Protein Alignment NKCC and kcc-1

DIOPT Version :10

• Sequence 1: NP_730938.1
• Gene: NKCC / 40663
• FlyBaseID: FBgn0051547
• Length: 1068
• Species: Drosophila melanogaster
• Sequence 2: NP_001293846.1
• Gene: kcc-1 / 177495
• WormBaseID: WBGene00006504
• Length: 1156
• Species: Caenorhabditis elegans
• Alignment Length: 1229
• Identity: 301/1229 - (24%)
• Similarity: 489/1229 - (39%)
• Gaps: 356/1229 - (28%)

  Fly    26 ESDQTDAAHPLPPTSNENHLHPKASG----ETGENRRSSRLSFRGFGNFLRKSDAERKFSLAQLT 86
            :.|:|      .|..::..:.|:.:|    :...|..::.:..|....:....||....:||...
 Worm    92 DDDKT------APVQSDTVISPENAGNGLADHHRNISTASVGDRELYAWGTNKDAGGNHNLALFE 150

  Fly    87 KESLPRLDNYRISMRNLKRPSIGELQGEAVDQSITIPEP----EPEATGGH---IKLGWIVGVLI 144
            :.|:|...:|                   :...|| |.|    :..:.|||   ..||.::||.:
 Worm   151 EPSMPFFSSY-------------------LKAHIT-PGPLERAQSSSHGGHGAKADLGVLLGVYL 195

  Fly   145 PCLLNIWGVMLFLRLSWVVAESGILQSLIIITISAVVCVITTLSLSAISTNGEVKGGGVYFIISR 209
            |.:.:|.||.:|:||.|:|..:|:.|:.:::.:......:|.:|:||::|||.|:.||.||:|||
 Worm   196 PTIQHILGVTMFIRLFWLVGIAGLGQTFLLLFLCCFCTFLTCISISAVATNGVVESGGAYFMISR 260

  Fly   210 SLGPEFGASVGVVFAFANAVSASMNTIGFCESLNVLL----------KNNDLKIVDNGINDIRIV 264
            :||||||::||::|..||.|:.||..:|..|.|.:.:          ..:|..:.....|.:|..
 Worm   261 NLGPEFGSAVGILFYLANTVATSMYLVGGVEILLLYIFPGLTFGGVEGQHDTSMFGTMTNSLRFY 325

  Fly   265 GSITVLVLILICCVGMEWETKAQNFLIVTIVLAIF------------------------------ 299
            .:|.:|:...|..:|:::........:|.::|:|.
 Worm   326 STILLLIEFAIVAMGVKFVQMLAPVSLVCVILSILACYAGGVTKTIYPDSGQYVCMYNDRLLQSS 390

  Fly   300 --------------------NFLIGAAIGPQGNEEQIS--------RGFVGFSWA-TLKENFGSD 335
                                .||.....|.:.|...|.        .||.||... ||.||.|.:
 Worm   391 AVLNESIPLDEICNYCNINNTFLADRVCGGRCNSTTIPHVSPFRCINGFPGFQGGQTLLENLGPN 455

  Fly   336 Y----RYAEGVNHD------------FFSVFAIFFPSVTGIQAGANICGDLKDAGAAIPKGTF-W 383
            |    ..|.|...|            ||.:.||:||:||||..|||:.||||:..|:||.||. .
 Worm   456 YLEKGEAAHGTQADTKSDVYQDVRTSFFVLLAIYFPAVTGIFTGANMSGDLKNPQASIPAGTIAA 520

  Fly   384 SLLISMSSYALFVLFAG---GAAVRDASGIPADLVNGTIVSSELPCMATGNCTWGLFNSYEMMQE 445
            :|..|...::|..:|.|   .|.:||.:|   ..|.|.:|.:.|        :|
 Worm   521 NLTTSFVYFSLAFIFGGAIDNAVLRDKNG---QSVGGQMVVALL--------SW----------- 563

  Fly   446 MSLWGPLIYAGCFAATLSTALTNLLSVPRLVQALGIDQIYPGLIFFSKPYGKHGEPYRGYVLTFF 510
            .|.|..||  |.|.:|...||..|.|.|||:||:..|::.|.|..|.| ...:.||:.|.:||..
 Worm   564 PSPWVLLI--GSFLSTFGAALQCLCSAPRLLQAIAKDEVIPLLSPFKK-VTANNEPFLGLILTTI 625

