Protein Alignment NKCC and Slc12a1

DIOPT Version :9

• Sequence 1: NP_730938.1
• Gene: NKCC / 40663
• FlyBaseID: FBgn0051547
• Length: 1068
• Species: Drosophila melanogaster
• Sequence 2: XP_030104745.1
• Gene: Slc12a1 / 20495
• MGIID: 103150
• Length: 1154
• Species: Mus musculus
• Alignment Length: 1217
• Identity: 460/1217 - (37%)
• Similarity: 664/1217 - (54%)
• Gaps: 226/1217 - (18%)

  Fly     2 ADRFQISKVN-GTANAGYDGEARSAESDQTDAAHPLPPTSNENHLHPKASGETGENRRSSRLSFR 65
            |.|||:..:| |..:|       :|..|..|     ||     |....:.|:..:||  .|:|||
Mouse    14 ASRFQVHVINEGHGSA-------AAVGDSAD-----PP-----HYEETSFGDEAQNR--LRISFR 59

  Fly    66 G-----FGNFLRKSDAERKFSLAQL-----------TKESLPRLDNYR----ISMRNLKRPSIGE 110
            .     :.|||:..:..:..:....           |.:::|:::.||    :|...:.|||:.|
Mouse    60 PGNQECYDNFLQTGETAKTDTTFHAYDSHTNTYYLQTMDAVPKIEYYRNTGSVSGPKVNRPSLLE 124

  Fly   111 LQGEAVDQSITI-------------------PEPEPEATGGHIKLGWIVGVLIPCLLNIWGVMLF 156
            :. |.:.:::|:                   .|.:.|...|.:|.||:.|||:.|:|||||||||
Mouse   125 IH-EQLAKNVTVAPGSADRVANGDGMPGDEQAENKEEDMTGVVKFGWVKGVLVRCMLNIWGVMLF 188

  Fly   157 LRLSWVVAESG---------------------------------------ILQS----------- 171
            :||||:|.|:|                                       ||.|
Mouse   189 IRLSWIVGEAGIGLGVIIIGLAVTVTAITGLSTSAIATNGYVRGGLGVLIILLSTMVTSITGLST 253

  Fly   172 --------------LIIITISAVVCVITTLSLSAISTNGEVKGGGVYFIISRSLGPEFGASVGVV 222
                          :|||.:|.||..:|.:|:|||.|||.|:|||.|::||||||||||.|:|::
Mouse   254 SAIATNGFVRGGLGVIIIGLSVVVTTLTGISMSAICTNGVVRGGGAYYLISRSLGPEFGGSIGLI 318

  Fly   223 FAFANAVSASMNTIGFCESLNVLLKNNDLKIVDNGINDIRIVGSITVLVLILICCVGMEWETKAQ 287
            |||||||:.:|..:||.|::..|||.:|..:|| ..|||||:|||||::|:.|...|||||.|||
Mouse   319 FAFANAVAVAMYVVGFAETVVDLLKESDSMMVD-PTNDIRIIGSITVVILLGISVAGMEWEAKAQ 382

  Fly   288 NFLIVTIVLAIFNFLIGAAIGPQGNEEQISRGFVGFSWATLKENFGSDYRYAEGVNHDFFSVFAI 352
            ..|:|.:::||.||.||..| |..||:: ||||..:..:...||||..:...||    |||||||
Mouse   383 VILLVILLIAIANFFIGTVI-PSNNEKK-SRGFFNYQASIFAENFGPSFTKGEG----FFSVFAI 441

  Fly   353 FFPSVTGIQAGANICGDLKDAGAAIPKGTFWSLLISMSSYALFVLFAGGAAVRDASGIPADLVNG 417
            |||:.|||.|||||.|||:|...|||:||..::.|:..:|....:......||||:|    .:|.
Mouse   442 FFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVAYIGVAICVAACVVRDATG----SMND 502

  Fly   418 TIVSSELPCMATG--------------NCTWGLFNSYEMMQEMSLWGPLIYAGCFAATLSTALTN 468
            ||||. :.|..:.              .|.:||.|::::|..:|.:||||.||.|:||||:||.:
Mouse   503 TIVSG-MNCNGSAACGLGYDFSRCQHEPCQYGLMNNFQVMSMVSGFGPLITAGIFSATLSSALAS 566

  Fly   469 LLSVPRLVQALGIDQIYPGLIFFSKPYGKHGEPYRGYVLTFFITTGFLLIGELNLIAPLISTFYL 533
            |:|.|::.|||..|.|:.||.||:|.|||:.||.|||.|||.|...|:||.|||:|||:||.|:|
Mouse   567 LVSAPKVFQALCKDNIFKGLQFFAKGYGKNNEPLRGYFLTFVIAMAFILIAELNVIAPIISNFFL 631

