DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment NKCC and slc12a3

DIOPT Version :9

Sequence 1:NP_730938.1 Gene:NKCC / 40663 FlyBaseID:FBgn0051547 Length:1068 Species:Drosophila melanogaster
Sequence 2:NP_001038545.1 Gene:slc12a3 / 565439 ZFINID:ZDB-GENE-030131-9505 Length:1012 Species:Danio rerio


Alignment Length:1089 Identity:420/1089 - (38%)
Similarity:603/1089 - (55%) Gaps:157/1089 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    56 NRRSSRLSFRGFGNFLRKSDAERKFSLAQL--------------------TKESLPRLDNYR--- 97
            |.:|:|..|.  .:.|...| :|||||...                    |.::.|..|.|.   
Zfish     2 NLQSARSPFS--VSSLSNGD-DRKFSLGGCSSYDTDSVASRSSGVFSGYDTLDAPPSYDFYTNTE 63

  Fly    98 -ISMRNLKRPSIGELQGEAVDQSITIP-------------------EPEPEATGGHIKLGWIVGV 142
             .......|||:.||.....|.....|                   ||.||..    :.||..||
Zfish    64 VFGRAKKSRPSLFELHSNPQDDPSPPPLYEESSVDKQSPEDEDEPTEPPPEPA----RFGWAQGV 124

  Fly   143 LIPCLLNIWGVMLFLRLSWVVAESGILQSLIIITISAVVCVITTLSLSAISTNGEVKGGGVYFII 207
            :|.|:||||||:|:|||.|:.|::||..:.|||.:|:.:..||.||.|||:|||:|||||.||:|
Zfish   125 MIRCMLNIWGVILYLRLPWITAQAGIGLTWIIILVSSSITGITGLSTSAIATNGKVKGGGTYFLI 189

  Fly   208 SRSLGPEFGASVGVVFAFANAVSASMNTIGFCESLNVLLKNNDLKIVDNGINDIRIVGSITVLVL 272
            |||||||.|.|:|::|||||||:.:|:|:||.|::.||::..::.:||. :|||||:|.|||..|
Zfish   190 SRSLGPELGGSIGLIFAFANAVAVAMHTVGFAETVQVLMQETEVSMVDK-LNDIRIIGVITVTCL 253

  Fly   273 ILICCVGMEWETKAQNFLIVTIVLAIFNFLIGAAIGPQGNEEQISRGFVGFSWATLKENFGSDYR 337
            :.|...|||||:|||......|:::..:::||..| |...::| :|||..:.......||...:|
Zfish   254 LAISMAGMEWESKAQVLFFFVIMISFASYIIGTII-PATPQKQ-ARGFFSYRADIFATNFVPGWR 316

  Fly   338 YAEGVNHDFFSVFAIFFPSVTGIQAGANICGDLKDAGAAIPKGTFWSLLISMSSYALFVLFAGGA 402
            ..||   .||.:|:|||||.|||.|||||.|||||...|||:||..::..:..||.:.....|..
Zfish   317 GPEG---SFFGMFSIFFPSATGILAGANISGDLKDPNVAIPRGTMLAIFWTTVSYLIISATIGSC 378

  Fly   403 AVRDASGIPADLVNGTIVS--------------SELPCMATGNCTWGLFNSYEMMQEMSLWGPLI 453
            .||||||.    ||.||.|              :...||....||:||.|.|:.|..:|...|||
Zfish   379 VVRDASGD----VNDTISSLTGECLGVGCNYGWNFTDCMTNNTCTYGLSNYYQSMSMVSAVAPLI 439

  Fly   454 YAGCFAATLSTALTNLLSVPRLVQALGIDQIYPGLIFFSKPYGKHGEPYRGYVLTFFITTGFLLI 518
            .||.|.||||:||..|:|.|::.|.|..|::|||:.||.|.|||:.||.|.|:|.:.|...|:||
Zfish   440 TAGIFGATLSSALACLVSAPKVFQCLCKDKLYPGIGFFGKGYGKNNEPLRSYLLAYIIAICFILI 504

  Fly   519 GELNLIAPLISTFYLASYALINFCTFHAAFVKPLGWRPTFKYYNAWLSLFGFAMCVAIMFLINYV 583
            .|||.|||:||.|:|.|||||||..|||:.....||||||::|:.||||.|..:.|.||||:.:.
Zfish   505 AELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPTFRFYSKWLSLLGAVVSVIIMFLLTWW 569