  Fly   511 ITTGFLLIGELNLIAPLISTFYLASYALIN-FCTFHAAFVKPLGWRPTFKYYNAWLSLFGFAMCV 574
            |....:|:|.::.||.::..|:|..||.:| .||.|:....| .|||.||||:.:|||.|..:|.
 Worm   626 IAEIAILMGSMDTIAAVVDFFFLMCYAFVNIICTLHSLLGAP-NWRPRFKYYHWFLSLLGAVLCF 689

  Fly   575 AIMFLINYVAAIITFGIIFALYLVVMYRKPEANWGSTTQAQQYKAALMAVHRLQNVSDHVKNYHP 639
            .|||..::..||:...:...:|..|.::..:..||...:......|..::.::::...|.||:.|
 Worm   690 FIMFSTHWDYAIVACLLCLVIYKYVEWKGAKKEWGDGIRGLALTTAQYSLMKIEDKEPHPKNWRP 754

  Fly   640 QVLVLSGDPKTRPPLVDFGYLLTKNNSLMFVANIIPVRVGYKNRQHLVKDGQKYLDARKIKAFYN 704
            |:|:|.                    |:.:...||.||  |.|..:|         |.::||.
 Worm   755 QLLLLL--------------------SMQWSKEIIDVR--YLNLLNL---------ASQLKAG-- 786

  Fly   705 VIDGFSLEDGINALTKSTGFGKMSPNIVLVGYKPDWNRCRKEEVESYFSILYNAFSQRMGVALLR 769
                       ..||..|.|.:..|.      .|| ::.:.|:|::           ||
 Worm   787 -----------KGLTVVTAFLQGDPT------SPD-DKKKGEQVKA-----------RM------ 816

  Fly   770 LPNGLDFSELSSEVTLPANGMGHMHTANAHGFTNELMPAANAASELLHIDSNLNLASMDSPNSSF 834
                 ||.               |:.....||          |..|:|.:..:.       .|..
 Worm   817 -----DFD---------------MNQVRLRGF----------AKTLVHSEDQVR-------GSMS 844

  Fly   835 TMPQPAPMPNMQRNSR--SYKVTSSDEPAVTYHT------------------KGGSDIPQNLLDA 879
            |:.|...:..::.|:.  |:.|...:|....|:|                  ||..|.|.
 Worm   845 TLVQSVGLGGLKPNTMLISWPVHEREEDMTEYNTFIEKVHAASINDMAIVVAKGIIDFPS----- 904

  Fly   880 MTIFTRKQPKGTIDVFWLYDDGGLTILLPYIISMRSHWQNSKLRVFAMCHGKD-----EEQEEKS 939
             .:|   :..|.|||:|:..||||.:|:.|::.....|:..||||..:....|     :|..:|.
 Worm   905 -AVF---RMSGMIDVYWIVHDGGLCLLMGYLLKQHKVWRGCKLRVIGIAQESDNNVKMQEDLQKY 965

  Fly   940 MASLLTKFRIKYSEL--------------------IMLK--------GVS-EQPRADTVLKHKRL 975
            :..|....:|...||                    :|::        |:| ..|.|:.......|
 Worm   966 VYQLRIDAKIMIVELADPEISKNAFERTLLMEERTMMMRDLQKVSGGGMSLSLPPANAPRAPSPL 1030

  Fly   976 IEPFRRG----------------ARNEFGITDDELQSMSEKTNRQ----------------LRIH 1008
            :...||.                ...:...||:|..:...||.::                :|::
 Worm  1031 VTSERRANSKDSDEGTPTESEETTEKKSTSTDNEQANQETKTKKERMKALDRSKVSKMHTAVRLN 1095

  Fly  1009 ELVVKHSSNASLVVMSLPMP--RKEAISAPLYMSWLEMLTSDMKCPVALARGNQTPVLT 1065
            ||:::||:|:.|::::||.|  .|:..:...|:.:||::|..:. .|...||....|:|
 Worm  1096 ELLLQHSANSQLILLNLPKPPVHKDQQALDDYVHYLEVMTDKLN-RVIFVRGTGKEVIT 1153

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NKCC	NP_730938.1	AA_permease_2	85..1068	CDD:459263	290/1166 (25%)
kcc-1	NP_001293846.1	AA_permease_2	166..1153	CDD:459263	285/1128 (25%)