Protein Alignment NKCC and Ncc69

DIOPT Version :10

• Sequence 1: NP_730938.1
• Gene: NKCC / 40663
• FlyBaseID: FBgn0051547
• Length: 1068
• Species: Drosophila melanogaster
• Sequence 2: NP_001261758.1
• Gene: Ncc69 / 39410
• FlyBaseID: FBgn0036279
• Length: 1207
• Species: Drosophila melanogaster
• Alignment Length: 1207
• Identity: 525/1207 - (43%)
• Similarity: 730/1207 - (60%)
• Gaps: 158/1207 - (13%)

  Fly     3 DRFQISKVNGT---------------------ANAGYDG-----------EARSAESDQTDAAHP 35
            :|||::.|||.                     |.||.||           |....|.|..||...
  Fly    18 NRFQVNPVNGNSRKSQGADGPGSGSGAGAGAGAGAGEDGPHEVYRRLTNAEGELLEDDTFDATQM 82

  Fly    36 LPPTSNENHLHPKASGETGENRRSSRLSFRGFGNFLR-----------------------KSDAE 77
            |      |...|:      :.|:|.:.|||......|                       .|..|
  Fly    83 L------NQRQPR------QQRQSIKSSFRDKDKPSRFKDLQTTTRFQVDPQNEESDESNDSQEE 135

  Fly    78 RKF-----------SLAQLTKESLPRLDNYR--ISMRNLKRPSIGELQGEAV----DQSIT-IPE 124
            |:.           |....|:|:||||||||  :|::...||::.||....:    ..|:| ..:
  Fly   136 RELLDNEYDTKYGKSFRHFTREALPRLDNYRNMMSIQAAYRPTLDELHNATLVGKNTHSLTRNQD 200

  Fly   125 PEPEATGGHIKLGWIVGVLIPCLLNIWGVMLFLRLSWVVAESGILQSLIIITISAVVCVITTLSL 189
            ||.....|.:|.|||.|||:.||||||||||||||||||.::|:::..::|..:..|..||.||:
  Fly   201 PESGILNGVLKFGWIKGVLVRCLLNIWGVMLFLRLSWVVGQAGVIEGFVLILTTTAVTTITALSM 265

  Fly   190 SAISTNGEVKGGGVYFIISRSLGPEFGASVGVVFAFANAVSASMNTIGFCESLNVLLKNNDLKIV 254
            |||||||.:||||.|::||||||||||.|:|::|:.||||:.:|..:|||||:..::.....:|:
  Fly   266 SAISTNGVIKGGGTYYMISRSLGPEFGGSIGLIFSLANAVACAMYVVGFCESMLAMMTTFGWEII 330

  Fly   255 DNGINDIRIVGSITVLVLILICCVGMEWETKAQNFLIVTIVLAIFNFLIGAAIGPQGNEEQISRG 319
            |.|:.|:||:|.||:|:|::|..||||||.|||..|::.:::||.:|:||:.|||:.:.| :::|
  Fly   331 DGGVQDVRIIGCITILLLLIIVVVGMEWEAKAQIGLLIILLVAIGDFVIGSFIGPKSDAE-MAKG 394

  Fly   320 FVGFSWATLKENFGSDYRYAE-GVNHDFFSVFAIFFPSVTGIQAGANICGDLKDAGAAIPKGTFW 383
            |:|::....|.|..:|||..: |:.||||||||||||:.|||.|||||.|||||...:|||||..
  Fly   395 FLGYNATLFKNNLFADYRPEKGGIQHDFFSVFAIFFPAATGILAGANISGDLKDPQKSIPKGTIL 459

  Fly   384 SLLISMSSYALFVLFAGGAAVRDASGIPADLVNGTIVSSELPCMATGNCTWGLFNSYEMMQEMSL 448
            :::|:..:|.:.||..|....|||:|..:|:||||.  :.|.|. .|.|.:||.||:::::.:|.
  Fly   460 AIVITTGTYLIMVLQCGATVARDATGNLSDVVNGTF--AFLDCQ-PGECNYGLQNSFQVIELVSA 521

  Fly   449 WGPLIYAGCFAATLSTALTNLLSVPRLVQALGIDQIYPGLIFFSKPYGKHGEPYRGYVLTFFITT 513
            :||||||||:|||||:||.:|:|.|::.|||..|::||.:::|:|.|||:.||.|||||||.|..
  Fly   522 FGPLIYAGCYAATLSSALASLVSAPKVFQALCKDELYPKIVWFAKGYGKNNEPVRGYVLTFIIAC 586

