DRSC/TRiP Functional Genomics Resources

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Protein Alignment NKCC and Slc12a4

DIOPT Version :9

Sequence 1:NP_730938.1 Gene:NKCC / 40663 FlyBaseID:FBgn0051547 Length:1068 Species:Drosophila melanogaster
Sequence 2:NP_062102.1 Gene:Slc12a4 / 29501 RGDID:3687 Length:1085 Species:Rattus norvegicus


Alignment Length:1259 Identity:305/1259 - (24%)
Similarity:486/1259 - (38%) Gaps:372/1259 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 FQISKVNGTANAGYD----------GEARSAESDQTDAAHPLPPTSNENHLHPKASGETGENRRS 59
            |.:..|:|.....||          ||  .||.:.:|.                    .|.:|.:
  Rat     4 FTVVPVDGPRRGDYDNLEGLSWVDYGE--RAEREDSDG--------------------QGNHREN 46

  Fly    60 SRLSFRGFGNFLRKSDAER-----KFSLAQLTKESLPRLDNYRISMRNLKRPSIGELQGEAVD-- 117
            |        .||...||.|     ..:||...:|    ||         .||.:..|.|:.|.  
  Rat    47 S--------PFLSPLDASRGNDYYDRNLALFEEE----LD---------IRPKVSSLLGKLVSYT 90

  Fly   118 ---QSITIPEPEPEATGGHIK------LGWIVGVLIPCLLNIWGVMLFLRLSWVVAESGILQSLI 173
               |.....|......||..:      :|.::||.:|||.||:||:|||||:|:|..:|:||:|:
  Rat    91 NLTQGAKEHEEAESGEGGRRRAAKAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALL 155

  Fly   174 IITISAVVCVITTLSLSAISTNGEVKGGGVYFIISRSLGPEFGASVGVVFAFANAVSASMNTIGF 238
            |:.|.....::|.:|:|||:|||.|..||.||:||||||||||.:||:.|......:|:|..:|.
  Rat   156 IVLICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGA 220

  Fly   239 CESLNVLLKNNDLKIVDNG--------INDIRIVGSITVLVLILICCVGMEWETKAQNFLIVTIV 295
            .|.|...:.........:|        :|::|:.|:|.:..:.|:..||:::..|..:..:..::
  Rat   221 IEILLTYIAPPAAIFYPSGTHDMSSATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVI 285

  Fly   296 LAIFNFLIG---AAIGPQ--------------------------GNEEQISR------------- 318
            ::|.:..:|   :|..|.                          .||...:|             
  Rat   286 ISILSIYVGGIKSAFDPPVFPVCMLGNRTLSRDQFDICAKTVVVDNETVATRLWTFFCHSPNLTA 350

  Fly   319 ----------------GFVGFSWATLKENFGSDY--------------------------RYAEG 341
                            |..|.:...|:||..|.|                          .....
  Rat   351 DSCDPYFLLNNVTEIPGIPGAAAGVLQENLWSAYLEKGEVVEKHGLPSTDTLGLKESLSLYVVAD 415

  Fly   342 VNHDFFSVFAIFFPSVTGIQAGANICGDLKDAGAAIPKGTFWSL----LISMSSYALFVLFAGGA 402
            :...|..:..|||||||||.||:|..|||:||..:||.||..::    |:..||..||.....|.
  Rat   416 IATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIVTTSLVYFSSVILFGACIEGV 480

  Fly   403 AVRD--ASGIPADLVNGTIVSSELPCMATGNCTWGLFNSYEMMQEMSLWGPLIYAGCFAATLSTA 465
            .:||  ..|:..:||.||:             .|           .|.|  :|..|.|.:|....
  Rat   481 VLRDKYGDGVSRNLVVGTL-------------AW-----------PSPW--VIVVGSFFSTCGAG 519

  Fly   466 LTNLLSVPRLVQALGIDQIYPGLIFFSKPYGK-HGEPYRGYVLTFFITTGFLLIGELNLIAPLIS 529
            |.:|...|||:||:..|.|.|.|..|.  :|| :|||....:||..|....:||..|:::||::|
  Rat   520 LQSLTGAPRLLQAIAKDNIIPFLRVFG--HGKANGEPTWALLLTALIAELGILIASLDMVAPILS 582

