|            |.|:..|::
Zfish    57 SR--------QDSRRPSIYS--TIDAMPHLEFYANATTTGRIRRSRPSLETLRKVCDNGECGVNS 111

  Fly   106 --------PSIGELQGEAVDQSITIPEPEPEATGGHIKLGWIVGVLIPCLLNIWGVMLFLRLSWV 162
                    .::.|.:.::.:...|..:.||      ::.||:.||:|.|:||||||:|||||||:
Zfish   112 GDSCAGSIAALQETENKSEENGETAKKSEP------VRFGWVTGVMIRCMLNIWGVILFLRLSWI 170

  Fly   163 VAESGILQSLIIITISAVVCVITTLSLSAISTNGEVKGGGVYFIISRSLGPEFGASVGVVFAFAN 227
            .:::|||.:.:||.:|.:|..||.||:|||||||.|..||.||:|||:||||.|..:||||:|||
Zfish   171 TSQAGILLTWLIILMSVLVTSITALSVSAISTNGRVSSGGAYFMISRTLGPELGGPIGVVFSFAN 235

  Fly   228 AVSASMNTIGFCESLNVLLKNNDLKIVDNGINDIRIVGSITVLVLILICCVGMEWETKAQNFLIV 292
            |::.::||:||.|::..||..|:.:|||: :||:||:|||||..|:||...|||||:|.|....:
Zfish   236 ALACALNTVGFSETVRDLLIENNSQIVDS-VNDVRIIGSITVTALLLISLAGMEWESKTQILFFL 299

  Fly   293 TIVLAIFNFLIGAAIGPQGNEEQISRGFVGFSWATLKENFGSDYRYAEGVNHDFFSVFAIFFPSV 357
            .::::..|:.:|:.| |...::| |.||..:......||...|:|..:|   |||.:|||||||.
Zfish   300 VLMVSFTNYFVGSVI-PATPQKQ-SIGFFSYRSEIFVENLFPDWRGPDG---DFFRMFAIFFPSA 359

  Fly   358 TGIQAGANICGDLKDAGAAIPKGTFWSLLISMSSYALFVLFAGGAAVRDASGIPADL--VNGTIV 420
            .||.|||||.||||:...|||:||..::..:..||.......|...:|||||...|.  :|.|..
Zfish   360 IGILAGANISGDLKEPEIAIPRGTLMAIFCTTISYLAISSTVGACVLRDASGNMNDSLPLNFTEA 424

  Fly   421 SSELPCM---------ATGNCTWGLFNSYEMMQEMSLWGPLIYAGCFAATLSTALTNLLSVPRLV 476
            ...|.|.         .:|:|::||.||::::.::|.:|||||||.||||||:||..|:|.|::.
Zfish   425 CDSLSCSLGWNFTECEQSGSCSYGLSNSFQVLVQVSGFGPLIYAGIFAATLSSALAFLVSAPKIF 489

  Fly   477 QALGIDQIYPGLIFFSKPYGKHGEPYRGYVLTFFITTGFLLIGELNLIAPLISTFYLASYALINF 541
            |.|..|.|||.:.||.|.|||:.||.|.|:|.:.|...|:||.|||.||||||.|:|.|||||||
Zfish   490 QCLCRDNIYPYIGFFGKGYGKNSEPLRAYLLCYIIAMCFILIAELNTIAPLISNFFLCSYALINF 554

  Fly   542 CTFHAAFVKPLGWRPTFKYYNAWLSLFGFAMCVAIMFLINYVAAIITFGIIFALYLVVMYRKPEA 606
            ..|||:.....||||:|:||:.|..|||.|:.|.:|||:.:.||:|:..:|..|:..|.|:|||.
Zfish   555 SCFHASITNSPGWRPSFRYYSPWTGLFGAAISVVLMFLLTWWAALISLALIIFLFGYVAYKKPEV 619