  Fly   514 GFLLIGELNLIAPLISTFYLASYALINFCTFHAAFVKPLGWRPTFKYYNAWLSLFGFAMCVAIMF 578
            .|:|||||||||||||.|:||:|.||||.||||:..||:||||||||||.||||.|..:|||:||
  Fly   587 AFILIGELNLIAPLISNFFLAAYMLINFSTFHASLAKPVGWRPTFKYYNMWLSLLGAILCVAVMF 651

  Fly   579 LINYVAAIITFGIIFALYLVVMYRKPEANWGSTTQAQQYKAALMAVHRLQNVSDHVKNYHPQVLV 643
            ||::..|:|||..:.||||:|.||||:.|||||||||.||.|||:|.:|.||.:|||||.||:||
  Fly   652 LISWATALITFAAVLALYLIVAYRKPDVNWGSTTQAQTYKNALMSVQQLNNVEEHVKNYRPQILV 716

  Fly   644 LSGDPKTRPPLVDFGYLLTKNNSLMFVANIIPVRVGYKNRQHLVKDGQKYLDARKIKAFYNVIDG 708
            |||.|.|||.|||..|:||||.||:...:::......|.|.:|.:....:....::|.||.::||
  Fly   717 LSGLPNTRPVLVDLAYMLTKNLSLLVCGHVLKGSSSQKYRTYLQERAGNWFRKHRVKGFYALVDG 781

  Fly   709 FSLEDGINALTKSTGFGKMSPNIVLVGYKPDWNRCRKEEVESYFSILYNAFSQRMGVALLRLPNG 773
            ...|.|..||.::||.||:.|||:|:|||.||..|..:|::.||::::.|....:.||:||:|.|
  Fly   782 EDFESGTRALMQATGIGKLKPNIILMGYKTDWQTCDHKELDQYFNVMHKALDMYLSVAILRVPQG 846

  Fly   774 LDFSEL---------SSEV--TL-PANGMGHMHTANA---HGFTNELMPAANAAS-------ELL 816
            ||.|::         .|:|  || |....|.:...::   :|.:..:...:...|       :|:
  Fly   847 LDCSQVLGSQDGWKTVSDVPRTLQPNESSGDLQAVDSSVRNGLSGSIDSLSRNVSQEDRNRNQLV 911

  Fly   817 HIDSN-LNL-----------------ASMDSPNSSFT----------MPQP--APMPNMQRNSRS 851
            |.:.| |.:                 |:..:.:.||.          ||.|  |...|:..||..
  Fly   912 HSEQNSLKIVKLRFKQGLRRMRSWPGAASSTSDLSFIAGNQSKDVSGMPDPLDAKSANLVSNSLR 976

  Fly   852 YKVTSSDEPAVTYHTKGGSDIPQNLLDAMTIFTRKQPKGTIDVFWLYDDGGLTILLPYIISMRSH 916
            ......|:||..|...||:::|:.:|..:|.||||:....|||:|||||||||:|||||||.|..
  Fly   977 KSKLKHDDPASLYKGPGGAELPKEVLADLTQFTRKRSHAVIDVWWLYDDGGLTLLLPYIISTRRT 1041

  Fly   917 WQNSKLRVFAMCHGKDE-EQEEKSMASLLTKFRIKYSELIMLKGVSEQPRADTVLKHKRLIEPF- 979
            ||:.||||:|:.:...| |.|::||||||:||||.||:|.::..::::|:..:......||:.|
  Fly  1042 WQSCKLRVYALANKNSELEFEQRSMASLLSKFRIDYSDLTLIPDITKKPQETSTQFFNELIKDFV 1106

  Fly   980 -----------RRGARNEFG--ITDDELQSMSEKTNRQLRIHELVVKHSSNASLVVMSLPMPRKE 1031
                       .|...||..  ||||:|.::.:||||.||:.|.:.:.|:.:.||||:||||||.
  Fly  1107 VTEKDGENGTSSRATLNEDDALITDDDLLAVQDKTNRYLRLREYLREQSTKSDLVVMTLPMPRKN 1171

  Fly  1032 AISAPLYMSWLEMLTSDMKCPVALARGNQTPVLTLYS 1068
            .:||||||:|||.|:.||. |....|||||.|||.||
  Fly  1172 IVSAPLYMAWLESLSRDMP-PFLFVRGNQTSVLTFYS 1207

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NKCC	NP_730938.1	AA_permease_2	85..1068	CDD:459263	494/1057 (47%)
Ncc69	NP_001261758.1	AA_permease_2	155..1207	CDD:459263	494/1056 (47%)