  Fly   584 AAIITFGIIFALYLVVMYRKPEANWGSTTQAQQYKAALMAVHRLQNVSDHVKNYHPQVLVLSGDP 648
            ||:|..||:..|...|:|:|||.||||:.||..|..||.....|..|.||:|||.||.|||||.|
Zfish   570 AALIAIGIVIFLLGYVLYKKPEVNWGSSMQASSYNMALSQCVGLNQVEDHIKNYRPQCLVLSGPP 634

  Fly   649 KTRPPLVDFGYLLTKNNSLMFVANII-----PVRVGYKNRQHLVKDGQKYLDARKIKAFYNVIDG 708
            ..||.||||....|||.|||..||::     |......:..||     |:|:.||||:||:.:..
Zfish   635 CARPSLVDFIGAFTKNQSLMICANVLASGPSPGTADSMSSTHL-----KWLNNRKIKSFYHTVVA 694

  Fly   709 FSLEDGINALTKSTGFGKMSPNIVLVGYKPDWNRCRKEEVESYFSILYNAFSQRMGVALLRLPNG 773
            ..|..|:..|.:|||.|:|.||::::|||.:|.:.:...:|:|..||::||..:.||.:||:..|
Zfish   695 DDLRTGVQMLLQSTGLGRMKPNVLVMGYKKNWRKVQPGIIENYVGILHDAFDLQYGVCVLRMKEG 759

  Fly   774 LDFSE-LSSEVTLPANGMGHMHTANAHGF-TNELMPAANAASELLHIDSNLNLASMDSPNSSFTM 836
            ||.:. :.::|.|      ...|:...|. ||...|.:....           ||:| |.:...:
Zfish   760 LDITRTIQAQVNL------GFETSTEQGLDTNSTAPTSPTIE-----------ASLD-PETLMAL 806

  Fly   837 PQPAPMPNMQRNSRSYKVTSSDEPAVTYHTKGGSDIPQNLLDAMTIFTRKQPKGTIDVFWLYDDG 901
            .||:                                        |:|..:|.|.||||:||.|||
Zfish   807 TQPS----------------------------------------TLFQTRQGKKTIDVYWLSDDG 831

  Fly   902 GLTILLPYIISMRSHWQNSKLRVFAMCHGKDEEQEEKSMASLLTKFRIKYSELIMLKGVSEQPRA 966
            |||:|:||:::.:..|...|:|||.....:..|:::|.:..|:::||:.:.::.:|..::..|::
Zfish   832 GLTLLIPYLLTRKKRWGRCKVRVFVGGEAQQIEEQKKELKGLISRFRLGFKDIQVLPDINGAPQS 896

  Fly   967 DTVLKHKRLIEPFRRG-----------ARNEFG--ITDDELQSMSEKTNRQLRIHELVVKHSSNA 1018
            :.:.|.:..|.|:|..           |..||.  ::|:|:::...|:.||:|::|::..:|.:|
Zfish   897 EHIRKFEDFIAPYRVSSVQKDGQEADEATKEFSWMVSDEEMETFKAKSLRQIRLNEVIQDYSRDA 961

  Fly  1019 SLVVMSLPMPRKEAISAPLYMSWLEMLTSDMKCPVALARGNQTPVLTLY 1067
            :|:|:::|:.|:.:..:||||:|||:::.|::.||.|.||||..|||.|
Zfish   962 ALIVVTMPVGRRGSCPSPLYMAWLEIVSRDLRPPVLLVRGNQENVLTQY 1010

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NKCCNP_730938.1 2a30 85..1068 CDD:273347 409/1060 (39%)
DUF502 507..>643 CDD:294696 71/135 (53%)
SLC12 651..1068 CDD:281515 135/437 (31%)
slc12a3NP_001038545.1 AA_permease_N 34..101 CDD:285588 11/66 (17%)
2a30 48..1011 CDD:273347 409/1040 (39%)
GtrA <490..589 CDD:303012 51/98 (52%)
SLC12 637..1011 CDD:281515 135/437 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 817 1.000 Inparanoid score I458
OMA 1 1.010 - - QHG57166
OrthoDB 1 1.010 - - D135130at33208
OrthoFinder 1 1.000 - - FOG0001536
OrthoInspector 1 1.000 - - mtm6412
orthoMCL 1 0.900 - - OOG6_101360
Panther 1 1.100 - - O PTHR11827
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
ZFIN 00.000 Not matched by this tool.
109.940

Return to query results.
Submit another query.