Protein Alignment NKCC and SLC12A9

DIOPT Version :10

• Sequence 1: NP_730938.1
• Gene: NKCC / 40663
• FlyBaseID: FBgn0051547
• Length: 1068
• Species: Drosophila melanogaster
• Sequence 2: NP_064631.2
• Gene: SLC12A9 / 56996
• HGNCID: 17435
• Length: 914
• Species: Homo sapiens
• Alignment Length: 1044
• Identity: 278/1044 - (26%)
• Similarity: 476/1044 - (45%)
• Gaps: 200/1044 - (19%)

  Fly    85 LTKESLPRLDNYRISMRNLKRPSIGELQGEAVDQSITIPEPEPEATGGHI--KLGWIVGVLIPCL 147
            :..||.|.| .||:         :||       :.:.:|.......||..  ||...:||::|.:
Human     1 MASESSPLL-AYRL---------LGE-------EGVALPANGAGGPGGASARKLSTFLGVVVPTV 48

  Fly   148 LNIWGVMLFLRLSWVVAESGILQSLIIITISAVVCVITTLSLSAISTNGEVKGGGVYFIISRSLG 212
            |:::.:::|||:.:||..:|:||:|.::.::..:..:|.||:.||:|||.|:|||.||:|||:||
Human    49 LSMFSIVVFLRIGFVVGHAGLLQALAMLLVAYFILALTVLSVCAIATNGAVQGGGAYFMISRTLG 113

  Fly   213 PEFGASVGVVFAFANAVSASMNTIGFCES-LNVLLKN----NDLKIVDNGINDIRIVGSITVLVL 272
            ||.|.|:|::|..||....:::.:|..|| |:|...:    :.|:::..|.....:.||:.:.::
Human   114 PEVGGSIGLMFYLANVCGCAVSLLGLVESVLDVFGADATGPSGLRVLPQGYGWNLLYGSLLLGLV 178

  Fly   273 ILICCVGMEWETKAQ--NFLIVTIVLA--IFNFLIGAAIGPQ-----------GNEEQISRG-FV 321
            ..:|.:|.....:|.  .||:|:..||  :.:|:   |:||:           |:......| |.
Human   179 GGVCTLGAGLYARASFLTFLLVSGSLASVLISFV---AVGPRDIRLTPRPGPNGSSLPPRFGHFT 240

  Fly   322 GFSWATLKENFGSDYR--YAEGVNHDFFSVFAIFFPSVTGIQAGANICGDLKDAGAAIPKGTFWS 384
            ||:.:|||:|.|:.|.  |..|...:|.||||:.|...|||.||||:.|:|||...|||.||..:
Human   241 GFNSSTLKDNLGAGYAEDYTTGAVMNFASVFAVLFNGCTGIMAGANMSGELKDPSRAIPLGTIVA 305

  Fly   385 LLISMSSYALFVLFAGGAAVRDASGIPADLVNGTIVSSELPCMATGNCTWGLFNSYEMMQEMSLW 449
            :..:...|.|....:.....|            |::..:          :|.|.:      :|||
Human   306 VAYTFFVYVLLFFLSSFTCDR------------TLLQED----------YGFFRA------ISLW 342

  Fly   450 GPLIYAGCFAATLSTALTNLLSVPRLVQALGIDQIYPGLIFFSKPYGKHGEPYRGYVLTFFITTG 514
            .||:..|.:|..||.::::|:...|::.||..|.::..::..:|...:.|.|:...:.::.:...
Human   343 PPLVLIGIYATALSASMSSLIGASRILHALARDDLFGVILAPAKVVSRGGNPWAAVLYSWGLVQL 407

  Fly   515 FLLIGELNLIAPLISTFYLASYALINFCTFHAAFVKPLGWRPTFKYYNAWLSLFGFAMCVAIMFL 579
            .||.|:||.:|.:::.|||.:||.::.......:.....:||||..::....|.|.|.|:.:|||
Human   408 VLLAGKLNTLAAVVTVFYLVAYAAVDLSCLSLEWASAPNFRPTFSLFSWHTCLLGVASCLLMMFL 472

