Protein Alignment NKCC and Slc12a7

DIOPT Version :9

• Sequence 1: NP_730938.1
• Gene: NKCC / 40663
• FlyBaseID: FBgn0051547
• Length: 1068
• Species: Drosophila melanogaster
• Sequence 2: XP_006517233.1
• Gene: Slc12a7 / 20499
• MGIID: 1342283
• Length: 1117
• Species: Mus musculus
• Alignment Length: 1269
• Identity: 310/1269 - (24%)
• Similarity: 498/1269 - (39%)
• Gaps: 353/1269 - (27%)

  Fly     1 MADRFQISKV-NGTANAGYDGEARS----AESDQTDAAHPLPPTSNENHL--------------- 45
            |:.||.::.. :||.:||...|..:    ::||......|.|..|....|
Mouse     1 MSQRFVVTPAQSGTGDAGTRAEGGNQRLCSDSDPDPDLDPNPDPSLAAALKIQEVDALPILRYCR 65

  Fly    46 HPKASGETGENRRSSRLSFRGFGNFLRKSDAERK-------FSLAQLTKESLPRLDNYRISMRNL 103
            .|...|: |..|.:|        .|:...:.||:       .:|.:...:|.|.:.:....:.|.
Mouse    66 EPSRYGD-GNPRENS--------PFINNVEVERESYFEGKNMALFEEEMDSNPMVSSLLNKLANY 121

  Fly   104 KRPSIGELQGEAVDQSITIPEPEPEATGGHIKLGWIVGVLIPCLLNIWGVMLFLRLSWVVAESGI 168
            ...|.|.::.|..:.|.......|       ::|..:||.:|||.||.||:|||||:|:|..:|:
Mouse   122 TNLSQGVVEHEEDEDSRRREVKAP-------RMGTFIGVYLPCLQNILGVILFLRLTWIVGAAGV 179

  Fly   169 LQSLIIITISAVVCVITTLSLSAISTNGEVKGGGVYFIISRSLGPEFGASVGVVFAFANAVSASM 233
            ::|.:|:.:.....::|.:|:|||:|||.|..||.|::||||||||||.:||:.|......:.:|
Mouse   180 MESFLIVAMCCTCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAM 244

  Fly   234 NTIGFCESLNVLLKNN----DLKIVDNG----INDIRIVGSITVLVLILICCVGMEWETK-AQNF 289
            ..:|..|.....:..:    ..:..|..    :|::|:.||..:.::.::..||:::..| |..|
Mouse   245 YILGTIEIFLTYISPSAAIFQAETADGEAAALLNNMRVYGSCALALMAVVVFVGVKYVNKLALVF 309

  Fly   290 L--IVTIVLAIFNFLIGAAIGP------------------------------------------- 309
            |  :|..:|||:..:|..|..|
Mouse   310 LACVVLSILAIYAGVIKTAFAPPDIPVCLLGNRTLANRNFDTCAKMQVVSNGTVTTALWRLFCNG 374

  Fly   310 ------------QGNEEQISRGFVGFSWATLKENFGSDY----RYAE--GVNH------------ 344
                        |.|..:| :|..|.:.....:|..|.|    .:.|  ||:.
Mouse   375 SSLGATCDEYFAQNNVTEI-QGIPGVASGVFLDNLWSTYSDKGAFVEKKGVSSVPVSEESRPGGL 438

  Fly   345 -----DFFSVF----AIFFPSVTGIQAGANICGDLKDAGAAIPKGTFWSLL----ISMSSYALFV 396
                 |..:.|    .|:|||||||.||:|..||||||..:||.||..:::    |.:|...||.
Mouse   439 PYVLTDIMTYFTMLVGIYFPSVTGIMAGSNRSGDLKDAQKSIPTGTILAIVTTSFIYLSCIVLFG 503

  Fly   397 LFAGGAAVRDASGIPADLVNGTIVSSELPCMATGNCTWGLFNSYEMMQEMSLWGPLIYAGCFAAT 461
            ....|..:||..|   :.:.|.:|        .|...|           .|.|  :|..|.|.:|
Mouse   504 ACIEGVVLRDKFG---EALQGNLV--------IGMLAW-----------PSPW--VIVIGSFFST 544

  Fly   462 LSTALTNLLSVPRLVQALGIDQIYPGLIFFSKPYGK-HGEPYRGYVLTFFITTGFLLIGELNLIA 525
            ....|.:|...|||:||:..|.|.|.|..|.  :|| :|||....:||..|....:||..|:.:|
Mouse   545 CGAGLQSLTGAPRLLQAIARDGIIPFLQVFG--HGKANGEPTWALLLTALICETGILIASLDSVA 607

