DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment NKCC and Slc12a3

DIOPT Version :9

Sequence 1:NP_730938.1 Gene:NKCC / 40663 FlyBaseID:FBgn0051547 Length:1068 Species:Drosophila melanogaster
Sequence 2:NP_062218.3 Gene:Slc12a3 / 54300 RGDID:3686 Length:1002 Species:Rattus norvegicus


Alignment Length:1084 Identity:413/1084 - (38%)
Similarity:591/1084 - (54%) Gaps:167/1084 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    37 PPTSNEN----HLHPKASGETGENRRSSRLSFRGFG-NFLRKSDAERKFSLAQLTKESLPRLDNY 96
            ||.:.:|    ||           ...|.|..|.|| |.:....|...::.:.|..|  ||  ..
  Rat    31 PPAACDNSQPSHL-----------THGSTLYLRTFGYNTIDVVPAYEHYANSALPGE--PR--KV 80

  Fly    97 RISMRNLK-----------------RPSIGELQGEAVDQSITIPEPEPEATGGHIKLGWIVGVLI 144
            |.::.:|.                 ||......|...|::....|..|   |..::.||:.||:|
  Rat    81 RPTLADLHSFLKQEGSHLHALAFDGRPGHELTDGLVEDETGANSEKSP---GEPVRFGWVKGVMI 142

  Fly   145 PCLLNIWGVMLFLRLSWVVAESGILQSLIIITISAVVCVITTLSLSAISTNGEVKGGGVYFIISR 209
            .|:||||||:|:|||.|:.|::||:.:.:||.:|.:|..||.||:|||||||:||.||.||:|||
  Rat   143 RCMLNIWGVILYLRLPWITAQAGIVLTWLIILLSVMVTSITGLSISAISTNGKVKSGGTYFLISR 207

  Fly   210 SLGPEFGASVGVVFAFANAVSASMNTIGFCESLNVLLKNNDLKIVDNGINDIRIVGSITVLVLIL 274
            |||||.|.|:|::|||||||..:|:|:||.|::..||:.|...||| .||||||:|.:||.||:.
  Rat   208 SLGPELGGSIGLIFAFANAVGVAMHTVGFAETVRDLLQENGTPIVD-PINDIRIIGVVTVTVLLA 271

  Fly   275 ICCVGMEWETKAQNFLIVTIVLAIFNFLIGAAIGPQGNEEQISRGFVGFSWATLKENFGSDYRYA 339
            |...|||||:|||....:.|:::..|:|:|..|  ..::::.|:||..:......:|...|:|  
  Rat   272 ISLAGMEWESKAQVLFFLVIMVSFANYLVGTLI--PASKDKASKGFYSYHGDIFVQNLVPDWR-- 332

  Fly   340 EGVNHDFFSVFAIFFPSVTGIQAGANICGDLKDAGAAIPKGTFWSLLISMSSYALFVLFAGGAAV 404
             |::..||.:|:|||||.|||.|||||.|||||...||||||..::..:..||.......|...|
  Rat   333 -GIDGSFFGMFSIFFPSATGILAGANISGDLKDPAVAIPKGTLMAIFWTTISYLAISATIGSCVV 396

  Fly   405 RDASGIPADLVNGTIVSSELPC--MATG------------NCTWGLFNSYEMMQEMSLWGPLIYA 455
            |||||.    ||.|:......|  :|.|            :|.:||.|.|:.|..:|.:.|||.|
  Rat   397 RDASGD----VNDTVTPGPGLCEGLACGYGWNFTECSQQHSCRYGLINYYQTMSMVSAFAPLITA 457

  Fly   456 GCFAATLSTALTNLLSVPRLVQALGIDQIYPGLIFFSKPYGKHGEPYRGYVLTFFITTGFLLIGE 520
            |.|.||||:||..|:|..::.|.|..||:||.:.||.|.|||:.||.|||:|.:.|...|::|.|
  Rat   458 GIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAVAFIIIAE 522