  Fly   580 INYVAA---IITFGIIFALYLVVMYRKPEANWGSTTQAQQYKAALMAVHRLQNVSDHVKNYHPQV 641
            |:..||   ::..|::.||   :..|...::||..:||..:......:.||....||||.:.||:
Human   473 ISPGAAGGSLLLMGLLAAL---LTARGGPSSWGYVSQALLFHQVRKYLLRLDVRKDHVKFWRPQL 534

  Fly   642 LVLSGDPKTRPPLVDFGYLLTKNNSLMFVANII----------PVRVGYKNRQHLVKDGQKYLDA 696
            |:|.|:|:...||:.....| |...|..:.::.          ||:..|.....||       |.
Human   535 LLLVGNPRGALPLLRLANQL-KKGGLYVLGHVTLGDLDSLPSDPVQPQYGAWLSLV-------DR 591

  Fly   697 RKIKAFYNVIDGFSLEDGINALTKSTGFGKMSPNIVLVGYKPDWNRCRKEEVESYFSILYNAFSQ 761
            .::|||.::....|:..|...|.:.:|.|.|.||.:::|:..|      ...:.:| :...|||:
Human   592 AQVKAFVDLTLSPSVRQGAQHLLRISGLGGMKPNTLVLGFYDD------APPQDHF-LTDPAFSE 649

  Fly   762 RMGVALLRLPNGLDFSELSSEVTLPANGMGHMHT----ANAHGFTNELMPAANAA--SELLHIDS 820
            .              ::.:.|.:.||     :.|    ..|.|....|.|....|  ::.|.::.
Human   650 P--------------ADSTREGSSPA-----LSTLFPPPRAPGSPRALNPQDYVATVADALKMNK 695

  Fly   821 NLNLASMDSPNSSFTMPQPAPMPNMQRNSRSYKVTSSDEPAVTYHTKGGSDI-PQNLLDAMTIFT 884
            |:.||     .:|..:|.       :|.||....||.     .:|.    |: |.|||
Human   696 NVVLA-----RASGALPP-------ERLSRGSGGTSQ-----LHHV----DVWPLNLL------- 732

  Fly   885 RKQPK---GTIDVFWLYDDGGLTILLPYIISMRSHWQNSKLRVFAMCHGKDEE--QEEKSMASLL 944
              :|:   |.:||..|:     .:.:..|:.|...|.:::||:| :|.|..|.  ..|..:.:||
Human   733 --RPRGGPGYVDVCGLF-----LLQMATILGMVPAWHSARLRIF-LCLGPREAPGAAEGRLRALL 789

  Fly   945 TKFRIK--YSELIMLKGV-SEQPRADTVLKHKRLIEPFRRGARNEFGITDDELQSMSEKTNRQLR 1006
            ::.||:  ..|::..:|. :.:|.|:            ..|.....|..|.|.::::...|..:|
Human   790 SQLRIRAEVQEVVWGEGAGAGEPEAE------------EEGDFVNSGRGDAEAEALARSANALVR 842

  Fly  1007 IH------------ELVVKHSSNASLVVMSLPMPRKEAISAPLYMSWLEMLTSDMKCPVALARGN 1059
            ..            |.........:|..:.||.|..:....|.|::.||.||.|:. |..|..|
Human   843 AQQGRGTGGGPGGPEGGDAEGPITALTFLYLPRPPADPARYPRYLALLETLTRDLG-PTLLVHG- 905

  Fly  1060 QTPV 1063
            .|||
Human   906 VTPV 909

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NKCC	NP_730938.1	AA_permease_2	85..1068	CDD:459263	278/1044 (27%)
SLC12A9	NP_064631.2	AA_permease_2	36..905	CDD:459263	263/985 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	642..678		9/54 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	844..863		1/18 (6%)