Protein Alignment NKCC and kcc

DIOPT Version :9

• Sequence 1: NP_730938.1
• Gene: NKCC / 40663
• FlyBaseID: FBgn0051547
• Length: 1068
• Species: Drosophila melanogaster
• Sequence 2: NP_001286795.1
• Gene: kcc / 37800
• FlyBaseID: FBgn0261794
• Length: 1077
• Species: Drosophila melanogaster
• Alignment Length: 1238
• Identity: 286/1238 - (23%)
• Similarity: 492/1238 - (39%)
• Gaps: 352/1238 - (28%)

  Fly    21 EARSAESDQTDAAHPLPPTSNENHLHPKASGETGENRRSSRLSFRGFGNFLRKSDAERKFSLAQL 85
            ::.||:.|..:.  .:.|:.:...:|...:.::|:..|:..         .:||..:....|...
  Fly     2 QSNSAKDDSDEM--EIIPSEHNGTVHETKNEDSGDIHRAEE---------NQKSSIDPNLYLYDD 55

  Fly    86 TKESLPRLDNYRISMRNLKRPSIGELQGEAVDQSITIP---EPEPEATGGHIKLGWIVGVLIPCL 147
            ..|:.|.:..:..|:.|.:.               |||   :|:.:......::|.::||.:||:
  Fly    56 DLETRPHISTFISSIANYEN---------------TIPAATDPDAKPAAPSARMGTLIGVFLPCI 105

  Fly   148 LNIWGVMLFLRLSWVVAESGILQSLIIITISAVVCVITTLSLSAISTNGEVKGGGVYFIISRSLG 212
            .||:||:||:||:|||..:|.:...:|:.....|.::|.:|:|||:|||.|..||.||:||||||
  Fly   106 QNIFGVILFIRLTWVVGTAGAVCGFLIVLTCCCVTMLTAISMSAIATNGVVPAGGSYFMISRSLG 170

  Fly   213 PEFGASVGVVFAFANAVSASMNTIGFCESLNVLLK------NNDLKIVDNGINDIRIVGSITVLV 271
            ||||.:||::|.....::|:|..:|..|.:...:.      .:..|..|...|:.|:.|::.::.
  Fly   171 PEFGGAVGMLFYTGTTLAAAMYIVGAVEIVLTYMAPWASIFGDFTKDADAMYNNFRVYGTLLLIF 235

  Fly   272 LILICCVGMEWETKAQNFLIVTIVLAIFNFLIGAAIGPQGNEEQIS------------------- 317
            :.||..:|:::..|.....:..::|:|....:|......|||:...
  Fly   236 MGLIVFLGVKFVNKFATVALACVILSIIAVYVGIFDNIHGNEKLYMCVLGKRLLKDIPLENCTKE 300

  Fly   318 --------------------------RGFVGFSWATLKENF------------------------ 332
                                      :|..|.:.....:|.
  Fly   301 DSFLRDIYCPDGKCEEYYLANNVTKVKGIKGLASGVFYDNIFPSFLEKGQFISYGKSAIDIENTS 365

  Fly   333 GSDY-RYAEGVNHDFFSVFAIFFPSVTGIQAGANICGDLKDAGAAIPKGTFWSLLISMSSYALFV 396
            |..| :....:...|..:..|||||||||.||:|..|||.||..:||.||..::|.:.:.|...|
  Fly   366 GESYNQIMADITTSFTLLIGIFFPSVTGIMAGSNRSGDLADAQKSIPIGTICAILTTSTVYLSSV 430

  Fly   397 LFAGGAA----VRDASGIPADLVNGTIVSSELPCMATGNCTWGLFNSYEMMQEMSLWGPLIYAGC 457
            :|..|..    :||..|   ..:.|.:|        ..|..|           .:.|  :|..|.
  Fly   431 MFFAGTVDNLLLRDKFG---QSIGGKLV--------VANIAW-----------PNQW--VILIGS 471

  Fly   458 FAATLSTALTNLLSVPRLVQALGIDQIYPGLIFFSKPYGKHGEPYRGYVLTFFITTGFLLIGELN 522
            |.:||...|.:|...|||:||:..|:|.|.|..|:|. .|.|||.|..:||..|....:|:|.::
  Fly   472 FLSTLGAGLQSLTGAPRLLQAIARDEIIPFLAPFAKS-SKRGEPTRALLLTIVICQCGILLGNVD 535