  Fly   534 ASYALINFCTFHAAFVKPLGWRPTFKYYNAWLSLFGFAMCVAIMFLINYVAAIITFGIIFALYLV 598
            ||||||||..|||::.|..||||.:..||.|:||||..:|.|:||:||:.||:||:.|...||:.
Mouse   632 ASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAILCCAVMFVINWWAAVITYVIELFLYIY 696

  Fly   599 VMYRKPEANWGSTTQAQQYKAALMAVHRLQNVSDHVKNYHPQVLVLSGDPKTRPPLVDFGYLLTK 663
            |.|:||:.||||:|||..|.:||.....|..|.|||||:.||.:||:|.|.|||.|:|..:..||
Mouse   697 VTYKKPDVNWGSSTQALSYVSALDNALELTTVEDHVKNFRPQCIVLTGGPMTRPALLDITHAFTK 761

  Fly   664 NNSLMFVANII--PVRVGYKNRQHLVKDGQKYLDARKIKAFYNVIDGFSLEDGINALTKSTGFGK 726
            |:.|.....:.  |.::..|.....:...|.:|...||||||..:......||:.:|.:::|.|:
Mouse   762 NSGLCICCEVFVGPRKLCVKEMNSGMAKKQAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGR 826

  Fly   727 MSPNIVLVGYKPDWNRCRKEEVESYFSILYNAFSQRMGVALLRLPNGLDFS-------------- 777
            |.||.:::|||.:|.:....|:|:|..|:::||...:||.::|:..|.|.|
Mouse   827 MKPNTLVIGYKKNWRKAPLSELENYVGIIHDAFDFEIGVVIVRISQGFDISPVLQVQDELEKLEQ 891

  Fly   778 -ELSSEVTLPANGMGHMHTANAHGFTNELMPAANAASELLHIDSNLNLASMDSPNSSFTMPQPAP 841
             .|:.|..:.               .||..........|......||:..              |
Mouse   892 ERLALEAAIK---------------DNECEEGKGGIRGLFKKAGKLNITK--------------P 927

  Fly   842 MPNMQRNSRSYKVTSSDEPAVTYHTKGGSDIPQNLLDAMTIFTRKQPKGTIDVFWLYDDGGLTIL 906
            .|....|..|.:         :.|.   .:..|.|::|...|.:||.||||||:||:||||||:|
Mouse   928 APKKDGNISSIQ---------SMHV---GEFNQKLVEASAQFKKKQGKGTIDVWWLFDDGGLTLL 980

  Fly   907 LPYIISMRSHWQNSKLRVFAMCHGKDE--EQEEKSMASLLTKFRIKYSELIMLKGVSEQPRADTV 969
            :|||:::|..|::.|||::.  .||..  |:|:.||||||:|||||::::.::..::.:|..::.
Mouse   981 IPYILTLRKKWKDCKLRIYV--GGKINRIEEEKISMASLLSKFRIKFADIHIIGDINIKPNKESW 1043

  Fly   970 LKHKRLIEPFRRGARNE-------------FGITDDELQSMSEKTNRQLRIHELVVKHSSNASLV 1021
            ...:.:|||:|....::             :.|||.||:::.||:.||:|::||:.:||..|:|:
Mouse  1044 KVFEEMIEPYRLHESHKDLTTAEKLKRESPWKITDAELEAVKEKSYRQVRLNELLQEHSRAANLI 1108

  Fly  1022 VMSLPMPRKEAISAPLYMSWLEMLTSDMKCPVALARGNQTPVLTLYS 1068
            |:|||:.||.:||..|||:|||:||.::. ||.|.|||...|||.||
Mouse  1109 VLSLPVARKGSISDLLYMAWLEILTKNLP-PVLLVRGNHKNVLTFYS 1154

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NKCC	NP_730938.1	2a30	85..1068	CDD:273347	435/1126 (39%)
		DUF502	507..>643	CDD:294696	76/135 (56%)
		SLC12	651..1068	CDD:281515	144/448 (32%)
Slc12a1	XP_030104745.1	2a30	96..1154	CDD:273347	435/1114 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2083
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57166
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001536
OrthoInspector	1	1.000	-	-		mtm8718
orthoMCL	1	0.900	-	-		OOG6_101360
Panther	1	1.100	-	-	O	PTHR11827
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.780