Protein Alignment NKCC and nkcc-1

DIOPT Version :10

• Sequence 1: NP_730938.1
• Gene: NKCC / 40663
• FlyBaseID: FBgn0051547
• Length: 1068
• Species: Drosophila melanogaster
• Sequence 2: NP_001255790.1
• Gene: nkcc-1 / 3565648
• WormBaseID: WBGene00012543
• Length: 1235
• Species: Caenorhabditis elegans
• Alignment Length: 1217
• Identity: 438/1217 - (35%)
• Similarity: 651/1217 - (53%)
• Gaps: 169/1217 - (13%)

  Fly     4 RFQISKVNGTANAGYDGEARSAESDQTDAAHPLPPT------------------------SNENH 44
            |||:||.:...... |...|..:|    .:.|.|||                        :|...
 Worm    36 RFQVSKTDEDEKTS-DDNLRKLKS----GSEPPPPTQNHEAVTLVTRKMSATGRFMVTSDTNPGQ 95

  Fly    45 LHPKASGETG---------ENRRSSR-------LSFRGFGNFLRKSDAERKFSLAQLTK------ 87
            |..:.:.|.|         |...:||       :..:..|:.....|.:|..:....|.
 Worm    96 LVAEVADELGIDVPIDPPAEKSPASRAKGVHFSVGDKDSGSMSEDGDEKRNITHENQTTFNMKSW 160

  Fly    88 ------ESLPRLDNYRISMRN---LKRPSIGEL-QG-EAVDQSITIPE-----------PEPEA- 129
                  |..|.:|.||.|:..   ..|||:.:| .| |..:|.:...|           |..|.
 Worm   161 RNMKTIEHPPIIDFYRNSIDTDGVFNRPSMAQLIHGKEHKEQDLGFEELNAQHHHLEDSPVHETK 225

  Fly   130 ------------TGGHIKLGWIVGVLIPCLLNIWGVMLFLRLSWVVAESGILQSLIIITISAVVC 182
                        :...:|.|||.||.:.|||||:||||:||:|||..::|:.....|:.:::||.
 Worm   226 NEYRMEKMHAPPSQNRVKFGWIQGVFVRCLLNIFGVMLYLRVSWVSGQAGVGLGSCIVLLASVVT 290

  Fly   183 VITTLSLSAISTNGEVKGGGVYFIISRSLGPEFGASVGVVFAFANAVSASMNTIGFCESL-NVLL 246
            .||.||..||.|||:|||||.||:||||||||||.|:|::|:.||||.|:|..:||.||. :||:
 Worm   291 TITALSTCAICTNGDVKGGGAYFLISRSLGPEFGGSIGIIFSIANAVGAAMYIVGFAESFRDVLI 355

  Fly   247 KNNDLKIVDNGINDIRIVGSITVLVLILICCVGMEWETKAQNFLIVTIVLAIFNFLIGAAIGPQG 311
            ..|...|.|.|:.|:|::|.:|.::|:.|..:|.|:|:|.|..|:|.::::|.|::.|:...|
 Worm   356 DYNIGTIFDGGLWDVRVIGFVTCVILMGIVFIGSEFESKMQLGLLVILLVSIANYVFGSFFPP-- 418

  Fly   312 NEEQISRGFVGFSWATLKENFGSDYRYAEGVNHDFFSVFAIFFPSVTGIQAGANICGDLKDAGAA 376
            ||..::||..|:|..||:.||...:.    .|:.|||||:::||:.|||.|||||.|||.:...|
 Worm   419 NEIAMNRGATGYSLDTLQSNFMPHFT----ENNTFFSVFSVYFPAATGIMAGANISGDLANPQQA 479

  Fly   377 IPKGTFWSLLISMSSYALFVLFAGGAAVRDASGI-PADLVNGTIVSSELPCMATGNCTWGLFNSY 440
            ||.||..::|::...|.|.|...|...|..::|. ||...|...|    |...|.:|.:||.:.|
 Worm   480 IPLGTLLAILVTTIVYLLTVWMTGSTVVAFSNGTEPAVFNNSYFV----PPDCTPDCPFGLVSYY 540

  Fly   441 EMMQEMSLWGPLIYAGCFAATLSTALTNLLSVPRLVQALGIDQIYPGLIFFSKPYGKHGEPYRGY 505
            ::::..|.|||||.||.||||||:||.:|:|.|::.||:..|:::|.:.:|:|.|||:.||.|.|
 Worm   541 QVVEMSSFWGPLITAGIFAATLSSALASLVSAPKVFQAVCKDRLFPRIDYFAKTYGKNEEPKRAY 605