  Fly   526 PLISTFYLASYALINFCTFHAAFVKPLGWRPTFKYYNAWLSLFGFAMCVAIMFLINYVAAIITFG 590
            |::|.|:|..|..:|........::...|||.||:|:..||..|.::|:|:||:.::..|:....
Mouse   608 PILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFKFYHWTLSFLGMSLCLALMFICSWYYALFAML 672

  Fly   591 IIFALYLVVMYRKPEANWGSTTQAQQYKAALMAVHRLQNVSDHVKNYHPQVLVL----SGDPKTR 651
            |...:|..:.||..|..||...:.....||..|:.|:::...|.||:.|||||:    |......
Mouse   673 IAGCIYKYIEYRGAEKEWGDGIRGLSLNAARYALLRVEHGPPHTKNWRPQVLVMLNLDSEQCVKH 737

  Fly   652 PPLVDFGYLLTKNNSLMFVANIIPVRVGYKN--RQHLVKDGQKYLDARKIKAFYNVIDGFSLEDG 714
            |.|:.|...|.....|..|.:::......|:  .|...::.:..:.|.|.|.|..::...:|.||
Mouse   738 PRLLSFTSQLKAGKGLTIVGSVLEGTYLDKHVEAQRAEENIRSLMSAEKTKGFCQLVVSSNLRDG 802

  Fly   715 INALTKSTGFGKMSPNIVLVGYKPDWNRCRKEEVESYFSILYNAFSQRMGVALLRLPNGLDFSEL 779
            .:.|.:|.|.|.|..|.||:.:...|     :|.:       |.||.:            :|.:.
Mouse   803 ASHLIQSAGLGGMKHNTVLMAWPEAW-----KEAD-------NPFSWK------------NFVDT 843

  Fly   780 SSEVTLPANGMGHMHTANAHGFTNELMPAANAASELLHIDSNLNLASMDSPNSSFTMPQPAPMPN 844
            ..:.|                          ||.:.|.:..|::|           .||     |
Mouse   844 VRDTT--------------------------AAHQALLVAKNIDL-----------FPQ-----N 866

  Fly   845 MQRNSRSYKVTSSDEPAVTYHTKGGSDIPQNLLDAMTIFTRKQPKGTIDVFWLYDDGGLTILLPY 909
            .:|.|                                       .|.|||:|:..|||:.:|||:
Mouse   867 QERFS---------------------------------------DGNIDVWWIVHDGGMLMLLPF 892

  Fly   910 IISMRSHWQNSKLRVFAMCHGKDEE-QEEKSMASLLTKFRIK-----------------YSELIM 956
            ::.....|:..::|:|.:....|.. |.:|.:...|...||.                 |.:.:|
Mouse   893 LLRQHKVWRKCRMRIFTVAQVDDNSIQMKKDLQMFLYHLRISAEVEVVEMVENDISAFTYEKTLM 957

  Fly   957 LKGVSEQ------------------------------------PRADTV----LKHKRLIEPFRR 981
            ::..|:.                                    |..|.|    .|.|.:.|..|.
Mouse   958 MEQRSQMLKQMQLSKNEREREAQLIHDRNTASHTTATARTQAPPTPDKVQMTWTKEKLIAEKHRN 1022

  Fly   982 ------------GARNEFGITDDELQSMSEKTNRQLRIHELVVKHSSNASLVVMSLPMPRKEAIS 1034
                        ..:.|:|..|   ||...:.:..::::.:|:..|.:|.||::::|.|.|....
Mouse  1023 KDTGPSGFKDLFSLKPEWGNLD---QSNVRRMHTAVKLNGVVLNKSQDAQLVLLNMPGPPKSRQG 1084

  Fly  1035 APLYMSWLEMLTSDMKCPVALARGNQTPVLTLYS 1068
            ...||.:||:||..:. .|.|.||....|:|:||
Mouse  1085 DENYMEFLEVLTEGLN-RVLLVRGGGREVITIYS 1117

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NKCC	NP_730938.1	2a30	85..1068	CDD:273347	285/1156 (25%)
		DUF502	507..>643	CDD:294696	44/135 (33%)
		SLC12	651..1068	CDD:281515	95/488 (19%)
Slc12a7	XP_006517233.1	2a30	74..1117	CDD:273347	291/1193 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57166
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920