DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NKCC and slc7a14a

DIOPT Version :9

Sequence 1:	NP_730938.1	Gene:	NKCC / 40663	FlyBaseID:	FBgn0051547	Length:	1068	Species:	Drosophila melanogaster
Sequence 2:	NP_001334618.1	Gene:	slc7a14a / 566270	ZFINID:	ZDB-GENE-070912-112	Length:	785	Species:	Danio rerio

Alignment Length:	451	Identity:	92/451 - (20%)
Similarity:	179/451 - (39%)	Gaps:	105/451 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 TGGH-IKLGWIVGVLIPCLLNIW---GVMLFLRLSWVVAES----GILQSLIIITISAV---VCV 183
            ||.| .||..::..:....|.:.   |..::: :|.:||:.    |::.|.||..::::   ||.
Zfish    42 TGAHGTKLARVLSTVDLVSLGVGSCVGTGMYV-VSGLVAKEMAGPGVIVSFIIAAVASILSGVCY 105

  Fly   184 ------ITTLSLSAISTNGEVKGGGVYFIISRSLGPEF--GASVGVVFAFANAVSASMNTI---- 236
                  :...:.||.:.:....|..|.|.|..:|..|:  |.:.|     |:|:|:..:::
Zfish   106 AEFGVRVPKTTGSAYTYSYVTVGEFVAFFIGWNLILEYLIGTAAG-----ASALSSMFDSLANHS 165

  Fly   237 --GFCESLNVLLKNNDLKIVDNGINDI--RIVGSITVLVLILICCVGMEWETKAQNFL-IVTIVL 296
              ||  .:|.:...|.|...:....||  .::|   :||.::: .:|::......|.| ::.:|:
Zfish   166 ISGF--MINHIGTLNGLGKGEQSYPDILALVIG---ILVTVIV-ALGVKNSVGFNNVLNVINLVV 224

  Fly   297 AIFNFLIGAAIGPQGNEEQISRGFVGFSWATLKENFGSDYRYAEGVNHDFFSVFAIFFPSVTGIQ 361
            .:|..:.|.......|.::  ..|:.:.|:.:          .:|....|::.......:.||.:
Zfish   225 WVFIMIAGLFFVSGSNWDE--GRFLPYGWSGV----------MQGAATCFYAFIGFDIIATTGEE 277

  Fly   362 AGANICGDLKDAGAAIPKGTFWSLLISMSSYALFVLFAGGAAVRDASGIPADLVNGTIVSSELPC 426
            |        |....:||.....||:..:::|.            ..|.|...:|..|.:.|:.|
Zfish   278 A--------KSPNTSIPYAITASLVTCLTAYV------------SVSVILTLMVPYTEIDSDAP- 321

  Fly   427 MATGNCTWGLFNSYEMMQEMSLWG-----PLIYAGCFAATLSTALTNLLSVPRLVQALGIDQIYP 486
                           :|:..||.|     .::..|..|....:.|.:|..:||::.|:..|
Zfish   322 ---------------LMEMFSLHGFQTAKYIVAIGSIAGLTVSLLGSLFPMPRVIYAMAGD---- 367

  Fly   487 GLIFFSKPYGKHGEPYRGYVLTFFITTGFL-----LIGELNLIAPLISTFYLASYALINFC 542
            ||:|   .:..|...|........:.:|||     |:..|..:..::|...|.:|.|::.|
Zfish   368 GLLF---RFLAHVSTYTETPAVACVVSGFLSALLALLVSLRDLIEMMSIGTLLAYTLVSVC 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NKCC	NP_730938.1	2a30	85..1068	CDD:273347	92/451 (20%)
		DUF502	507..>643	CDD:294696	10/41 (24%)
		SLC12	651..1068	CDD:281515
slc7a14a	NP_001334618.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	715..785
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910