  Fly   523 LIAPLISTFYLASYALINFCTFHAAFVKPLGWRPTFKYYNAWLSLFGFAMCVAIMFLINYVAAII 587
            |:|||:|.|:|..|..:|........::...|||.||:|:..|||.|..:|:::|.:.::..|:|
  Fly   536 LLAPLLSMFFLMCYGFVNLACAVQTLLRTPNWRPRFKFYHWSLSLIGLTLCISVMIMTSWYFALI 600

  Fly   588 TFGIIFALYLVVMYRKPEANWGSTTQAQQYKAALMAVHRLQNVSDHVKNYHPQVLVLS--GD--- 647
            ..|:...:|..:.||..|..||...:.....||..::.||:....|.||:.||:||||  .|
  Fly   601 AMGMAIIIYKYIEYRGAEKEWGDGIRGMALTAARYSLLRLEEGPPHTKNWRPQILVLSKLNDNLL 665

  Fly   648 PKTRPPLVDFGYLLTKNNSLMFVANIIPVRVGYKNRQHLVKDG----QKYLDARKIKAFYNVIDG 708
            ||.| .:..|...|.....|....::|  :..:....:...|.    :||:...|:|.|.:|:..
  Fly   666 PKYR-KIFSFATQLKAGKGLTICVSVI--KGDHTKITNKAVDAKATLRKYMTDEKVKGFCDVLVA 727

  Fly   709 FSLEDGINALTKSTGFGKMSPNIVLVGYKPDWNRCRKEEVESYFSILYNAFSQRMGVALLRLPNG 773
            ..:.:|::::.::.|.|.|.||.|::|:...|.:..:...:::...:....:..|.   |.:|.|
  Fly   728 QQIGEGLSSVIQTIGLGGMKPNTVIIGWPYSWRQEGRNSWKTFIQTVRTVAACHMA---LMVPKG 789

  Fly   774 LDFSELSSEVTLPANGMGHMHTANAHGFTNELMPAANAASELLHIDSNLNLASMDSPNSSFTMPQ 838
            ::|                             .|.:|
  Fly   790 INF-----------------------------YPESN---------------------------- 797

  Fly   839 PAPMPNMQRNSRSYKVTSSDEPAVTYHTKGGSDIPQNLLDAMTIFTRKQPKGTIDVFWLYDDGGL 903
                                      |..||:                     ||::|:..||||
  Fly   798 --------------------------HKIGGN---------------------IDIWWIVHDGGL 815

  Fly   904 TILLPYIISMRSHWQNSKLRVFAMCHGKDEE-QEEKSMASLLTKFRIK----------------- 950
            .:|||:::.....|:|.|||:|.:...:|.. |.:|.:.:.|...||:
  Fly   816 LMLLPFLLKQHRTWRNCKLRIFTVAQIEDNSIQMKKDLKTFLYHLRIEADVEVVEMNNSDISAYT 880

  Fly   951 YSELIMLKGVSEQPRA------------DTVLKHK----------------------------RL 975
            |...:|::..::..||            .|::.:|                            |.
  Fly   881 YERTLMMEQRNQMLRALGLNKKENSKVVQTIMDYKETPSDNKMSLVQTIVDHHYDATKTASKVRF 945

  Fly   976 IEPFRRGARNEFGITDDELQSM-----------------SEKTNR-------------------- 1003
            .:|.....::.....|::..|:                 .|.|.:
  Fly   946 ADPTIEETQHHDSQNDEKRNSIDLDGPENADTPETTSNKDESTEKADGDFKSSVKPDEFNVRRMH 1010

  Fly  1004 -QLRIHELVVKHSSNASLVVMSLPMPRKE--AISAPLYMSWLEMLTSDMKCPVALARGNQTPVLT 1065
             .::::|::|:.|.:|.||:|:||.|.:|  |.....||.:||:||..:: .|.:.||....|:|
  Fly  1011 TAIKLNEVIVEKSQDAQLVIMNLPGPPREVRAERERNYMEFLEVLTEGLE-KVLMVRGGGREVIT 1074

  Fly  1066 LYS 1068
            :||
  Fly  1075 IYS 1077

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NKCC	NP_730938.1	2a30	85..1068	CDD:273347	274/1172 (23%)
		DUF502	507..>643	CDD:294696	44/135 (33%)
		SLC12	651..1068	CDD:281515	88/518 (17%)
kcc	NP_001286795.1	2a30	49..1077	CDD:273347	275/1178 (23%)
		SLC12	674..1077	CDD:281515	87/512 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2083
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D20017at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11827
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.920