Protein Alignment NKCC and vhc1

DIOPT Version :10

• Sequence 1: NP_730938.1
• Gene: NKCC / 40663
• FlyBaseID: FBgn0051547
• Length: 1068
• Species: Drosophila melanogaster
• Sequence 2: NP_001342720.1
• Gene: vhc1 / 2540830
• PomBaseID: SPBC18H10.16
• Length: 1050
• Species: Schizosaccharomyces pombe
• Alignment Length: 934
• Identity: 243/934 - (26%)
• Similarity: 406/934 - (43%)
• Gaps: 166/934 - (17%)

  Fly    59 SSRLSFRGFGNFLRKSDAERKFSLAQLTKE-SLPRLDNYRISMRNLKRPSIGELQGEAVDQSITI 122
            :.|||       :|||   |:|...|...| |.|.|...:.|.|:   .|..||  ..:.:|:|.
pombe    16 ADRLS-------VRKS---RRFWETQENLESSTPLLQEPQQSYRS---NSFNEL--PPLSRSVTF 65

  Fly   123 PEPEP--EATGGHIKLGWIVGVLIPCLLNIWGVMLFLRLSWVVAESGILQSLIIITISAVVCVIT 185
            .|.|.  ||    :|||...|..||..||:..::|:||..|::.|:|:|::|:::.||..|.:.|
pombe    66 AENEQPNEA----VKLGTFEGCFIPTTLNVLSILLYLRFPWIIGEAGVLKTLLMLFISYAVGIFT 126

  Fly   186 TLSLSAISTNGEVKGGGVYFIISRSLGPEFGASVGVVFAFANAVSASMNTIGFCES-LNVLLKNN 249
            :||:|||.|||.|:|||.|:.:|||:|||.|.|:|::|.....::..||..||.|. :::..|.:
pombe   127 SLSISAICTNGMVRGGGAYYAVSRSIGPELGGSIGLIFYVGQILNTGMNISGFVEPIISIFGKES 191

  Fly   250 DL--KIVDNGINDIRIVGSITVLVLILICCVGMEWETKAQNFLIVTIVLAIFNFLIGAAIGPQGN 312
            ..  :.:..|...:.:..:..:.:..::||:|.....||.|.|.|.|:|:..:..|.:.......
pombe   192 GTISQFLPEGYWWVFLYTTCVLAMCCILCCLGSAIFAKASNALFVVIILSTISIPISSIFVHPFK 256

  Fly   313 EEQISRGFVGFSWATLKENFGSDYRYAE-GVNHDFF-SVFAIFFPSVTGIQAGANICGDLKDAGA 375
            :..:...|.|..|:||.:|..|.|...| |..::.| |.|.:|||:..|:.|||::.||||....
pombe   257 DPSLLVHFTGLKWSTLMKNLASAYTENEKGTGYESFKSTFGVFFPATAGLLAGASMSGDLKAPSR 321

  Fly   376 AIPKGTFWSLLISMSSYALFVLFAGGAAVRDASGIPADLVNGTIVSSELPCMATGNCTWGLFNSY 440
            :|||||..|...:...|.|.:|..|.:..|.                            ||....
pombe   322 SIPKGTISSQATTFLLYLLVILCVGASVTRT----------------------------GLLLDM 358

  Fly   441 EMMQEMSLWGPLIYAGCFAATLSTALTNLLSVPRLVQALGIDQIYPGLIFFSKPYGKHGEPYRGY 505
            ::|:.:||....|.:|..::...::...:....:|:||:..|.:.||:.||:|.......||...
pombe   359 DVMEHISLHPLFIISGILSSGAFSSFMGIFGAAKLLQAIARDDLIPGMFFFAKGSSYDDIPYVAI 423

  Fly   506 VLTFFITTGFLLIGELNLIAPLISTFYLASYALINFCTFHAAFVKPLGWRPTFKYYNAWLSLFGF 570
            .:|:.||. ..|..::|:::.:|:..:|.::..||...|.........:||||:|:|...:|.|.
pombe   424 GVTYLITQ-ISLFWDINMLSSMITMTFLLTFGFINLSCFLLRISSTPNFRPTFRYFNRRTTLVGT 487

  Fly   571 AMCVAIMFLINYVAAIITFGIIFALYLVVMYRKPEANWGSTTQAQQYKAALMAVHRLQNVSDHVK 635
            .:...:||.::.:.|.|:|.|...|.:|:.:..|..|||..:|...|......:.:.....:::|
pombe   488 ILSFGVMFYVDRLNAFISFLIAGILVVVIYFTCPPKNWGDVSQGIIYHQLRKYLLQTNKARENIK 552

  Fly   636 NYHPQVLVLSGDPKTRPPLVDFGYLLTKNNSLMFVANIIPVRVGYKNRQHLVKDGQK-----YLD 695
            .:.||:|:|..:|.....::.|...| |..||..:.::| |...::.....::..|:     .||
pombe   553 FWRPQILLLINNPNRSENVIRFCNSL-KKGSLYILGHVI-VSDDFQASMDDLRKQQRLWHQFVLD 615

  Fly   696 ARKIKAFYNVIDGFSLEDGINALTKSTGFGKMSPNI-VLVGYKPDWNRCRKEEVESYFSILYNAF 759
             |.||||..:........||..|..|.|.|.:.||| ||.....::.|.|          :|:..
pombe   616 -RGIKAFVELTIAPDEVWGIRGLISSAGLGGIRPNIAVLTFINTNYRRHR----------IYSGS 669

  Fly   760 SQRMGVALLRLPNGLDFSELSSEVTLPANGMGHMHTANAHGFTNELMPAANAASELLHIDSNLNL 824
            |       ..|.|..:.||..|:...               ..::::|.     :.:.|..::.:
pombe   670 S-------FSLENTSEESESDSKKEF---------------VEHDILPV-----KWVQILEDMLV 707

  Fly   825 ASMDSPNSSFTMPQPAPMPNMQRNSRSYKVTSSDEPAVTYHTKGGSDIPQNLLDAMTIFTRKQPK 889
            .|:|                       ..||                   |..|.:....||..|
pombe   708 GSVD-----------------------VMVT-------------------NGFDRLNWPKRKGEK 730

  Fly   890 GTIDVFWLYDDGG--------------------LTILLPYIISMRSHW-QNSKLRVFAMCHGKDE 933
            ..||:|.::...|                    :...|.:|:...|.| |..:||:..:...::|
pombe   731 QYIDMFPIHRISGVGSEVNESTPTFATNFETYTMVFQLSWILHTASDWKQGCRLRLITLVEFENE 795

  Fly   934 -EQEEKSMASLLTKFRIKYSELIM 956
             |.|.:||..:|..||||...:::
pombe   796 IEAERESMHQMLETFRIKADVVVL 819

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NKCC	NP_730938.1	AA_permease_2	85..1068	CDD:459263	234/908 (26%)
vhc1	NP_001342720.1	AA_permease_2	57..818	CDD:459263	225/875 (26%)