  Fly   607 NWGSTTQAQQYKAALMAVHRLQNVSDHVKNYHPQVLVLSGDPKTRPPLVDFGYLLTKNNSLMFVA 671
            ||||:.||..|..||.....|..|.||||||.||.|||:|.|..||.||||....|||.|||...
Zfish   620 NWGSSVQASTYNMALSYSVSLAGVEDHVKNYRPQCLVLTGPPTLRPALVDFVGSFTKNVSLMICG 684

  Fly   672 NIIPVRVGYKNRQHLVKDGQ-----KYLDARKIKAFYNVIDGFSLEDGINALTKSTGFGKMSPNI 731
            :||     .::.:.::.:..     |:|:.||:::||......||.:|...|.:::|.||:.|||
Zfish   685 DII-----MEDEKSIMSECNTNEMLKWLNQRKVRSFYTAFRSSSLREGARHLLQASGLGKLRPNI 744

  Fly   732 VLVGYKPDWNRCRKEEVESYFSILYNAFSQRMGVALLRLPNGLDF-SELSSEVTLPANGMGHMHT 795
            :::|:|.:|.....:::|.|.:.:|::|....||.:||:.:|||. .||.:||
Zfish   745 LVMGFKMNWQESNSQDIEDYINTIYDSFDSNHGVCVLRMMDGLDIRDELQTEV------------ 797

  Fly   796 ANAHGFTNELMPAANAASELLHIDSNLNLASMDSPNSSFTMPQPAPMPNMQRNSRSYKVTSSDEP 860
                                               |..|...:|....  |:||.|    .||
Zfish   798 -----------------------------------NPVFEPDEPIEFD--QQNSDS----DSD-- 819

  Fly   861 AVTYHTKGGSDIPQNLLD--AMTIFTRKQPKGTIDVFWLYDDGGLTILLPYIISMRSHWQNSKLR 923
                     .|..:|:.:  ..|:|..||.|.||||:|:.||||||:|:||:::.|..|:.||:|
Zfish   820 ---------VDNTKNIANDQIKTVFQTKQGKKTIDVYWISDDGGLTLLVPYLLTRRKRWRRSKVR 875

  Fly   924 VFAMCHGKDEEQEEKSMASLLTKFRIKYSELIMLKGVSEQPRADTVLKHKRLIEPFR-------- 980
            ||.:...|..|.|.|.|.:||.:||:...::|::.....||.|..:.:.:..:.|||
Zfish   876 VFIVGEQKTMEDERKEMKTLLQRFRLDVHDVIVMTDSKRQPLAKNMQRFEDTVAPFRLNDAQLDE 940

  Fly   981 -----RGARNEFGITDDELQSMSEKTNRQLRIHELVVKHSSNASLVVMSLPMPRKEAISAPLYMS 1040
                 :...|.:.:||.::.::..|:.|::|::|::.::|.:|:||::|||:|:.:..|: |||:
Zfish   941 RTVQQQRMENPWKVTDKQMDALRLKSERKVRLNEIIRRNSQHAALVLVSLPVPQADCPSS-LYMA 1004

  Fly  1041 WLEMLTSDMKCPVALARGNQTPVLTLY 1067
            ||:.|:..:.|||.|.||||..|:|.|
Zfish  1005 WLDTLSCGLHCPVLLIRGNQQNVMTFY 1031

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NKCC	NP_730938.1	2a30	85..1068	CDD:273347	402/1046 (38%)
		DUF502	507..>643	CDD:294696	71/135 (53%)
		SLC12	651..1068	CDD:281515	134/438 (31%)
slc12a10.1	NP_001154850.2	2a30	69..1032	CDD:273347	402/1045 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	817	1.000	Inparanoid score	I458
OMA	1	1.010	-	-		QHG57166
OrthoDB	1	1.010	-	-		D135130at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6412
orthoMCL	1	0.900	-	-		OOG6_101360
Panther	1	1.100	-	-	O	PTHR11827
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.980