Protein Alignment NKCC and Slc12a7

DIOPT Version :10

• Sequence 1: NP_730938.1
• Gene: NKCC / 40663
• FlyBaseID: FBgn0051547
• Length: 1068
• Species: Drosophila melanogaster
• Sequence 2: XP_063144456.1
• Gene: Slc12a7 / 308069
• RGDID: 1359672
• Length: 1179
• Species: Rattus norvegicus
• Alignment Length: 1227
• Identity: 302/1227 - (24%)
• Similarity: 482/1227 - (39%)
• Gaps: 346/1227 - (28%)

  Fly     1 MADRF-QISKVNGTANAGYDGEARSAESDQTDAAHPLPPTSNENHLHPK--ASGETGE------- 55
            |:.|| .|...:||.:||...|..|..| |...:.|.|....:....|.  |:.:|.|
  Rat     1 MSQRFVVIPAQSGTGDAGPRAEGGSGGS-QRLCSDPDPDPDPDPDPDPSLAAALKTQEVDALPIL 64

  Fly    56 --NRRSSRLSFRGFGN------FLRKSDAERK-------FSLAQLTKESLPRLDNYRISMRNLKR 105
              .|..||.   |.||      |:...:.||:       .:|.:...:|.|.:.:....:.|...
  Rat    65 RYCREPSRY---GDGNPRENSPFINNVEVERESYFEGKNMALFEEEMDSNPMVSSLLNKLANYTN 126

  Fly   106 PSIGELQGEAVDQS----ITIPEPEPEATGGHIKLGWIVGVLIPCLLNIWGVMLFLRLSWVVAES 166
            .|.|.::.|..:.|    |..|           ::|..:||.:|||.||.||:|||||:|:|..:
  Rat   127 LSQGVVEHEEDEDSRRREIKAP-----------RMGTFIGVYLPCLQNILGVILFLRLTWIVGAA 180

  Fly   167 GILQSLIIITISAVVCVITTLSLSAISTNGEVKGGGVYFIISRSLGPEFGASVGVVFAFANAVSA 231
            |:|:|.:|:.:.....::|.:|:|||:|||.|..||.|::||||||||||.:||:.|......:.
  Rat   181 GVLESFLIVAMCCTCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAG 245

  Fly   232 SMNTIGFCESLNVLLKNN----DLKIVDNG----INDIRIVGSITVLVLILICCVGMEWETK-AQ 287
            :|..:|..|.....:..:    ..:..|..    :|::|:.||..:.::.::..||:::..| |.
  Rat   246 AMYILGTIEIFLTYISPSAAIFQAETADGEAAALLNNMRVYGSCALALMAVVVFVGVKYVNKLAL 310

  Fly   288 NFL--IVTIVLAIFNFLIGAAIGP----------------------------------------- 309
            .||  :|..:|||:..:|..|..|
  Rat   311 VFLACVVLSILAIYAGVIKTAFAPPDIPVCLLGNRTLANRNFDTCAKMQVVSNGTVTTALWRLFC 375

  Fly   310 --------------QGNEEQISRGFVGFSWATLKENFGSDY----RYAE--GVNH---------- 344
                          |.|..:| :|..|.:.....:|..|.|    .:.|  ||:.
  Rat   376 NGSSLGASCDEYFVQNNVTEI-QGIPGVASGVFLDNLWSTYSDKGAFVEKKGVSSVPVSEESRPG 439

  Fly   345 -------DFFSVF----AIFFPSVTGIQAGANICGDLKDAGAAIPKGTFWSLL----ISMSSYAL 394
                   |..:.|    .|:|||||||.||:|..||||||..:||.||..:::    |.:|...|
  Rat   440 GLPYVLTDIMTYFTMLVGIYFPSVTGIMAGSNRSGDLKDAQKSIPTGTILAIVTTSFIYLSCIVL 504

  Fly   395 FVLFAGGAAVRDASGIPADLVNGTIVSSELPCMATGNCTWGLFNSYEMMQEMSLWGPLIYAGCFA 459
            |.....|..:||..|   :.:.|.:|        .|...|           .|.|  :|..|.|.
  Rat   505 FGACIEGVVLRDKFG---EALQGNLV--------IGMLAW-----------PSPW--VIVIGSFF 545