  Fly   506 VLTFFITTGFLLIGELNLIAPLISTFYLASYALINFCTFHAAFVKPLGWRPTFKYYNAWLSLFGF 570
            ||.||:..|.:.||:||:|||:||.|:|.||||||:..|..:|....|:||.|.|||.|:||.|.
 Worm   606 VLGFFLAMGIVAIGDLNVIAPIISNFFLGSYALINYACFDQSFADSPGFRPGFTYYNMWISLVGA 670

  Fly   571 AMCVAIMFLINYVAAIITFGIIFALYLVVMYRKPEANWGSTTQAQQYKAALMAVHRLQNVSDHVK 635
            .:||.:||:|::.:|::||....|:::.:::|||:.||||:|||..||.||.|:.:|....:|||
 Worm   671 LLCVFVMFIIDWFSALVTFFCFGAIFMYLLHRKPDVNWGSSTQAHSYKNALSAMIKLSTTEEHVK 735

  Fly   636 NYHPQVLVLSGDPKTRPPLVDFGYLLTKNNSLMFVANIIPV----RVGYKNRQHLVKDGQKYLDA 696
            ||.||||||||:|.:|..||||...:||.:||:....::|.    || |...:.|.::...:|..
 Worm   736 NYRPQVLVLSGNPASRSCLVDFANNITKGSSLLVCGQVVPYEPSDRV-YMVMKRLDENINVWLRK 799

  Fly   697 RKIKAFYNVIDGFSLEDGINALTKSTGFGKMSPNIVLVGYKPDW-----NRCRKEEVESYFSILY 756
            |.:||||..:...:...|..:|.:.||..||.|||||:|:|.:|     ......|:..||..:.
 Worm   800 RHLKAFYRAVANSNFRKGAQSLIQLTGIAKMKPNIVLMGFKSNWYKGGPTETNLNEMNEYFGTIQ 864

  Fly   757 NAFSQRMGVALLRLPN-GLDFSELSSEVTL-PANGMG----------------------HMHTAN 797
            :.|...|.:.:||... ||||||....:.| ..|.:.                      |:...:
 Worm   865 DVFDWNMAMCVLRNGQVGLDFSEAMRNLNLIEPNRLNVPPIEEKEKEKEKTNENSPETVHLIEKD 929

  Fly   798 AHGFTN--------------------ELMPAANA--------ASELLHIDSNLNLASMDSPNSSF 834
            ....|:                    |:....||        .:|....|.|...|..|..|.:.
 Worm   930 ETARTDKSGDDGSSARLSYRGSCRSVEMFQRINAFYINASISINETYVSDENQEDADGDDDNDND 994

  Fly   835 TMPQPAPMPNMQRNSRSYKVTSSDEPAVTYHTKGGS---DIPQN-LLDAMTIFTRKQPKGTIDVF 895
            .....|...:.:.:.....|....|.......:.||   .:.|. ||.::..|.||..||||||:
 Worm   995 GEESGADDEHQKEDDVELGVIDEQEKRHFSLRRRGSRRHTVEQKALLSSIQRFNRKVKKGTIDVW 1059

  Fly   896 WLYDDGGLTILLPYIISM-RSHWQNSKLRVFAM-CHGKDEEQEEKSMASLLTKFRIKYSELIMLK 958
            |||||||||:|:|::::: :|:.:.::||:|.: ...:..|||::.||:||:||||.||::.::.
 Worm  1060 WLYDDGGLTLLIPHLLAIPKSYLEGARLRIFTISTSSRTMEQEQRGMAALLSKFRIDYSDVYVIA 1124

  Fly   959 GVSEQPRADTVLKHKRLIEPF-RRGARNEFGI-TDDELQSMSEKTNRQLRIHELVVKHSSNASLV 1021
            .:.::||.:|:...:.:|:|| .:......|: |..||.:..:||.||||..||:.:||.||.|:
 Worm  1125 DIGKKPRQETMNTWQSVIDPFIAQDGSCPIGMTTKSELSAQRDKTYRQLRAGELLNEHSINADLI 1189

  Fly  1022 VMSLPMPRKEAISAPLYMSWLEMLTSDMKCPVALARGNQTPVLTLYS 1068
            ||:||:|||..:|:.|||||||::|.::. ||.|.||||..|||.||
 Worm  1190 VMTLPVPRKGMVSSSLYMSWLEVMTRNLP-PVLLVRGNQQSVLTFYS 1235

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NKCC	NP_730938.1	AA_permease_2	85..1068	CDD:459263	414/1094 (38%)
nkcc-1	NP_001255790.1	AA_permease_2	165..1235	CDD:459263	413/1081 (38%)