  Fly   521 LNLIAPLISTFYLASYALINFCTFHAAFVKPLGWRPTFKYYNAWLSLFGFAMCVAIMFLINYVAA 585
            ||.|||:||.|:|.|||||||..|||:.....||||:|:||:.|.:|||..:.|.||||:.:.||
  Rat   523 LNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFRYYSKWAALFGAVISVVIMFLLTWWAA 587

  Fly   586 IITFGIIFALYLVVMYRKPEANWGSTTQAQQYKAALMAVHRLQNVSDHVKNYHPQVLVLSGDPKT 650
            :|..|::..|.|.|:|:|||.||||:.||..|..||.....|..|.||:|||.||.|||:|.|..
  Rat   588 LIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDHIKNYRPQCLVLTGPPNF 652

  Fly   651 RPPLVDFGYLLTKNNSLMFVANIIPVRVGYKNR---QHLVKDGQ-KYLDARKIKAFYNVIDGFSL 711
            ||.||||....|:|.|||...::: :..| |.|   ..|:..|. |:|:.|||||||:.:....|
  Rat   653 RPALVDFVSTFTQNLSLMICGHVL-IAPG-KQRVPELRLIASGHTKWLNKRKIKAFYSDVIAEDL 715

  Fly   712 EDGINALTKSTGFGKMSPNIVLVGYKPDWNRCRKEEVESYFSILYNAFSQRMGVALLRLPNGLDF 776
            ..|:..|.:::|.|:|.|||::||:|.:|.......:|.|..||::||....||.::|:..||:.
  Rat   716 RSGVQILMQASGLGRMKPNILVVGFKKNWQSAHPATLEDYIGILHDAFDFNYGVCIMRMREGLNV 780

  Fly   777 SELSSEVTLPANGMGHMHTANAHGFTNELMPAANAASELLHIDSNLNLASMDSPNSSFTMPQPAP 841
            ||..           ..|||          |.|....|                           
  Rat   781 SEAL-----------QTHTA----------PEALVQEE--------------------------- 797

  Fly   842 MPNMQRNSRSYKVTSSDEPAVTYHTKGGSDIPQNLLDAMTIFTRKQPKGTIDVFWLYDDGGLTIL 906
                                                ...|||..:|.|.|||::||:||||||:|
  Rat   798 ------------------------------------QTSTIFQSEQGKKTIDIYWLFDDGGLTLL 826

  Fly   907 LPYIISMRSHWQNSKLRVFAMCHGKDEEQEEKSMASLLTKFRIKYSELIMLKGVSEQPRADTVLK 971
            :||::..:..|...|:|||........::|.|::.|||:|||:.:.|:.:|..::::|:.:...:
  Rat   827 IPYLLHRKKRWGKCKIRVFVGGQINRMDEERKAIISLLSKFRLGFHEVHVLPDINQKPQVEHTKR 891

  Fly   972 HKRLIEPFR--RGARNE-----------FGITDDELQSMSEKTNRQLRIHELVVKHSSNASLVVM 1023
            .:.:|.|||  .|.::|           :.|:|:|:.....|:.||:|::|:::.:|.:|:|:::
  Rat   892 FEDMIAPFRLNDGFKDEATVAEMRRDYPWKISDEEINKNRIKSLRQVRLNEILLDYSRDAALIIL 956

  Fly  1024 SLPMPRKEAISAPLYMSWLEMLTSDMKCPVALARGNQTPVLTLY 1067
            :||:.||....:.|||:|||.|:.|:..||.|.||||..|||.|
  Rat   957 TLPIGRKGKCPSSLYMAWLETLSQDLSPPVLLIRGNQENVLTFY 1000

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NKCCNP_730938.1 2a30 85..1068 CDD:273347 401/1031 (39%)
DUF502 507..>643 CDD:294696 69/135 (51%)
SLC12 651..1068 CDD:281515 132/434 (30%)
Slc12a3NP_062218.3 2a30 57..1001 CDD:273347 403/1047 (38%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG57166
OrthoDB 1 1.010 - - D135130at33208
OrthoFinder 1 1.000 - - FOG0001536
OrthoInspector 1 1.000 - - mtm8955
orthoMCL 1 0.900 - - OOG6_101360
Panther 1 1.100 - - O PTHR11827
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
98.930

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