  Fly   530 TFYLASYALINFCTFHAAFVKPLGWRPTFKYYNAWLSLFGFAMCVAIMFLINYVAAIITFGIIFA 594
            .|:|..|..:|........::...|||.||||:..||..|.::|:|:||:.::..|::...|...
  Rat   583 MFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSWYYALVAMVIAGM 647

  Fly   595 LYLVVMYRKPEANWGSTTQAQQYKAALMAVHRLQNVSDHVKNYHPQVLV---LSGDPKTR-PPLV 655
            :|..:.|:..|..||...:.....||..|:.||:....|.||:.||:||   |..|...: |.|:
  Rat   648 IYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLL 712

  Fly   656 DFGYLLTKNNSLMFVANII--PVRVGYKNRQHLVKDGQKYLDARKIKAFYNVIDGFSLEDGINAL 718
            .|...|.....|..|.::|  .....|...|...:..:..::..|:|.|..|:....:.:|:..|
  Rat   713 TFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHL 777

  Fly   719 TKSTGFGKMSPNIVLVGYKPDWNRCRKEEVESYFSILYNAFSQRMGVALLRLPNGLDFSELSSEV 783
            .:|.|.|.|..|.|::|:...|.:.........|            :..:|.             
  Rat   778 IQSCGLGGMRHNSVVLGWPYGWRQSEDPRAWKTF------------IDTVRC------------- 817

  Fly   784 TLPANGMGHMHTANAHGFTNELMPAANAASELLHIDSNLNLASMDSPNSSFTMPQPAPMPNMQRN 848
                       |..||                        ||.:...|.:|              
  Rat   818 -----------TTAAH------------------------LALLVPKNIAF-------------- 833

  Fly   849 SRSYKVTSSDEPAVTYHTKGGSDIPQNLLDAMTIFTRKQPKGTIDVFWLYDDGGLTILLPYIISM 913
                                   .|.|        ..:..:|.|||:|:..|||:.:|||:::..
  Rat   834 -----------------------YPSN--------HERYLEGHIDVWWIVHDGGMLMLLPFLLRQ 867

  Fly   914 RSHWQNSKLRVFAMCHGKDEE-QEEKSMASLLTKFRIK-----------------YSELIMLKGV 960
            ...|:..::|:|.:....|.. |.:|.:|..|...|::                 |...:|::..
  Rat   868 HKVWKKCRMRIFTVAQMDDNSIQMKKDLAIFLYHLRLEAEVEVVEMHNSDISAYTYERTLMMEQR 932

  Fly   961 SEQPRADTVLKHKR-----LIEPFRRGARNEFGITDDELQSMS---------------------- 998
            |:..|...:.|.:|     |::......|.|...:|:|.:|::                      
  Rat   933 SQMLRQMRLTKTERDREAQLVKDRHSALRLESLYSDEEDESVTGADKIQMTWTRDKYMAEPWDPS 997

  Fly   999 -------------------EKTNRQLRIHELVVKHSSNASLVVMSLPMPRKEAISAPLYMSWLEM 1044
                               .:.:..::::|::|..|.:|.||::::|.|.|.:.....||.:||:
  Rat   998 HAPDNFRELVHIKPDQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPPKNSEGDENYMEFLEV 1062

  Fly  1045 LTSDMKCPVALARGNQTPVLTLYS 1068
            ||..:: .|.|.||....|:|:||
  Rat  1063 LTEGLE-RVLLVRGGGREVITIYS 1085

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NKCCNP_730938.1 2a30 85..1068 CDD:273347 283/1162 (24%)
DUF502 507..>643 CDD:294696 44/135 (33%)
SLC12 651..1068 CDD:281515 87/483 (18%)
Slc12a4NP_062102.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 32..56 9/51 (18%)
2a30 42..1085 CDD:273347 292/1197 (24%)
SLC5-6-like_sbd 142..>303 CDD:294310 51/160 (32%)
SLC12 709..1085 CDD:281515 87/481 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG57166
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.920

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