  Fly   460 ATLSTALTNLLSVPRLVQALGIDQIYPGLIFFSKPYGK-HGEPYRGYVLTFFITTGFLLIGELNL 523
            :|....|.:|...|||:||:..|.|.|.|..|.  :|| :|||....:||..|....:||..|:.
  Rat   546 STCGAGLQSLTGAPRLLQAIARDGIIPFLQVFG--HGKANGEPTWALLLTALICETGILIASLDS 608

  Fly   524 IAPLISTFYLASYALINFCTFHAAFVKPLGWRPTFKYYNAWLSLFGFAMCVAIMFLINYVAAIIT 588
            :||::|.|:|..|..:|........::...|||.||:|:..||..|.::|:|:||:.::..|:..
  Rat   609 VAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFKFYHWTLSFLGMSLCLALMFICSWYYALFA 673

  Fly   589 FGIIFALYLVVMYRKPEANWGSTTQAQQYKAALMAVHRLQNVSDHVKNYHPQVLVL----SGDPK 649
            ..|...:|..:.||..|..||...:.....||..|:.|:::...|.||:.|||||:    |....
  Rat   674 MLIAGCIYKYIEYRGAEKEWGDGIRGLSLNAARYALLRVEHGPPHTKNWRPQVLVMLNLDSEQCV 738

  Fly   650 TRPPLVDFGYLLTKNNSLMFVANIIPVRVGYKN--RQHLVKDGQKYLDARKIKAFYNVIDGFSLE 712
            ..|.|:.|...|.....|..|.:::......|:  .|...::.:..:.|.|:|.|..::...:|.
  Rat   739 KHPRLLSFTSQLKAGKGLTIVGSVLEGTYLDKHVEAQRAEENIRSLMSAEKMKGFCQLVVSSNLR 803

  Fly   713 DGINALTKSTGFGKMSPNIVLVGYKPDWNRCRKEEVESYFSILYNAFSQRMGVALLRLPNGLDFS 777
            ||.:.|.:|.|.|.|..|.||:.:...|.:..            |.||.:            :|.
  Rat   804 DGASHLIQSAGLGGMKHNTVLMAWPEAWKQAD------------NPFSWK------------NFV 844

  Fly   778 ELSSEVTLPANGMGHMHTANAHGFTNELMPAANAASELLHIDSNLNLASMDSPNSSFTMPQPAPM 842
            :...:.|                          ||.:.|.:..|::|           .||
  Rat   845 DTVRDTT--------------------------AAHQALLVAKNIDL-----------FPQ---- 868

  Fly   843 PNMQRNSRSYKVTSSDEPAVTYHTKGGSDIPQNLLDAMTIFTRKQPKGTIDVFWLYDDGGLTILL 907
             |.:|.|                                       .|.|||:|:..|||:.:||
  Rat   869 -NQERFS---------------------------------------DGNIDVWWIVHDGGMLMLL 893

  Fly   908 PYIISMRSHWQNSKLRVFAMCHGKDEE-QEEKSMASLLTKFRIK-----------------YSEL 954
            |:::.....|:..::|:|.:....|.. |.:|.:...|...||.                 |.:.
  Rat   894 PFLLRQHKVWRKCRMRIFTVAQVDDNSIQMKKDLQMFLYHLRISAEVEVVEMVENDISAFTYEKT 958

  Fly   955 IMLKGVSEQ------------------------------------PRADTV----LKHKRLIEPF 979
            :|::..|:.                                    |..|.|    .|.|.:.|..
  Rat   959 LMMEQRSQMLKQMQLSKNEREREAQLIHDRNTASHTVATARTEAPPTPDKVQMTWTKEKLIAEKH 1023

  Fly   980 RR------GARNEFGITDDELQSMSEKTNRQLRIHELVVKHSSNASLVVMSLPMPRK 1030
            |.      |.::.|.:..|  ||...:.:..::::.:|:..|.:|.||::::|.|.|
  Rat  1024 RNKDTGTSGFKDLFSLKPD--QSNVRRMHTAVKLNGVVLNKSQDAQLVLLNMPGPPK 1078

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NKCC	NP_730938.1	AA_permease_2	85..1068	CDD:459263	274/1118 (25%)
Slc12a7	XP_063144456.1	None