DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NKCC and slc12a7b

DIOPT Version :9

Sequence 1:	NP_730938.1	Gene:	NKCC / 40663	FlyBaseID:	FBgn0051547	Length:	1068	Species:	Drosophila melanogaster
Sequence 2:	XP_005162967.1	Gene:	slc12a7b / 567667	ZFINID:	ZDB-GENE-030829-61	Length:	1138	Species:	Danio rerio

Alignment Length:	1307	Identity:	310/1307 - (23%)
Similarity:	504/1307 - (38%)	Gaps:	408/1307 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MADRFQISKVNGTANAGYDGEARSAESDQTDAAHPLPPTSNENHLHPKASGETGENRRSSR---- 61
            |::||.:..|   |:|     ..||..|:||.|...               :.||:.|:.:
Zfish     1 MSERFMVVPV---AHA-----EESAFGDETDGAPVF---------------DAGEDARAEQRGSL 42

  Fly    62 --LSFR------GFGN------FLRKSDAE-------RKFSLAQLTKESLPRLDNYRISMRNLKR 105
              |.:.      |.||      |:..:|.:       :..:|.:...:|.|.:.:....:.|...
Zfish    43 PILRYNREPNKYGDGNPRESSPFINNTDDDKGNLYDGKNMALFEEEMDSNPMVSSLLNKLANYTN 107

  Fly   106 PSIGELQGEAVDQ-----SITIPEPEPEATGGHIKLGWIVGVLIPCLLNIWGVMLFLRLSWVVAE 165
            .:.|..:.|..|:     ..|:..|:         :|..:||.:|||.||.||:||||::|:|..
Zfish   108 LTQGVREHEEADEDEGAKKQTVKSPQ---------MGTFIGVYLPCLQNILGVILFLRMTWIVGT 163

  Fly   166 SGILQSLIIITISAVVCVITTLSLSAISTNGEVKGGGVYFIISRSLGPEFGASVGVVFAFANAVS 230
            :|||::.||:::.....::|.:|:|||:|||.|..||.|::||||||||||.:||:.|......:
Zfish   164 AGILEAFIIVSMCCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFA 228

  Fly   231 ASMNTIGFCESL-------NVLLKNNDLKIVDNG---INDIRIVGSITVLVLILICCVGMEWETK 285
            .:|..:|..|.|       ..:.|..|.  .|..   :|::|:.|:..:.::.|:..||:::..|
Zfish   229 GAMYILGTIEILLTYIVPSAAIFKAEDK--ADEAEALLNNMRVYGTCCLTLMALVVFVGVKYVNK 291

  Fly   286 AQNFLIVTIVLAIFNFLIGA--------------------------------------------- 305
            .....:..:||:|.....|.
Zfish   292 LALVFLACVVLSILAIYAGVIKTIFEPPVFPVCVLGNRTLQNHDFDKCMKTEIIDNVTVTTKLWS 356

  Fly   306 --AIGPQGN---EEQIS-------RGFVGFSWATLKENFGSDY---------------------- 336
              ..||:.|   .|..:       :|..|.:...:.||....|
Zfish   357 LFCSGPELNASCNEYFTLNSVTEIQGIPGLTSGVISENMWGKYGPAGMLVEKDIPSVSASDSSQD 421

  Fly   337 RYAEGVNHD---FFSVF-AIFFPSVTGIQAGANICGDLKDAGAAIPKGTFWSL----LISMSSYA 393
            :|...|.:|   ||::. .|:|||||||.||:|..|||:||..:||.||..::    :|.:|...
Zfish   422 KYMPYVVNDITAFFTLLVGIYFPSVTGIMAGSNRSGDLRDAQRSIPIGTILAIATTTIIYLSCVV 486

  Fly   394 LFVLFAGGAAVRDASGIPADLVNGTIVSSELPCMATGNCTWGLFNSYEMMQEMSLWGPLIYAGCF 458
            ||.....|..:||..|   |.|.|.:|        .|..:|           .|.|  :|..|.|
Zfish   487 LFGACIEGVVLRDKFG---DSVKGNLV--------IGTLSW-----------PSPW--VIVIGSF 527

  Fly   459 AATLSTALTNLLSVPRLVQALGIDQIYPGLIFFSKPYGK-HGEPYRGYVLTFFITTGFLLIGELN 522
            .:.....|.:|...|||:||:..|.|.|.|..|.  :|| :|||....:||..|....:||..|:
Zfish   528 FSCCGAGLQSLTGAPRLLQAIARDGIVPFLEVFG--HGKANGEPTWALLLTALICESGILIASLD 590

  Fly   523 LIAPLISTFYLASYALINFCTFHAAFVKPLGWRPTFKYYNAWLSLFGFAMCVAIMFLINYVAAII 587
            .:||::|.|:|..|..:|........::...|||.||||:..||..|.::|:|:||:.::..|::
Zfish   591 AVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFKYYHWALSFLGMSLCLALMFISSWYYALV 655

  Fly   588 TFGIIFALYLVVMYRKPEANWGSTTQAQQYKAALMAVHRLQNVSDHVKNYHPQVLVLSG-DPK-- 649
            ...|...:|..:.||..|..||...:.....||..|:.||:....|.||:.||:|||.. |.:
Zfish   656 AMLIAGCIYKYIEYRGAEKEWGDGIRGLSLNAARYALIRLEEAPPHTKNWRPQMLVLLNLDSELC 720

  Fly   650 -TRPPLVDFGYLLTKNNSLMFVANIIPVRVGYKNRQHLVKDGQKYLD----ARKIKAFYNVIDGF 709
             ..|.|:.|...|.....|..|.:::  ...|.:|::..|..::.:.    |.|.|.|.:|:...
Zfish   721 VKHPRLLSFTTQLKAGKGLTIVGSVL--EGTYLSRENQAKRAEQNIKSAMAAEKTKGFCHVVVSS 783

  Fly   710 SLEDGINALTKSTGFGKMSPNIVLVGYKPDWNRCRKEEVESYFSILYNAFSQRMGVALLRLPNGL 774
            :|.|||:.|.:|.|.|.|..|.||:.:..:|.  :..:..::.|
Zfish   784 NLRDGISHLVQSAGLGGMKHNSVLMAWPSNWR--QSSDPHTWRS--------------------- 825

  Fly   775 DFSELSSEVTLPANGMGHMHTANAHGFTNELMPAANAASELLHIDSNLNLASMDSPNSSFTMPQP 839
             |.|...|.|.       .|.|        |:.|.|       :||
Zfish   826 -FIETVRETTA-------AHLA--------LLVAKN-------VDS------------------- 848

  Fly   840 APMPNMQRNSRSYKVTSSDEPAVTYHTKGGSDIPQNLLDAMTIFTRKQPKGTIDVFWLYDDGGLT 904
              .|:.:|.:                                       :|||||:|:..|||:.
Zfish   849 --FPHQERLT---------------------------------------EGTIDVWWIVHDGGML 872

  Fly   905 ILLPYIISMRSHWQNSKLRVFAMCHGKDEE-QEEKSMASLLTKFRIK-----------------Y 951
            :|||:::.....|:..|:|:|.:....|.. |.:|.:...|...|:.                 |
Zfish   873 MLLPFLLRQHKVWKKCKMRIFTVAQMDDNSIQMKKDLQMFLYHLRLNAEVEVVEMHDSDISAFTY 937

  Fly   952 SE-LIM--------------------LKGVSEQPRAD---------------------------- 967
            .: |:|                    ::.::::.|:.
Zfish   938 EKTLVMEQRSQMLKQMQLSRTEREREIQSITDESRSSIRRKNQSEAHSSSLQNQNTAHEQQDEAQ 1002

  Fly   968 --------------------------TVLKHKRLIEPFRRGARN-EFGITD-----DELQSMSEK 1000
                                      |..|.|...|..||...| ...:.|     .|.:|:::.
Zfish  1003 LIHDRNTASHTAMNDKADATPERVHMTWTKEKLFSERSRRTEANASMAVRDLFNMKPEWESLNQS 1067

  Fly  1001 TNR----QLRIHELVVKHSSNASLVVMSLPMPRKEAISAPLYMSWLEMLTSDMKCPVALARGNQT 1061
            ..|    .::::|::|..|..|.||::::|.|.|.......||.::|::...:. .|.|.||...
Zfish  1068 NVRCMHTAVKLNEVIVNKSQGAHLVLLNMPGPPKNRGGDENYMEFMEVMMEGLN-RVLLVRGGGR 1131

  Fly  1062 PVLTLYS 1068
            .|:|:||
Zfish  1132 EVITIYS 1138

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NKCC	NP_730938.1	2a30	85..1068	CDD:273347	286/1196 (24%)
		DUF502	507..>643	CDD:294696	45/135 (33%)
		SLC12	651..1068	CDD:281515	95/523 (18%)
slc12a7b	XP_005162967.1	2a30	58..1138	CDD:273347	290/1225 (24%)
		SLC5-6-like_sbd	182..>319	CDD:294310	43/138 (31%)
		SLC12	724..978	CDD:281515	66/361 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57166
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920